JP2020530494A - 健康な腸バリアを維持及び回復するための組成物及び方法 - Google Patents
健康な腸バリアを維持及び回復するための組成物及び方法 Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
Abstract
Description
この出願は、2017年8月7日に出願された米国出願番号62/542,035の利益及び優先権を主張し、その内容はその全体が参照により本明細書に組み込まれる。
本明細書において電子的に提出されたテキストファイルの内容は、参照によりその全体が本明細書に組み込まれる:配列表のコンピューター読み取り可能な形式のコピー(ファイル名:FIN−004PC−SequenceListing_ST25、記録日:2018年8月7日、ファイルサイズ:1.83MB)。
本発明は、腸内に導入されて腸バリアの適切な維持及び欠損腸バリアの回復を促進する細菌株の混合物の医薬組成物(結腸への標的送達用に処方)に関する。
A−OTUのGreenGenes ID
B−OTUが存在する糞便ドナーの数
C−OTUが存在する全ての糞便ドナーの割合
D−そのOTUの分類
E−OTUの16S rRNA配列の配列番号
2この列では、文字は系統分類を指す(例えば、「k」は「界」を指し、「p」は門を指す、など)。
A−その属の分類
B−その属に属する健康な糞便ドナーで見つかったOTU数
C−その属のOTUの16S rRNA配列の配列番号
本発明は、細菌株の新規混合物(及び/又は追加の治療薬)を含む様々な組成(formulation)の医薬組成物を提供する。本明細書に記載の任意の医薬組成物(及び/又は追加の治療薬)は、錠剤、丸剤、ペレット、カプセル、液体を含むカプセル、多粒子を含むカプセル、粉末、溶液、エマルジョン、ドロップ、坐剤、エマルジョン、エアロゾル、スプレー、懸濁液、遅延放出製剤、持続放出製剤、制御放出製剤、又は使用に適した他の形態をとることができる。
本発明に従って投与されるべき細菌株(及び/又は追加の治療薬)の実際の用量は、例えば、特定の剤形及び投与様式に従って変化することが理解されるであろう。細菌株の作用を変更する可能性のある多くの要因(例えば、体重、性別、食事、投与時間、投与経路、排泄率、対象の状態、薬物の組み合わせ、遺伝的素因、及び反応感受性)は、当業者によって考慮され得る。投与は、連続的に、又は最大耐量内の1又は複数の別個の用量で実施することができる。所定の条件のセットに対する最適な投与率は、従来の用法・用量試験を使用して、当業者によって確認され得る。
本発明の製剤の投与は、追加の治療薬と組み合わせてもよい。追加の治療薬と本発明の製剤の同時投与は、同時又は逐次的であってもよい。さらに、本発明の製剤は、追加の治療薬を(例えば、共製剤を介して)含んでもよい。例えば、追加の治療薬と前記細菌株とを組み合わせて単一の製剤にしてもよい。
様々な実施形態では、本発明は、患者の微生物叢を調節して生態学的バランスを提供又は回復する方法を提供する。例えば、様々な実施形態では、本明細書には、本明細書の他の記載における1種類又は複数種類の病原性細菌を減少又は抑制する方法が提供される。様々な実施形態では、本発明の細菌株の混合物は、投与前に患者の消化管に検出可能に存在しない少なくとも1種類の細菌の増殖を促進し、様々な実施形態では、非病原性である。
えヒトパピローマウイルス(HPV)9価ワクチン、組換えヒトパピローマウイルス(HPV)4価ワクチン、レゴラフェニブ、Relistor(臭化メチルナルトレキソン)、R−EPOCH、Revlimid(レナリドミド)、Rheumatrex(メトトレキサート)、リボシクリブ、R−ICE、ロラピタント塩酸塩、ロミデプシン、ロミプロスチム、Rubex(ドキソルビシン)、Rubidomycin(ダウノルビシン塩酸塩)、Rubraca(ルカパリブ)、ルカパリブカンシル酸塩、ルキソリチニブリン酸塩、Rydapt(ミドスタウリン)、Sandostatin(オクトレオチド)、Sandostatin LAR Depot(オクトレオチド)、Sclerosol Intrapleural Aerosol(タルク)、Soltamox(タモキシフェン)、Somatuline Depot(ランレオチド酢酸塩)、ソニデジブ、トシル酸ソラフェニブ、Sprycel(ダサチニブ)、STANFORD V、Sterapred(プレドニゾン)、Sterapred DS(プレドニゾン)、滅菌タルクパウダー(タルク)、Steritalc(タルク)、Sterecyst(プレドニマスチン)、Stivarga(レゴラフェニブ)、リンゴ酸スニチニブ、Supprelin LA(ヒストレリン)、Sutent(リンゴ酸スニチニブ)、Sutent(スニチニブ)、Synribo(オマセタキシンメペスクシナート)、Tabloid(チオグアニン)、TAC、Tafinlar(ダブラフェニブ)、Tagrisso(オシメルチニブ)、タルク、タリモジェンラヘルパレプベク、タモキシフェンクエン酸塩、Tarabine PFS(シタラビン)、Tarceva(エルロチニブ)、Targretin(ベキサロテン)、Tasigna(ダカルバジン)、Tasigna(ニロチニブ)、Taxol(パクリタキセル)、Taxotere(ドセタキセル)、Temodar(テモゾロミド)、テモゾロミド、テムシロリムス、Tepadina(チオテパ)、サリドマイド、Thalomid(サリドマイド)、TheraCys BCG(BCG)、チオグアニン、Thioplex(チオテパ)、チオテパ、TICE BCG(BCG)、チサゲンレクロイセル、Tolak(フルオロウラシル−局所用)、Toposar(エトポシド)、トポテカン塩酸塩、トレミフェン、Torisel(テムシロリムス)、Totect(デクスラゾキサン塩酸塩)、TPF、トラベクテジン、トラメチニブ、Treanda(ベンダムスチン塩酸塩)、Trelstar(トリプトレリン)、Trexall(メトトレキサート)、トリフルリジン・チピラシル塩酸塩、Trisenox(三酸化二ヒ素)、Tykerb(ラパチニブ)、ウリジントリアセタート、VAC、バルルビシン、Valstar(バルルビシン膀胱内投与用)、Valstar(バルルビシン)、VAMP、バンデタニブ、Vantas(ヒストレリン)、Varubi(ロラピタント)、VeIP、Velban(ビンブラスチン)、Velcade(ボルテゾミブ)、Velsar(ビンブラスチン硫酸塩)、ベムラフェニブ、Venclexta(ベネトクラックス)、Vepesid(エトポシド)、Verzenio(アベマシクリブ)、Vesanoid(トレチノイン)、Viadur(ロイプロリド酢酸塩)、Vidaza(アザシチジン)、ビンブラスチン硫酸塩、Vincasar PFS(ビンクリスチン)、Vincrex(ビンクリスチン)、ビンクリスチン硫酸塩、ビンクリスチン硫酸塩リポソーム、ビノレルビン酒石酸塩、VIP、ビスモデギブ、Vistogard(ウリジントリアセテート)、Voraxaze(グルカルピダーゼ)、Vorinostat、Votrient(パゾパニブ)、Vumon(テニポシド)、Vyxeos(ダウノルビシン塩酸塩・シタラビンリポソーム)、Wellcovorin(ロイコボリンカルシウム)、Wellcovorin IV(ロイコボリン)、Xalkori(クリゾチニブ)、XELIRI、Xeloda(カペシタビン)、XELOX、Xofigo(塩化ラジウム223)、Xtandi(エンザルタミド)、Yescarta(アキシカブタゲンシロロイセル)、Yondelis(トラベクテジン)、Zaltrap(アフリベルセプト)、Zanosar(ストレプトゾトシン)、Zarxio(フィルグラスチム)、Zejula(ニラパリブ)、Zelboraf(ベムラフェニブ)、Zinecard(デキスラゾキサン塩酸塩)、アフリベルセプト、Zofran(オンダンセトロン塩酸塩)、Zoladex(ゴセレリン)、ゾレドロン酸、Zolinza(ボリノスタット)、Zometa(ゾレドロン酸)、Zortress(エベロリムス)、Zydelig(イデラリシブ)、Zykadia(セリチニブ)、Zytiga(酢酸アビラテロン)、及びZytiga(アビラテロン)が挙げられる。
本明細書で使用する場合、「単離された」又は「純化された」とは、(1)最初に(自然又は実験的環境において)産生されたときに関連していた成分の少なくとも一部から分離された、及び/又は(2)人工的に生産、調製、純化、及び/又は製造された、細菌又は他の実体若しくは物質を指す。単離又は純化された細菌は、最初に関連付けられていた他の成分の少なくとも約10%、約20%、約30%、約40%、約50%、約60%、約70%、約80%、約90%又はそれ以上から分離可能である。
表5及び表5(上記)は、腸バリアの維持及び回復に役立つ細菌株を特定するために、公的及び私的ソースからの16S rRNA配列データを使用した分析の結果である。
腸バリアの完全性を、例えば、抗がん療法を受ける前、受けている時、及び/又は受けた後に、保護、維持、及び/又は回復する共生細菌株の新規の混合物を含む製品候補が開発されている。
する能力、機能的欠損を有する微生物群(例えば、病原菌が感染した及び/又はコロニー形成した患者の微生物群)の能力を補完して健康な個体に匹敵するレベルのSCFAを産生する能力、分泌物の産生を通じて病原性細菌を直接阻害する能力、粘膜治癒を可能にする能力、粘膜バリア機能を改善する能力、及び/又は炎症を軽減する能力、SCFAの産生を強化すること、SCFAの病原性細菌産生を根絶すること、粘膜バリア機能を改善する能力、欠損腸バリアを維持及び/又は修復するのを助ける能力、結腸上皮粘液の肥厚化を誘導する能力、IgA産生の増加を誘導する能力、タイトジャンクションの完全性の改善を誘導する能力、及び/又は粘膜バリア機能の回復を促進する能力に基づくものである。
実施例1及び/又は実施例2で選択された菌株は、独立して培養され、投与前に混合されてもよい。培養株は、支持培地、例えば、37℃及びpH7で、1g/Lシステイン・HClで予め還元したGMM又はその他の動物性製品非含有培地で独立して増殖される。各菌株が十分なバイオマスに達した後、所望により15%のグリセロールを添加して細胞バンク用に保存した後−80°Cで1mlのクライオチューブ内で凍結する。
腸内細菌叢異常を有する対象には、腸内細菌叢異常を治療するために本発明の細菌混合物を含む医薬組成物が投与される。
腸内細菌叢異常のリスクを有する対象には、腸内細菌叢異常を予防するために本発明の細菌混合物を含む医薬組成物が投与される。
本発明をその特定の実施形態に関連して説明したが、さらなる修正が可能であり、本出願は、本発明のあらゆる変形、使用、又は適応を網羅することを意図しており、一般に本発明の原理に従い、本開示からのかかる逸脱を含み、本発明が関係する技術分野内の既知又は慣例の範囲内であり、添付の特許請求の範囲内で前述及び以下の本質的特徴に適用できるものであることが理解されるであろう。
本明細書で参照される全ての特許及び刊行物は、その全体が参照により本明細書に組み込まれる。
Claims (99)
- 細菌混合物を含む医薬組成物であって、前記細菌混合物中の少なくとも1種類の細菌株が、表5に記載の操作的分類単位(OTU)のいずれか1つの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含む、細菌混合物を含む医薬組成物。
- 細菌混合物を含む医薬組成物であって、前記細菌混合物中の少なくとも1種類の細菌株が、表6に記載される属のいずれか1つの操作的分類単位(OTU)の16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含む、細菌混合物を含む医薬組成物。
- 前記細菌混合物中の前記少なくとも1種類の細菌株の16S rRNA配列が、表5に記載のOTUのいずれか1つ又は表6に記載される属のいずれか1つのOTUの16S rRNA配列に対して約98%超の同一性を有する、請求項1又は請求項2に記載の医薬組成物。
- 前記細菌混合物中の前記少なくとも1種類の細菌株の16S rRNA配列が、表5に記載のOTUのいずれか1つ又は表6に記載される属のいずれか1つのOTUの16S rRNA配列に対して約99%超の同一性を有する、請求項1〜請求項3のいずれか一項に記載の医薬組成物。
- 前記細菌混合物中の前記少なくとも1種類の細菌株の16S rRNA配列が、表5に記載のOTUのいずれか1つ又は表6に記載される属のいずれか1つのOTUの16S rRNA配列に対して約99.5%超の同一性を有する、請求項1〜請求項4のいずれか一項に記載の医薬組成物。
- 前記細菌混合物中の前記少なくとも1種類の細菌株の16S rRNA配列が、表5に記載のOTUのいずれか1つ又は表6に記載される属のいずれか1つのOTUの16S rRNA配列と同一である、請求項1〜請求項5のいずれか一項に記載の医薬組成物。
- 前記少なくとも1種類の細菌株が、共生細菌株である、請求項1〜請求項6のいずれか一項に記載の医薬組成物。
- 前記少なくとも1種類の細菌株が、1人又は複数人のヒトから得られる、請求項1〜請求項7のいずれか一項に記載の医薬組成物。
- 前記1人又は複数人のヒトが健康なヒトである、及び/又は、少なくとも1つの選択基準を満たす、請求項8に記載の医薬組成物。
- 前記少なくとも1種類の細菌株が1人のヒトから得られる、請求項8又は請求項9に記載の医薬組成物。
- 前記少なくとも1種類の細菌株が複数人のヒトから得られる、請求項8又は請求項9に記載の医薬組成物。
- 前記少なくとも1種類の細菌株が、前記細菌混合物を形成する前にその由来材料から単離及び/又は純化される、請求項1〜請求項11のいずれか一項に記載の医薬組成物。
- 前記少なくとも1種類の細菌株が、前記細菌混合物を形成する前に培養される、請求項1〜請求項12のいずれか一項に記載の医薬組成物。
- 前記少なくとも1種類の細菌株が、前記細菌混合物を形成する前に培養されない、請求項1〜請求項12のいずれか一項に記載の医薬組成物。
- 前記少なくとも1種類の細菌株が、前記細菌混合物を形成する前にその由来材料から単離及び/又は純化されない、請求項1〜請求項11のいずれか一項に記載の医薬組成物。
- 前記少なくとも1種類の細菌株が、前記細菌混合物を形成する前に培養されない、請求項15に記載の医薬組成物。
- 前記少なくとも1種類の細菌株が、実験用ストック又は細菌細胞バンクから取得される、請求項1〜請求項7のいずれか一項に記載の医薬組成物。
- 前記少なくとも1種類の細菌株が、前記細菌混合物を形成する前にその由来材料から単離及び/又は純化される、請求項17に記載の医薬組成物。
- 前記少なくとも1種類の細菌株が、前記細菌混合物を形成する前に培養される、請求項17又は請求項18に記載の医薬組成物。
- 前記細菌混合物が、表5に記載のOTUのうち1つの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含む細菌株を2種類以上含む、請求項1〜請求項19のいずれか一項に記載の医薬組成物。
- 前記細菌混合物が約5種類以上の細菌株を含み、前記細菌株のうち複数種類が、表5に記載のOTUのうち1つの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含む、請求項20に記載の医薬組成物。
- 前記細菌混合物が約10種類以上の細菌株を含み、前記細菌株のうち複数種類が、表5に記載のOTUのうち1つの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含む、請求項21に記載の医薬組成物。
