WO2008156217A3 - Pharmaceutical solid preparation comprising benzazepines and production method thereof - Google Patents

Pharmaceutical solid preparation comprising benzazepines and production method thereof Download PDF

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Publication number
WO2008156217A3
WO2008156217A3 PCT/JP2008/061686 JP2008061686W WO2008156217A3 WO 2008156217 A3 WO2008156217 A3 WO 2008156217A3 JP 2008061686 W JP2008061686 W JP 2008061686W WO 2008156217 A3 WO2008156217 A3 WO 2008156217A3
Authority
WO
WIPO (PCT)
Prior art keywords
solid preparation
pharmaceutical solid
benzazepines
production method
particle diameter
Prior art date
Application number
PCT/JP2008/061686
Other languages
French (fr)
Other versions
WO2008156217A2 (en
Inventor
Shinsuke Nakagawa
Kai Suzuki
Tadashi Mukai
Original Assignee
Otsuka Pharma Co Ltd
Shinsuke Nakagawa
Kai Suzuki
Tadashi Mukai
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40070798&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2008156217(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to KR1020107001313A priority Critical patent/KR101526625B1/en
Priority to AT08777650T priority patent/ATE489944T1/en
Priority to DK08777650.6T priority patent/DK2167046T3/en
Priority to MX2009014193A priority patent/MX2009014193A/en
Priority to US12/665,642 priority patent/US10905694B2/en
Priority to AU2008264445A priority patent/AU2008264445B2/en
Priority to DE602008003816T priority patent/DE602008003816D1/en
Priority to PL08777650T priority patent/PL2167046T3/en
Priority to SI200830150T priority patent/SI2167046T1/en
Application filed by Otsuka Pharma Co Ltd, Shinsuke Nakagawa, Kai Suzuki, Tadashi Mukai filed Critical Otsuka Pharma Co Ltd
Priority to CA002689467A priority patent/CA2689467A1/en
Priority to JP2009553855A priority patent/JP5289338B2/en
Priority to BRPI0813100-7A2A priority patent/BRPI0813100A2/en
Priority to CN200880021079A priority patent/CN101686941A/en
Priority to EP08777650A priority patent/EP2167046B1/en
Publication of WO2008156217A2 publication Critical patent/WO2008156217A2/en
Publication of WO2008156217A3 publication Critical patent/WO2008156217A3/en
Priority to IL202179A priority patent/IL202179A/en
Priority to HR20100676T priority patent/HRP20100676T1/en
Priority to US17/099,221 priority patent/US20210069207A1/en
Priority to US17/132,852 priority patent/US20210113582A1/en
Priority to US18/336,534 priority patent/US20230321113A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The subject invention provides a novel pharmaceutical solid preparation that has superior disintegration properties and excellent solubility, leading to sufficient absorbability of active ingredients through the gastrointestinal tract. The pharmaceutical solid preparation of the present invention comprises: (a) 7-chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzoazepine and/or salt thereof; (b) hydroxypropylcellulose containing a hydroxypropoxyl group in an amount of 50 wt.% or greater; and (c) at least one member selected from the group consisting of carmellose, sodium carboxy methyl starch, crospovidone, and low substituted hydroxypropylcellulose with an average particle diameter of 30 to 70µm, and a 90% cumulative particle diameter of 100 to 200µm.
PCT/JP2008/061686 2007-06-21 2008-06-20 Pharmaceutical solid preparation comprising benzazepines and production method thereof WO2008156217A2 (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
CA002689467A CA2689467A1 (en) 2007-06-21 2008-06-20 Pharmaceutical solid preparation comprising benzazepines and production method thereof
JP2009553855A JP5289338B2 (en) 2007-06-21 2008-06-20 Pharmaceutical solid preparation and method for producing the same
AT08777650T ATE489944T1 (en) 2007-06-21 2008-06-20 PHARMACEUTICAL SOLID PREPARATION CONTAINING BENZAZEPINES AND PRODUCTION PROCESS THEREOF
MX2009014193A MX2009014193A (en) 2007-06-21 2008-06-20 Pharmaceutical solid preparation comprising benzazepines and production method thereof.
US12/665,642 US10905694B2 (en) 2007-06-21 2008-06-20 Pharmaceutical solid preparation comprising benzazepines and production method thereof
AU2008264445A AU2008264445B2 (en) 2007-06-21 2008-06-20 Pharmaceutical solid preparation comprising benzazepines and production method thereof
DE602008003816T DE602008003816D1 (en) 2007-06-21 2008-06-20 PHARMACEUTICAL SOLUTION PREPARATION WITH BENZAZEPINE AND MANUFACTURING METHOD THEREFOR
PL08777650T PL2167046T3 (en) 2007-06-21 2008-06-20 Pharmaceutical solid preparation comprising benzazepines and production method thereof
BRPI0813100-7A2A BRPI0813100A2 (en) 2007-06-21 2008-06-20 PHARMACEUTICAL SOLID PREPARATION AND METHOD OF PRODUCTION
KR1020107001313A KR101526625B1 (en) 2007-06-21 2008-06-20 Pharmaceutical solid preparation comprising benzazepines and production method thereof
EP08777650A EP2167046B1 (en) 2007-06-21 2008-06-20 Pharmaceutical solid preparation comprising benzazepines and production method thereof
DK08777650.6T DK2167046T3 (en) 2007-06-21 2008-06-20 Pharmaceutical solid composition comprising benzazepines and their preparation processes
SI200830150T SI2167046T1 (en) 2007-06-21 2008-06-20 Pharmaceutical solid preparation comprising benzazepines and production method thereof
CN200880021079A CN101686941A (en) 2007-06-21 2008-06-20 Pharmaceutical solid preparation and production method thereof
IL202179A IL202179A (en) 2007-06-21 2009-11-17 Pharmaceutical solid preparation comprising benzazepines and production method thereof
HR20100676T HRP20100676T1 (en) 2007-06-21 2010-12-07 Pharmaceutical solid preparation comprising benzazepines and production method thereof
US17/099,221 US20210069207A1 (en) 2007-06-21 2020-11-16 Pharmaceutical solid preparation comprising benzazepines and production method thereof
US17/132,852 US20210113582A1 (en) 2007-06-21 2020-12-23 Pharmaceutical solid preparation comprising benzazepines and production method thereof
US18/336,534 US20230321113A1 (en) 2007-06-21 2023-06-16 Pharmaceutical solid preparation comprising benzazepines and production method thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007163551 2007-06-21
JP2007-163551 2007-06-21

