JP2010523553A5 - - Google Patents
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- JP2010523553A5 JP2010523553A5 JP2010501660A JP2010501660A JP2010523553A5 JP 2010523553 A5 JP2010523553 A5 JP 2010523553A5 JP 2010501660 A JP2010501660 A JP 2010501660A JP 2010501660 A JP2010501660 A JP 2010501660A JP 2010523553 A5 JP2010523553 A5 JP 2010523553A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- treatment
- cyclosporine
- drug
- hours
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 claims 30
- 229940079593 drug Drugs 0.000 claims 14
- 239000003814 drug Substances 0.000 claims 14
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 13
- 108010036949 Cyclosporine Proteins 0.000 claims 13
- 229960001265 ciclosporin Drugs 0.000 claims 13
- 229930182912 cyclosporin Natural products 0.000 claims 12
- 239000002775 capsule Substances 0.000 claims 11
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 6
- 208000024908 graft versus host disease Diseases 0.000 claims 6
- 230000002265 prevention Effects 0.000 claims 5
- 206010009900 Colitis ulcerative Diseases 0.000 claims 4
- 208000011231 Crohn disease Diseases 0.000 claims 4
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 210000001072 colon Anatomy 0.000 claims 4
- 238000009472 formulation Methods 0.000 claims 4
- 239000001856 Ethyl cellulose Substances 0.000 claims 3
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 3
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 3
- 239000013543 active substance Substances 0.000 claims 3
- 238000004090 dissolution Methods 0.000 claims 3
- 235000019325 ethyl cellulose Nutrition 0.000 claims 3
- 229920001249 ethyl cellulose Polymers 0.000 claims 3
- 230000002496 gastric effect Effects 0.000 claims 3
- 210000003405 ileum Anatomy 0.000 claims 3
- 239000007788 liquid Substances 0.000 claims 3
- RPTUSVTUFVMDQK-UHFFFAOYSA-N Hidralazin Chemical compound C1=CC=C2C(NN)=NN=CC2=C1 RPTUSVTUFVMDQK-UHFFFAOYSA-N 0.000 claims 2
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 2
- 239000011248 coating agent Substances 0.000 claims 2
- 238000000576 coating method Methods 0.000 claims 2
- 238000013270 controlled release Methods 0.000 claims 2
- 238000001816 cooling Methods 0.000 claims 2
- 230000002708 enhancing effect Effects 0.000 claims 2
- 239000000499 gel Substances 0.000 claims 2
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 230000003232 mucoadhesive effect Effects 0.000 claims 2
- 239000000419 plant extract Substances 0.000 claims 2
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 2
- 229960002930 sirolimus Drugs 0.000 claims 2
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 229920000856 Amylose Polymers 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 102000014914 Carrier Proteins Human genes 0.000 claims 1
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 208000019399 Colonic disease Diseases 0.000 claims 1
- 229930105110 Cyclosporin A Natural products 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 229940122439 Hydroxylase inhibitor Drugs 0.000 claims 1
- 102000014150 Interferons Human genes 0.000 claims 1
- 108010050904 Interferons Proteins 0.000 claims 1
- 206010051606 Necrotising colitis Diseases 0.000 claims 1
- 206010036774 Proctitis Diseases 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 1
- 108091008324 binding proteins Proteins 0.000 claims 1
- 229940046731 calcineurin inhibitors Drugs 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000000824 cytostatic agent Substances 0.000 claims 1
- 230000001085 cytostatic effect Effects 0.000 claims 1
- BNJOZDZCRHCODO-UHFFFAOYSA-N dimethyloxalylglycine Chemical compound COC(=O)CNC(=O)C(=O)OC BNJOZDZCRHCODO-UHFFFAOYSA-N 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 239000000284 extract Substances 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000007903 gelatin capsule Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 229960002474 hydralazine Drugs 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 229940047124 interferons Drugs 0.000 claims 1
- 208000023569 ischemic bowel disease Diseases 0.000 claims 1
- 239000010410 layer Substances 0.000 claims 1
- 210000003750 lower gastrointestinal tract Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- RTGDFNSFWBGLEC-SYZQJQIISA-N mycophenolate mofetil Chemical compound COC1=C(C)C=2COC(=O)C=2C(O)=C1C\C=C(/C)CCC(=O)OCCN1CCOCC1 RTGDFNSFWBGLEC-SYZQJQIISA-N 0.000 claims 1
- 229960004866 mycophenolate mofetil Drugs 0.000 claims 1
- 208000004995 necrotizing enterocolitis Diseases 0.000 claims 1
- 229940005483 opioid analgesics Drugs 0.000 claims 1
- 239000006186 oral dosage form Substances 0.000 claims 1
- 239000001814 pectin Substances 0.000 claims 1
- 235000010987 pectin Nutrition 0.000 claims 1
- 229920001277 pectin Polymers 0.000 claims 1
- 201000006195 perinatal necrotizing enterocolitis Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000002356 single layer Substances 0.000 claims 1
- 210000000813 small intestine Anatomy 0.000 claims 1
- 239000008137 solubility enhancer Substances 0.000 claims 1
- 229960001967 tacrolimus Drugs 0.000 claims 1
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 239000000341 volatile oil Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90749007P | 2007-04-04 | 2007-04-04 | |
| US60/907,490 | 2007-04-04 | ||
| US649808P | 2008-01-16 | 2008-01-16 | |
| US61/006,498 | 2008-01-16 | ||
| PCT/IE2008/000038 WO2008122965A2 (en) | 2007-04-04 | 2008-04-04 | Pharmaceutical cyclosporin compositions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010523553A JP2010523553A (ja) | 2010-07-15 |
| JP2010523553A5 true JP2010523553A5 (https=) | 2011-05-19 |
| JP5553747B2 JP5553747B2 (ja) | 2014-07-16 |
Family
ID=39745242
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010501660A Expired - Fee Related JP5553747B2 (ja) | 2007-04-04 | 2008-04-04 | シクロスポリン医薬組成物 |
| JP2010501662A Pending JP2010523555A (ja) | 2007-04-04 | 2008-04-04 | 「経口医薬組成物」 |
| JP2010501661A Withdrawn JP2010523554A (ja) | 2007-04-04 | 2008-04-04 | タクロリムスの医薬組成物 |
| JP2014149027A Expired - Fee Related JP6059688B2 (ja) | 2007-04-04 | 2014-07-22 | 「経口医薬組成物」 |
| JP2015221221A Active JP6149090B2 (ja) | 2007-04-04 | 2015-11-11 | 「経口医薬組成物」 |
| JP2017091572A Pending JP2017160241A (ja) | 2007-04-04 | 2017-05-02 | 「経口医薬組成物」 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010501662A Pending JP2010523555A (ja) | 2007-04-04 | 2008-04-04 | 「経口医薬組成物」 |