- 前記細菌混合物が約20種類以上の細菌株を含み、前記細菌株のうち複数種類が、表5に記載のOTUのうち1つの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含む、請求項22に記載の医薬組成物。
- 前記細菌混合物が約30種類以上の細菌株を含み、前記細菌株のうち複数種類が、表5に記載のOTUのうち1つの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含む、請求項23に記載の医薬組成物。
- 前記細菌混合物が約40種類以上の細菌株を含み、前記細菌株のうち複数種類が、表5に記載のOTUのうち1つの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含む、請求項24に記載の医薬組成物。
- 前記細菌混合物が約50種類以上の細菌株を含み、前記細菌株のうち複数種類が、表5に記載のOTUのうち1つの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含む、請求項25に記載の医薬組成物。
- 前記細菌混合物が2種類以上の細菌株を含み、前記細菌混合物中の各細菌株が、表5に記載のOTUのうち1つの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含む、請求項1〜請求項26のいずれか一項に記載の医薬組成物。
- 前記細菌混合物が、前記細菌混合物中に約5種類〜約100種類の細菌株を含み、前記細菌株のうち複数種類が、表5に記載のOTUのうち1つの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含む、請求項1〜請求項26のいずれか一項に記載の医薬組成物。
- 前記細菌混合物が、前記細菌混合物中に約10種類〜約75種類の細菌株を含み、前記細菌株のうち複数種類が、表5に記載のOTUのうち1つの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含む、請求項28に記載の医薬組成物。
- 前記細菌混合物が、前記細菌混合物中に約15種類〜約50種類の細菌株を含み、前記細菌株のうち複数種類が、表5に記載のOTUのうち1つの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含む、請求項29に記載の医薬組成物。
- 前記細菌混合物が、前記細菌混合物中に約20種類〜約45種類の細菌株を含み、前記細菌株のうち複数種類が、表5に記載のOTUのうち1つの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含む、請求項30に記載の医薬組成物。
- 前記細菌混合物が、前記細菌混合物中に約25種類〜約40種類の細菌株を含み、前記細菌株のうち複数種類が、表5に記載のOTUのうち1つの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含む、請求項31に記載の医薬組成物。
- 前記細菌混合物が、前記細菌混合物中に約30種類〜約35種類の細菌株を含み、前記細菌株のうち複数種類が、表5に記載のOTUのうち1つの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含む、請求項32に記載の医薬組成物。
- 前記細菌混合物が、前記細菌混合物中に約5種類〜約100種類の細菌株を含み、各細菌株が、表5に記載のOTUのうち1つの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含む、請求項1〜請求項21のいずれか一項に記載の医薬組成物。
- 前記細菌混合物が、単一のドナーからの実質的に完全な糞便微生物叢調製物を含む、請求項1〜請求項27のいずれか一項に記載の医薬組成物。
- 前記細菌混合物が、表6に記載される属のいずれか1つのOTUの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含む細菌株を2種類以上含む、請求項1〜請求項19のいずれか一項に記載の医薬組成物。
- 前記細菌混合物が約5種類以上の細菌株を含み、前記細菌株のうち複数種類が、表6に記載される属のいずれか1つのOTUの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含む、請求項36記載の医薬組成物。
- 前記細菌混合物が約10種類以上の細菌株を含み、前記細菌株のうち複数種類が、表6に記載される属のいずれか1つのOTUの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含む、請求項37記載の医薬組成物。
- 前記細菌混合物が約20種類以上の細菌株を含み、前記細菌株のうち複数種類が、表6に記載される属のいずれか1つのOTUの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含む、請求項38記載の医薬組成物。
- 前記細菌混合物が約30種類以上の細菌株を含み、前記細菌株のうち複数種類が、表6に記載される属のいずれか1つのOTUの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含む、請求項39記載の医薬組成物。
- 前記細菌混合物が約40種類以上の細菌株を含み、前記細菌株のうち複数種類が、表6に記載される属のいずれか1つのOTUの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含む、請求項40記載の医薬組成物。
- 前記細菌混合物が約50種類以上の細菌株を含み、前記細菌株のうち複数種類が、表6に記載される属のいずれか1つのOTUの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含む、請求項41記載の医薬組成物。
- 前記細菌混合物が2種類以上の細菌株を含み、前記細菌混合物中の各細菌株が、表6に記載される属のいずれか1つのOTUの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含む、請求項1〜請求項19のいずれか一項に記載の医薬組成物。
- 前記細菌混合物が、前記細菌混合物中に約5種類〜約100種類の細菌株を含み、前記細菌株のうち複数種類が、表6に記載される属のいずれか1つのOTUの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含む、請求項1〜請求項19のいずれか一項に記載の医薬組成物。
- 前記細菌混合物が、前記細菌混合物中に約10種類〜約75種類の細菌株を含み、前記細菌株のうち複数種類が、表6に記載される属のいずれか1つのOTUの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含む、請求項44に記載の医薬組成物。
- 前記細菌混合物が、前記細菌混合物中に約15種類〜約50種類の細菌株を含み、前記細菌株のうち複数種類が、表6に記載される属のいずれか1つのOTUの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含む、請求項45に記載の医薬組成物。
- 前記細菌混合物が、前記細菌混合物中に約20種類〜約45種類の細菌株を含み、前記細菌株のうち複数種類が、表6に記載される属のいずれか1つのOTUの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含む、請求項46に記載の医薬組成物。
- 前記細菌混合物が、前記細菌混合物中に約25種類〜約40種類の細菌株を含み、前記細菌株のうち複数種類が、表6に記載される属のいずれか1つのOTUの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含む、請求項47に記載の医薬組成物。
- 前記細菌混合物が、前記細菌混合物中に約30種類〜約35種類の細菌株を含み、前記細菌株のうち複数種類が、表6に記載される属のいずれか1つのOTUの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含む、請求項48に記載の医薬組成物。
- 前記細菌混合物が、前記細菌混合物中に約5種類〜約100種類の細菌株を含み、各細菌株が、表6に記載される属のいずれか1つのOTUの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含む、請求項1〜請求項19のいずれか一項に記載の医薬組成物。
- 前記細菌混合物が、単一のドナーからの実質的に完全な糞便微生物叢調製物を含む、請求項36〜請求項43のいずれか一項に記載の医薬組成物。
- 少なくとも1種類の細菌株が、血流感染(BSI)を発症した対象の糞便中の当該細菌株の量と比較して、BSIを発症しなかった対象の糞便中の当該細菌株の量が多量であるために前記細菌混合物に含まれる、請求項1〜請求項51のいずれか一項に記載の医薬組成物。
- 少なくとも1種類の細菌株が、血流感染(BSI)を発症した化学療法を受けている対象の糞便中の当該細菌株の量と比較して、BSIを発症しなかった化学療法を受けている対象の糞便中の当該細菌株の量が多量であるために前記細菌混合物に含まれる、請求項1〜請求項51のいずれか一項に記載の医薬組成物。
- 前記多量が2倍以上である、請求項53に記載の医薬組成物。
- 少なくとも1種類の細菌株が、グラム陰性菌により生じる血流感染(BSI)を発症した対象の糞便中の当該細菌株の量と比較して、グラム陰性菌により生じるBSIを発症しなかった対象の糞便中の当該細菌株の量が多量であるために前記細菌混合物に含まれる、請求項1〜請求項51のいずれか一項に記載の医薬組成物。
- 少なくとも1種類の細菌株が、当該細菌株が、分泌産物の産生を通じて病原性細菌を直接阻害することにより、Toll様受容体(TLR)を活性化することにより、結腸上皮粘液の肥厚を誘発することにより、IgA産生の増加を誘導することにより、抗菌ペプチド産生の増加を誘導することにより、改善されたタイトジャンクションの完全性(integrity)を誘導することにより、短鎖脂肪酸(SCFA)を産生することにより、SCFAの産生を強化することにより、結腸細胞の健康を維持することにより、IgA産生を誘導することにより、腸内の酪酸レベルを増加させることにより、一酸化窒素合成酵素活性を阻害することにより、及び/又は腸内における宿主由来の硝酸塩濃度を下げることにより、腸管バリアの維持及び/又は修復を助ける能力を有するために前記細菌混合物に含まれる、請求項1〜請求項55のいずれか一項に記載の医薬組成物。
- 複数の細菌株が、当該細菌株が、分泌産物の産生を通じて病原性細菌を直接阻害することにより、Toll様受容体(TLR)を活性化することにより、結腸上皮粘液の肥厚を誘導することにより、IgA産生の増加を誘導することにより、抗菌ペプチド産生の増加を誘導することにより、改善されたタイトジャンクションの完全性を誘導することにより、短鎖脂肪酸(SCFA)を産生することにより、SCFAの産生を強化することにより、結腸細胞の健康を維持することにより、IgA産生を誘導することにより、腸内の酪酸レベルを増加させることにより、一酸化窒素合成酵素活性を阻害することにより、及び/又は腸内における宿主由来の硝酸塩濃度を下げることにより、腸管バリアの維持及び/又は修復を助ける能力があるために前記細菌混合物に含まれる、請求項56に記載の医薬組成物。
- TLRを活性化すると、抗菌ペプチドの産生が調節される、請求項56又は請求項57に記載の医薬組成物。
- 前記病原性細菌は抗生物質耐性菌(ARB)である、請求項56〜請求項58のいずれか一項に記載の医薬組成物。
- 医薬的に許容される添加剤をさらに含む、請求項1〜請求項59のいずれか一項に記載の医薬組成物。
- 前記医薬組成物は、経口投与用及び/又は前記細菌混合物の腸への送達用に製剤化される、請求項1〜請求項60のいずれか一項に記載の医薬組成物。
- 前記腸が小腸又は大腸を含む、請求項61に記載の医薬組成物。
- 前記腸が小腸及び大腸を含む、請求項62に記載の医薬組成物。
- 前記腸が大腸を含む、請求項62に記載の医薬組成物。
- 前記大腸が盲腸を含む、請求項62〜請求項64のいずれか一項に記載の医薬組成物。
- 送達が、直腸より前で実質的に完了する、請求項61〜請求項65のいずれか一項に記載の医薬組成物。
- 前記医薬組成物がカプセルとして製剤化される、請求項61〜請求項66のいずれか一項に記載の医薬組成物。
- 前記カプセルが遅延放出コーティングを含む、請求項67に記載の医薬組成物。
- 前記細菌混合物中の前記細菌株のうち複数種類が、生きている栄養細胞、及び/又は凍結乾燥細胞である、請求項1〜請求項68のいずれか一項に記載の医薬組成物。
- 前記細菌混合物中の前記細菌株のうち複数種類が胞子である、請求項1〜請求項69のいずれか一項に記載の医薬組成物。
- 前記細菌混合物中の前記細菌株のうち複数種類が非病原性細菌である、請求項1〜請求項70のいずれか一項に記載の医薬組成物。
- 前記細菌混合物中の各細菌株が非病原性細菌である、請求項1〜請求項71のいずれか一項に記載の医薬組成物。
- 前記医薬組成物は、対象における健康な腸バリアを維持及び/又は回復することができる、請求項1〜請求項72のいずれか一項に記載の医薬組成物。
- 前記対象がヒトである、請求項73に記載の医薬組成物。
- 前記細菌混合物中の少なくとも1種類の細菌株は、表5又は表6に記載されるバルネシエラ(Barnesiellaceae)科由来のOTUの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含み、前記細菌混合物中の少なくとも1種類の細菌株は、表5又は表6に記載されるS24−7科由来のOTUの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含み、前記細菌混合物中の少なくとも1種類の細菌株は、表5又は表6に記載されるMogibacteriaceae科由来のOTUの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含み、前記細菌混合物中の少なくとも1種類の細菌株は、表5又は表6に記載されるクリステンセネラ(Chrissensenellaceae)科由来のOTUの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含み、前記細菌混合物中の少なくとも1種類の細菌株は、表5又は表6に記載されるラクノスピラ(Lachnospiraceae)科由来のOTUの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含み、及び/又は前記細菌混合物中の少なくとも1種類の細菌株は、表5又は表6に記載されるルミノコッカス(Ruminococcaceae)科由来のOTUの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含む、請求項1〜請求項74のいずれか一項に記載の医薬組成物。
