WO2009041651A1 - 速崩壊性固形製剤 - Google Patents

速崩壊性固形製剤 Download PDF

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Publication number
WO2009041651A1
WO2009041651A1 PCT/JP2008/067549 JP2008067549W WO2009041651A1 WO 2009041651 A1 WO2009041651 A1 WO 2009041651A1 JP 2008067549 W JP2008067549 W JP 2008067549W WO 2009041651 A1 WO2009041651 A1 WO 2009041651A1
Authority
WO
WIPO (PCT)
Prior art keywords
solid preparation
disintegrating solid
rapidly disintegrating
sugar
rapidly
Prior art date
Application number
PCT/JP2008/067549
Other languages
English (en)
French (fr)
Inventor
Akiko Ookawa
Yasushi Imada
Yasunari Shinkai
Hideaki Matsumoto
Original Assignee
Mitsubishi Tanabe Pharma Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tanabe Pharma Corporation filed Critical Mitsubishi Tanabe Pharma Corporation
Priority to EP08834316A priority Critical patent/EP2196221A4/en
Priority to US12/733,900 priority patent/US20100233278A1/en
Priority to JP2009534441A priority patent/JP5537943B2/ja
Publication of WO2009041651A1 publication Critical patent/WO2009041651A1/ja
Priority to US13/419,847 priority patent/US20120171296A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)

Abstract

　口腔内の唾液または少量の水の存在下において速やかに崩壊する固形製剤、とりわけ口腔内崩壊性固形製剤として有用な速崩壊性固形製剤を提供する。 　具体的には、平均粒子径７５μｍ以上、かつ、溶解速度の速い糖類または糖アルコールをセルロース類で被覆した被覆造粒物を含有する速崩壊性固形製剤、並びに、ａ）活性成分、ｂ）平均粒子径４００μｍ以上の糖または糖アルコール、ｃ）セルロース類およびｄ）崩壊剤を含有する速崩壊性固形製剤を提供する。
PCT/JP2008/067549 2007-09-27 2008-09-26 速崩壊性固形製剤 WO2009041651A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP08834316A EP2196221A4 (en) 2007-09-27 2008-09-26 SOLID PREPARATION WITH QUICK DISINTEGRATION
US12/733,900 US20100233278A1 (en) 2007-09-27 2008-09-26 Rapidly disintegrating solid preparation
JP2009534441A JP5537943B2 (ja) 2007-09-27 2008-09-26 速崩壊性固形製剤
US13/419,847 US20120171296A1 (en) 2007-09-27 2012-03-14 Rapidly disintegrating solid preparation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-250920 2007-09-27
JP2007250920 2007-09-27

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/419,847 Continuation US20120171296A1 (en) 2007-09-27 2012-03-14 Rapidly disintegrating solid preparation

Publications (1)

Publication Number Publication Date
WO2009041651A1 true WO2009041651A1 (ja) 2009-04-02

Family

ID=40511531

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/067549 WO2009041651A1 (ja) 2007-09-27 2008-09-26 速崩壊性固形製剤

Country Status (4)

Country Link
US (2) US20100233278A1 (ja)
EP (1) EP2196221A4 (ja)
JP (1) JP5537943B2 (ja)
WO (1) WO2009041651A1 (ja)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010137613A1 (ja) * 2009-05-28 2010-12-02 第一三共株式会社 貯蔵安定性が改善された固形製剤
JP2011213695A (ja) * 2010-04-02 2011-10-27 Taisho Pharm Ind Ltd ドネペジル塩酸塩含有口腔内速崩壊錠
WO2012005359A1 (ja) * 2010-07-09 2012-01-12 帝人ファーマ株式会社 口腔内崩壊錠剤
JP2014210746A (ja) * 2013-04-19 2014-11-13 マイクロフーズジャパン株式会社 直打用エリスリトール球形顆粒及びその製造方法並びに該エリスリトール顆粒を薬効成分又は栄養成分とともに打錠する製造方法及びその製造方法で得られた錠剤または一般飲食錠菓
JP5995284B2 (ja) * 2010-12-03 2016-09-21 日本曹達株式会社 固形製剤
WO2019131411A1 (ja) * 2017-12-27 2019-07-04 物産フードサイエンス株式会社 口腔内崩壊錠用エリスリトール顆粒およびその製造方法ならびにそれを用いた口腔内崩壊錠

