JP2015521195A5 - - Google Patents
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- Publication number
- JP2015521195A5 JP2015521195A5 JP2015514534A JP2015514534A JP2015521195A5 JP 2015521195 A5 JP2015521195 A5 JP 2015521195A5 JP 2015514534 A JP2015514534 A JP 2015514534A JP 2015514534 A JP2015514534 A JP 2015514534A JP 2015521195 A5 JP2015521195 A5 JP 2015521195A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- cycloalkyl
- substituents
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 103
- 125000001424 substituent group Chemical group 0.000 claims description 63
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 41
- 150000002391 heterocyclic compounds Chemical class 0.000 claims description 40
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 39
- 125000000623 heterocyclic group Chemical group 0.000 claims description 34
- 229920006395 saturated elastomer Polymers 0.000 claims description 34
- 125000001072 heteroaryl group Chemical group 0.000 claims description 30
- 125000001624 naphthyl group Chemical group 0.000 claims description 27
- 229910052760 oxygen Inorganic materials 0.000 claims description 23
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 22
- 229910052717 sulfur Inorganic materials 0.000 claims description 22
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 21
- 150000001875 compounds Chemical class 0.000 claims description 19
- 125000003545 alkoxy group Chemical group 0.000 claims description 17
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 17
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 17
- 229910052736 halogen Inorganic materials 0.000 claims description 17
- 150000002367 halogens Chemical class 0.000 claims description 17
- 125000005842 heteroatom Chemical group 0.000 claims description 17
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims description 17
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 17
- 229940124530 sulfonamide Drugs 0.000 claims description 17
- 150000003456 sulfonamides Chemical class 0.000 claims description 17
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 17
- 150000003573 thiols Chemical class 0.000 claims description 17
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims description 16
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims description 15
- 229910052739 hydrogen Inorganic materials 0.000 claims description 15
- 239000001257 hydrogen Substances 0.000 claims description 15
- 125000004429 atom Chemical group 0.000 claims description 14
- 208000035475 disorder Diseases 0.000 claims description 14
- 230000000495 immunoinflammatory effect Effects 0.000 claims description 13
- 150000003839 salts Chemical class 0.000 claims description 13
- 125000004043 oxo group Chemical group O=* 0.000 claims description 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 10
- 229910052757 nitrogen Inorganic materials 0.000 claims description 10
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 9
- 201000010099 disease Diseases 0.000 claims description 8
- 206010009900 Colitis ulcerative Diseases 0.000 claims description 7
- 208000011231 Crohn disease Diseases 0.000 claims description 7
- 206010020751 Hypersensitivity Diseases 0.000 claims description 7
- 201000004681 Psoriasis Diseases 0.000 claims description 7
- 208000025747 Rheumatic disease Diseases 0.000 claims description 7
- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 7
- 230000007815 allergy Effects 0.000 claims description 7
- 229910052799 carbon Inorganic materials 0.000 claims description 7
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims description 6
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 6
- 125000001326 naphthylalkyl group Chemical group 0.000 claims description 6
- 125000003884 phenylalkyl group Chemical group 0.000 claims description 6
- 125000005843 halogen group Chemical group 0.000 claims description 5
- 150000002431 hydrogen Chemical class 0.000 claims description 5
- 208000026935 allergic disease Diseases 0.000 claims description 4
- 125000001841 imino group Chemical group [H]N=* 0.000 claims description 4
- 238000004132 cross linking Methods 0.000 claims description 3
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 3
- 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 claims description 3
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 3
- 125000002433 cyclopentenyl group Chemical group C1(=CCCC1)* 0.000 claims description 3
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 3
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 3
- 125000003003 spiro group Chemical group 0.000 claims description 3
- 239000002671 adjuvant Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 4