| JP2010501661A Withdrawn JP2010523554A (ja) | 2007-04-04 | 2008-04-04 | タクロリムスの医薬組成物 |
| JP2014149027A Expired - Fee Related JP6059688B2 (ja) | 2007-04-04 | 2014-07-22 | 「経口医薬組成物」 |
| JP2015221221A Active JP6149090B2 (ja) | 2007-04-04 | 2015-11-11 | 「経口医薬組成物」 |
| JP2017091572A Pending JP2017160241A (ja) | 2007-04-04 | 2017-05-02 | 「経口医薬組成物」 |
Country Status (11)
| Country | Link |
|---|---|
| US (11) | US9114071B2 (https=) |
| EP (5) | EP2061440A2 (https=) |
| JP (6) | JP5553747B2 (https=) |
| CN (6) | CN101686948B (https=) |
| CA (3) | CA2683407C (https=) |
| CY (1) | CY1113882T1 (https=) |
| DK (1) | DK2079456T3 (https=) |
| ES (3) | ES2393814T3 (https=) |
| HR (1) | HRP20130173T1 (https=) |
| PT (1) | PT2079456E (https=) |
| WO (3) | WO2008122967A2 (https=) |
Families Citing this family (134)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2922402B2 (ja) | 1993-10-14 | 1999-07-26 | 住友重機械工業株式会社 | 熱成形方法及びその熱成形装置 |
| ES2393814T3 (es) | 2007-04-04 | 2012-12-28 | Sigmoid Pharma Limited | Una composición farmacéutica oral |
| CA2685118C (en) * | 2007-04-26 | 2016-11-01 | Sigmoid Pharma Limited | Manufacture of multiple minicapsules |
| WO2008132712A2 (en) * | 2007-05-01 | 2008-11-06 | Sigmoid Pharma Limited | Combination pharmaceutical compositions |
| CA2719134C (en) | 2008-03-21 | 2015-06-30 | The University Of Chicago | Treatment with opioid antagonists and mtor inhibitors |
| RU2593939C2 (ru) | 2008-11-13 | 2016-08-10 | Ногра Фарма Лимитед | Антисмысловые композиции и способы их получения и применения |
| ES2530049T3 (es) | 2009-05-18 | 2015-02-26 | Sigmoid Pharma Limited | Composición que comprende gotas de aceite |
| CN102573802A (zh) * | 2009-08-12 | 2012-07-11 | 希格默伊德药业有限公司 | 包含聚合物基质和油相的免疫调节组合物 |
| WO2015161139A1 (en) | 2014-04-16 | 2015-10-22 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
| US8628554B2 (en) | 2010-06-13 | 2014-01-14 | Virender K. Sharma | Intragastric device for treating obesity |
| US10420665B2 (en) | 2010-06-13 | 2019-09-24 | W. L. Gore & Associates, Inc. | Intragastric device for treating obesity |
| US9526648B2 (en) | 2010-06-13 | 2016-12-27 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| US10010439B2 (en) | 2010-06-13 | 2018-07-03 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| KR101245078B1 (ko) * | 2010-11-11 | 2013-03-18 | 부산대학교 산학협력단 | 대장 선택성 셀레콕시브 전구체 화합물 및 이를 유효성분으로 함유하는 대장성 질환 치료 또는 예방용 약학조성물 |
| GB201020032D0 (en) * | 2010-11-25 | 2011-01-12 | Sigmoid Pharma Ltd | Composition |
| US11241391B2 (en) | 2011-03-23 | 2022-02-08 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
| AU2012230733B2 (en) | 2011-03-23 | 2016-10-20 | Ironshore Pharmaceuticals & Development, Inc. | Methods and compositions for treatment of attention deficit disorder |
| US9603809B2 (en) | 2011-03-23 | 2017-03-28 | Ironshore Pharmaceuticals & Development, Inc. | Methods of treatment of attention deficit hyperactivity disorder |
| US10905652B2 (en) | 2011-03-23 | 2021-02-02 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
| US8916588B2 (en) | 2011-03-23 | 2014-12-23 | Ironshore Pharmaceuticals & Development, Inc. | Methods for treatment of attention deficit hyperactivity disorder |
| US10292937B2 (en) | 2011-03-23 | 2019-05-21 | Ironshore Pharmaceuticals & Development, Inc. | Methods of treatment of attention deficit hyperactivity disorder |
| US9119809B2 (en) | 2011-03-23 | 2015-09-01 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
| US8927010B2 (en) | 2011-03-23 | 2015-01-06 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
| US9498447B2 (en) | 2011-03-23 | 2016-11-22 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
| US9283214B2 (en) | 2011-03-23 | 2016-03-15 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
| WO2012145749A1 (en) | 2011-04-22 | 2012-10-26 | Napo Pharmaceuticals, Inc. | Pharmacologically optimized multimodal drug delivery system for nordihydroguiaretic acid (ndga) |
| MX374963B (es) | 2011-04-29 | 2025-03-06 | Selecta Biosciences Inc | Nanoportadores sintéticos tolerogénicos para reducir las respuestas de anticuerpos. |
| US9561241B1 (en) * | 2011-06-28 | 2017-02-07 | Medicis Pharmaceutical Corporation | Gastroretentive dosage forms for minocycline |
| WO2013124416A1 (en) * | 2012-02-23 | 2013-08-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Calcineurin inhibitors for use in the treatment of lesional vestibular disorders |
| CA3008794C (en) * | 2012-03-29 | 2021-03-16 | Therabiome, Llc | Gastrointestinal site-specific oral vaccination formulations active on the ileum and appendix |
| CN104470361A (zh) * | 2012-05-04 | 2015-03-25 | 芝加哥大学 | 利用基于磷脂酰胆碱的制剂增加口服甲基纳曲酮的生物利用度 |
| DE102012105528A1 (de) * | 2012-06-25 | 2014-01-02 | Hennig Arzneimittel Gmbh & Co. Kg | Arzneiform zur Freisetzung von Wirkstoffen |
| GB201212010D0 (en) | 2012-07-05 | 2012-08-22 | Sigmoid Pharma Ltd | Formulations |
| JP5992247B2 (ja) * | 2012-08-13 | 2016-09-14 | 国立大学法人大阪大学 | 核酸医薬経口製剤 |
| JP6062802B2 (ja) * | 2012-08-23 | 2017-01-18 | 日清ファルマ株式会社 | キトサン含有組成物及びキトサンコーティング組成物 |
| GB201304662D0 (en) | 2013-03-14 | 2013-05-01 | Sigmoid Pharma Ltd | Compositions |
| AU2014239883B2 (en) | 2013-03-14 | 2019-01-17 | Therabiome, Llc | Targeted gastrointestinal tract delivery of probiotic organisms and/or therapeutic agents |
| SG11201507140PA (en) * | 2013-03-15 | 2015-10-29 | Galleon Pharmaceuticals Inc | Novel breathing control modulating compounds, and methods of using same |
| BR122020023215B1 (pt) | 2013-05-03 | 2022-11-22 | Selecta Biosciences, Inc | Composição e kit de nanocarreadores sintéticos tolerogênicos para reduzir ou prevenir anafilaxia em resposta a um antígeno não alergênico |
| US9415110B1 (en) | 2013-05-08 | 2016-08-16 | The Arizona Board of Regents on behalf of the Univeristy of Arizona | Method and compositions for targeted drug delivery to the lower GI tract |
| CN104127466B (zh) * | 2013-08-23 | 2018-05-22 | 江苏省中医药研究院 | 一种淫羊藿总黄酮口服肠溶制剂及其应用 |
| CN104548063A (zh) * | 2013-10-29 | 2015-04-29 | 中国科学院上海有机化学研究所 | 一种免疫抑制剂在制备线粒体丝氨酸/苏氨酸蛋白磷酸酶抑制剂中的用途 |
| GB201319792D0 (en) | 2013-11-08 | 2013-12-25 | Sigmoid Pharma Ltd | Formulations |
| GB201319791D0 (en) | 2013-11-08 | 2013-12-25 | Sigmoid Pharma Ltd | Formulations |
| HUP1300647A2 (hu) | 2013-11-12 | 2015-05-28 | Druggability Technologies Ip Holdco Jersey Ltd | Ciklosporin A és származékainak komplexei, elõállításuk és gyógyszerészeti kompozícióik |
