CN110036005A - 酰胺衍生物及其在药物中的应用 - Google Patents
酰胺衍生物及其在药物中的应用 Download PDFInfo
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- CN110036005A CN110036005A CN201780070415.8A CN201780070415A CN110036005A CN 110036005 A CN110036005 A CN 110036005A CN 201780070415 A CN201780070415 A CN 201780070415A CN 110036005 A CN110036005 A CN 110036005A
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/4196—1,2,4-Triazoles
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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Abstract
一种酰胺衍生物及其在药物中的应用被公开。具体地,一种新型的用做ASK1活性调节剂的酰胺衍生物及其立体异构体、几何异构体、互变异构体、氮氧化物、水合物、溶剂化物、代谢产物、药学上可接受的盐或前药以及所述衍生物在制备治疗ASK1调节的疾病和/或病症药物中的用途被公开。含有所述化合物的药物组合物和使用所述化合物或药物组合物治疗ASK1调节的疾病和/或病症的方法进一步被公开。
Description
PCT国内申请,说明书已公开。
Claims (15)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201611008179 | 2016-11-16 | ||
CN2016110081790 | 2016-11-16 | ||
PCT/CN2017/110326 WO2018090869A1 (zh) | 2016-11-16 | 2017-11-10 | 酰胺衍生物及其在药物中的应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN110036005A true CN110036005A (zh) | 2019-07-19 |
CN110036005B CN110036005B (zh) | 2022-09-27 |
Family
ID=62146129
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201780070415.8A Active CN110036005B (zh) | 2016-11-16 | 2017-11-10 | 酰胺衍生物及其在药物中的应用 |
Country Status (2)
Country | Link |
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CN (1) | CN110036005B (zh) |
WO (1) | WO2018090869A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115504986A (zh) * | 2017-03-03 | 2022-12-23 | 江苏豪森药业集团有限公司 | 凋亡信号调节激酶抑制剂及其制备方法和应用 |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10683279B2 (en) | 2017-05-12 | 2020-06-16 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
WO2018218042A1 (en) | 2017-05-25 | 2018-11-29 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
US10246439B2 (en) | 2017-05-25 | 2019-04-02 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
US10450301B2 (en) | 2017-05-25 | 2019-10-22 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
US10597382B2 (en) | 2017-08-28 | 2020-03-24 | Enanta Pharmaceuticals, Inc. | Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
US10683289B2 (en) | 2018-05-02 | 2020-06-16 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
AU2019262016B2 (en) | 2018-05-02 | 2024-07-11 | Enanta Pharmaceuticals, Inc. | Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
CN110818683B (zh) * | 2018-08-10 | 2023-04-14 | 中国科学院上海药物研究所 | 2-吡啶取代脲结构小分子化合物及其合成和应用 |
CN111132984A (zh) * | 2018-08-14 | 2020-05-08 | 江苏豪森药业集团有限公司 | 凋亡信号调节激酶1抑制剂的盐及其晶型 |
WO2020041417A1 (en) | 2018-08-22 | 2020-02-27 | Enanta Pharmaceuticals, Inc. | Cycloalkyl-containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
CN111170995A (zh) * | 2018-11-09 | 2020-05-19 | 山东轩竹医药科技有限公司 | Ask1抑制剂及其应用 |
WO2020106707A1 (en) | 2018-11-19 | 2020-05-28 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
WO2020198214A1 (en) | 2019-03-25 | 2020-10-01 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
JP7406008B2 (ja) * | 2020-05-12 | 2023-12-26 | 蘇州阿尓脈生物科技有限公司 | Cdk9阻害剤としての多環式アミド系誘導体、その調製方法及び用途 |
AU2021356641A1 (en) * | 2020-10-09 | 2023-06-15 | Buck Institute For Research On Aging | Heteroaryl amide inhibitors of cd38 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101878212A (zh) * | 2007-08-31 | 2010-11-03 | 默克雪兰诺有限公司 | 三唑并吡啶化合物及其作为ask抑制剂的用途 |
CN102482257A (zh) * | 2009-07-13 | 2012-05-30 | 吉利德科学股份有限公司 | 凋亡信号调节激酶抑制剂 |
WO2015187499A1 (en) * | 2014-06-03 | 2015-12-10 | Gilead Sciences, Inc. | Use of an ask1 inhibitor for the treatment of liver disease, optionally in combination with a loxl2 inhibitor |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ604831A (en) * | 2010-07-02 | 2014-12-24 | Gilead Sciences Inc | Apoptosis signal-regulating kinase inhibitors |
UY35212A (es) * | 2012-12-21 | 2014-06-30 | Gilead Sciences Inc | Inhibidores de la quinasa que regula la señal de la apoptosis |
AU2014366235B2 (en) * | 2013-12-20 | 2017-04-13 | Gilead Sciences, Inc. | Apoptosis signal-regulating kinase inhibitors |
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2017
- 2017-11-10 WO PCT/CN2017/110326 patent/WO2018090869A1/zh active Application Filing
- 2017-11-10 CN CN201780070415.8A patent/CN110036005B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101878212A (zh) * | 2007-08-31 | 2010-11-03 | 默克雪兰诺有限公司 | 三唑并吡啶化合物及其作为ask抑制剂的用途 |
CN102482257A (zh) * | 2009-07-13 | 2012-05-30 | 吉利德科学股份有限公司 | 凋亡信号调节激酶抑制剂 |
WO2015187499A1 (en) * | 2014-06-03 | 2015-12-10 | Gilead Sciences, Inc. | Use of an ask1 inhibitor for the treatment of liver disease, optionally in combination with a loxl2 inhibitor |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115504986A (zh) * | 2017-03-03 | 2022-12-23 | 江苏豪森药业集团有限公司 | 凋亡信号调节激酶抑制剂及其制备方法和应用 |
CN115504986B (zh) * | 2017-03-03 | 2024-05-14 | 江苏豪森药业集团有限公司 | 凋亡信号调节激酶抑制剂及其制备方法和应用 |
Also Published As
Publication number | Publication date |
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WO2018090869A1 (zh) | 2018-05-24 |
CN110036005B (zh) | 2022-09-27 |
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Address after: 523808 No.1, Gongye North Road, Songshanhu Park, Dongguan City, Guangdong Province Patentee after: Guangdong Dongyangguang Pharmaceutical Co.,Ltd. Address before: 523808 Songshan Lake Science and Technology Industrial Park, Dongguan City, Guangdong Province Patentee before: SUNSHINE LAKE PHARMA Co.,Ltd. |
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