- 前記細菌混合物中の少なくとも1種類の細菌株は、表5又は表6に記載されるバルネシエラ(Barnesiellaceae)科由来のOTUの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含み、前記細菌混合物中の少なくとも1種類の細菌株は、表5又は表6に記載されるS24−7科由来のOTUの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含み、前記細菌混合物中の少なくとも1種類の細菌株は、表5又は表6に記載されるMogibacteriaceae科由来のOTUの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含み、前記細菌混合物中の少なくとも1種類の細菌株は、表5又は表6に記載されるクリステンセネラ(Chrissensenellaceae)科由来のOTUの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含み、前記細菌混合物中の少なくとも1種類の細菌株は、表5又は表6に記載されるラクノスピラ(Lachnospiraceae)科由来のOTUの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含み、及び前記細菌混合物中の少なくとも1種類の細菌株は、表5又は表6に記載されるルミノコッカス(Ruminococcaceae)科由来のOTUの16S rRNA配列に対して約97%超の同一性を有する16S rRNA配列を含む、請求項75に記載の医薬組成物。
- 有効量の請求項1〜請求項76のいずれか一項に記載の医薬組成物を、投与を必要とする対象に投与することを含む、1種類又は複数種類の病原性細菌が腸バリアを越えて移動するのを防ぐ方法。
- 前記1種類又は複数種類の病原性細菌は、まだ腸バリアを越えて移動して対象の血流に入ることはしていない、請求項77に記載の方法。
- 前記1種類又は複数種類の病原性細菌は、腸バリアを越えて移動して対象の血流に既に入っている、請求項77に記載の方法。
- 有効量の前記医薬組成物の投与は、腸バリアを超える前記1種類又は複数種類の病原性細菌のさらなる移動及び対象の血流への進入を防ぐ、請求項79に記載の方法。
- 前記1種類又は複数種類の病原性細菌による血流への進入は、血流感染(BSI)、カテーテル又は血管内ライン感染、肝障害、例えば血液透析に関連した慢性炎症、慢性炎症性疾患、化学療法による細胞毒性、凝固亢進、腸から離れた部位での感染、例えば潰瘍性大腸炎やクローン病などの炎症性腸疾患、過敏性腸症候群、例えばII型糖尿病を含むインスリン抵抗性などの代謝性疾患、その他の公知の抗生物質耐性感染、関節リウマチ、例えば抗生物質耐性尿路感染及びカテーテル関連尿路感染などの尿路感染(UTI)、及び創傷感染から選択される疾患を引き起こす、請求項77〜請求項80のいずれか一項に記載の方法。
- 前記1種類又は複数種類の病原性細菌は、エロモナス・ハイドロフィラ(Aeromonas hydrophila)、バチルス・セレウス(Bacillus cereus)などのバチルス属(Bacillus)、ビフィドバクテリウム属(Bifidobacterium)、ボルデテラ属(Bordetella)、ボレリア属(Borrelia)、ブルセラ属(Brucella)、バークホルデリア属(Burkholderia)、クロストリディオイデス・ディフィシル(C. difficile)、カンピロバクター・フェタス(Campylobacter fetus)及びカンピロバクター・ジェジュニ(Campylobacter jejuni)などのカンピロバクター属(Campylobacter)、クラミジア属(Chlamydia)、クラミドフィラ属(Chlamydophila)、クロストリジウム・ボツリヌム(Clostridium botulinum)、クロストリジウム・ディフィシル(Clostridium difficile)、及びクロストリジウム・パーフリンジェンス(Clostridium perfringens)などのクロストリジウム属(Clostridium)、コリネバクテリウム属(Corynebacterium)、コクシエラ属(Coxiella)、エーリキア属(Ehrlichia)、カルバペネム耐性腸内細菌(Carbapenem−resistent Enterobacteriaceae、CRE)フルオロキノロン耐性腸内細菌(fluoroquinolone−resistant Enterobacteriaceae)、及び基質特異性拡張型βラクタマーゼ産生腸内細菌(Extended Spectrum Beta−Lactamase producing Enterobacteriaceae、ESBL−E)などの腸内細菌(Enterobacteriaceae)、バンコマイシン耐性腸球属菌(vancomycin−resistant enterococcus spp.)、基質特異性拡張型βラクタマーゼ耐性腸球菌(extended spectrum beta−lactam resistant Enterococci、ESBL)、及びバンコマイシン耐性腸球菌(vancomycin−resistant Enterococci、VRE)などの腸球菌属(Enterococcus)、腸管凝集性大腸菌(enteroaggregative Escherichia coli)、腸管出血性大腸菌(enterohemorrhagic Escherichia coli)、腸管侵入性大腸菌(enteroinvasive Escherichia coli)、腸管病原性大腸菌(enteropathogenic E. coli)、毒素原性大腸菌(enterotoxigenic Escherichia coli(限定されるものではないがLT及び/又はSTなど))、大腸菌O157:H7(Escherichia coli O157:H7)、及び多剤耐性大腸菌などのエシェリキア属(Escherichia)、フランシセラ属(Francisella)、ヘモフィルス属(Haemophilus)、ヘリコバクター・ピロリ(Helicobacter pylori)などのヘリコバクター属(Helicobacter)、クレブシエラ・ニューモニエ(Klebsiellia pneumonia)及び多剤耐性クレブシエラ菌などのクレブシエラ属(Klebsiella)、レジオネラ属(Legionella)、レプトスピラ属(Leptospira)、リステリア・モノサイトゲネス(Lysteria monocytogenes)などのリステリア属(Listeria)、モルガネラ属(Morganella)、マイコバクテリウム属(Mycobacterium)、マイコプラズマ属(Mycoplasma)、ナイセリア属(Neisseria)、オリエンティア属(Orientia)、プレシオモナス・シゲロイデス(Plesiomonas shigelloides)、抗生物質耐性プロテオバクテリア属(Antibiotic−resistant Proteobacteria)、プロテウス属(Proteus)、シュードモナス属(Pseudomonas)、リケッチア属(Rickettsia)、パラチフス菌(Salmonella paratyphi)、サルモネラ属菌(Salmonella spp.)、及びチフス菌(Salmonella typhi)などのサルモネラ属(Salmonella)、赤痢菌(Shigella spp)などのシゲラ属(Shigella)、黄色ブドウ球菌(Staphylococcus aureus)及びスタフィロコッカス属菌(Staphylococcus spp.)などのスタフィロコッカス属(Staphylococcus)、ストレプトコッカス属(Streptococcus)、トレポネーマ属(Treponema)、コレラ菌(Vibrio cholerae)、腸炎ビブリオ(Vibrio parahaemolyticus)、ビブリオ属菌(Vibrio spp.)、及びビブリオ・バルニフィカス(Vibrio vulnificus)などのビブリオ属(Vibrio)、及びエルシニア・エンテロコリチカ(Yersinia enterocolitica)などのエルシニア属(Yersinia)のうちの1種類又は複数種類を含む、請求項77〜請求項81のいずれか一項に記載の方法。
- 前記1種類又は複数種類の病原性細菌の少なくとも1つが抗生物質耐性菌(ARB)である、請求項77〜請求項82のいずれか一項に記載の方法。
- 前記ARBが抗生物質耐性プロテオバクテリア(Antibiotic−resistant Proteobacteria)、バンコマイシン耐性腸球菌(Vancomycin Resistant Enterococcus、VRE)、カルバペネム耐性腸内細菌(Carbapenem Resistant Enterobacteriaceae、CRE)、フルオロキノロン耐性腸内細菌(fluoroquinolone−resistant Enterobacteriaceae)、又は基質特異性拡張型βラクタマーゼ産生腸内細菌(Extended Spectrum Beta−Lactamase producing Enterobacteriaceae、ESBL−E)である、請求項83に記載の方法。
- 前記投与を必要とする対象が慢性腎臓病を有する、がんを有する、及び/又は臓器移植を受けた、請求項77〜請求項84のいずれか一項に記載の方法。
- 前記投与を必要とする対象が、外来患者である、入院している、及び/又は長期介護施設にいる、請求項77〜請求項85のいずれか一項に記載の方法。
- 前記投与を必要とする対象が、血流感染(BSI)、カテーテル又は血管内ライン感染、肝障害、例えば血液透析に関連した慢性炎症、慢性炎症性疾患、髄膜炎、例えば人工呼吸器関連肺炎などの肺炎、皮膚及び軟部組織の感染、手術部位感染、化学療法による細胞毒性、凝固亢進、腸から離れた部位での感染、例えば潰瘍性大腸炎やクローン病などの炎症性腸疾患、過敏性腸症候群、例えばII型糖尿病を含むインスリン抵抗性などの代謝性疾患、その他の公知の抗生物質耐性感染、その他の公知の抗生物質耐性感染、関節リウマチ、例えば抗生物質耐性尿路感染及びカテーテル関連尿路感染などの尿路感染(UTI)、及び創傷感染から選択される疾患を有するか、又はそのリスクを有する、請求項77〜請求項86のいずれか一項に記載の方法。
- 前記対象が、抗がん治療薬及び/又は抗がん療法を受けた又は受けている、請求項77〜請求項87のいずれか一項に記載の方法。
- 前記抗がん療法が、手術、放射線療法、化学療法、及び/又は標的療法を含む、請求項88に記載の方法。
- 前記化学療法がホルモン療法である又は前記標的療法が免疫療法である、請求項89に記載の方法。
- 前記対象が、腸内細菌叢異常によって引き起こされる抗がん療法の副作用を患っている、請求項88〜請求項90のいずれか一項に記載の方法。
- 前記細菌混合物が、前記抗がん治療薬の副作用及び/又は抗がん療法の副作用を低減、治療、又は予防する、請求項91に記載の方法。
- 有効量の請求項1〜請求項76のいずれか一項に記載の医薬組成物を、投与を必要とする対象に投与することを含む、抗がん治療薬及び/又は抗がん療法の有効性を高める方法。
- 前記抗がん療法が、手術、放射線療法、化学療法、及び/又は標的療法を含む、請求項93に記載の方法。
- 前記医薬組成物が、前記抗がん治療薬及び/又は前記抗がん療法の後に投与される、請求項93又は請求項94に記載の方法。
- 前記医薬組成物が、前記抗がん治療薬及び/又は前記抗がん療法の前に投与される、請求項93又は請求項94に記載の方法。
- 前記医薬組成物が、前記抗がん治療薬及び/又は前記抗がん療法と同時に投与される、請求項93又は請求項94に記載の方法。
- 前記抗がん療法がチェックポイント分子を指向した標的療法であり、前記対象が前記チェックポイント分子を指向した前記治療に不応性及び/又は非応答性である、請求項94〜請求項97のいずれか一項に記載の方法。
- 前記チェックポイント分子を指向した前記治療が、キイトルーダ(ペンブロリズマブ)、オプジーボ(ニボルマブ)、ヤーボイ(イピリムマブ)、テセントリク(アテゾリズマブ)、バベンチオ(アベルマブ)、又はイミフィンジ(デュルバルマブ)の投与を含む、請求項98に記載の方法。
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2020530493A (ja) * | 2017-08-07 | 2020-10-22 | フィンチ セラピューティクス、インコーポレイテッド. | 腸内の抗生物質耐性菌を除菌するための組成物及び方法 |
WO2022158244A1 (ja) * | 2021-01-21 | 2022-07-28 | 株式会社晩聲社 | 細菌叢移植用組成物、その製造方法及び移植方法 |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017100420A1 (en) * | 2015-12-08 | 2017-06-15 | Mayo Foundation For Medical Education And Research | Biomarkers for predicting clostridium difficile infection treatment outcome |
CN111328284A (zh) | 2017-08-07 | 2020-06-23 | 芬奇治疗公司 | 用于维持和恢复健康的肠道屏障的组合物和方法 |
AU2019253714A1 (en) | 2018-04-10 | 2020-11-26 | Siolta Therapeutics, Inc. | Microbial consortia |
US20220054561A1 (en) * | 2018-12-14 | 2022-02-24 | The University Of North Carolina At Chapel Hill | Lachnospiraceae mitigates against radiation-induced hematopoietic/gastrointestinal injury and death, and promotes cancer control by radiation |
US20220339212A1 (en) * | 2019-08-28 | 2022-10-27 | Xbiome Inc. | Compositions comprising bacterial species and methods related thereto |
JP2022551201A (ja) | 2019-10-07 | 2022-12-07 | シオルタ・セラピューティクス,インコーポレイテッド | 治療用医薬組成物 |
KR102215596B1 (ko) * | 2019-12-11 | 2021-02-15 | 주식회사 에이치이엠 | 신규한 스트렙토코커스 써모필러스 hem 14 균주, 및 상기 균주 또는 이의 배양물을 포함하는 장내 환경 개선용 조성물 |
KR102363098B1 (ko) * | 2020-06-19 | 2022-02-16 | 한국식품연구원 | 장내 미생물을 이용한 신질환 위험도 예측 또는 진단용 조성물, 그를 이용한 진단키트, 정보제공방법 및 신질환 예방 또는 치료제 스크리닝 방법 |
FR3114106A1 (fr) * | 2020-09-16 | 2022-03-18 | Lnc Therapeutics | Souche bactérienne appartenant au genre Christensenella et compositions |
IL303884A (en) * | 2020-12-23 | 2023-08-01 | Maat Pharma France Sa A Conseil Dadministration | A method for expanding a complex community of microorganisms |