| AU2014354599A1 (en) * | 2013-11-27 | 2016-06-09 | Research Foundation Of The City University Of New York | Activity enhancing curcumin compositions and methods of use |
| EP3089737B1 (en) | 2013-12-31 | 2021-11-03 | Rapamycin Holdings, LLC | Oral rapamycin nanoparticle preparations and use |
| GB201400442D0 (en) * | 2014-01-10 | 2014-02-26 | Sigmoid Pharma Ltd | Compositions for use in the treatment of ulcerative colitis |
| US10220076B2 (en) | 2014-05-15 | 2019-03-05 | Incube Labs, Llc | Pharmaceutical compositions and methods for fabrication of solid masses comprising glucose regulating proteins |
| WO2016003536A1 (en) * | 2014-06-30 | 2016-01-07 | Salix Pharmaceuticals, Inc. | Methods for retreating irritable bowel syndrome (ibs) |
| MA40071A (fr) | 2014-07-01 | 2016-01-07 | Probi Usa Inc | Comprimés probiotiques bi-couche à double libération |
| WO2016020336A1 (en) * | 2014-08-04 | 2016-02-11 | Dbv Technologies | Compositions of food allergens |
| WO2016036578A1 (en) | 2014-09-02 | 2016-03-10 | Purecircle Sdn Bhd | Stevia extracts |
| JP7242180B2 (ja) | 2014-09-07 | 2023-03-20 | セレクタ バイオサイエンシーズ インコーポレーテッド | 抗ウイルス導入ベクター免疫応答を減弱化するための方法および組成物 |
| CN104224732B (zh) * | 2014-09-29 | 2017-06-30 | 江苏大学 | 一种口服骨架型环孢素a缓释微丸制剂及其制备方法 |
| CA2936740C (en) | 2014-10-31 | 2017-10-10 | Purdue Pharma | Methods and compositions particularly for treatment of attention deficit disorder |
| JP6716582B2 (ja) * | 2014-11-07 | 2020-07-01 | サブリミティ・セラピューティクス・リミテッドＳｕｂｌｉｍｉｔｙ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ | シクロスポリンを含む組成物 |
| EP3236993B1 (en) | 2014-12-23 | 2023-09-13 | Theriva Biologics, Inc. | Methods and compositions for inhibiting or preventing adverse effects of oral antibiotics |
| CN104473907A (zh) * | 2014-12-25 | 2015-04-01 | 北京华禧联合科技发展有限公司 | 一种他克莫司的口服缓释制剂 |
| US20180036382A1 (en) | 2015-02-09 | 2018-02-08 | Entera Bio Ltd. | Formulations for oral administration of active agents with controlled absorption profile |
| SG11201706840WA (en) | 2015-03-31 | 2017-09-28 | Vhsquared Ltd | Peptide construct having a protease-cleavable linker |
| WO2016156468A1 (en) | 2015-03-31 | 2016-10-06 | Vhsquared Limited | Polypeptides |
| CN113546036A (zh) | 2015-05-01 | 2021-10-26 | 拉尼医疗有限公司 | 药物组合物和用于制备包含多肽和/或蛋白质的固体块的方法 |
| US10286009B2 (en) * | 2015-05-16 | 2019-05-14 | Asterias Biotherapeutics, Inc. | Pluripotent stem cell-derived oligodendrocyte progenitor cells for the treatment of spinal cord injury |
| AU2016272089B2 (en) | 2015-06-03 | 2021-02-18 | Triastek, Inc. | Dosage forms and use thereof |
| SG11201807402PA (en) * | 2016-03-31 | 2018-09-27 | Vhsquared Ltd | Compositions |
| US10779980B2 (en) | 2016-04-27 | 2020-09-22 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| TR201610597A2 (tr) * | 2016-07-29 | 2016-12-21 | Kamil Varlik Erel | Mide ve bağırsak içine yerleştirilen tüp veya sondalardan kullanıma uygun ilaç |
| CN116850132A (zh) * | 2016-08-17 | 2023-10-10 | 安提拉生物有限公司 | 用于口服的活性剂的制剂 |
| EA201892396A1 (ru) | 2016-12-02 | 2019-04-30 | Ресептор Лайф Сайенсиз, Инк. | Быстродействующие растительные лекарственные соединения и биологически активные добавки |
| JP2020513280A (ja) | 2016-12-14 | 2020-05-14 | プロジェニティ， インコーポレイテッド | 消化管疾病の免疫抑制剤による治療 |
| CN117045784A (zh) * | 2016-12-14 | 2023-11-14 | 比奥拉治疗股份有限公司 | 使用利用可摄入装置释放的il-12/il-23抑制剂治疗胃肠道疾病 |
| US20200253506A1 (en) * | 2016-12-14 | 2020-08-13 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an integrin inhibitor |
| EP3554541B1 (en) * | 2016-12-14 | 2023-06-07 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor |
| EP3573602A4 (en) * | 2017-01-26 | 2020-09-16 | Triastek, Inc. | DOSAGE FORMS OF CONTROLLED RELEASE AT SPECIFIC GASTROINTESTINAL SITES |
| ES3036482T3 (en) | 2017-03-11 | 2025-09-19 | Cartesian Therapeutics Inc | Methods and compositions related to combined treatment with anti-inflammatories and synthetic nanocarriers comprising an immunosuppressant |
| WO2018183929A1 (en) * | 2017-03-30 | 2018-10-04 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with an immune modulatory agent released using an ingestible device |
| CA3054159A1 (en) * | 2017-03-30 | 2018-10-04 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a chst15 inhibitor |
| CA3054156A1 (en) * | 2017-03-30 | 2018-10-04 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with il-10 or an il-10 agonist |
| DK3638211T3 (da) * | 2017-06-14 | 2024-01-22 | SpecGx LLC | Farmaceutiske sammensætninger med forsinket vedvarende frigivelse |
| JP2020530494A (ja) | 2017-08-07 | 2020-10-22 | フィンチ セラピューティクス、インコーポレイテッド． | 健康な腸バリアを維持及び回復するための組成物及び方法 |
| US20200323772A1 (en) * | 2017-08-15 | 2020-10-15 | Progenity, Inc. | Treatment of inflammatory disease using ingestible device to release immune modulator |
| EP3459527B1 (en) | 2017-09-20 | 2022-11-23 | Tillotts Pharma Ag | Method for preparing a solid dosage form comprising antibodies by wet granulation, extrusion and spheronization |
| JP2020536858A (ja) * | 2017-10-05 | 2020-12-17 | レセプター・ホールディングス・インコーポレイテッド | 改善されたバイオアベイラビリティーを有するハーブ組成物 |
| CA3075292A1 (en) * | 2017-10-20 | 2019-04-25 | Purdue Pharma L.P. | Pharmaceutical dosage forms |
| CA3085330A1 (en) * | 2017-12-14 | 2019-06-20 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a s1p modulator |
| US11338020B2 (en) | 2018-01-09 | 2022-05-24 | Synthetic Biologics, Inc. | Alkaline phosphatase agents for treatment of neurodevelopmental disorders |
| CN108379238B (zh) * | 2018-01-17 | 2020-07-14 | 南昌大学 | 一种储存物理稳定性好的环孢素固体脂质纳米粒及其制备方法 |
| KR20200125637A (ko) | 2018-02-23 | 2020-11-04 | 크레스토보 홀딩스 엘엘씨 | 마이크로바이옴 관련 면역요법 |
| CA3092930A1 (en) * | 2018-03-07 | 2019-09-12 | Anabio Technologies Ltd. | A composition for type ii diabetics and for use in providing sustained energy release over time |
| US10835489B2 (en) | 2018-03-09 | 2020-11-17 | University Of Saskatchewan | Modified release formulations of mycophenolate mofetil |
| KR20200134271A (ko) * | 2018-03-19 | 2020-12-01 | 제미니 라보라토리스, 엘엘씨 | 면역억제성 투약형 및 사용 방법 |
| ES3032290T3 (en) | 2018-03-20 | 2025-07-16 | Theriva Biologics Inc | Intestinal alkaline phosphatase formulations |
| US11654184B2 (en) | 2018-03-20 | 2023-05-23 | Theriva Biologics, Inc. | Alkaline phosphatase agents for treatment of radiation disorders |
| WO2020106330A1 (en) * | 2018-07-18 | 2020-05-28 | Pillsy, Inc. | Smart drug delivery and monitoring device, kit, and method of use for pill compounds |
| CA3110250A1 (en) | 2018-08-22 | 2020-02-27 | Bacainn Therapeutics, Ltd. | Cyclosporine compositions and methods of use |
