JP2010523553A5 - - Google Patents
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- JP2010523553A5 JP2010523553A5 JP2010501660A JP2010501660A JP2010523553A5 JP 2010523553 A5 JP2010523553 A5 JP 2010523553A5 JP 2010501660 A JP2010501660 A JP 2010501660A JP 2010501660 A JP2010501660 A JP 2010501660A JP 2010523553 A5 JP2010523553 A5 JP 2010523553A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- treatment
- cyclosporine
- drug
- hours
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 claims 30
- 229940079593 drug Drugs 0.000 claims 14
- 239000003814 drug Substances 0.000 claims 14
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 13
- 108010036949 Cyclosporine Proteins 0.000 claims 13
- 229960001265 ciclosporin Drugs 0.000 claims 13
- 229930182912 cyclosporin Natural products 0.000 claims 12
- 239000002775 capsule Substances 0.000 claims 11
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 6
- 208000024908 graft versus host disease Diseases 0.000 claims 6
- 230000002265 prevention Effects 0.000 claims 5
- 206010009900 Colitis ulcerative Diseases 0.000 claims 4
- 208000011231 Crohn disease Diseases 0.000 claims 4
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 210000001072 colon Anatomy 0.000 claims 4
- 238000009472 formulation Methods 0.000 claims 4
- 239000001856 Ethyl cellulose Substances 0.000 claims 3
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 3
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 3
- 239000013543 active substance Substances 0.000 claims 3
- 238000004090 dissolution Methods 0.000 claims 3
- 235000019325 ethyl cellulose Nutrition 0.000 claims 3
- 229920001249 ethyl cellulose Polymers 0.000 claims 3
- 230000002496 gastric effect Effects 0.000 claims 3
- 210000003405 ileum Anatomy 0.000 claims 3
- 239000007788 liquid Substances 0.000 claims 3
- RPTUSVTUFVMDQK-UHFFFAOYSA-N Hidralazin Chemical compound C1=CC=C2C(NN)=NN=CC2=C1 RPTUSVTUFVMDQK-UHFFFAOYSA-N 0.000 claims 2
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 2
- 239000011248 coating agent Substances 0.000 claims 2
- 238000000576 coating method Methods 0.000 claims 2
- 238000013270 controlled release Methods 0.000 claims 2
- 238000001816 cooling Methods 0.000 claims 2
- 230000002708 enhancing effect Effects 0.000 claims 2
- 239000000499 gel Substances 0.000 claims 2
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 230000003232 mucoadhesive effect Effects 0.000 claims 2
- 239000000419 plant extract Substances 0.000 claims 2
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 2
- 229960002930 sirolimus Drugs 0.000 claims 2
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 229920000856 Amylose Polymers 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 102000014914 Carrier Proteins Human genes 0.000 claims 1
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 208000019399 Colonic disease Diseases 0.000 claims 1
- 229930105110 Cyclosporin A Natural products 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 229940122439 Hydroxylase inhibitor Drugs 0.000 claims 1
- 102000014150 Interferons Human genes 0.000 claims 1
- 108010050904 Interferons Proteins 0.000 claims 1
- 206010051606 Necrotising colitis Diseases 0.000 claims 1
- 206010036774 Proctitis Diseases 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 1
- 108091008324 binding proteins Proteins 0.000 claims 1
- 229940046731 calcineurin inhibitors Drugs 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000000824 cytostatic agent Substances 0.000 claims 1
- 230000001085 cytostatic effect Effects 0.000 claims 1