WO2023225573A2 (en) * | 2022-05-17 | 2023-11-23 | Purdue Research Foundation | Assays, kits and methods for detection of contamination |
CN114933998B (zh) * | 2022-06-14 | 2023-07-07 | 善恩康生物科技(苏州)有限公司 | 能够改善衰老状态或提升运动能力的德氏乳杆菌保加利亚亚种菌株及其应用 |
KR102626402B1 (ko) * | 2022-08-31 | 2024-01-19 | 주식회사 바이오뱅크힐링 | 크리스텐세넬라 미누타 균주, 및 그의 유래의 소포체 및 그의 항염증 및 항균 용도 |
WO2024049207A1 (ko) * | 2022-08-31 | 2024-03-07 | 주식회사 바이오뱅크힐링 | 신규 균주, 및 그의 유래의 소포체 및 그의 항염증 및 항균 용도 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2014507481A (ja) * | 2011-03-09 | 2014-03-27 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | 結腸微生物相移植のための組成物及び方法 |
JP2015520176A (ja) * | 2012-06-06 | 2015-07-16 | シャンハイ ジャオ トン ユニバーシティ | 腸内細菌叢集団を改善する方法および組成物 |
JP2016155880A (ja) * | 2005-06-17 | 2016-09-01 | ウィスコンシン アラムニ リサーチ ファンデーション | 癌の化学療法および放射線療法の際に細胞を保護するための局所的血管収縮剤および方法 |
WO2017091783A2 (en) * | 2015-11-24 | 2017-06-01 | Seres Therapeutics, Inc. | Designed bacterial compositions |
JP2017514872A (ja) * | 2014-05-02 | 2017-06-08 | アトランティック ファーマシューティカルズ(ホールディングス)リミテッド | 消化管における放射線誘発性疾患のアンチセンス治療 |
Family Cites Families (234)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US891777A (en) | 1907-03-05 | 1908-06-23 | Walter Langstroth | Drafting instrument. |
DE1118403B (de) | 1960-01-27 | 1961-11-30 | Hoechst Ag | Verfahren zur Gewinnung von antitumorwirksamen Sporen |
FR1275M (fr) | 1961-05-06 | 1962-05-02 | Rene Roger | Médicament a base de colibacilles vivants. |
BE634858A (ja) | 1962-07-19 | 1900-01-01 | ||
FR2828M (fr) | 1963-03-01 | 1964-11-02 | Lucien Nouvel | Médicament renfermant des colibacilles antibiorésistants. |
FR5528M (ja) | 1965-10-01 | 1967-11-13 | ||
GB1271674A (en) | 1968-07-09 | 1972-04-26 | Nisshin Flour Milling Co | Process and preparation for treating diarrhoea in pigs |
SE371209B (ja) | 1969-10-13 | 1974-11-11 | Cernelle Ab | |
DE2134179A1 (de) | 1971-07-09 | 1973-01-25 | Rolf Dr Schuler | Bifidobakterien enthaltendes praeparat und verfahren zur herstellung desselben |
FR2244464A1 (en) | 1973-06-26 | 1975-04-18 | Serozym Laboratoires | Yeast, lacto- and colibacillus based compsns - used to modify intestinal flora, treat colitis and digestive disorders, etc. |
US4098728A (en) | 1976-01-02 | 1978-07-04 | Solomon Rosenblatt | Medical surgical sponge and method of making same |
FR2385389A1 (fr) | 1977-03-29 | 1978-10-27 | Capsugel Ag | Capsule emboitee remplie d'une matiere visqueuse telle que, notamment, une preparation pharmaceutique liquide |
DE2722806C2 (de) | 1977-05-20 | 1984-12-13 | Capsugel AG, Basel | Kapselkörper für eine Steckkapsel für Arzneimittel oder andere portionsweise zu verpackende Stoffe, sowie Verfahren zu seiner Herstellung |
DE2722822C2 (de) | 1977-05-20 | 1984-11-08 | Capsugel AG, Basel | Verfahren zum Herstellen einer zum Aufnehmen eines viskosen Stoffes, insbesondere eines flüssigen Arzneimittels, geeigneten Steckkapsel |
DE2722807A1 (de) | 1977-05-20 | 1978-11-23 | Capsugel Ag | Verfahren zum herstellen einer mit viskosem stoff gefuellten steckkapsel |
US4335107A (en) | 1978-06-05 | 1982-06-15 | Snoeyenbos Glenn H | Mixture to protect poultry from salmonella |
CH642990A5 (de) | 1978-07-24 | 1984-05-15 | Parke Davis & Co | Verfahren zum faerben von gelatine fuer kapseln mit hilfe eines gegen den abbau durch licht oder oxidation stabilisierten natuerlichen farbstoffes. |
CH637297A5 (fr) | 1978-12-05 | 1983-07-29 | Nestle Sa | Microbille comprenant un microorganisme et son procede de fabrication. |
US4309782A (en) | 1980-09-11 | 1982-01-12 | Esteban Paulin | Device for collecting fecal specimens |
US4536409A (en) | 1981-01-23 | 1985-08-20 | American Can Company | Oxygen scavenger |
US4394377A (en) | 1981-07-31 | 1983-07-19 | Syntex (U.S.A.) Inc. | Ruminant animal performance by co-administering choline and propionate enchancers |
US4452779A (en) | 1982-02-03 | 1984-06-05 | Cockerill Vernon | Composition and method of treating lactating mammals |
US4537776A (en) | 1983-06-21 | 1985-08-27 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions containing N-(2-hydroxyethyl) pyrrolidone |
FI840816A0 (fi) | 1984-03-01 | 1984-03-01 | Farmos Oy | Bakteriepreparat |
JPS615022A (ja) | 1984-06-19 | 1986-01-10 | Advance Res & Dev Co Ltd | 腸内細菌叢改善剤 |
US4892731A (en) | 1986-12-11 | 1990-01-09 | Tadashi Arai | Biological intestinal antiseptics |
IL86859A (en) | 1987-07-10 | 1991-12-15 | E Z Em Inc | Aqueous cathartic solution containing inorganic salts |
EP0303246A3 (en) | 1987-08-12 | 1990-06-20 | The B.F. Goodrich Company | Hydrogenated, ring-opened polymers of cycloolefins |
US4948734A (en) | 1987-08-12 | 1990-08-14 | Mycogen Corporation | Novel isolates of bacillus thuringiensis having activity against nematodes |
WO1990001335A1 (en) | 1988-08-02 | 1990-02-22 | Borody Thomas J | Treatment of gastro-intestinal disorders |
US5443826A (en) | 1988-08-02 | 1995-08-22 | Borody; Thomas J. | Treatment of gastro-intestinal disorders with a fecal composition or a composition of bacteroides and E. Coli |
US5213807A (en) | 1990-05-03 | 1993-05-25 | Chemburkar Pramod B | Pharmaceutical composition containing ibuprofen and a prostaglandin |
JP2961184B2 (ja) | 1990-05-07 | 1999-10-12 | ミヤリサン株式会社 | クロストリジウム・ディフィシル下痢症および偽膜性大腸炎の予防ならびに治療用医薬組成物 |
US5266315A (en) | 1990-05-07 | 1993-11-30 | Kabushiki Kaisha Miyarisan Seibutsu Igaku Kenkyusho | Composite for Clostridium difficile diarrhea and pseudomembranous colitis |
GB9107305D0 (en) | 1991-04-08 | 1991-05-22 | Unilever Plc | Probiotic |
JP3047143B2 (ja) | 1992-04-24 | 2000-05-29 | 堀井薬品工業株式会社 | 腸管洗浄液用組成物及び腸管洗浄液 |
US5317849A (en) | 1992-08-07 | 1994-06-07 | Sauter Manufacturing Corporation | Encapsulation equipment and method |
JP3850891B2 (ja) | 1994-03-01 | 2006-11-29 | ゼリア新薬工業株式会社 | 緩下効果を有する組成物 |
JPH07242557A (ja) | 1994-03-03 | 1995-09-19 | Ss Pharmaceut Co Ltd | 乳酸菌含有瀉下薬組成物 |
US6984513B2 (en) | 1994-03-03 | 2006-01-10 | The Board Of Trustees Of The Leland Stanford Junior University | Anaerobe targeted enzyme-mediated prodrug therapy |
DK0760848T3 (da) | 1994-05-26 | 1998-09-23 | Bracco Spa | Lactobacillusstammer af menneskelig oprindelse, deres sammensætninger og anvendelse deraf |
US5599795A (en) | 1994-08-19 | 1997-02-04 | Mccann; Michael | Method for treatment of idiopathic inflammatory bowel disease (IIBD) |
AUPM864894A0 (en) | 1994-10-07 | 1994-11-03 | Borody, Thomas Julius | Treatment of bowel-dependent neurological disorders |
US5800821A (en) | 1995-03-10 | 1998-09-01 | New England Medical Center Hospitals, Inc. | Bacterial spores as a heat stable vaccine delivery system |
US7048906B2 (en) | 1995-05-17 | 2006-05-23 | Cedars-Sinai Medical Center | Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions |
US5858356A (en) | 1995-12-21 | 1999-01-12 | Abbott Laboratories | Lactobacillus acidophilus to inhibit cryptosporidiosis in mammals |
US5902578A (en) | 1996-03-25 | 1999-05-11 | Abbott Laboratories | Method and formula for the prevention of diarrhea |