| US12365872B2 (en) | 2018-09-19 | 2025-07-22 | Lineage Cell Therapeutics, Inc. | Methods for differentiating pluripotent stem cells in dynamic suspension culture |
| CN110934831B (zh) * | 2018-09-25 | 2021-09-14 | 天津大学 | 二甲基乙二酰甘氨酸-白藜芦醇核壳型纳米材料及其制备方法 |
| CA3113948A1 (en) * | 2018-10-11 | 2020-04-16 | Alivio Therapeutics, Inc. | Non-injectable hydrogel formulations for smart release |
| US10722473B2 (en) | 2018-11-19 | 2020-07-28 | Purdue Pharma L.P. | Methods and compositions particularly for treatment of attention deficit disorder |
| EP3883595A4 (en) | 2018-11-19 | 2022-12-14 | Receptor Holdings, Inc. | N-ACYLATED FATTY AMINO ACIDS TO REDUCE ABSORPTION VARIABILITY IN CANNABINOID-BASED COMPOSITIONS |
| EP3934677A4 (en) | 2019-03-13 | 2022-11-16 | University of Virginia Patent Foundation | COMPOSITIONS AND METHODS TO PROMOTE ISLAND VIABILITY AND INCREASE INSULINE SECRETION |
| US10752642B1 (en) | 2019-04-30 | 2020-08-25 | George Mason University | Macrocyclic lactones |
| AU2020287627A1 (en) | 2019-06-04 | 2021-11-18 | Selecta Biosciences, Inc. | Formulations and doses of PEGylated uricase |
| US12559552B2 (en) | 2019-06-21 | 2026-02-24 | Sorriso Pharmaceuticals, Inc. | IL-23 and TNF-alpha binding bi-specific heavy chain polypeptides |
| KR20220063148A (ko) | 2019-06-21 | 2022-05-17 | 소리소 파마슈티컬스 인크. | 조성물 |
| CA3144567A1 (en) | 2019-06-21 | 2020-12-24 | Scott Crowe | Polypeptides |
| EP3999637B1 (en) | 2019-07-18 | 2025-04-02 | Theriva Biologics, Inc. | Intestinal alkaline phosphatase-based treatments of metabolic disorders |
| PH12021553137A1 (en) | 2019-07-19 | 2022-07-25 | Finch Therapeutics Holdings Llc | Methods and products for treatment of gastrointestinal disorders |
| JP2022544239A (ja) | 2019-08-12 | 2022-10-17 | マサチューセッツ インスティテュート オブ テクノロジー | 治療薬の投与のための物品及び方法 |
| MX2022001975A (es) | 2019-08-16 | 2022-03-11 | Applied Molecular Transport Inc | Composiciones, formulaciones y produccion y purificacion de interleucinas. |
| AU2020346061A1 (en) | 2019-09-13 | 2022-03-31 | Finch Therapeutics Holdings Llc | Compositions and methods for treating Autism Spectrum Disorder |
| CN115279382A (zh) | 2019-10-18 | 2022-11-01 | 芬奇治疗控股有限责任公司 | 用于向受试者递送细菌代谢物的组合物和方法 |
| WO2021097288A1 (en) | 2019-11-15 | 2021-05-20 | Finch Therapeutics Holdings Llc | Compositions and methods for treating neurodegenerative diseases |
| CN111297953A (zh) * | 2019-12-20 | 2020-06-19 | 卓和药业集团有限公司 | 一种预防肾脏移植后移植排斥反应的复方制剂 |
| WO2021142347A1 (en) | 2020-01-10 | 2021-07-15 | Finch Therapeutics Holdings Llc | Compositions and methods for non-alcoholic steatohepatitis (nash) |
| TW202140049A (zh) | 2020-01-10 | 2021-11-01 | 美商芬奇治療控股有限責任公司 | 用於治療ｂ型肝炎（ｈｂｖ）及ｄ型肝炎（ｈｄｖ）之組合物及方法 |
| WO2021142358A1 (en) | 2020-01-10 | 2021-07-15 | Finch Therapeutics Holdings Llc | Compositions and methods for treating hepatic encephalopathy (he) |
| EP4117718A4 (en) * | 2020-03-09 | 2024-05-08 | University of Houston System | INFLAMMATORY BOWEL DISEASE (IBD)-ASSOCIATED STEM CELLS, AGENTS TARGETING IBD-ASSOCIATED STEM CELLS AND RELATED USES THEREOF |
| US20230201265A1 (en) | 2020-03-31 | 2023-06-29 | Finch Therapeutics Holdings Llc | Compositions comprising non-viable fecal microbiota and methods of use thereof |
| GB202006390D0 (en) * | 2020-04-30 | 2020-06-17 | Aqilion Ab | Novel treatments |
| US11426353B2 (en) * | 2020-06-24 | 2022-08-30 | 13400719 Canada Inc. | Composite coating for an active agent |
| US11666560B2 (en) | 2020-09-24 | 2023-06-06 | George Mason University | Anti-fibrotic agent |
| IL302773A (en) | 2020-11-10 | 2023-07-01 | Medregen Llc | Formulations, methods, kits, and dosage forms |
| US20240009137A1 (en) * | 2020-11-30 | 2024-01-11 | Royal Melbourne Institute Of Technology | Oral therapeutic delivery |
| WO2022178294A1 (en) | 2021-02-19 | 2022-08-25 | Finch Therapeutics Holdings Llc | Compositions and methods for providing secondary bile acids to a subject |
| ES2924573B2 (es) * | 2021-03-18 | 2024-04-24 | Aora Health S L | Sistema de administracion en multiples sitios para administracion diferencial en el tracto gastrointestinal |
| EP4401712A4 (en) * | 2021-09-14 | 2025-08-27 | Nulixir Inc | ORAL COMPOSITIONS WITH IMPROVED BIOAVAILABILITY AND METHODS OF MANUFACTURE THEREOF |
| KR102874663B1 (ko) * | 2021-12-22 | 2025-10-23 | 알고케어 주식회사 | 구 형상의 제형을 제공하는 디스펜서 |
| CN114916591A (zh) * | 2022-06-09 | 2022-08-19 | 江西维尔宝食品生物有限公司 | 一种起酥性烘焙专用可塑性粉末油脂组合物 |
| US11806430B1 (en) | 2023-02-24 | 2023-11-07 | King Faisal University | Rectal gel with date palm phenolics and vanillic acid |
| AU2024252387A1 (en) * | 2023-04-14 | 2025-10-02 | Vitakey Inc. | Compositions and methods of controlling mammalian satiety |
| CN116650444B (zh) * | 2023-07-31 | 2023-10-31 | 国药集团川抗制药有限公司 | 一种他克莫司缓释药物及其制备方法 |
| US12303604B1 (en) | 2024-10-16 | 2025-05-20 | Currax Pharmaceuticals Llc | Pharmaceutical formulations comprising naltrexone and/or bupropion |
Family Cites Families (216)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
| US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US3971852A (en) | 1973-06-12 | 1976-07-27 | Polak's Frutal Works, Inc. | Process of encapsulating an oil and product produced thereby |
| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| IT1090703B (it) | 1976-12-03 | 1985-06-26 | Scherer Ltd R P | Perfezionamento nelle composizioni utili quali veicolo per farmaci |
| DE2907460A1 (de) | 1978-03-07 | 1979-09-13 | Sandoz Ag | Neue resorbierbare galenische kompositionen |
| US4279632A (en) | 1979-05-08 | 1981-07-21 | Nasa | Method and apparatus for producing concentric hollow spheres |
| IT1148784B (it) | 1980-04-09 | 1986-12-03 | Eurand Spa | Procedimento per la preparazione di microcapsule in un veicolo liquido |
| US4379454A (en) | 1981-02-17 | 1983-04-12 | Alza Corporation | Dosage for coadministering drug and percutaneous absorption enhancer |
| JPS6415Y2 (https=) | 1981-05-29 | 1989-01-05 | ||
| JPS5813508A (ja) | 1981-07-14 | 1983-01-26 | Taiho Yakuhin Kogyo Kk | ポリグリセロール飽和脂肪酸エステルを含む経口薬剤組成物 |
| JPS5877810A (ja) | 1981-11-01 | 1983-05-11 | Taiho Yakuhin Kogyo Kk | ポリグリセロ−ル不飽和脂肪酸エステルを含む経口薬剤組成物 |
| DE3224619A1 (de) | 1981-07-14 | 1983-05-19 | Freund Industrial Co., Ltd., Tokyo | Orale pharmazeutische zusammensetzung |
| US4481157A (en) | 1982-04-27 | 1984-11-06 | Morishita Jintan Co., Ltd. | Method and apparatus for production of microcapsules |
