JP7553450B2 - ユビキチン特異的プロテアーゼ１を阻害するための組成物 - Google Patents

ユビキチン特異的プロテアーゼ１を阻害するための組成物 Download PDF

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JP7553450B2
JP7553450B2 JP2021537781A JP2021537781A JP7553450B2 JP 7553450 B2 JP7553450 B2 JP 7553450B2 JP 2021537781 A JP2021537781 A JP 2021537781A JP 2021537781 A JP2021537781 A JP 2021537781A JP 7553450 B2 JP7553450 B2 JP 7553450B2
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alkyl
nitrogen
sulfur
oxygen
heteroatoms selected
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JP2022516469A (ja
JP2022516469A5 (https=
JPWO2020139988A5 (https=
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アレクサンダー ジョセフ バックメルター，
ジャスティン アンドリュー カラベラ，
ジャン リン，
エドワード エル． フリッツェン，
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フォーマ セラピューティクス，インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2021537781A 2018-12-28 2019-12-27 ユビキチン特異的プロテアーゼ１を阻害するための組成物 Active JP7553450B2 (ja)

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US201862785733P 2018-12-28 2018-12-28
US62/785,733 2018-12-28
PCT/US2019/068648 WO2020139988A1 (en) 2018-12-28 2019-12-27 Compositions for inhibiting ubiquitin specific protease 1

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JP2022516469A JP2022516469A (ja) 2022-02-28
JP2022516469A5 JP2022516469A5 (https=) 2022-12-22
JPWO2020139988A5 JPWO2020139988A5 (https=) 2022-12-22
JP7553450B2 true JP7553450B2 (ja) 2024-09-18

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JP2021537781A Active JP7553450B2 (ja) 2018-12-28 2019-12-27 ユビキチン特異的プロテアーゼ１を阻害するための組成物

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US (1) US20220073525A1 (https=)
EP (1) EP3902802A4 (https=)
JP (1) JP7553450B2 (https=)
CN (1) CN113474346B (https=)
WO (1) WO2020139988A1 (https=)

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US10189841B2 (en) 2015-11-20 2019-01-29 Forma Therapeutics, Inc. Purinones as ubiquitin-specific protease 1 inhibitors
US20240182481A1 (en) * 2021-02-15 2024-06-06 Tango Therapeutics, Inc. Pyrrolo[3,2-d]pyrimidine compounds and methods of use in the treatment of cancer
MX2023011709A (es) * 2021-04-07 2023-10-12 Forma Therapeutics Inc Inhibidor de la proteasa 1 especifica de ubiquitina (usp1).
EP4321515A4 (en) * 2021-04-09 2025-06-25 Hainan Simcere Zaiming Pharmaceutical Co., Ltd. UBIQUITIN-SPECIFIC PROTEASE-1 INHIBITOR
KR102910851B1 (ko) * 2021-04-21 2026-01-09 장춘 진사이언스 파마슈티컬 씨오., 엘티디. 이미다졸 함유 축합고리계 유도체, 이의 제조방법 및 이의 의약적 용도
WO2022253188A1 (en) * 2021-05-31 2022-12-08 Impact Therapeutics (Shanghai) , Inc Nitrogen-containing fused heteroaromatic bicyclic compounds as usp1 inhibitors and the use thereof
JP2024540921A (ja) * 2021-10-19 2024-11-06 上海瑛派▲薬▼▲業▼有限公司 Ｕｓｐ１阻害剤としての置換トリアゾロヘテロアリール化合物及びその応用
CR20240191A (es) 2021-11-12 2024-09-13 Insilico Medicine Ip Ltd Inhibidores de molécula pequeña de proteasa 1 específica de ubiquitina (usp1) y usos de los mismos
US20250163049A1 (en) * 2022-02-03 2025-05-22 Exelixis, Inc. Fused bicyclic heterocyclyl compounds as usp1 inhibitors
AU2023261809A1 (en) * 2022-04-29 2024-12-05 Asieris Pharmaceuticals (Shanghai) Co., Ltd. Pyrimidine compound, method for preparing same, and pharmaceutical use thereof
WO2024006879A1 (en) * 2022-06-29 2024-01-04 Zentaur Therapeutics Usa Inc. Usp1 inhibitors and uses thereof
WO2024022519A1 (zh) * 2022-07-28 2024-02-01 先声再明医药有限公司 杂环并嘧啶类化合物及其应用
CN119790043A (zh) * 2022-08-26 2025-04-08 海南先声再明医药股份有限公司 三环类化合物及其应用
WO2024078436A1 (zh) * 2022-10-09 2024-04-18 海南先声再明医药股份有限公司 杂环并嘧啶类化合物、药物组合物及其应用
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CN120603835A (zh) * 2023-01-20 2025-09-05 杭州英创医药科技有限公司 作为usp1抑制剂的化合物
WO2024233665A1 (en) 2023-05-08 2024-11-14 Tango Therapeutics, Inc. Compounds and their use against cancer
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WO2025010245A1 (en) 2023-07-06 2025-01-09 Exelixis, Inc. Fused pyrazole derivatives as usp1 inhibitors
CN119930633B (zh) * 2023-11-06 2025-11-18 中国医学科学院药物研究所 一种吡咯并蝶啶酮类泛素特异性蛋白酶1抑制剂及其制备方法、用途和药物组合物
CN119930632B (zh) * 2023-11-06 2025-11-18 中国医学科学院药物研究所 一种三并环类泛素特异性蛋白酶1抑制剂及其制备方法、用途和药物组合物
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Publication number Publication date
JP2022516469A (ja) 2022-02-28
EP3902802A1 (en) 2021-11-03
CN113474346A (zh) 2021-10-01
CN113474346B (zh) 2024-12-27
EP3902802A4 (en) 2022-09-07
US20220073525A1 (en) 2022-03-10
WO2020139988A1 (en) 2020-07-02

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