US5837238A (en) | 1996-06-05 | 1998-11-17 | Biogaia Biologics Ab | Treatment of diarrhea |
US6087386A (en) | 1996-06-24 | 2000-07-11 | Merck & Co., Inc. | Composition of enalapril and losartan |
WO1998013068A1 (fr) | 1996-09-26 | 1998-04-02 | Vladimir Borisovich Kuperman | Medicament prophylactique 'trisan' |
US5948787A (en) | 1997-02-28 | 1999-09-07 | Alza Corporation | Compositions containing opiate analgesics |
US6162464A (en) | 1997-03-31 | 2000-12-19 | Inkine Pharmaceutical, Inc. | Non-aqueous colonic purgative formulations |
US7374753B1 (en) | 1997-06-03 | 2008-05-20 | Ganeden Biotech, Inc. | Probiotic lactic acid bacterium to treat bacterial infections associated with SIDS |
US6428783B1 (en) | 1998-03-11 | 2002-08-06 | Medtech Center, Inc. | Bank of autochthonous strains of microorganisms and methods of its use for recovery of intestinal microbiocenosis of the men |
US5902743A (en) | 1998-03-20 | 1999-05-11 | Wisconsin Alumni Research Foundation | Probiotic bifidobacterium strain |
CA2331966A1 (en) | 1998-05-06 | 1999-11-11 | Keijiro Nakamura | Microbial culture liquors containing microorganisms differing in characteristics and living in symbiosis and metabolites thereof, carriers and absorbents containing the active components of the culture liquors and utilization of the same |
US6368591B2 (en) | 1998-05-15 | 2002-04-09 | Shanghai Sine Pharmaceutical Corporation Ltd. | Beneficial microbe composition, new protective materials for the microbes, method to prepare the same and uses thereof |
FR2779962B1 (fr) | 1998-06-17 | 2002-12-06 | Karim Ioualalen | Composition cosmetique ou dermopharmaceutique sous forme de perles et procedes pour la preparation |
AT407008B (de) | 1998-08-06 | 2000-11-27 | Viernstein Helmut Dr | Formulierungen mit probiotisch wirksamen mikroorganismen |
US6461607B1 (en) | 1998-08-24 | 2002-10-08 | Ganeden Biotech, Inc. | Probiotic, lactic acid-producing bacteria and uses thereof |
PL347058A1 (en) | 1998-09-17 | 2002-03-11 | North American Vaccine | Streptococcal c beta protein compositions |
EP1005863A1 (en) | 1998-12-04 | 2000-06-07 | Synthelabo | Controlled-release dosage forms comprising a short acting hypnotic or a salt thereof |
EP1137423B1 (en) | 1998-12-11 | 2005-03-09 | Urex Biotech, Inc. | Oral administration of lactobacillus for the treatment and prevention of urogenital infection |
US6245740B1 (en) | 1998-12-23 | 2001-06-12 | Amgen Inc. | Polyol:oil suspensions for the sustained release of proteins |
ID29150A (id) | 1999-01-15 | 2001-08-02 | Entpr Ireland Cs | Penggunaan lactobacillus salivarius |
WO2000051570A1 (fr) | 1999-02-26 | 2000-09-08 | Shionogi & Co., Ltd. | Capsules molles a croquer presentant des proprietes d'administration ameliorees et leur procede de production |
BR0012869A (pt) | 1999-07-30 | 2002-05-21 | Smithkline Beecham Plc | Forma de dosagem farmacêutica de componentes múltiplos |
FR2808689B1 (fr) | 2000-05-11 | 2004-09-03 | Agronomique Inst Nat Rech | Utilisation de souches acetogenes hydrogenotrophes pour la prevention ou le traitement de troubles digestifs |
US20020013270A1 (en) | 2000-06-05 | 2002-01-31 | Bolte Ellen R. | Method for treating a mental disorder |
US20040170617A1 (en) | 2000-06-05 | 2004-09-02 | Finegold Sydney M. | Method of treating diseases associated with abnormal gastrointestinal flora |
US20040062757A1 (en) | 2001-06-05 | 2004-04-01 | Finegold Sydney M. | Method of testing gastrointestinal diseases associated with species of genus clostridium |
US6756032B1 (en) | 2000-07-12 | 2004-06-29 | The Procter & Gamble Company | Method to enhance and/or prolong the effects of a primary challenge to a responsive system with a secondary challenge |
EP1303285A2 (en) | 2000-07-17 | 2003-04-23 | Chr. Hansen A/S | Methods and formulations with probiotic microorganisms and medicaments |
AUPQ899700A0 (en) | 2000-07-25 | 2000-08-17 | Borody, Thomas Julius | Probiotic recolonisation therapy |
US7214370B2 (en) | 2000-12-18 | 2007-05-08 | Probiohealth, Llc | Prebiotic and preservative uses of oil-emulsified probiotic encapsulations |
US6790453B2 (en) | 2001-03-14 | 2004-09-14 | Mccormick & Company, Inc. | Encapsulation compositions and process for preparing the same |
US7815956B2 (en) | 2001-04-27 | 2010-10-19 | Pepsico | Use of erythritol and D-tagatose in diet or reduced-calorie beverages and food products |
MXPA03011017A (es) | 2001-06-01 | 2005-04-29 | Pozen Inc | Composiciones farmaceuticas para la entrega coordinada de nsaids. |
PE20030284A1 (es) | 2001-07-26 | 2003-05-01 | Alimentary Health Ltd | Cepas de bifidobacterium |
US20030092724A1 (en) | 2001-09-18 | 2003-05-15 | Huaihung Kao | Combination sustained release-immediate release oral dosage forms with an opioid analgesic and a non-opioid analgesic |
GB0122935D0 (en) | 2001-09-24 | 2001-11-14 | Meridica Ltd | Dispensing small quantities of particles |
GB0124580D0 (en) | 2001-10-12 | 2001-12-05 | Univ Reading | New composition |
JP4620355B2 (ja) | 2002-04-05 | 2011-01-26 | ユーロ−セルティーク エス.エイ. | 活性化合物の持続、不変及び独立放出のためのマトリクス |
CA2391422A1 (en) | 2002-07-12 | 2004-01-12 | David William Molloy | Rifampin (rifadin, rimactone, rifampicin) and doxycycline, (doryx, vibramycin) and the tetracyclines and other compounds currently classified as antibiotics and anti-tuberculous drugs as a treatment to prevent, modify disease progression and/or improve symptoms for neurodegenerative diseases including alzheimers disease, lewy body dementia, schizophrenia,... |
EP1396263A1 (en) | 2002-08-09 | 2004-03-10 | Warner-Lambert Company | Film coating for tablets and caplets |
IL152127A0 (en) | 2002-10-06 | 2003-05-29 | Bio Balance Corp | Probiotic compositions for the treatment of inflammatory bowel disease |
FR2852843B1 (fr) | 2003-03-24 | 2008-05-23 | Karim Ioualalen | Systeme galenique permettant le masquage du gout |
RU2006108554A (ru) | 2003-08-18 | 2007-09-27 | Дзе Байо Бэлэнс Корпорейшн (Us) | Устойчивая жидкая пробиотическая композиция, ее получение и применения |
US8192733B2 (en) | 2003-08-29 | 2012-06-05 | Cobb & Associates | Probiotic composition useful for dietary augmentation and/or combating disease states and adverse physiological conditions |
US7749509B2 (en) | 2003-08-29 | 2010-07-06 | Cobb And Company, Llp | Treatment of autism using probiotic composition |
US20060177424A1 (en) | 2003-08-29 | 2006-08-10 | Cobb Mark L | Treatment of disease states and adverse physiological conditions utilizing anti-fungal compositions |
US7759105B2 (en) | 2003-08-29 | 2010-07-20 | Cobb & Company, Llp | Probiotic composition useful for dietary augmentation and/or combating disease states and adverse physiological conditions |
US8016816B2 (en) | 2003-09-09 | 2011-09-13 | Convatec Technologies Inc. | Fecal management appliance and method and apparatus for introducing same |
US8025911B2 (en) * | 2004-04-13 | 2011-09-27 | Meiji Dairies Corporation | Preventive and/or remedy for inflammatory bowel diseases |