| US4597959A (en) | 1982-04-30 | 1986-07-01 | Arthur Barr | Sustained release breath freshener, mouth and palate coolant wafer composition and method of use |
| US4422985A (en) | 1982-09-24 | 1983-12-27 | Morishita Jintan Co., Ltd. | Method and apparatus for encapsulation of a liquid or meltable solid material |
| JPS5988420A (ja) | 1982-11-12 | 1984-05-22 | Teisan Seiyaku Kk | シ−ムレスカプセル化ニフエジピン製剤 |
| JPS5988420U (ja) | 1982-12-04 | 1984-06-15 | 有限会社三和ボタン店 | 学生服の詰襟構造 |
| JPS59131355A (ja) | 1983-01-17 | 1984-07-28 | 森下仁丹株式会社 | 多重軟カプセルの製法 |
| HU187215B (en) | 1983-01-26 | 1985-11-28 | Egyt Gyogyszervegyeszeti Gyar | Method for producing pharmaceutical product of high actor content and prolonged effect |
| DE3331009A1 (de) | 1983-08-27 | 1985-03-14 | Basf Ag, 6700 Ludwigshafen | Verfahren zur erhoehung der enteralen resorbierbarkeit von heparin bzw. heparinoiden sowie das so erhaeltliche heparin- bzw. heparinoidpraeparat |
| JPS60100516A (ja) | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
| JPS6115A (ja) | 1984-06-12 | 1986-01-06 | Kyowa Hakko Kogyo Co Ltd | リポキシゲナ−ゼ代謝産物に起因する疾患の予防治療剤 |
| IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| JPS61115462A (ja) | 1984-11-13 | 1986-06-03 | Denka Seiyaku Kk | 甘味増強ステビア葉の製法 |
| JPS61151119A (ja) | 1984-12-24 | 1986-07-09 | Taisho Pharmaceut Co Ltd | ソフトカプセル |
| US4601894A (en) | 1985-03-29 | 1986-07-22 | Schering Corporation | Controlled release dosage form comprising acetaminophen, pseudoephedrine sulfate and dexbrompheniramine maleate |
| US4658441A (en) * | 1985-12-13 | 1987-04-21 | Smith Steven A | One piece thumb support and protector |
| US4749574A (en) | 1986-04-14 | 1988-06-07 | Fujisawa Pharmaceutical Co., Ltd. | Sustained-release transdermal delivery preparations |
| US4857335A (en) | 1987-03-27 | 1989-08-15 | Lim Technology Laboratories, Inc. | Liquid controlled release formulations and method of producing same via multiple emulsion process |
| KR920003601B1 (ko) | 1987-09-03 | 1992-05-04 | 유니버시티 어브 죠지아 리서취 화운데이션 인코포레이티드 | 점안 싸이클로스포린(cyclosporin)의 조성물 |
| US4891223A (en) | 1987-09-03 | 1990-01-02 | Air Products And Chemicals, Inc. | Controlled release delivery coating formulation for bioactive substances |
| US4910191A (en) * | 1988-06-28 | 1990-03-20 | Merrell Dow Pharmaceuticals Inc. | 19-substituted progesterone derivatives useful as 19-hydroxylase inhibitors |
| US5073543A (en) | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
| US5350741A (en) | 1988-07-30 | 1994-09-27 | Kanji Takada | Enteric formulations of physiologically active peptides and proteins |
| KR0148748B1 (ko) * | 1988-09-16 | 1998-08-17 | 장 크라메르, 한스 루돌프 하우스 | 사이클로스포린을 함유하는 약학조성물 |
| US5342625A (en) | 1988-09-16 | 1994-08-30 | Sandoz Ltd. | Pharmaceutical compositions comprising cyclosporins |
| WO1990006775A1 (en) | 1988-12-14 | 1990-06-28 | Liposome Technology, Inc. | A novel nonphospholipid liposome composition for sustained release of drugs |
| IT1229203B (it) | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
| US5133974A (en) | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
| JP2806564B2 (ja) | 1989-07-20 | 1998-09-30 | 森下仁丹株式会社 | 親水性物質を内容物とするシームレスカプセルおよびその製法 |
| US5120548A (en) | 1989-11-07 | 1992-06-09 | Merck & Co., Inc. | Swelling modulated polymeric drug delivery device |
| GB8926639D0 (en) | 1989-11-24 | 1990-01-17 | Agricultural & Food Res | Delayed release formulations |
| US5260071A (en) | 1989-12-18 | 1993-11-09 | Lemelson Jerome H | Drug units and methods for using same |
| BE1003677A3 (nl) | 1990-01-29 | 1992-05-19 | Schacht Etienne | Werkwijze voor het bereiden van azobevattende polymeren en het gebruik ervan als geneesmiddelafgiftesystemen. |
| IL98087A (en) | 1990-05-04 | 1996-11-14 | Perio Prod Ltd | Preparation for dispensing drugs in the colon |
| US5733566A (en) | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
| DK0465238T3 (da) | 1990-07-04 | 1994-05-02 | Shionogi & Co | Fremgangsmåde til fremstilling af ikke-kohæsive overtræk |
| US5418010A (en) | 1990-10-05 | 1995-05-23 | Griffith Laboratories Worldwide, Inc. | Microencapsulation process |
| US5102668A (en) | 1990-10-05 | 1992-04-07 | Kingaform Technology, Inc. | Sustained release pharmaceutical preparation using diffusion barriers whose permeabilities change in response to changing pH |
| US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| GB9113872D0 (en) | 1991-06-27 | 1991-08-14 | Sandoz Ag | Improvements in or relating to organic compounds |
| WO1993000063A1 (en) | 1991-06-28 | 1993-01-07 | Brown University Research Foundation | Capsule extrusion systems |
| JP3313124B2 (ja) | 1991-07-31 | 2002-08-12 | 森下仁丹株式会社 | 親水性物質を内容物とするシームレスカプセルおよびその製法 |
| JPH0549899A (ja) | 1991-08-09 | 1993-03-02 | Japan Tobacco Inc | ビーズ及びこれを製造するための液滴生成装置 |
| US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| AU666895B2 (en) | 1991-12-30 | 1996-02-29 | Hercules Incorporated | High load spray dry encapsulation |
| DE4201179A1 (de) | 1992-01-17 | 1993-07-22 | Alfatec Pharma Gmbh | Wirkstoff(e) enthaltendes granulat oder pellet mit einem geruest aus hydrophilen makromolekuelen und verfahren zu seiner herstellung |
| EP0621775B1 (de) | 1992-01-17 | 1997-08-06 | ALFATEC-PHARMA GmbH | Peptidarzneistoffe enthaltende pellets und ihre herstellung sowie deren verwendung |
| US5571533A (en) | 1992-02-07 | 1996-11-05 | Recordati, S.A., Chemical And Pharmaceutical Company | Controlled-release mucoadhesive pharmaceutical composition for the oral administration of furosemide |
| DE69324523T2 (de) | 1992-06-12 | 1999-09-09 | Kao Corp. | Badezusatzzusammensetzung enthaltend oberflächenaktive Mittel enthaltende nahtlose Kapsel und Verfahren zur Herrstellung der Kapsel |
| JP3405746B2 (ja) | 1992-10-28 | 2003-05-12 | フロイント産業株式会社 | シームレスカプセルの製造方法 |
| NZ259285A (en) | 1993-01-08 | 1996-07-26 | Csl Ltd | Vaccine preparations in stable particulate form comprising an immunogen absorbed to an aluminium salt adjuvant or biodegradable polymer matrix |
| GB9300875D0 (en) | 1993-01-18 | 1993-03-10 | Ucb Sa | Nanocapsule containing pharmaceutical compositions |
| US5591767A (en) | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
| US5914132A (en) | 1993-02-26 | 1999-06-22 | The Procter & Gamble Company | Pharmaceutical dosage form with multiple enteric polymer coatings for colonic delivery |
| US5686105A (en) | 1993-10-19 | 1997-11-11 | The Procter & Gamble Company | Pharmaceutical dosage form with multiple enteric polymer coatings for colonic delivery |
