JP2010535032A - 多重特異性エピトープ結合性タンパク質およびその用途 - Google Patents

多重特異性エピトープ結合性タンパク質およびその用途 Download PDF

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JP2010535032A
JP2010535032A JP2010520165A JP2010520165A JP2010535032A JP 2010535032 A JP2010535032 A JP 2010535032A JP 2010520165 A JP2010520165 A JP 2010520165A JP 2010520165 A JP2010520165 A JP 2010520165A JP 2010535032 A JP2010535032 A JP 2010535032A
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region
terminus
epitope binding
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JP2010535032A5 (cg-RX-API-DMAC7.html
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ウー,ヘレン
ガオ,チャンショウ
ヘイ,カール
ディマシー,ナッツァレーノ
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メディミューン,エルエルシー
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • C07K16/468Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/522CH1 domain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2010520165A 2007-07-31 2008-07-30 多重特異性エピトープ結合性タンパク質およびその用途 Pending JP2010535032A (ja)

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US93519907P 2007-07-31 2007-07-31
US1265607P 2007-12-10 2007-12-10
US7433008P 2008-06-20 2008-06-20
PCT/US2008/071656 WO2009018386A1 (en) 2007-07-31 2008-07-30 Multispecific epitope binding proteins and uses thereof

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JP2010535032A5 JP2010535032A5 (cg-RX-API-DMAC7.html) 2011-09-22

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EP (2) EP2626371A1 (cg-RX-API-DMAC7.html)
JP (1) JP2010535032A (cg-RX-API-DMAC7.html)
KR (1) KR20100058509A (cg-RX-API-DMAC7.html)
CN (1) CN101952312A (cg-RX-API-DMAC7.html)
AU (1) AU2008282218A1 (cg-RX-API-DMAC7.html)
CA (1) CA2694488A1 (cg-RX-API-DMAC7.html)
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JP2014529402A (ja) * 2011-08-23 2014-11-13 ロシュ グリクアート アーゲー 二重特異性t細胞活性化抗原結合分子
JP2014529600A (ja) * 2011-08-23 2014-11-13 ロシュ グリクアート アーゲー T細胞活性化抗原に対して特異的な二重特異性抗体及び腫瘍抗原および使用方法
JP2014530009A (ja) * 2011-09-29 2014-11-17 エーピーオー‐ティー ビー.ヴイ. 異常細胞を標的とする多重特異性結合分子
JP2014533249A (ja) * 2011-11-07 2014-12-11 メディミューン,エルエルシー 多重特異性を持つ多価結合タンパク質およびその使用
JP2015523320A (ja) * 2012-04-30 2015-08-13 メディミューン,エルエルシー 低減されたエフェクター機能及び延長された半減期を有する分子、組成物、並びにそれらの使用
JP2016503069A (ja) * 2013-01-09 2016-02-01 メセレシス・トランスレイショナル・リサーチ・ソシエタ・アノニマMetheresis Translational Research S.A. 新規な抗体フラグメント、組成物およびその使用
JP2016525551A (ja) * 2013-07-25 2016-08-25 シトムクス セラピューティクス,インコーポレイティド 多重特異性抗体、多重特異性活性化可能抗体、及びそれらの使用方法
JP2017506215A (ja) * 2013-12-30 2017-03-02 エピムアブ バイオセラピューティクス インコーポレイテ タンデム型Fab免疫グロブリン及びその使用
JP2020011969A (ja) * 2013-10-14 2020-01-23 ヤンセン バイオテツク,インコーポレーテツド システイン改変フィブロネクチンiii型ドメイン結合分子
JP2020516287A (ja) * 2017-04-11 2020-06-11 インヒブルクス インコーポレイテッド 制約されたcd3結合を有する多重特異性ポリペプチド構築物およびそれを使用する方法
JP2020528758A (ja) * 2017-07-31 2020-10-01 インスティテュート・フォー・リサーチ・イン・バイオメディシンInstitute For Research In Biomedicine 可変ドメインと定常ドメインとの間のエルボー領域に機能的ドメインを有する抗体
US10946104B2 (en) 2012-01-13 2021-03-16 Apo-Tb.V. Aberrant cell-restricted immunoglobulins provided with a toxic moiety
JP2021531785A (ja) * 2018-07-24 2021-11-25 インヒブルクス インコーポレイテッド 制約されたcd3結合ドメインおよび受容体結合領域を含有する多重特異性ポリペプチド構築物ならびにそれを使用する方法
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JP2023548346A (ja) * 2020-11-11 2023-11-16 ハン,ハック アクチビン/tgf-ベータおよびranklの二機能性アンタゴニストならびにその使用
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