US7541091B2 (en) | 2004-05-18 | 2009-06-02 | M & G Usa Corporation | Compartmentalized resin pellets for oxygen scavenging |
GB0414811D0 (en) | 2004-07-01 | 2004-08-04 | Meridica Ltd | Dispensing small quantities of particles |
JP2006018748A (ja) | 2004-07-05 | 2006-01-19 | Canon Inc | 情報処理装置及びその制御方法、並びにコンピュータプログラム及びコンピュータ可読記憶媒体 |
EP1800688A1 (en) | 2004-08-05 | 2007-06-27 | Anidral S.R.L. | Folic acid producing bifidobacterium bacterial strains, formulations and use thereof |
BRPI0418986A (pt) | 2004-08-05 | 2007-12-11 | Anidral Srl | cepas bacterianas bifidobacterium produtoras de ácido fólico, formulações e seus usos |
US20070254314A1 (en) | 2004-09-16 | 2007-11-01 | Geier Mark R | Methods of treating autism and autism spectrum disorders |
CA2581764A1 (en) | 2004-09-27 | 2006-04-06 | Sigmoid Biotechnologies Limited | Minicapsule formulations |
US20060076536A1 (en) | 2004-09-29 | 2006-04-13 | Barshied Scott R | Oxygen scavenging pharmaceutical package and methods for making same |
US20060115465A1 (en) | 2004-10-29 | 2006-06-01 | Macfarlane George | Treatment of gastrointestinal disorders |
US7799328B2 (en) | 2004-12-23 | 2010-09-21 | Biocodex | Method for treating weight loss in patients suffering from inflammatory bowel diseases |
ATE526952T1 (de) | 2005-05-20 | 2011-10-15 | Dow Global Technologies Llc | Überwachung der korrekten zufuhr oraler arzneimittel mittels radiofrequenzidentifikationsetiketten |
US20060275223A1 (en) | 2005-06-02 | 2006-12-07 | Burr James B | Erythritol compositions for teeth and gums |
TWI362949B (en) | 2005-09-13 | 2012-05-01 | Bion Tech Inc | Intestines dissolving nature is able to bear the hydrochloric acid in gastric juice and wrap up the benefit covered and grow the fungus of makes up |
ATE489079T1 (de) | 2005-12-29 | 2010-12-15 | Osmotica Kereskedelmi Es Szolgaltata Kft | Mehrschichtige tablette mit dreifacher freisetzungskombination |
JP5006567B2 (ja) | 2006-04-14 | 2012-08-22 | 花王株式会社 | 口腔用固形製剤 |
US7845475B2 (en) | 2006-05-19 | 2010-12-07 | Her Yuan Chyun Co., Ltd. | Controller for magnetic wheels |
EP1886784A1 (en) | 2006-08-09 | 2008-02-13 | Pfizer Products Inc. | Clamping apparatus and method |
US7998510B2 (en) | 2006-08-17 | 2011-08-16 | C. B. Fleet Company, Inc. | Low dose colonic cleansing system |
JP2008106066A (ja) | 2006-09-25 | 2008-05-08 | Tashiro Yasuaki | サポニン及び生菌を含有する組成物 |
WO2008050209A1 (en) | 2006-10-27 | 2008-05-02 | Pfizer Products Inc. | Hydroxypropyl methyl cellulose hard capsules and process of manufacture |
DE102006062250A1 (de) | 2006-12-22 | 2008-06-26 | Roland Saur-Brosch | Verwendung einer Zusammensetzung aus Mineralstoffen und/oder Vitaminen und gegebenenfalls acetogenen und/oder butyrogenen Bakterien zur oralen oder rektalen Verabreichung für die Behandlung und Vorbeugung von abdominalen Beschwerden |
DK2136825T3 (da) | 2007-03-01 | 2014-02-24 | Probi Ab | Anvendelse af Lactobacillus plantarum til forøgelse af bakteriediversiteten |
US8557233B2 (en) | 2007-03-28 | 2013-10-15 | Alimentary Heath Limited | Probiotic bifidobacterium strains |
GB2460781B (en) | 2007-03-28 | 2012-01-25 | Alimentary Health Ltd | Probiotic bifidobacterium strains |
CN103316326B (zh) | 2007-04-04 | 2016-06-15 | 希格默伊德药业有限公司 | 环孢菌素药物组合物 |
US8951570B2 (en) | 2007-04-26 | 2015-02-10 | Sigmoid Pharma Limited | Manufacture of multiple minicapsules |
SI2152250T1 (sl) | 2007-05-07 | 2020-06-30 | Evonik Operations Gmbh | Trdne dozirne oblike, ki vsebujejo enterično oplaščenje s pospešenim sproščanjem zdravila |
EP2155167A2 (en) | 2007-06-04 | 2010-02-24 | Egalet A/S | Controlled release pharmaceutical compositions for prolonged effect |
KR20160083132A (ko) | 2007-06-06 | 2016-07-11 | 바스프 에스이 | 급속 붕해 정제의 제조를 위한 제약 제제 |
CN101686931B (zh) | 2007-06-06 | 2013-06-19 | 巴斯夫欧洲公司 | 用于制备可咀嚼片剂和锭剂的药物配制剂 |
CN101765606A (zh) | 2007-07-27 | 2010-06-30 | 卡吉尔公司 | 多元醇的微粉化 |
EP2030623A1 (en) | 2007-08-17 | 2009-03-04 | Nestec S.A. | Preventing and/or treating metabolic disorders by modulating the amount of enterobacteria |
US20110008554A1 (en) | 2007-08-31 | 2011-01-13 | Invista North America S.A.R.I. | Oxygen scavenging plastic compositions |
WO2009041651A1 (ja) | 2007-09-27 | 2009-04-02 | Mitsubishi Tanabe Pharma Corporation | 速崩壊性固形製剤 |
JP2010540588A (ja) | 2007-10-01 | 2010-12-24 | ラボラトリオス、レスビ、ソシエダッド、リミターダ | 口腔内崩壊錠剤 |
MX2010004222A (es) | 2007-10-19 | 2010-09-14 | Purdue Research Foundation | Formulaciones solidas de compuestos cristalinos. |
JP5327984B2 (ja) | 2007-10-20 | 2013-10-30 | ユニベルシテ・ド・リエージュ | ビフィズス菌の種 |
NZ585210A (en) | 2007-10-26 | 2012-07-27 | Brenda e moore | Probiotic compositions comprising bacteroides and methods for inducing and supporting weight loss |
JP5258268B2 (ja) | 2007-11-19 | 2013-08-07 | フロイント産業株式会社 | 球形粒の製造方法 |
WO2009084678A1 (ja) | 2007-12-28 | 2009-07-09 | Sawai Pharmaceutical Co., Ltd. | 口腔内崩壊錠およびその製造方法 |
CN101496819A (zh) | 2008-01-31 | 2009-08-05 | 青岛东海药业有限公司 | 真杆菌、梭菌制剂及其应用 |
KR100913405B1 (ko) | 2008-03-25 | 2009-08-21 | 광주과학기술원 | Th2-매개 면역 질환의 예방 또는 치료용 조성물 |
WO2009149149A1 (en) | 2008-06-04 | 2009-12-10 | Trustees Of Dartmouth College | Prevention or treatment of immune-relevant disease by modification of microfloral populations |
EP2337569A4 (en) * | 2008-09-25 | 2013-04-03 | Univ New York | COMPOSITIONS AND METHODS FOR CHARACTERIZING AND RESTORING THE GASTROINTESTINAL, SKIN AND NASAL MICROBIOTA |
JP6037615B2 (ja) | 2008-10-02 | 2016-12-07 | サリックス ファーマシューティカルズ リミテッド | 肝性脳症を治療する方法 |
TW201018819A (en) | 2008-10-02 | 2010-05-16 | Pfizer | Rotary supply joint, rotary timing valve and product handling apparatus |
ES2417779T3 (es) | 2008-11-20 | 2013-08-09 | Capsugel Belgium Nv | Aparato para manipular cápsulas y equipo de procesamiento de cápsulas que incluye un aparato de este tipo |
US20100178413A1 (en) | 2008-12-17 | 2010-07-15 | Mark Gorris | Food-based Supplement Delivery System |
WO2010103132A1 (es) | 2009-03-10 | 2010-09-16 | Hero España, S.A. | Aislamiento, identificación y caracterización de cepas con actividad probiótica a partir de heces de lactantes alimentados exclusivamente con leche materna |
US20100255231A1 (en) | 2009-04-01 | 2010-10-07 | Multisorb Technologies, Inc. | Oxygen scavenging films |
CN102414310B (zh) | 2009-04-30 | 2015-05-06 | 阿克图杰尼斯公司 | 用于冷冻干燥乳酸菌的冷冻保护剂 |
US20100285164A1 (en) | 2009-05-11 | 2010-11-11 | Jrs Pharma | Orally Disintegrating Excipient |
WO2010133609A2 (en) | 2009-05-18 | 2010-11-25 | Sigmoid Pharma Limited | Composition comprising oil drops |
WO2010138439A1 (en) | 2009-05-28 | 2010-12-02 | Aptapharma, Inc. | Multiparticulate controlled-release selective serotonin reuptake inhibitor formulations |
CN201441672U (zh) | 2009-07-14 | 2010-04-28 | 赵伟华 | 一次性灌肠装置 |
GB2485327A (en) | 2009-08-12 | 2012-05-09 | Sigmoid Pharma Ltd | Immunomodulatory compositions comprising a polymer matrix and an oil phase |
US20110045222A1 (en) | 2009-08-19 | 2011-02-24 | Eastman Chemical Company | Oxygen-scavenging polymer blends suitable for use in packaging |