| US5843347A (en) | 1993-03-23 | 1998-12-01 | Laboratoire L. Lafon | Extrusion and freeze-drying method for preparing particles containing an active ingredient |
| DK66493D0 (da) | 1993-06-08 | 1993-06-08 | Ferring A S | Praeparater, isaer til brug ved behandling af inflammatoriske tarmsygdomme eller til at opnaa forbedret saarheling |
| CN1077800C (zh) * | 1993-07-01 | 2002-01-16 | 韩美药品工业株式会社 | 环孢菌素软胶囊组合物 |
| FR2707184B1 (fr) | 1993-07-08 | 1995-08-11 | Rhone Poulenc Nutrition Animal | Procédé de préparation de sphérules contenant un principe actif alimentaire ou pharmaceutique. |
| DE4329503A1 (de) | 1993-09-01 | 1995-03-02 | Galenik Labor Freiburg Gmbh | Pharmazeutische Präparate zur gezielten Behandlung von Morbus Crohn und Colitis Ulcerosa |
| US6204243B1 (en) * | 1993-09-01 | 2001-03-20 | Novatis Ag | Pharmaceutical preparations for the targeted treatment of crohn's disease and ulcerative colitis |
| DE4332041C2 (de) | 1993-09-21 | 1997-12-11 | Rentschler Arzneimittel | Verwendung von Pentoxifyllin bei bestimmten Lungenerkrankungen |
| US5961970A (en) | 1993-10-29 | 1999-10-05 | Pharmos Corporation | Submicron emulsions as vaccine adjuvants |
| WO1995022343A1 (en) | 1994-02-17 | 1995-08-24 | Shiseido Company, Ltd. | Cyclosporin-containing emulsion composition |
| US5498439A (en) | 1994-03-04 | 1996-03-12 | Arnhem, Inc. | Process for encapsulating the flavor with colloid gel matrix |
| GB9405304D0 (en) | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
| ES2188657T3 (es) | 1994-04-22 | 2003-07-01 | Yamanouchi Pharma Co Ltd | Sistema para la liberacion especifica en el colon de un farmaco. |
| GB9412394D0 (en) | 1994-06-21 | 1994-08-10 | Danbiosyst Uk | Colonic drug delivery composition |
| FR2721510B1 (fr) | 1994-06-22 | 1996-07-26 | Rhone Poulenc Rorer Sa | Nanoparticules filtrables dans des conditions stériles. |
| IT1270594B (it) | 1994-07-07 | 1997-05-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida |
| DE4430127A1 (de) * | 1994-08-25 | 1996-03-14 | Hoechst Ag | Kombinationspräparat, enthaltend Cyclosporin A oder FK506 und ein Xanthinderivat |
| US5650232A (en) | 1994-10-07 | 1997-07-22 | Warner-Lambert Company | Method for making seamless capsules |
| FR2725623A1 (fr) | 1994-10-18 | 1996-04-19 | Flamel Tech Sa | Microcapsules medicamenteuses et/ou nutritionnelles pour administration per os |
| US5827531A (en) | 1994-12-02 | 1998-10-27 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Microcapsules and methods for making |
| US5529783A (en) | 1994-12-19 | 1996-06-25 | Mcneil-Ppc, Inc. | Rotor granulation and coating of acetaminophen, pseudoephedrine, chlorpheniramine, and, optionally dextromethorphan |
| KR0167613B1 (ko) | 1994-12-28 | 1999-01-15 | 한스 루돌프 하우스, 니콜 케르커 | 사이클로스포린-함유 연질캅셀제 조성물 |
| US5510118A (en) | 1995-02-14 | 1996-04-23 | Nanosystems Llc | Process for preparing therapeutic compositions containing nanoparticles |
| US5674495A (en) | 1995-02-27 | 1997-10-07 | Purdue Research Foundation | Alginate-based vaccine compositions |
| US5595757A (en) | 1995-03-29 | 1997-01-21 | Warner-Lambert Company | Seamless capsules |
| US5767153A (en) | 1995-06-07 | 1998-06-16 | Insite Vision Incorporated | Sustained release emulsions |
| US5716928A (en) | 1995-06-07 | 1998-02-10 | Avmax, Inc. | Use of essential oils to increase bioavailability of oral pharmaceutical compounds |
| US5665386A (en) | 1995-06-07 | 1997-09-09 | Avmax, Inc. | Use of essential oils to increase bioavailability of oral pharmaceutical compounds |
| IE80467B1 (en) | 1995-07-03 | 1998-07-29 | Elan Corp Plc | Controlled release formulations for poorly soluble drugs |
| SE504582C2 (sv) | 1995-07-06 | 1997-03-10 | Gs Dev Ab | Cyklosporinkomposition baserad på en L2-fas |
| JP2682818B2 (ja) | 1995-08-04 | 1997-11-26 | 大成化工株式会社 | 害虫誘引阻止材 |
| WO1997007787A1 (en) * | 1995-08-25 | 1997-03-06 | Sangstat Medical Corporation | Oral cyclosporin formulations |
| EP0760237A1 (en) | 1995-08-30 | 1997-03-05 | Cipla Limited | Oil-in-water microemulsions |
| DE19544507B4 (de) | 1995-11-29 | 2007-11-15 | Novartis Ag | Cyclosporin enthaltende Präparate |
| JP3759986B2 (ja) * | 1995-12-07 | 2006-03-29 | フロイント産業株式会社 | シームレスカプセルおよびその製造方法 |
| KR19990077278A (ko) | 1996-01-16 | 1999-10-25 | 마이클 오코넬 | 약물의 하부 위장관으로의 국소적 전달 |
| US5858401A (en) | 1996-01-22 | 1999-01-12 | Sidmak Laboratories, Inc. | Pharmaceutical composition for cyclosporines |
| US5686133A (en) | 1996-01-31 | 1997-11-11 | Port Systems, L.L.C. | Water soluble pharmaceutical coating and method for producing coated pharmaceuticals |
| US5889028A (en) * | 1996-02-09 | 1999-03-30 | Mayo Foundation For Medical Education And Research | Colonic delivery of nicotine to treat inflammatory bowel disease |
| US5958876A (en) | 1996-06-19 | 1999-09-28 | Novartis Ag | Cyclosporin-containing pharmaceutical compositions |
| KR0183449B1 (ko) * | 1996-06-19 | 1999-05-01 | 한스 루돌프 하우스, 니콜 케르커 | 사이클로스포린-함유 연질캅셀제 |
| CA2269806C (en) | 1996-10-28 | 2006-01-24 | Bernhard H. Van Lengerich | Embedding and encapsulation of controlled release particles |
| US5891474A (en) | 1997-01-29 | 1999-04-06 | Poli Industria Chimica, S.P.A. | Time-specific controlled release dosage formulations and method of preparing same |
| CA2283780A1 (en) | 1997-03-12 | 1998-09-17 | Abbott Laboratories | Lipophilic binary systems for the administration of lipophilic compounds |
| DZ2479A1 (fr) * | 1997-05-05 | 2003-02-01 | Pfizer | Composés inhibiteurs sélectifs de cox-2 anti-inflammatoires et compositions pharmaceutiques les contenant. |
| AU7201998A (en) | 1997-05-06 | 1998-11-27 | Zhi Liu | Drug delivery system |
| JP4102459B2 (ja) | 1997-05-14 | 2008-06-18 | 森下仁丹株式会社 | 生体高分子を合成するシームレスカプセルおよびその製造方法 |
| SE9702533D0 (sv) | 1997-07-01 | 1997-07-01 | Astra Ab | New oral formulation |
| ATE265847T1 (de) | 1997-07-29 | 2004-05-15 | Upjohn Co | Selbstemulgierbare formulierung enthaltend lipophile verbindungen |
| DE19732903A1 (de) | 1997-07-30 | 1999-02-04 | Falk Pharma Gmbh | Pellet-Formulierung zur Behandlung des Intestinaltraktes |
| ES2137862B1 (es) | 1997-07-31 | 2000-09-16 | Intexim S A | Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion. |
| JP3090198B2 (ja) | 1997-08-21 | 2000-09-18 | 日本電気株式会社 | 半導体装置の構造およびその製造方法 |
| HUP9701554D0 (en) * | 1997-09-18 | 1997-11-28 | Human Oltoanyagtermeloe Gyogys | Pharmaceutical composition containing plazma proteins |