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US12/665,642 A-371-Of-International US10905694B2 (en) 2007-06-21 2008-06-20 Pharmaceutical solid preparation comprising benzazepines and production method thereof
US17/099,221 Continuation US20210069207A1 (en) 2007-06-21 2020-11-16 Pharmaceutical solid preparation comprising benzazepines and production method thereof
US17/132,852 Continuation US20210113582A1 (en) 2007-06-21 2020-12-23 Pharmaceutical solid preparation comprising benzazepines and production method thereof

Publications (2)

Publication Number Publication Date
WO2008156217A2 WO2008156217A2 (en) 2008-12-24
WO2008156217A3 true WO2008156217A3 (en) 2009-02-26

Family

ID=40070798

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/061686 WO2008156217A2 (en) 2007-06-21 2008-06-20 Pharmaceutical solid preparation comprising benzazepines and production method thereof

Country Status (25)

Country Link
US (4) US10905694B2 (en)
EP (1) EP2167046B1 (en)
JP (1) JP5289338B2 (en)
KR (1) KR101526625B1 (en)
CN (3) CN103989644A (en)
AR (1) AR067077A1 (en)
AT (1) ATE489944T1 (en)
AU (1) AU2008264445B2 (en)
BR (1) BRPI0813100A2 (en)
CA (1) CA2689467A1 (en)
CY (1) CY1111939T1 (en)
DE (1) DE602008003816D1 (en)
DK (1) DK2167046T3 (en)
ES (1) ES2354030T3 (en)
HK (1) HK1201719A1 (en)
HR (1) HRP20100676T1 (en)
IL (1) IL202179A (en)
MX (1) MX2009014193A (en)
MY (1) MY147599A (en)
PL (1) PL2167046T3 (en)
PT (1) PT2167046E (en)
RU (1) RU2466717C2 (en)
SI (1) SI2167046T1 (en)
TW (1) TWI405574B (en)
WO (1) WO2008156217A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102293734A (en) * 2010-06-25 2011-12-28 江苏恒瑞医药股份有限公司 Tolvaptan solid dispersion and preparation method thereof
CN102552278A (en) * 2010-12-23 2012-07-11 天津泰普药品科技发展有限公司 Medicinal composition for enhancing solubility of slightly-soluble medicament tolvaptan
CN102228423B (en) * 2011-06-29 2013-03-06 重庆市庆余堂制药有限公司 Tolvaptan oral solid medicinal composition and preparation method thereof
JP6057628B2 (en) * 2012-09-06 2017-01-11 クリーンケミカル株式会社 Priming method for artificial dialysis machine
TWI660748B (en) 2013-03-01 2019-06-01 日商大塚製藥股份有限公司 Suspension for oral administration comprising amorphous tolvaptan
TW201605488A (en) 2013-10-15 2016-02-16 大塚製藥股份有限公司 Drug for preventing and/or treating polycystic kidney disease
JP6761695B2 (en) * 2016-08-16 2020-09-30 信越化学工業株式会社 Low degree of substitution hydroxypropyl cellulose and solid formulations
JP6838446B2 (en) * 2017-03-22 2021-03-03 ニプロ株式会社 Tolvaptan preparation and its manufacturing method
JP7352175B2 (en) * 2019-12-25 2023-09-28 ニプロ株式会社 tolvaptan formulation
CN111888335A (en) * 2020-08-21 2020-11-06 福安药业集团重庆礼邦药物开发有限公司 Tolvaptan pharmaceutical solid preparation and preparation method thereof
WO2022256378A1 (en) 2021-06-02 2022-12-08 Esperion Therapeutics, Inc. Compositions containing and therapies using bempedoic acid and tolvaptan
EP4321154A1 (en) 2022-08-03 2024-02-14 Sanovel Ilac Sanayi Ve Ticaret A.S. A tablet of tolvaptan and at least one binder processed with spray granulation