GB0916335D0 (en) | 2009-09-17 | 2009-10-28 | Martin W J | Medicaments |
WO2011036601A1 (en) | 2009-09-24 | 2011-03-31 | Pfizer Inc. | Acid resistant capsules |
US20110081320A1 (en) | 2009-10-06 | 2011-04-07 | Nubiome, Inc. | Treatment/Cure of Autoimmune Disease |
EP2485744A4 (en) | 2009-10-09 | 2014-01-22 | Prothera Inc | COMPOSITIONS AND METHODS COMPRISING THE PEDIOCOCCUS TO REDUCE AT LEAST ONE SYMPTOM ASSOCIATED WITH DEVELOPMENT-INVASIVE DISORDER IN A PERSON IN WHICH A DEVELOPMENT-INVASIVE DISORDER HAS BEEN DIAGNOSED |
WO2011046616A2 (en) | 2009-10-15 | 2011-04-21 | New York University | Methods for modulating bacterial infection |
AU2010317423C1 (en) | 2009-11-11 | 2015-01-22 | Alimentary Health Limited | A bifidobacterium strain |
US8810259B2 (en) | 2009-11-13 | 2014-08-19 | Capsugel Belgium Nv | Method of inspection of sealed capsules with a process of determination of the quality of the seal and related equipment for in-line inspection |
AU2011206574B2 (en) | 2010-01-15 | 2015-01-22 | Chu De Brest | Compounds for the treatment of autism |
US20110218216A1 (en) | 2010-01-29 | 2011-09-08 | Kumaravel Vivek | Extended release pharmaceutical composition of donepezil |
US7888062B1 (en) | 2010-02-01 | 2011-02-15 | Microbios, Inc. | Process and composition for the manufacture of a microbial-based product |
HRP20220751T1 (hr) | 2010-02-01 | 2022-09-02 | Rebiotix, Inc. | Bakterioterapija clostridium difficile kolitisa |
US8853269B2 (en) | 2010-02-04 | 2014-10-07 | Copperhead Chemical Company Inc. | Composition and method for treating infections and promoting intestinal health |
CA2792647A1 (en) | 2010-03-10 | 2011-09-15 | Nogra Pharma Limited | Compositions for colon lavage and methods of making and using same |
US9707207B2 (en) | 2010-05-26 | 2017-07-18 | The United States Of America As Represented By The Department Of Veterans Affairs | Method for diagnosing, preventing, and treating neurological diseases |
WO2011151941A1 (ja) | 2010-06-04 | 2011-12-08 | 国立大学法人東京大学 | 制御性t細胞の増殖または集積を誘導する作用を有する組成物 |
US20120020941A1 (en) | 2010-07-26 | 2012-01-26 | Suomen Punainen Risti Veripalvelu | Use of blood group status iii |
EP2598155A2 (en) | 2010-07-26 | 2013-06-05 | Suomen Punainen Risti Veripalvelu | Use of blood group status iii |
EP3311825A1 (en) | 2010-08-04 | 2018-04-25 | Thomas Julius Borody | Compositions for fecal floral transplantation and methods for making and using them |
WO2012045150A1 (en) | 2010-10-04 | 2012-04-12 | British Columbia Cancer Agency Branch | Detection of fusobacterium in a gastrointestinal sample to diagnose gastrointestinal cancer |
PL3072524T3 (pl) | 2010-10-07 | 2018-06-29 | California Institute Of Technology | Probiotyczne terapie dla autyzmu |
ES2920962T3 (es) | 2010-10-08 | 2022-08-12 | Capsugel Belgium Nv | Aparato y procedimiento para adquirir una imagen bidimensional de la superficie de un objeto tridimensional |
GB201020032D0 (en) | 2010-11-25 | 2011-01-12 | Sigmoid Pharma Ltd | Composition |
EP2663294B1 (en) | 2011-01-11 | 2015-09-30 | Capsugel Belgium NV | New hard capsules comprising pullulan |
US10940169B2 (en) * | 2015-11-30 | 2021-03-09 | Joseph E. Kovarik | Method for reducing the likelihood of developing cancer in an individual human being |
WO2012122274A1 (en) | 2011-03-08 | 2012-09-13 | Zalicus Pharmaceuticals Ltd. | Self-emulsifying formulations and methods of use thereof |
US20150374761A1 (en) | 2011-03-09 | 2015-12-31 | Regents Of The University Of Minnesota | Freeze dried fecal microbiota for use in fecal microbial transplantation |
WO2014152484A1 (en) | 2013-03-14 | 2014-09-25 | Regents Of The University Of Minnesota | Freeze dried fecal microbiota for use in fecal microbial transplantation |
WO2013037067A1 (en) | 2011-09-14 | 2013-03-21 | University Of Guelph | Media supplements and methods to culture human gastrointestinal anaerobic microorganisms |
US20140227357A1 (en) | 2011-09-14 | 2014-08-14 | Capsugel Belgium Nv | Fill formulations and capsules and method of use to avoid migration of fill into or through the shell |
DK2750682T3 (en) * | 2011-10-11 | 2016-08-22 | Achim Biotherapeutics Ab | A composition comprising anaerobically cultured human intestinal flora |
GB201118232D0 (en) | 2011-10-21 | 2011-12-07 | M W Encap Ltd | Pharmaceutical composition |
CA2892588A1 (en) | 2011-12-01 | 2013-06-06 | School Corporation, Azabu Veterinary Medicine Educational Institution | Human-derived bacteria that induce proliferation or accumulation of regulatory t cells |
WO2013090825A1 (en) | 2011-12-15 | 2013-06-20 | Pureflora, Inc. | Device for the collection, refinement, and administration of gastrointestinal microflora |
ES2692644T3 (es) | 2012-05-02 | 2018-12-04 | Capsugel Belgium Nv | Dispersiones acuosas de polímeros de liberación controlada y cubiertas y cápsulas para las mismas |
EP2769218B1 (en) | 2012-05-02 | 2016-08-10 | Charles River Laboratories, Inc. | Viability staining method |
US9719144B2 (en) | 2012-05-25 | 2017-08-01 | Arizona Board Of Regents | Microbiome markers and therapies for autism spectrum disorders |
GB201212010D0 (en) | 2012-07-05 | 2012-08-22 | Sigmoid Pharma Ltd | Formulations |
US10220089B2 (en) | 2012-08-29 | 2019-03-05 | California Institute Of Technology | Diagnosis and treatment of autism spectrum disorder |
BR112015009975A2 (pt) | 2012-11-01 | 2017-07-11 | Academisch Ziekenhuis Groningen | métodos e composições para a estimulação das bactérias benéficas no trato gastrointestinal |
US8906668B2 (en) | 2012-11-23 | 2014-12-09 | Seres Health, Inc. | Synergistic bacterial compositions and methods of production and use thereof |
CN104918624A (zh) | 2012-11-26 | 2015-09-16 | 托马斯·朱利叶斯·波洛迪 | 恢复排泄物微生物群的组合物及其制造和使用方法 |
AU2014212003C1 (en) | 2013-02-04 | 2020-07-16 | Seres Therapeutics, Inc. | Compositions and methods for inhibition of pathogenic bacterial growth |
GB201304662D0 (en) | 2013-03-14 | 2013-05-01 | Sigmoid Pharma Ltd | Compositions |
AU2014239883B2 (en) | 2013-03-14 | 2019-01-17 | Therabiome, Llc | Targeted gastrointestinal tract delivery of probiotic organisms and/or therapeutic agents |
WO2014176632A1 (en) | 2013-04-30 | 2014-11-06 | Borody Thomas J | Compositions and methods for treating microbiota-related psychotropic conditions and diseases |
WO2014182966A1 (en) * | 2013-05-10 | 2014-11-13 | California Institute Of Technology | Probiotic prevention and treatment of colon cancer |
CA2914636C (en) | 2013-06-05 | 2021-04-06 | Rebiotix, Inc. | Microbiota restoration therapy (mrt), compositions and methods of manufacture |
US9511100B2 (en) | 2013-06-05 | 2016-12-06 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
US9511099B2 (en) | 2013-06-05 | 2016-12-06 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
US9782445B2 (en) | 2013-06-05 | 2017-10-10 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