| US6531150B1 (en) | 1997-10-30 | 2003-03-11 | Morishita Jintan Co., Ltd. | Encapsulated unsaturated fatty acid substance and method for producing the same |
| US5891845A (en) | 1997-11-21 | 1999-04-06 | Fuisz Technologies Ltd. | Drug delivery systems utilizing liquid crystal structures |
| IT1296585B1 (it) | 1997-11-28 | 1999-07-14 | Uni Di Pavia | Microcapsule contenenti materiale seminale per l'inseminazione strumentale nella specie suina |
| US6509346B2 (en) | 1998-01-21 | 2003-01-21 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US20040062802A1 (en) | 1998-04-02 | 2004-04-01 | Hermelin Victor M. | Maximizing effectiveness of substances used to improve health and well being |
| US6174466B1 (en) | 1998-05-08 | 2001-01-16 | Warner-Lambert Company | Methods for making seamless capsules |
| DE19821951A1 (de) * | 1998-05-15 | 1999-11-18 | Basf Ag | Cyclosporin-Zubereitungen |
| JPH11322587A (ja) | 1998-05-18 | 1999-11-24 | Sumitomo Chem Co Ltd | 常温で固体の生理活性物質のマイクロカプセル化方法およびこの方法により得られるマイクロカプセル組成物 |
| KR100336090B1 (ko) | 1998-06-27 | 2002-05-27 | 윤승원 | 오일, 지방산 또는 이들의 혼합물을 함유한 난용성 약물의 고형분산제제 |
| MXPA01003197A (es) | 1998-09-28 | 2004-04-21 | Warner Lambert Co | Suministro enterico y colonico utilizando capsulas de chpm. |
| DE19848849A1 (de) | 1998-10-22 | 2000-04-27 | Knoll Ag | Verfahren zur Herstellung von festen, sphärischen Formen, enthaltend eine biologisch aktive Substanz |
| US6638522B1 (en) | 1998-12-11 | 2003-10-28 | Pharmasolutions, Inc. | Microemulsion concentrate composition of cyclosporin |
| JP3039863B1 (ja) | 1998-12-25 | 2000-05-08 | 不二精工株式会社 | ロッキングプレス装置 |
| US7374779B2 (en) * | 1999-02-26 | 2008-05-20 | Lipocine, Inc. | Pharmaceutical formulations and systems for improved absorption and multistage release of active agents |
| US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| US6294192B1 (en) | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
| US6267985B1 (en) | 1999-06-30 | 2001-07-31 | Lipocine Inc. | Clear oil-containing pharmaceutical compositions |
| US6761903B2 (en) | 1999-06-30 | 2004-07-13 | Lipocine, Inc. | Clear oil-containing pharmaceutical compositions containing a therapeutic agent |
| JP2000247911A (ja) | 1999-02-26 | 2000-09-12 | Hisamitsu Pharmaceut Co Inc | 大腸用吸収促進剤 |
| US20030104048A1 (en) | 1999-02-26 | 2003-06-05 | Lipocine, Inc. | Pharmaceutical dosage forms for highly hydrophilic materials |
| JP2000302654A (ja) | 1999-04-16 | 2000-10-31 | Kao Corp | 歯磨組成物の製造法 |
| US8663692B1 (en) | 1999-05-07 | 2014-03-04 | Pharmasol Gmbh | Lipid particles on the basis of mixtures of liquid and solid lipids and method for producing same |
| WO2000069420A1 (en) | 1999-05-14 | 2000-11-23 | Coraltis Ltd. | Pulse-delivery oral compositions |
| AU5108200A (en) | 1999-06-09 | 2000-12-28 | Mochida Pharmaceutical Co., Ltd. | System for release in lower digestive tract |
| US20030235595A1 (en) | 1999-06-30 | 2003-12-25 | Feng-Jing Chen | Oil-containing, orally administrable pharmaceutical composition for improved delivery of a therapeutic agent |
| US6309663B1 (en) | 1999-08-17 | 2001-10-30 | Lipocine Inc. | Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents |
| US20030236236A1 (en) | 1999-06-30 | 2003-12-25 | Feng-Jing Chen | Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs |
| US6458383B2 (en) | 1999-08-17 | 2002-10-01 | Lipocine, Inc. | Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin |
| EP1204410B1 (en) | 1999-07-30 | 2012-09-12 | Capsugel Belgium NV | Multi-component pharmaceutical dosage form |
| EP1227793A1 (en) | 1999-11-02 | 2002-08-07 | Cipla Ltd. | Cyclosporin formulation |
| US20030180352A1 (en) * | 1999-11-23 | 2003-09-25 | Patel Mahesh V. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| US20060034937A1 (en) | 1999-11-23 | 2006-02-16 | Mahesh Patel | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| US20010026800A1 (en) * | 2000-01-07 | 2001-10-04 | Michael Jacob G. | Selective activation of a TH1 or TH2 lymphocyte regulated immune response |
| WO2001080831A2 (en) | 2000-04-27 | 2001-11-01 | Verion Inc. | Zero order release and temperature-controlled microcapsules and process for the preparation thereof |
| ES2243497T3 (es) | 2000-05-12 | 2005-12-01 | PHARMACIA & UPJOHN COMPANY LLC | Composicion de vacuna, procedimiento de preparacion de la misma y procedimiento para vacunacion de vertebrados. |
| GB0018527D0 (en) | 2000-07-27 | 2000-09-13 | Photocure Asa | Composition |
| FI20002215A0 (fi) | 2000-10-06 | 2000-10-06 | Orion Yhtymae Oyj | Yhdistelmäpartikkelit |
| CA2359812C (en) | 2000-11-20 | 2004-02-10 | The Procter & Gamble Company | Pharmaceutical dosage form with multiple coatings for reduced impact of coating fractures |
| AU2002254205B2 (en) | 2001-03-15 | 2007-05-10 | Enteron Pharmaceuticals, Inc. | Method of treating inflammatory disorders of the gastrointestinal tract using topical active corticosteroids |
| US6585997B2 (en) | 2001-08-16 | 2003-07-01 | Access Pharmaceuticals, Inc. | Mucoadhesive erodible drug delivery device for controlled administration of pharmaceuticals and other active compounds |
| US20030083286A1 (en) | 2001-08-22 | 2003-05-01 | Ching-Leou Teng | Bioadhesive compositions and methods for enhanced intestinal drug absorption |
| US6669955B2 (en) | 2001-08-28 | 2003-12-30 | Longwood Pharmaceutical Research, Inc. | Combination dosage form containing individual dosage units of a cholesterol-lowering agent, an inhibitor of the renin-angiotensin system, and aspirin |
| FR2830447B1 (fr) | 2001-10-09 | 2004-04-16 | Flamel Tech Sa | Forme galenique orale microparticulaire pour la liberation retardee et controlee de principes actifs pharmaceutiques |
| US6951655B2 (en) | 2001-10-11 | 2005-10-04 | Imi Biomed, Inc. | Pro-micelle pharmaceutical compositions |
| US20040126428A1 (en) | 2001-11-02 | 2004-07-01 | Lyn Hughes | Pharmaceutical formulation including a resinate and an aversive agent |
| CA2471241A1 (en) | 2001-12-20 | 2003-07-03 | Bernard Charles Sherman | Pharmaceutical compositions comprising a cyclosporin, a hydrophilic surfactant and a lipophilic surfactant |
| BR0215421B1 (pt) | 2002-01-10 | 2014-04-29 | Firmenich & Cie | Processo para a preparação de um sistema de distribuição de ingrediente ou composição hidrófoba granular |
| GB0203421D0 (en) | 2002-02-13 | 2002-04-03 | Alizyme Therapeutics Ltd | Composition |
| US6974592B2 (en) | 2002-04-11 | 2005-12-13 | Ocean Nutrition Canada Limited | Encapsulated agglomeration of microcapsules and method for the preparation thereof |
