JP2014511892A5 - - Google Patents

Info

Publication number

JP2014511892A5

JP2014511892A5 JP2014505612A JP2014505612A JP2014511892A5 JP 2014511892 A5 JP2014511892 A5 JP 2014511892A5 JP 2014505612 A JP2014505612 A JP 2014505612A JP 2014505612 A JP2014505612 A JP 2014505612A JP 2014511892 A5 JP2014511892 A5 JP 2014511892A5

Authority

JP

Japan

Prior art keywords

compound

salt

pharmaceutically acceptable

alkyl

acceptable salt

Prior art date

2012-04-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 150000001875 compounds Chemical class 0.000 claims 22
• 150000003839 salts Chemical class 0.000 claims 22
• 125000000217 alkyl group Chemical group 0.000 claims 6
• 201000010099 disease Diseases 0.000 claims 4
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
• 229910052739 hydrogen Inorganic materials 0.000 claims 3
• 239000001257 hydrogen Substances 0.000 claims 3
• 229940125763 bromodomain inhibitor Drugs 0.000 claims 2
• 125000000623 heterocyclic group Chemical group 0.000 claims 2
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
• 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
• 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 1
• SYWATAHTVWWKEE-CCLHPLFOSA-N 2-[4-[(2s,4r)-1-acetyl-4-[(5-cyanopyridin-2-yl)amino]-2-methyl-3,4-dihydro-2h-quinolin-6-yl]phenyl]-n-[2-(dimethylamino)ethyl]acetamide Chemical compound N([C@@H]1C[C@@H](N(C2=CC=C(C=C21)C=1C=CC(CC(=O)NCCN(C)C)=CC=1)C(C)=O)C)C1=CC=C(C#N)C=N1 SYWATAHTVWWKEE-CCLHPLFOSA-N 0.000 claims 1
• XZPYLOTVLUIJBU-QMHKHESXSA-N 6-[(2s,4r)-1-acetyl-4-[(5-cyanopyridin-2-yl)amino]-2-methyl-3,4-dihydro-2h-quinolin-6-yl]-n-(2-hydroxyethyl)pyridine-3-carboxamide Chemical compound N([C@@H]1C[C@@H](N(C2=CC=C(C=C21)C=1N=CC(=CC=1)C(=O)NCCO)C(C)=O)C)C1=CC=C(C#N)C=N1 XZPYLOTVLUIJBU-QMHKHESXSA-N 0.000 claims 1
• OSDXAECFLKDYBD-AVRWGWEMSA-N 6-[(2s,4r)-1-acetyl-4-[(5-cyanopyridin-2-yl)amino]-2-methyl-3,4-dihydro-2h-quinolin-6-yl]-n-[2-(dimethylamino)ethyl]pyridine-3-carboxamide Chemical compound N([C@@H]1C[C@@H](N(C2=CC=C(C=C21)C=1N=CC(=CC=1)C(=O)NCCN(C)C)C(C)=O)C)C1=CC=C(C#N)C=N1 OSDXAECFLKDYBD-AVRWGWEMSA-N 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 239000013543 active substance Substances 0.000 claims 1
• 125000003277 amino group Chemical group 0.000 claims 1
• 230000001363 autoimmune Effects 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 230000001684 chronic effect Effects 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 229910052736 halogen Inorganic materials 0.000 claims 1
• 150000002367 halogens Chemical class 0.000 claims 1
• 125000005842 heteroatom Chemical group 0.000 claims 1
• 230000004968 inflammatory condition Effects 0.000 claims 1
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 230000003287 optical effect Effects 0.000 claims 1
• 229910052760 oxygen Inorganic materials 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 239000000825 pharmaceutical preparation Substances 0.000 claims 1
• 229940127557 pharmaceutical product Drugs 0.000 claims 1
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
• 125000003373 pyrazinyl group Chemical group 0.000 claims 1
• 125000004076 pyridyl group Chemical group 0.000 claims 1
• 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
• 229920006395 saturated elastomer Polymers 0.000 claims 1
• 125000001424 substituent group Chemical group 0.000 claims 1
• 229910052717 sulfur Inorganic materials 0.000 claims 1
• 238000002560 therapeutic procedure Methods 0.000 claims 1
• VAWXXAHAIYEJAS-UHFFFAOYSA-N C=Cc(nc1)ccc1N Chemical compound C=Cc(nc1)ccc1N VAWXXAHAIYEJAS-UHFFFAOYSA-N 0.000 description 1
• KVFIJIWMDBAGDP-UHFFFAOYSA-N CCc1cnccn1 Chemical compound CCc1cnccn1 KVFIJIWMDBAGDP-UHFFFAOYSA-N 0.000 description 1
• RILVNLMOTMFTMQ-UHFFFAOYSA-N CCc1ncccn1 Chemical compound CCc1ncccn1 RILVNLMOTMFTMQ-UHFFFAOYSA-N 0.000 description 1