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997022340A1 (en) * 1995-12-20 1997-06-26 Bristol-Myers Squibb Company Rapid release tablet comprising tolfenamic acid or a pharmaceutically acceptable salt thereof
JPH1121241A (en) * 1997-07-03 1999-01-26 Otsuka Pharmaceut Co Ltd Solid preparation composition
US20050187210A1 (en) * 2003-02-24 2005-08-25 Atsushi Ozaki Method for treating severe heart failure and medicament therefor
US20070071811A1 (en) * 2005-09-28 2007-03-29 Mali Kadosh Stable combinations of amlodipine besylate and benazepril hydrochloride

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2071511A (en) * 1934-10-01 1937-02-23 Reed & Carnrick Enteric coating
DK0450097T3 (en) 1989-10-20 1996-05-20 Otsuka Pharma Co Ltd Benzoheterocyclic Compounds
JPH09278656A (en) * 1996-02-05 1997-10-28 Sankyo Co Ltd Oral 5-alpha-reductase-inhibitory preparation and its production
EP2277517A1 (en) * 1996-11-15 2011-01-26 Ajinomoto Co., Inc. Nateglinide tablet composition
ES2559766T3 (en) * 1998-05-18 2016-02-15 Takeda Pharmaceutical Company Limited Disintegrable tablets in the mouth
EP1054019A1 (en) * 1999-05-18 2000-11-22 Shin-Etsu Chemical Co., Ltd. Low-substituted hydroxypropyl cellulose
EP1385486A4 (en) * 2001-04-18 2006-05-17 Nostrum Pharmaceuticals Inc A novel coating for a sustained release pharmaceutical composition
JP2004026861A (en) * 2002-06-21 2004-01-29 Shin Etsu Chem Co Ltd Water-soluble cellulose ether of high filterability and its selection method
JP4684545B2 (en) * 2002-09-26 2011-05-18 大日本住友製薬株式会社 Oral preparation of isoxazole derivative with good dissolution
EP1607087A1 (en) * 2003-03-27 2005-12-21 Hisamitsu Pharmaceutical Co., Inc. Medicinal oral preparations for colon delivery, medicinal oral preparations for treating colon cancer and medicinal oral preparations for treating colitis
TW200507882A (en) * 2003-07-17 2005-03-01 Kyowa Hakko Kogyo Kk Solid formulations

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997022340A1 (en) * 1995-12-20 1997-06-26 Bristol-Myers Squibb Company Rapid release tablet comprising tolfenamic acid or a pharmaceutically acceptable salt thereof
JPH1121241A (en) * 1997-07-03 1999-01-26 Otsuka Pharmaceut Co Ltd Solid preparation composition
US20050187210A1 (en) * 2003-02-24 2005-08-25 Atsushi Ozaki Method for treating severe heart failure and medicament therefor
US20070071811A1 (en) * 2005-09-28 2007-03-29 Mali Kadosh Stable combinations of amlodipine besylate and benazepril hydrochloride

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 199914, Derwent World Patents Index; AN 1999-163176, XP002507337 *

Also Published As

Publication number Publication date
BRPI0813100A2 (en) 2014-12-23
CY1111939T1 (en) 2015-11-04
EP2167046B1 (en) 2010-12-01
DK2167046T3 (en) 2011-01-31
US20210069207A1 (en) 2021-03-11
RU2466717C2 (en) 2012-11-20
IL202179A (en) 2012-10-31
US10905694B2 (en) 2021-02-02
MX2009014193A (en) 2010-01-28
US20210113582A1 (en) 2021-04-22
SI2167046T1 (en) 2011-03-31
IL202179A0 (en) 2010-06-16
EP2167046A2 (en) 2010-03-31
HRP20100676T1 (en) 2011-01-31
CN103463095A (en) 2013-12-25
DE602008003816D1 (en) 2011-01-13
ES2354030T3 (en) 2011-03-09
KR101526625B1 (en) 2015-06-05
US20230321113A1 (en) 2023-10-12
PL2167046T3 (en) 2011-05-31
WO2008156217A2 (en) 2008-12-24
RU2010101797A (en) 2011-07-27
US20100323006A1 (en) 2010-12-23
TW200911270A (en) 2009-03-16
CN103989644A (en) 2014-08-20
KR20100038386A (en) 2010-04-14
PT2167046E (en) 2011-02-10
CA2689467A1 (en) 2008-12-24
AU2008264445B2 (en) 2013-06-27
HK1201719A1 (en) 2015-09-11
JP2010530355A (en) 2010-09-09
JP5289338B2 (en) 2013-09-11
AR067077A1 (en) 2009-09-30
MY147599A (en) 2012-12-31
TWI405574B (en) 2013-08-21
ATE489944T1 (en) 2010-12-15
AU2008264445A1 (en) 2008-12-24
CN101686941A (en) 2010-03-31

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