| US20030207907A1 (en) | 2002-05-03 | 2003-11-06 | Iversen Patrick L. | Delivery of microparticle-conjugated drugs for inhibition of stenosis |
| JP4226846B2 (ja) | 2002-06-07 | 2009-02-18 | キャタレント・ジャパン株式会社 | 口腔内で崩壊可能なソフトカプセル剤 |
| GB2391473B (en) | 2002-08-02 | 2004-07-07 | Satishchandra Punambhai Patel | Pharmaceutical compositions |
| GB2408729A (en) | 2002-09-04 | 2005-06-08 | Southwest Res Inst | Microencapsulation of oxygen or water sensitive materials |
| NZ540779A (en) | 2002-11-01 | 2008-05-30 | Univ Pennsylvania | Compositions and methods for siRNA inhibition of HIF-1 alpha |
| US7670627B2 (en) | 2002-12-09 | 2010-03-02 | Salvona Ip Llc | pH triggered targeted controlled release systems for the delivery of pharmaceutical active ingredients |
| US7524515B2 (en) | 2003-01-10 | 2009-04-28 | Mutual Pharmaceuticals, Inc. | Pharmaceutical safety dosage forms |
| WO2004064997A1 (en) | 2003-01-23 | 2004-08-05 | Inotech Ag | New microcapsules useful as extraction means in particular for extracting water or soil contaminants |
| US20060167435A1 (en) | 2003-02-18 | 2006-07-27 | Adamis Anthony P | Transscleral drug delivery device and related methods |
| ES2665464T3 (es) * | 2003-03-28 | 2018-04-25 | Sigmoid Pharma Limited | Forma de dosificación oral sólida que contiene microcápsulas sin costuras |
| AU2004226591B2 (en) | 2003-04-04 | 2009-06-04 | Zoetis Services Llc | Microfluidized oil-in-water emulsions and vaccine compositions |
| US8614204B2 (en) * | 2003-06-06 | 2013-12-24 | Fibrogen, Inc. | Enhanced erythropoiesis and iron metabolism |
| WO2005020993A1 (en) | 2003-08-29 | 2005-03-10 | Lifecycle Pharma A/S | Modified release compositions comprising tacrolimus |
| US7087237B2 (en) | 2003-09-19 | 2006-08-08 | Advanced Ocular Systems Limited | Ocular solutions |
| US20050095288A1 (en) | 2003-11-03 | 2005-05-05 | Andrx Labs, Llc | Decongestant and expectorant tablets |
| CA2545399C (en) | 2003-11-21 | 2013-01-29 | Commonwealth Scientific & Industrial Research Organisation | Protein-polysaccharide microcapsules for delivering active agents to the gi tract |
| CA2548992A1 (en) | 2003-12-11 | 2005-08-11 | Vaxdesign Corporation | Immunotherapy compositions, method of making and method of use thereof |
| CN1268325C (zh) | 2004-01-18 | 2006-08-09 | 浙江大学 | 三重复合微球制剂及其制备方法 |
| WO2005074913A2 (en) | 2004-01-30 | 2005-08-18 | Angiotech International Ag | Compositions and methods for treating contracture |
| PE20060003A1 (es) | 2004-03-12 | 2006-03-01 | Smithkline Beecham Plc | Formulacion farmaceutica polimerica para moldear por inyeccion |
| EP1576881A1 (en) * | 2004-03-15 | 2005-09-21 | Urea Casale S.A. | Process for the production of granules or pellets containing filamentary fungi |
| FR2867395B1 (fr) | 2004-03-15 | 2006-06-16 | Rhodia Chimie Sa | Emulsion sechee, son procede de preparation, et ses utilisations |
| ES2376466T3 (es) | 2004-05-07 | 2012-03-14 | Nycomed Gmbh | Forma de dosificación farmacéutica que comprende peletes, as�? como su procedimiento de fabricación. |
| GB0413730D0 (en) | 2004-06-18 | 2004-07-21 | Tillotts Pharma Ag | A pharmaceutical composition and its use |
| WO2006002365A2 (en) | 2004-06-24 | 2006-01-05 | Angiotech International Ag | Microparticles with high loadings of a bioactive agent |
| GB0417481D0 (en) | 2004-08-05 | 2004-09-08 | Etiologics Ltd | Combination therapy |
| WO2006026592A2 (en) | 2004-08-27 | 2006-03-09 | Spherics, Inc. | Oral administration of poorly absorbed drugs, methods and compositions related thereto |
| US7718624B2 (en) * | 2004-09-01 | 2010-05-18 | Sitkovsky Michail V | Modulation of immune response and inflammation by targeting hypoxia inducible factors |
| EP1789090A2 (en) | 2004-09-02 | 2007-05-30 | Bionaut Pharmaceuticals, Inc. | Combinatorial chemotherapy treatment using na+/k+-atpase inhibitors |
| EP1802287A2 (en) | 2004-09-27 | 2007-07-04 | Sigmoid Biotechnologies Limited | Minicapsule formulations |
| IE20050639A1 (en) * | 2004-09-27 | 2006-09-06 | Sigmoid Biotechnologies Ltd | Minicapsule formulations |
| FI20041425A0 (fi) * | 2004-11-05 | 2004-11-05 | Orion Corp | Transmukosaalinen veterinäärinen koostumus |
| EP1868567A4 (en) | 2005-03-29 | 2010-09-29 | Mcneil Ppc Inc | COMPOSITIONS WITH HYDROPHILIC DRUGS IN A HYDROPHOBIC MEDIUM |
| AU2006235478B2 (en) | 2005-04-12 | 2011-07-21 | Elan Pharma International Limited | Nanoparticulate and controlled release compositions comprising cyclosporine |
| JP2009502841A (ja) | 2005-07-26 | 2009-01-29 | グラクソ グループ リミテッド | 脂質をベースにした製剤の腸溶性ポリマー中へのカプセル化 |
| CA2615939A1 (en) * | 2005-08-02 | 2007-02-08 | Miv Therapeutics Inc. | Microdevices comprising nanocapsules for controlled delivery of drugs and method of manufacturing same |
| US7842312B2 (en) | 2005-12-29 | 2010-11-30 | Cordis Corporation | Polymeric compositions comprising therapeutic agents in crystalline phases, and methods of forming the same |
| ES2459018T3 (es) | 2006-02-09 | 2014-05-07 | Alba Therapeutics Corporation | Formulaciones de efectores de la unión estrecha |
| US20070274932A1 (en) * | 2006-05-15 | 2007-11-29 | The Procter & Gamble Company | Water in oil emulsion compositions containing sunscreen actives and siloxane elastomers |
| US8039010B2 (en) | 2006-11-03 | 2011-10-18 | Allergan, Inc. | Sustained release intraocular drug delivery systems comprising a water soluble therapeutic agent and a release modifier |
| US20080124279A1 (en) | 2006-11-17 | 2008-05-29 | Antoine Andremont | Colonic delivery using Zn/pectin beads with a Eudragit coating |
| ES2393814T3 (es) | 2007-04-04 | 2012-12-28 | Sigmoid Pharma Limited | Una composición farmacéutica oral |
| WO2008132712A2 (en) | 2007-05-01 | 2008-11-06 | Sigmoid Pharma Limited | Combination pharmaceutical compositions |
| US9833510B2 (en) | 2007-06-12 | 2017-12-05 | Johnson & Johnson Consumer Inc. | Modified release solid or semi-solid dosage forms |
| US8962530B2 (en) | 2007-06-27 | 2015-02-24 | Regents Of The University Of Colorado | Inflammatory bowel disease therapies |
| US8865692B2 (en) | 2007-11-13 | 2014-10-21 | Meritage Pharma, Inc | Compositions for the treatment of gastrointestinal inflammation |
-
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- 2008-04-04 ES ES08719898T patent/ES2393814T3/es active Active
- 2008-04-04 EP EP08719897A patent/EP2061440A2/en not_active Withdrawn
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