US9764019B2 (en) | 2013-07-09 | 2017-09-19 | Vedanta Biosciences, Inc. | Compositions containing combinations of bioactive molecules derived from microbiota for treatment of disease |
AU2014331610B2 (en) | 2013-10-03 | 2019-11-07 | Trustees Of The University Of Pennsylvania | Compositions comprising a defined microbiome and methods of use thereof |
US10058576B2 (en) | 2013-10-03 | 2018-08-28 | The Trustees Of The University Of Pennsylvania | Compositions and methods comprising a defined microbiome and methods of use thereof |
RU2722482C2 (ru) | 2013-11-25 | 2020-06-01 | Серес Терапеутикс, Инк. | Синергические бактериальные композиции и способы их получения и применения |
WO2015095241A2 (en) | 2013-12-16 | 2015-06-25 | Seres Health, Inc. | Bacterial compositions and methods of use thereof for treatment of immune system disorders |
US11213552B2 (en) * | 2015-11-30 | 2022-01-04 | Joseph E. Kovarik | Method for treating an individual suffering from a chronic infectious disease and cancer |
EP3107553B1 (en) | 2014-02-18 | 2021-12-01 | Universitätsklinikum Jena | Methods and compositions for intestinal microenvironment transfer |
WO2015147277A1 (ja) | 2014-03-28 | 2015-10-01 | 株式会社ヤクルト本社 | 酪酸産生菌及びその利用 |
US9176113B1 (en) | 2014-04-11 | 2015-11-03 | Synapdx Corporation | Methods and systems for determining autism spectrum disorder risk |
US20150294081A1 (en) | 2014-04-11 | 2015-10-15 | Synapdx Corporation | Methods and systems for determining autism spectrum disorder risk |
KR102471095B1 (ko) | 2014-06-11 | 2022-11-28 | 메사추세츠 인스티튜트 오브 테크놀로지 | 체류 구조체 및 관련 방법 |
MA41020A (fr) | 2014-11-25 | 2017-10-03 | Evelo Biosciences Inc | Compositions probiotiques et prébiotiques, et leurs procédés d'utilisation pour la modulation du microbiome |
SE1550189A1 (en) | 2015-02-19 | 2016-08-20 | Achim Biotherapeutics Ab | Therapeutic and prophylactic composition produced by microbiota |
CN116270718A (zh) * | 2015-04-23 | 2023-06-23 | Dsm营养产品有限责任公司 | 聚糖治疗剂和治疗方法 |
WO2016183577A1 (en) | 2015-05-14 | 2016-11-17 | Crestovo Llc | Compositions for fecal floral transplantation and methods for making and using them and devices for delivering them |
CA2986485A1 (en) | 2015-05-22 | 2016-12-01 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods for treating autism spectrum disorder and associated symptoms |
WO2017075098A1 (en) | 2015-10-26 | 2017-05-04 | Crestovo Llc | Compositions and methods for fecal microbiota-related therapy |
EP3423093A4 (en) | 2016-03-04 | 2019-11-13 | The Regents of The University of California | MICROBIAL CONSORTIUM AND USES THEREOF |
US20170348360A1 (en) | 2016-06-01 | 2017-12-07 | Crestovo Llc | Compositions and Methods for Treating Inflammatory Bowel Diseases (IBDs) and Other Disorders |
US10849936B2 (en) | 2016-07-01 | 2020-12-01 | Regents Of The University Of Minnesota | Compositions and methods for C. difficile treatment |
US20180000872A1 (en) | 2016-07-01 | 2018-01-04 | Regents Of The University Of Minnesota | Compositions and methods for c. difficile treatment |
US20180036352A1 (en) | 2016-08-03 | 2018-02-08 | Crestovo Holdings Llc | Methods for treating ulcerative colitis |
WO2018057747A1 (en) | 2016-09-21 | 2018-03-29 | Finch Therapeutics, Inc. | Pharmaceutical compositions and methods for delivering microbial compositions |
US10092601B2 (en) | 2016-10-11 | 2018-10-09 | Crestovo Holdings Llc | Compositions and methods for treating multiple sclerosis and related disorders |
FR3062063B1 (fr) * | 2017-01-26 | 2019-04-19 | Centre National De La Recherche Scientifique | Microbiote fecal pour traiter des patients subissant une greffe de cellules souches hematopoietiques |
CN110831606A (zh) | 2017-04-05 | 2020-02-21 | 克雷斯顿沃控股公司 | 治疗帕金森氏病(pd)和相关疾病的组合物和方法 |
CN110892081A (zh) * | 2017-07-17 | 2020-03-17 | 智能Dna股份有限公司 | 诊断菌群失调的方法 |
US20200360450A1 (en) | 2017-08-07 | 2020-11-19 | Finch Therapeutics, Inc. | Treatment of liver disease by modulation of the microbiome |
KR20200037851A (ko) | 2017-08-07 | 2020-04-09 | 핀치 테라퓨틱스, 인코포레이티드 | 장내 항생제 내성 박테리아를 탈콜론화하기 위한 조성물 및 방법 |
CN111328284A (zh) | 2017-08-07 | 2020-06-23 | 芬奇治疗公司 | 用于维持和恢复健康的肠道屏障的组合物和方法 |
WO2019075344A1 (en) | 2017-10-12 | 2019-04-18 | Crestovo Holdings Llc | FECAL MICROBIOTE TRANSPLANTATION TO TREAT HEMORRHAGIC RECTOCOLITE |
EP3755353A4 (en) | 2018-02-23 | 2022-03-09 | Finch Therapeutics Holdings LLC | IMMUNOTHERAPIES ASSOCIATED WITH THE MICROBIOME |
US20190358274A1 (en) | 2018-05-25 | 2019-11-28 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods for treating autism spectrum disorder and associated symptoms |
-
2018
- 2018-08-07 CN CN201880065160.0A patent/CN111328284A/zh active Pending
- 2018-08-07 AU AU2018313766A patent/AU2018313766A1/en active Pending
- 2018-08-07 KR KR1020207006803A patent/KR20200038506A/ko not_active Application Discontinuation
- 2018-08-07 US US16/636,828 patent/US11865145B2/en active Active
- 2018-08-07 EP EP18843863.4A patent/EP3664823A4/en active Pending
- 2018-08-07 WO PCT/US2018/045593 patent/WO2019032573A1/en unknown
- 2018-08-07 JP JP2020530424A patent/JP2020530494A/ja active Pending
- 2018-08-07 CA CA3072032A patent/CA3072032A1/en active Pending
-
2023
- 2023-09-26 US US18/474,845 patent/US20240033305A1/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2016155880A (ja) * | 2005-06-17 | 2016-09-01 | ウィスコンシン アラムニ リサーチ ファンデーション | 癌の化学療法および放射線療法の際に細胞を保護するための局所的血管収縮剤および方法 |
JP2014507481A (ja) * | 2011-03-09 | 2014-03-27 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | 結腸微生物相移植のための組成物及び方法 |
JP2015520176A (ja) * | 2012-06-06 | 2015-07-16 | シャンハイ ジャオ トン ユニバーシティ | 腸内細菌叢集団を改善する方法および組成物 |
JP2017514872A (ja) * | 2014-05-02 | 2017-06-08 | アトランティック ファーマシューティカルズ(ホールディングス)リミテッド | 消化管における放射線誘発性疾患のアンチセンス治療 |
WO2017091783A2 (en) * | 2015-11-24 | 2017-06-01 | Seres Therapeutics, Inc. | Designed bacterial compositions |
Non-Patent Citations (5)
Title |
---|
DAVIS,C.L. ET AL.: "Database DDBJ , ACCESSION NO: JQ465929", DEFINITION:UNCULTURED BACTERIUM CLONE 070047_240 16S RIBOSOMAL RNA GENE,PARTIAL SEQUENCE., vol. Submitted (09-JAN-2012), JPN6023003188, pages Direct Submission, ISSN: 0004977571 * |
EMBO MOLECULAR MEDICINE, vol. 9(4), JPN6022020967, February 2017 (2017-02-01), pages 448 - 461, ISSN: 0004977567 * |
PLOS ONE, vol. 10(9), JPN6022020960, 2015, pages 0138746 - 1, ISSN: 0004787229 * |
日消誌, vol. 112, JPN6022020959, 2015, pages 1973 - 1981, ISSN: 0004977570 * |
領域融合レビュー, vol. 5, JPN6022020963, 2016, pages 007 - 1, ISSN: 0004977568 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2020530493A (ja) * | 2017-08-07 | 2020-10-22 | フィンチ セラピューティクス、インコーポレイテッド. | 腸内の抗生物質耐性菌を除菌するための組成物及び方法 |
WO2022158244A1 (ja) * | 2021-01-21 | 2022-07-28 | 株式会社晩聲社 | 細菌叢移植用組成物、その製造方法及び移植方法 |
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EP3664823A1 (en) | 2020-06-17 |
EP3664823A4 (en) | 2021-05-12 |
US20200368295A1 (en) | 2020-11-26 |
CN111328284A (zh) | 2020-06-23 |
KR20200038506A (ko) | 2020-04-13 |
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