JP2006526629A5 - - Google Patents
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- Publication number
- JP2006526629A5 JP2006526629A5 JP2006513231A JP2006513231A JP2006526629A5 JP 2006526629 A5 JP2006526629 A5 JP 2006526629A5 JP 2006513231 A JP2006513231 A JP 2006513231A JP 2006513231 A JP2006513231 A JP 2006513231A JP 2006526629 A5 JP2006526629 A5 JP 2006526629A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- acyl
- alkenyl
- alkynyl
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC1([C@](N(C=CC(*)=N2)C2=O)O[C@@](COC(c2ccccc2)=O)C1OC(c1ccccc1)=O)F Chemical compound CC1([C@](N(C=CC(*)=N2)C2=O)O[C@@](COC(c2ccccc2)=O)C1OC(c1ccccc1)=O)F 0.000 description 15
- XIIWYLPDGBLLPP-VHEBQXMUSA-N CC(/C(/OCc1ccccc1)=C(/COCc1ccccc1)\OC)(O)F Chemical compound CC(/C(/OCc1ccccc1)=C(/COCc1ccccc1)\OC)(O)F XIIWYLPDGBLLPP-VHEBQXMUSA-N 0.000 description 1
- TXJUIVZHGIIJTQ-CZIZESTLSA-N CC(C(/C(/OC(c1ccccc1)=O)=C(/COC(c1ccccc1)=O)\OC)F)OC Chemical compound CC(C(/C(/OC(c1ccccc1)=O)=C(/COC(c1ccccc1)=O)\OC)F)OC TXJUIVZHGIIJTQ-CZIZESTLSA-N 0.000 description 1
- OXRYEARVCRCIST-NFJWQWPMSA-N CC1(C(O)=C(CO)O[C@H]1N(C=CC(N)=N1)C1=C)F Chemical compound CC1(C(O)=C(CO)O[C@H]1N(C=CC(N)=N1)C1=C)F OXRYEARVCRCIST-NFJWQWPMSA-N 0.000 description 1
- NYPIRLYMDJMKGW-VUJBXBEDSA-N CC1([C@H](N(C=CC(N)=N2)C2=O)O[C@H](CO)C1O)F Chemical compound CC1([C@H](N(C=CC(N)=N2)C2=O)O[C@H](CO)C1O)F NYPIRLYMDJMKGW-VUJBXBEDSA-N 0.000 description 1
- ARKKGZQTGXJVKW-PELMPBBBSA-N CC1([C@H](N(C=CC(O)=N2)C2=O)O[C@H](CO)[C@@H]1O)F Chemical compound CC1([C@H](N(C=CC(O)=N2)C2=O)O[C@H](CO)[C@@H]1O)F ARKKGZQTGXJVKW-PELMPBBBSA-N 0.000 description 1
- VFBFXQOTYAGOMP-HSJDOFJSSA-N CC1([C@H](N2[I]=NC3=C2N=C(N)NC3=O)O[C@H](CO)C1O)F Chemical compound CC1([C@H](N2[I]=NC3=C2N=C(N)NC3=O)O[C@H](CO)C1O)F VFBFXQOTYAGOMP-HSJDOFJSSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47436803P | 2003-05-30 | 2003-05-30 | |
| US60/474,368 | 2003-05-30 | ||
| PCT/US2004/012472 WO2005003147A2 (en) | 2003-05-30 | 2004-04-21 | Modified fluorinated nucleoside analogues |
Related Child Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011090084A Division JP2011201882A (ja) | 2003-05-30 | 2011-04-14 | 修飾されたフッ化ヌクレオシド類似体 |
| JP2011090054A Division JP5266357B2 (ja) | 2003-05-30 | 2011-04-14 | 修飾されたフッ化ヌクレオシド類似体 |
| JP2011090076A Division JP2011190264A (ja) | 2003-05-30 | 2011-04-14 | 修飾されたフッ化ヌクレオシド類似体 |
| JP2011090062A Division JP2011190263A (ja) | 2003-05-30 | 2011-04-14 | 修飾されたフッ化ヌクレオシド類似体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006526629A JP2006526629A (ja) | 2006-11-24 |
| JP2006526629A5 true JP2006526629A5 (enExample) | 2011-06-16 |