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AUPQ899700A0 (en) 2000-07-25 2000-08-17 Borody, Thomas Julius Probiotic recolonisation therapy
AUPS088702A0 (en) * 2002-03-04 2002-03-28 Borody, Thomas Julius Electrolyte purgative
US9308226B2 (en) 2010-08-04 2016-04-12 Thomas Julius Borody Compositions for fecal floral transplantation and methods for making and using them and devices for delivering them
DK2651415T3 (da) 2010-12-13 2020-11-30 Rite Prep Pty Ltd Mave- og tyktarmsformuleringer og fremgangsmåder til fremstilling og brug af dem
US9968638B2 (en) 2011-03-09 2018-05-15 Regents Of The University Of Minnesota Compositions and methods for transplantation of colon microbiota
US9719144B2 (en) 2012-05-25 2017-08-01 Arizona Board Of Regents Microbiome markers and therapies for autism spectrum disorders
EP3659598A1 (en) 2012-06-04 2020-06-03 Gaurav Agrawal Compositions and methods for treating crohn's disease and related conditions and infections
CA2880282C (en) 2012-07-27 2020-09-01 Redhill Biopharma Ltd. Formulations and methods of manufacturing formulations for use in colonic evacuation
CN105307654B (zh) 2013-04-30 2022-06-07 托马斯·朱利叶斯·波洛迪 用于治疗微生物区系相关的精神病况和疾病的组合物和方法
CN114159476A (zh) 2015-05-14 2022-03-11 克雷斯顿沃控股公司 用于粪便菌群移植的组合物以及用于制备和使用它们的方法和用于递送它们的装置
KR102358879B1 (ko) 2015-05-22 2022-02-08 아리조나 보드 오브 리젠츠 온 비하프 오브 아리조나 스테이트 유니버시티 자폐 스펙트럼 장애 및 관련된 증상을 치료하는 방법
EP3352773A4 (en) 2015-09-24 2019-03-27 San Diego State University (SDSU) Foundation DBA San Diego State University Research Foundation ANTIBACTERIAL AND PROTECTIVE BACTERIOPHAGE FORMULATIONS AND PROCESS FOR THE PREPARATION AND USE THEREOF
US20170360848A1 (en) 2016-06-15 2017-12-21 Arizona Board Of Regents On Behalf Of Arizona State University Methods for treating autism spectrum disorder and associated symptoms
WO2017217491A1 (ja) * 2016-06-16 2017-12-21 東和薬品株式会社 口腔内崩壊錠
US10849936B2 (en) 2016-07-01 2020-12-01 Regents Of The University Of Minnesota Compositions and methods for C. difficile treatment
US20180036352A1 (en) 2016-08-03 2018-02-08 Crestovo Holdings Llc Methods for treating ulcerative colitis
WO2018071537A1 (en) 2016-10-11 2018-04-19 Crestovo Holdings Llc Compositions and methods for treating multiple sclerosis and related disorders
US10092601B2 (en) 2016-10-11 2018-10-09 Crestovo Holdings Llc Compositions and methods for treating multiple sclerosis and related disorders
WO2018071536A1 (en) 2016-10-11 2018-04-19 Crestovo Holdings Llc Compositions and methods for treating primary sclerosing cholangitis and related disorders
WO2018187464A1 (en) 2017-04-05 2018-10-11 Crestovo Holdings Llc Compositions and methods for treating diverticulitis and related disorders
US11433102B2 (en) 2017-04-05 2022-09-06 Finch Therapeutics Holdings Llc Compositions and methods for treating Parkinson's disease (PD) and related disorders
CN110996917A (zh) 2017-05-26 2020-04-10 克雷斯顿沃控股公司 包含基于粪便微生物的治疗剂的冻干组合物及其制造和使用方法
AU2018313766A1 (en) 2017-08-07 2020-02-20 Finch Therapeutics, Inc. Compositions and methods for maintaining and restoring a healthy gut barrier
US11166990B2 (en) 2018-07-13 2021-11-09 Finch Therapeutics Holdings Llc Methods and compositions for treating ulcerative colitis
EP3856212A1 (en) 2018-09-27 2021-08-04 Finch Therapeutics Holdings LLC Compositions and methods for treating epilepsy and related disorders
CN113876730A (zh) * 2021-10-12 2022-01-04 合肥远志医药科技开发有限公司 一种舒必利制剂及其制备方法
CN117652655A (zh) * 2023-12-06 2024-03-08 浙江贝灵生物医药有限公司 一种闪释辅料及其制备方法和应用

Citations (8)

