JP2007520450A - 非開裂リンカーを介して連結した細胞結合物質メイタンシノイド複合体を用いて特定の細胞集団を標的とする方法、前記複合体、および前記複合体の製造法 - Google Patents

非開裂リンカーを介して連結した細胞結合物質メイタンシノイド複合体を用いて特定の細胞集団を標的とする方法、前記複合体、および前記複合体の製造法 Download PDF

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JP2007520450A
JP2007520450A JP2006533951A JP2006533951A JP2007520450A JP 2007520450 A JP2007520450 A JP 2007520450A JP 2006533951 A JP2006533951 A JP 2006533951A JP 2006533951 A JP2006533951 A JP 2006533951A JP 2007520450 A JP2007520450 A JP 2007520450A
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cell
maytansinoid
ester
antibody
monoclonal antibody
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スティーブス，リタ
ルッツ，ロバート
チャリ，ラヴィ
シェ，ホンシェン
コフトゥン，イェレナ
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イミュノジェン・インコーポレーテッド
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JP2006533951A 2003-10-10 2004-10-12 非開裂リンカーを介して連結した細胞結合物質メイタンシノイド複合体を用いて特定の細胞集団を標的とする方法、前記複合体、および前記複合体の製造法 Pending JP2007520450A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50990103P 2003-10-10 2003-10-10
US10/960,602 US8088387B2 (en) 2003-10-10 2004-10-08 Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
PCT/US2004/030917 WO2005037992A2 (en) 2003-10-10 2004-10-12 Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates

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JP2011148625A Division JP5718745B2 (ja) 2003-10-10 2011-07-04 非開裂リンカーを介して連結した細胞結合物質メイタンシノイド複合体を用いて特定の細胞集団を標的とする方法、前記複合体、および前記複合体の製造法

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JP2016056209A (ja) * 2009-09-09 2016-04-21 セントローズ， エルエルシー 細胞外標的化薬物複合体
JP2013506709A (ja) * 2009-10-06 2013-02-28 イミュノジェン・インコーポレーテッド 有効なコンジュゲートおよび親水性リンカー
JP2016106222A (ja) * 2009-10-26 2016-06-16 ネステク ソシエテ アノニム 抗ｔｎｆ薬及び自己抗体の検出用アッセイ
JP2013544253A (ja) * 2010-11-17 2013-12-12 ジェネンテック， インコーポレイテッド アラニニルメイタンシノール抗体コンジュゲート
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WO2019150985A1 (ja) * 2018-01-31 2019-08-08 国立大学法人東京大学 抗体薬物複合体及びそれを含む医薬組成物

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