| JP4958158B2 JP4958158B2 (ja) | 2012-06-20 |
Family
ID=33563735
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006513231A Expired - Lifetime JP4958158B2 (ja) | 2003-05-30 | 2004-04-21 | 修飾されたフッ化ヌクレオシド類似体 |
| JP2011090062A Withdrawn JP2011190263A (ja) | 2003-05-30 | 2011-04-14 | 修飾されたフッ化ヌクレオシド類似体 |
| JP2011090054A Expired - Lifetime JP5266357B2 (ja) | 2003-05-30 | 2011-04-14 | 修飾されたフッ化ヌクレオシド類似体 |
| JP2011090084A Withdrawn JP2011201882A (ja) | 2003-05-30 | 2011-04-14 | 修飾されたフッ化ヌクレオシド類似体 |
| JP2011090076A Withdrawn JP2011190264A (ja) | 2003-05-30 | 2011-04-14 | 修飾されたフッ化ヌクレオシド類似体 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011090062A Withdrawn JP2011190263A (ja) | 2003-05-30 | 2011-04-14 | 修飾されたフッ化ヌクレオシド類似体 |
| JP2011090054A Expired - Lifetime JP5266357B2 (ja) | 2003-05-30 | 2011-04-14 | 修飾されたフッ化ヌクレオシド類似体 |
| JP2011090084A Withdrawn JP2011201882A (ja) | 2003-05-30 | 2011-04-14 | 修飾されたフッ化ヌクレオシド類似体 |
| JP2011090076A Withdrawn JP2011190264A (ja) | 2003-05-30 | 2011-04-14 | 修飾されたフッ化ヌクレオシド類似体 |
Country Status (30)
| Country | Link |
|---|---|
| US (8) | US7429572B2 (enExample) |
| EP (8) | EP3521297B1 (enExample) |
| JP (5) | JP4958158B2 (enExample) |
| KR (1) | KR100883703B1 (enExample) |
| CN (1) | CN100503628C (enExample) |
| AR (6) | AR044566A1 (enExample) |
| AU (1) | AU2004253860B2 (enExample) |
| BR (3) | BRPI0419345B8 (enExample) |
| CA (5) | CA2733842A1 (enExample) |
| CO (1) | CO5660270A2 (enExample) |
| CY (2) | CY1118020T1 (enExample) |
| DK (1) | DK2604620T4 (enExample) |
| ES (3) | ES2726998T3 (enExample) |
| FI (1) | FI2604620T4 (enExample) |
| HR (1) | HRP20160873T4 (enExample) |
| HU (2) | HUE029877T2 (enExample) |
| IL (2) | IL172259A (enExample) |
| LT (2) | LT2604620T (enExample) |
| MX (1) | MXPA05012788A (enExample) |
| MY (1) | MY138477A (enExample) |
| NO (5) | NO333700B1 (enExample) |
| NZ (1) | NZ543867A (enExample) |
| PL (3) | PL3521297T3 (enExample) |
| PT (3) | PT2604620T (enExample) |
| RU (1) | RU2358979C2 (enExample) |
| SI (3) | SI2604620T2 (enExample) |
| TR (1) | TR201906767T4 (enExample) |
| TW (1) | TWI333956B (enExample) |
| WO (1) | WO2005003147A2 (enExample) |
| ZA (1) | ZA200509521B (enExample) |
Families Citing this family (216)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY164523A (en) * | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| CA2410579C (en) * | 2000-05-26 | 2010-04-20 | Jean-Pierre Sommadossi | Methods and compositions for treating flaviviruses and pestiviruses |
| US8481712B2 (en) | 2001-01-22 | 2013-07-09 | Merck Sharp & Dohme Corp. | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase |
| CN1678326A (zh) * | 2002-06-28 | 2005-10-05 | 埃迪尼克斯(开曼)有限公司 | 用于治疗黄病毒感染的2'-c-甲基-3'-o-l-缬氨酸酯核糖呋喃基胞苷 |
| RS114004A (sr) | 2002-06-28 | 2007-02-05 | Idenix (Cayman) Limited, | Modifikovani 2'i 3'-nukleozid prolekovi za lečenje flaviridae infekcija |
| US7608600B2 (en) * | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
| CN101172993A (zh) | 2002-06-28 | 2008-05-07 | 埃迪尼克斯(开曼)有限公司 | 用于治疗黄病毒感染的2′-c-甲基-3′-o-l-缬氨酸酯核糖呋喃基胞苷 |
| JP2006519753A (ja) * | 2002-11-15 | 2006-08-31 | イデニクス(ケイマン)リミテツド | 2’−分枝ヌクレオシドおよびフラビウイルス科ウイルス突然変異 |
| MXPA05006230A (es) | 2002-12-12 | 2005-09-20 | Idenix Cayman Ltd | Proceso para la produccion de nucleosidos ramificados-2'. |
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| GB0317009D0 (en) | 2003-07-21 | 2003-08-27 | Univ Cardiff | Chemical compounds |
| CN101023094B (zh) | 2004-07-21 | 2011-05-18 | 法莫赛特股份有限公司 | 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备 |
| NZ552927A (en) * | 2004-07-21 | 2010-05-28 | Pharmasset Inc | Preparation of alkyl-substituted 2-deoxy-2-fluoro-D-ribofuranosyl pyrimidines and purines and their derivatives |
| JP5001842B2 (ja) | 2004-09-14 | 2012-08-15 | ギリアド ファーマセット エルエルシー | 2’−フルオロ−2’−アルキル−置換又は他の置換されていてもよいリボフラノシルピリミジン類及びプリン類並びにそれらの誘導体の製造 |
| AU2005317081A1 (en) * | 2004-10-21 | 2006-06-22 | Merck & Co., Inc. | Fluorinated pyrrolo[2,3-d]pyrimidine nucleosides for the treatment of RNA-dependent RNA viral infection |
| EP1827460A4 (en) | 2004-12-09 | 2012-03-14 | Univ Minnesota | NUCLEOSIDE WITH ANTIVIRAL AND ANTI-CANCER EFFECT |
| US7524825B2 (en) | 2005-02-28 | 2009-04-28 | Smithkline Beecham Corporation | Tricyclic-nucleoside compounds for treating viral infections |
| WO2006130217A2 (en) * | 2005-04-01 | 2006-12-07 | The Regents Of The University Of California | Substituted phosphate esters of nucleoside phosphonates |
| US7405204B2 (en) | 2005-04-25 | 2008-07-29 | Genelabs Technologies, Inc. | Nucleoside compounds for treating viral infections |
| JP4705164B2 (ja) | 2005-05-02 | 2011-06-22 | メルク・シャープ・エンド・ドーム・コーポレイション | Hcvns3プロテアーゼ阻害剤 |
| CN100478349C (zh) * | 2005-06-20 | 2009-04-15 | 河南省凯特化学实业总公司 | 氟化核苷类化合物、其制备方法及其应用 |
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| EP3159351A3 (en) | 2005-09-26 | 2017-05-17 | Gilead Pharmasset LLC | Modified 3'-azido-4'-ethynyl-nucleosides as antiviral agents |
| MY150667A (en) * | 2005-12-09 | 2014-02-28 | Gilead Pharmasset Llc | Antiviral nucleosides |
| EP1976382B1 (en) * | 2005-12-23 | 2013-04-24 | IDENIX Pharmaceuticals, Inc. | Process for preparing a synthetic intermediate for preparation of branched nucleosides |
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