- BNJOZDZCRHCODO-UHFFFAOYSA-N dimethyloxalylglycine Chemical compound COC(=O)CNC(=O)C(=O)OC BNJOZDZCRHCODO-UHFFFAOYSA-N 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 239000000284 extract Substances 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000007903 gelatin capsule Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 229960002474 hydralazine Drugs 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 229940047124 interferons Drugs 0.000 claims 1
- 208000023569 ischemic bowel disease Diseases 0.000 claims 1
- 239000010410 layer Substances 0.000 claims 1
- 210000003750 lower gastrointestinal tract Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- RTGDFNSFWBGLEC-SYZQJQIISA-N mycophenolate mofetil Chemical compound COC1=C(C)C=2COC(=O)C=2C(O)=C1C\C=C(/C)CCC(=O)OCCN1CCOCC1 RTGDFNSFWBGLEC-SYZQJQIISA-N 0.000 claims 1
- 229960004866 mycophenolate mofetil Drugs 0.000 claims 1
- 208000004995 necrotizing enterocolitis Diseases 0.000 claims 1
- 229940005483 opioid analgesics Drugs 0.000 claims 1
- 239000006186 oral dosage form Substances 0.000 claims 1
- 239000001814 pectin Substances 0.000 claims 1
- 235000010987 pectin Nutrition 0.000 claims 1
- 229920001277 pectin Polymers 0.000 claims 1
- 201000006195 perinatal necrotizing enterocolitis Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000002356 single layer Substances 0.000 claims 1
- 210000000813 small intestine Anatomy 0.000 claims 1
- 239000008137 solubility enhancer Substances 0.000 claims 1
- 229960001967 tacrolimus Drugs 0.000 claims 1
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 239000000341 volatile oil Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90749007P | 2007-04-04 | 2007-04-04 | |
| US60/907,490 | 2007-04-04 | ||
| US649808P | 2008-01-16 | 2008-01-16 | |
| US61/006,498 | 2008-01-16 | ||
| PCT/IE2008/000038 WO2008122965A2 (en) | 2007-04-04 | 2008-04-04 | Pharmaceutical cyclosporin compositions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010523553A JP2010523553A (ja) | 2010-07-15 |
| JP2010523553A5 true JP2010523553A5 (https=) | 2011-05-19 |
| JP5553747B2 JP5553747B2 (ja) | 2014-07-16 |
Family
ID=39745242
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010501660A Expired - Fee Related JP5553747B2 (ja) | 2007-04-04 | 2008-04-04 | シクロスポリン医薬組成物 |
| JP2010501661A Withdrawn JP2010523554A (ja) | 2007-04-04 | 2008-04-04 | タクロリムスの医薬組成物 |
| JP2010501662A Pending JP2010523555A (ja) | 2007-04-04 | 2008-04-04 | 「経口医薬組成物」 |
| JP2014149027A Expired - Fee Related JP6059688B2 (ja) | 2007-04-04 | 2014-07-22 | 「経口医薬組成物」 |
| JP2015221221A Active JP6149090B2 (ja) | 2007-04-04 | 2015-11-11 | 「経口医薬組成物」 |
| JP2017091572A Pending JP2017160241A (ja) | 2007-04-04 | 2017-05-02 | 「経口医薬組成物」 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010501661A Withdrawn JP2010523554A (ja) | 2007-04-04 | 2008-04-04 | タクロリムスの医薬組成物 |
| JP2010501662A Pending JP2010523555A (ja) | 2007-04-04 | 2008-04-04 | 「経口医薬組成物」 |
| JP2014149027A Expired - Fee Related JP6059688B2 (ja) | 2007-04-04 | 2014-07-22 | 「経口医薬組成物」 |
| JP2015221221A Active JP6149090B2 (ja) | 2007-04-04 | 2015-11-11 | 「経口医薬組成物」 |
| JP2017091572A Pending JP2017160241A (ja) | 2007-04-04 | 2017-05-02 | 「経口医薬組成物」 |
Country Status (11)
| Country | Link |
|---|---|
| US (11) | US9114071B2 (https=) |
| EP (5) | EP2079456B1 (https=) |
| JP (6) | JP5553747B2 (https=) |
| CN (6) | CN103316326B (https=) |
| CA (3) | CA2683407C (https=) |
| CY (1) | CY1113882T1 (https=) |
| DK (1) | DK2079456T3 (https=) |
| ES (3) | ES2400964T3 (https=) |
| HR (1) | HRP20130173T1 (https=) |