- 125000003368 amide group Chemical group 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 241000255925 Diptera Species 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 238000000034 method Methods 0.000 description 5
- 208000005016 Intestinal Neoplasms Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 201000002313 intestinal cancer Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261654398P | 2012-06-01 | 2012-06-01 | |
| US61/654,398 | 2012-06-01 | ||
| PCT/EP2013/061328 WO2013178815A1 (en) | 2012-06-01 | 2013-05-31 | Bicyclic heterocycles capable of modulating t-cell responses, and methods of using same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015521195A JP2015521195A (ja) | 2015-07-27 |
| JP2015521195A5 true JP2015521195A5 (https=) | 2016-07-21 |
Family
ID=48538005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015514534A Pending JP2015521195A (ja) | 2012-06-01 | 2013-05-31 | Ｔ細胞受容体を調節することができる二環式複素環およびそれを使用するための方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20150126553A1 (https=) |
| EP (1) | EP2861563B1 (https=) |
| JP (1) | JP2015521195A (https=) |
| KR (1) | KR20150016377A (https=) |
| CN (1) | CN104619687A (https=) |
| AU (1) | AU2013269550A1 (https=) |
| BR (1) | BR112014030039A2 (https=) |
| CA (1) | CA2874919A1 (https=) |
| IN (1) | IN2014DN10214A (https=) |
| MX (1) | MX2014014657A (https=) |
| WO (1) | WO2013178815A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20050389A1 (it) | 2005-07-22 | 2007-01-23 | Giuliani Spa | Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico. |
| UA107562C2 (uk) | 2008-12-05 | 2015-01-26 | Спосіб лікування псоріазу | |
| WO2010091894A2 (en) | 2009-02-16 | 2010-08-19 | Giuliani International Limited | Methods of treating hair related conditions |
| CN109999017A (zh) | 2012-02-09 | 2019-07-12 | 诺格拉制药有限公司 | 治疗纤维化的方法 |
| CN104284655B (zh) | 2012-04-18 | 2017-10-27 | 诺格拉制药有限公司 | 治疗乳糖不耐受的方法 |
| US9013997B2 (en) | 2012-06-01 | 2015-04-21 | Broadcom Corporation | System for performing distributed data cut-through |
| CA3010615C (en) | 2016-01-14 | 2024-02-20 | Beth Israel Deaconess Medical Center, Inc. | Mast-cell modulators and uses thereof |
| MX2020010155A (es) * | 2018-03-27 | 2021-03-25 | Univ Texas | Compuestos de ox2r. |
| EP4495101A3 (en) | 2019-02-08 | 2025-04-30 | Nogra Pharma Limited | Process of making 3-(4'-aminophenyl)-2-methoxypropionic acid, and analogs and intermediates thereof |
| CR20220565A (es) | 2020-05-06 | 2023-01-13 | Merck Sharp & Dohme Llc | Inhibidores de il4i1 y métodos de uso |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1069385A1 (ru) * | 1982-05-07 | 1990-11-15 | Научно-исследовательский институт фармакологии АМН СССР | Бромид 2-амино-3-(1-адамантилкарбонилметил)-1-( @ -пиперидино-этил)-бензимидазоли , обладающий способностью угнетать иммунитет |
| US7868028B2 (en) * | 2002-06-17 | 2011-01-11 | Fred Drasner | Guanidine compounds as anesthetics and for treatment of nervous system disorders |
| CA2601458C (en) * | 2005-03-15 | 2011-04-26 | Pfizer Inc. | Benzimidazolone derivatives as cb2 receptor ligands |
| EP1926734A1 (en) * | 2005-08-22 | 2008-06-04 | Amgen Inc. | Pyrazolopyridine and pyrazolopyrimidine compounds useful as kinase enzymes modulators |
| WO2007084728A2 (en) * | 2006-01-19 | 2007-07-26 | Abbott Laboratories | 2-imino-benzimidazoles |
| US20080206287A1 (en) * | 2006-09-18 | 2008-08-28 | Reed John C | Use of cyclosporin A to sensitize resistant cancer cells to death receptor ligands |
| HRP20191953T8 (hr) * | 2008-03-07 | 2021-06-25 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. | DERIVATI 1-BENZIL-3-HIDROKSIMETILINDAZOLA I NJIHOVA UPORABA U LIJEČENJU BOLESTI KOJE SE BAZIRAJU NA EKSPRESIJI MCP-1, CX3CR1 i P40 |
| EP2262777B8 (en) * | 2008-03-07 | 2016-05-04 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A. | 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1 and cx3cr1 |
-
2013
- 2013-05-31 EP EP13726005.5A patent/EP2861563B1/en not_active Not-in-force
- 2013-05-31 CN CN201380033704.2A patent/CN104619687A/zh active Pending
- 2013-05-31 MX MX2014014657A patent/MX2014014657A/es unknown
- 2013-05-31 US US14/404,838 patent/US20150126553A1/en not_active Abandoned
- 2013-05-31 JP JP2015514534A patent/JP2015521195A/ja active Pending
- 2013-05-31 CA CA 2874919 patent/CA2874919A1/en not_active Abandoned
- 2013-05-31 IN IN10214DEN2014 patent/IN2014DN10214A/en unknown
- 2013-05-31 KR KR20147036702A patent/KR20150016377A/ko not_active Withdrawn
- 2013-05-31 AU AU2013269550A patent/AU2013269550A1/en not_active Abandoned
- 2013-05-31 WO PCT/EP2013/061328 patent/WO2013178815A1/en not_active Ceased
- 2013-05-31 BR BR112014030039A patent/BR112014030039A2/pt not_active IP Right Cessation
-
2016
- 2016-12-14 US US15/378,672 patent/US20170183313A1/en not_active Abandoned
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