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Publication number Priority date Publication date Assignee Title
WO1997047287A1 (fr) 1996-06-14 1997-12-18 Kyowa Hakko Kogyo Co., Ltd. Comprime intra-oral a desintegration rapide
JP2000178183A (ja) * 1998-12-17 2000-06-27 Lion Corp 固形製剤及びその製造方法
JP2001058944A (ja) 1999-06-18 2001-03-06 Takeda Chem Ind Ltd 速崩壊性固形製剤
WO2004064810A1 (ja) 2003-01-21 2004-08-05 Nippon Shinyaku Co., Ltd. 口腔内速崩性錠剤
JP2004315483A (ja) 2003-02-28 2004-11-11 Towa Yakuhin Kk 口腔内崩壊錠剤
JP2006022040A (ja) * 2004-07-08 2006-01-26 Towa Yakuhin Kk 高い安定性を有するシンバスタチン固形製剤
JP2007197438A (ja) 2005-12-28 2007-08-09 Dainippon Sumitomo Pharma Co Ltd 口腔内速崩壊錠剤
JP2007250920A (ja) 2006-03-17 2007-09-27 Sanyo Electric Co Ltd 固体電解コンデンサの製造方法

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DE69218687T2 (de) * 1991-07-26 1997-07-10 Mitsubishi Chem Corp Verfahren zur Herstellung von Erythritolkristallen
US5607697A (en) * 1995-06-07 1997-03-04 Cima Labs, Incorporated Taste masking microparticles for oral dosage forms
US5958453A (en) * 1996-10-31 1999-09-28 Takeda Chemical Industries, Ltd. Solid pharmaceutical preparation with improved buccal disintegrability and/or dissolubility
DK1561458T3 (da) * 1998-07-28 2010-10-25 Takeda Pharmaceutical Hurtigt henfaldende fast middel

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997047287A1 (fr) 1996-06-14 1997-12-18 Kyowa Hakko Kogyo Co., Ltd. Comprime intra-oral a desintegration rapide
JP2000178183A (ja) * 1998-12-17 2000-06-27 Lion Corp 固形製剤及びその製造方法
JP2001058944A (ja) 1999-06-18 2001-03-06 Takeda Chem Ind Ltd 速崩壊性固形製剤
WO2004064810A1 (ja) 2003-01-21 2004-08-05 Nippon Shinyaku Co., Ltd. 口腔内速崩性錠剤
JP2004315483A (ja) 2003-02-28 2004-11-11 Towa Yakuhin Kk 口腔内崩壊錠剤
JP2006022040A (ja) * 2004-07-08 2006-01-26 Towa Yakuhin Kk 高い安定性を有するシンバスタチン固形製剤
JP2007197438A (ja) 2005-12-28 2007-08-09 Dainippon Sumitomo Pharma Co Ltd 口腔内速崩壊錠剤
JP2007250920A (ja) 2006-03-17 2007-09-27 Sanyo Electric Co Ltd 固体電解コンデンサの製造方法

Non-Patent Citations (1)

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Title
See also references of EP2196221A4 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010137613A1 (ja) * 2009-05-28 2010-12-02 第一三共株式会社 貯蔵安定性が改善された固形製剤
JP2011213695A (ja) * 2010-04-02 2011-10-27 Taisho Pharm Ind Ltd ドネペジル塩酸塩含有口腔内速崩壊錠
WO2012005359A1 (ja) * 2010-07-09 2012-01-12 帝人ファーマ株式会社 口腔内崩壊錠剤
CN102958514A (zh) * 2010-07-09 2013-03-06 帝人制药株式会社 口腔内崩解片剂
JP5995284B2 (ja) * 2010-12-03 2016-09-21 日本曹達株式会社 固形製剤
JP2014210746A (ja) * 2013-04-19 2014-11-13 マイクロフーズジャパン株式会社 直打用エリスリトール球形顆粒及びその製造方法並びに該エリスリトール顆粒を薬効成分又は栄養成分とともに打錠する製造方法及びその製造方法で得られた錠剤または一般飲食錠菓
WO2019131411A1 (ja) * 2017-12-27 2019-07-04 物産フードサイエンス株式会社 口腔内崩壊錠用エリスリトール顆粒およびその製造方法ならびにそれを用いた口腔内崩壊錠
JPWO2019131411A1 (ja) * 2017-12-27 2020-12-10 物産フードサイエンス株式会社 口腔内崩壊錠用エリスリトール顆粒およびその製造方法ならびにそれを用いた口腔内崩壊錠

Also Published As

Publication number Publication date
JP5537943B2 (ja) 2014-07-02
US20100233278A1 (en) 2010-09-16
US20120171296A1 (en) 2012-07-05
EP2196221A1 (en) 2010-06-16
EP2196221A4 (en) 2011-12-28
JPWO2009041651A1 (ja) 2011-01-27

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