| PT (1) | PT2079456E (https=) |
| WO (3) | WO2008122966A2 (https=) |
Families Citing this family (134)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2922402B2 (ja) | 1993-10-14 | 1999-07-26 | 住友重機械工業株式会社 | 熱成形方法及びその熱成形装置 |
| EP2079456B1 (en) | 2007-04-04 | 2012-12-05 | Sigmoid Pharma Limited | Pharmaceutical cyclosporin compositions |
| EP2586428B1 (en) * | 2007-04-26 | 2023-11-08 | Sublimity Therapeutics Limited | Manufacture of multiple minicapsules |
| CA2685591A1 (en) * | 2007-05-01 | 2008-11-06 | Sigmoid Pharma Limited | Pharmaceutical nimodipine compositions |
| EP2278966B1 (en) | 2008-03-21 | 2019-10-09 | The University of Chicago | Treatment with opioid antagonists and mtor inhibitors |
| ES2627745T3 (es) * | 2008-11-13 | 2017-07-31 | Nogra Pharma Limited | Composiciones antisentido, y procedimientos de fabricación y uso de las mismas |
| ES2649112T3 (es) | 2009-05-18 | 2018-01-10 | Sigmoid Pharma Limited | Composición que comprende gotas de aceite |
| CN107582526A (zh) * | 2009-08-12 | 2018-01-16 | 希格默伊德药业有限公司 | 包含聚合物基质和油相的免疫调节组合物 |
| US20170079962A1 (en) | 2009-11-11 | 2017-03-23 | Rapamycin Holdings, Llc | Oral Rapamycin Preparation and Use for Stomatitus |
| US9526648B2 (en) | 2010-06-13 | 2016-12-27 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| US10010439B2 (en) | 2010-06-13 | 2018-07-03 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| US8628554B2 (en) | 2010-06-13 | 2014-01-14 | Virender K. Sharma | Intragastric device for treating obesity |
| US10420665B2 (en) | 2010-06-13 | 2019-09-24 | W. L. Gore & Associates, Inc. | Intragastric device for treating obesity |
| KR101245078B1 (ko) * | 2010-11-11 | 2013-03-18 | 부산대학교 산학협력단 | 대장 선택성 셀레콕시브 전구체 화합물 및 이를 유효성분으로 함유하는 대장성 질환 치료 또는 예방용 약학조성물 |
| GB201020032D0 (en) | 2010-11-25 | 2011-01-12 | Sigmoid Pharma Ltd | Composition |
| US8916588B2 (en) | 2011-03-23 | 2014-12-23 | Ironshore Pharmaceuticals & Development, Inc. | Methods for treatment of attention deficit hyperactivity disorder |
| DK3272342T3 (da) | 2011-03-23 | 2021-06-07 | Ironshore Pharmaceuticals & Dev Inc | Fremgangsmåder og sammensætninger til behandling af opmærksomhedsforstyrrelse |
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| US9119809B2 (en) | 2011-03-23 | 2015-09-01 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
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| US9498447B2 (en) | 2011-03-23 | 2016-11-22 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
| US10905652B2 (en) | 2011-03-23 | 2021-02-02 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
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| EP2699236B1 (en) | 2011-04-22 | 2018-06-20 | Napo Pharmaceuticals Inc | Pharmacologically optimized multimodal drug delivery system for nordihydroguiaretic acid (ndga) |
| KR20140041505A (ko) | 2011-04-29 | 2014-04-04 | 셀렉타 바이오사이언시즈, 인크. | 조절 b 세포 유도를 위한 관용원성 합성 나노운반체 |
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| CA2872400A1 (en) * | 2012-05-04 | 2013-11-07 | University Of Chicago | Bioavailability of oral methylnaltrexone increases with a phosphatidylcholine-based formulation |
| DE102012105528A1 (de) * | 2012-06-25 | 2014-01-02 | Hennig Arzneimittel Gmbh & Co. Kg | Arzneiform zur Freisetzung von Wirkstoffen |
| GB201212010D0 (en) | 2012-07-05 | 2012-08-22 | Sigmoid Pharma Ltd | Formulations |
| JP5992247B2 (ja) * | 2012-08-13 | 2016-09-14 | 国立大学法人大阪大学 | 核酸医薬経口製剤 |
| JP6062802B2 (ja) * | 2012-08-23 | 2017-01-18 | 日清ファルマ株式会社 | キトサン含有組成物及びキトサンコーティング組成物 |
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