JP2005505311A - 多孔性β−リン酸三カルシウム顆粒および同一のものを生成する方法 - Google Patents

多孔性β−リン酸三カルシウム顆粒および同一のものを生成する方法 Download PDF

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Publication number
JP2005505311A
JP2005505311A JP2002569200A JP2002569200A JP2005505311A JP 2005505311 A JP2005505311 A JP 2005505311A JP 2002569200 A JP2002569200 A JP 2002569200A JP 2002569200 A JP2002569200 A JP 2002569200A JP 2005505311 A JP2005505311 A JP 2005505311A
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Prior art keywords
tcp
bmp
porous
poly
gdf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2002569200A
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English (en)
Japanese (ja)
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JP2005505311A5 (enExample
Inventor
パレシュ エス． ダラル，
ゴドフレド アール． ディマーノ，
キャロル アン トス，
シャイレシュ シー． クルカーニ，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stryker Corp
Original Assignee
Stryker Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27121998&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2005505311(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US09/798,518 external-priority patent/US20030049328A1/en
Application filed by Stryker Corp filed Critical Stryker Corp
Publication of JP2005505311A publication Critical patent/JP2005505311A/ja
Publication of JP2005505311A5 publication Critical patent/JP2005505311A5/ja
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/811—Peptides or proteins is immobilized on, or in, an inorganic carrier

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Compositions Of Oxide Ceramics (AREA)
JP2002569200A 2001-03-02 2002-02-26 多孔性β−リン酸三カルシウム顆粒および同一のものを生成する方法 Pending JP2005505311A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/798,518 US20030049328A1 (en) 2001-03-02 2001-03-02 Porous beta-tricalcium phosphate granules and methods for producing same
US09/960,789 US6949251B2 (en) 2001-03-02 2001-09-21 Porous β-tricalcium phosphate granules for regeneration of bone tissue
PCT/US2002/005827 WO2002070029A2 (en) 2001-03-02 2002-02-26 Porous beta-tricalcium phosphate granules and methods for producing same

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2004173260A Division JP2004262758A (ja) 2001-03-02 2004-06-10 多孔性β−リン酸三カルシウム顆粒および同一のものを生成する方法
JP2008321674A Division JP2009101174A (ja) 2001-03-02 2008-12-17 多孔性β−リン酸三カルシウム顆粒および同一のものを生成する方法

Publications (2)

Publication Number Publication Date
JP2005505311A true JP2005505311A (ja) 2005-02-24
JP2005505311A5 JP2005505311A5 (enExample) 2005-12-22

Family

ID=27121998

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2002569200A Pending JP2005505311A (ja) 2001-03-02 2002-02-26 多孔性β−リン酸三カルシウム顆粒および同一のものを生成する方法
JP2004173260A Withdrawn JP2004262758A (ja) 2001-03-02 2004-06-10 多孔性β−リン酸三カルシウム顆粒および同一のものを生成する方法
JP2008321674A Pending JP2009101174A (ja) 2001-03-02 2008-12-17 多孔性β−リン酸三カルシウム顆粒および同一のものを生成する方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2004173260A Withdrawn JP2004262758A (ja) 2001-03-02 2004-06-10 多孔性β−リン酸三カルシウム顆粒および同一のものを生成する方法
JP2008321674A Pending JP2009101174A (ja) 2001-03-02 2008-12-17 多孔性β−リン酸三カルシウム顆粒および同一のものを生成する方法

Country Status (8)

Country Link
US (4) US6949251B2 (enExample)
EP (1) EP1372748B1 (enExample)
JP (3) JP2005505311A (enExample)
AT (1) ATE429256T1 (enExample)
CA (2) CA2659188A1 (enExample)
DE (1) DE60232061D1 (enExample)
ES (1) ES2325573T3 (enExample)
WO (1) WO2002070029A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014510763A (ja) * 2011-04-11 2014-05-01 インデュース バイオロジクス インコーポレイテッド 増殖因子の多相放出を行うためのシステムおよび方法
JP2022545185A (ja) * 2019-08-20 2022-10-26 セラダプティブ インク 骨インプラントにおける係留可能なタンパク質の送達のための材料

Families Citing this family (234)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6013591A (en) 1997-01-16 2000-01-11 Massachusetts Institute Of Technology Nanocrystalline apatites and composites, prostheses incorporating them, and method for their production
US20010016646A1 (en) * 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
US7041641B2 (en) * 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
US6458162B1 (en) 1999-08-13 2002-10-01 Vita Special Purpose Corporation Composite shaped bodies and methods for their production and use
US20060078847A1 (en) * 2000-09-29 2006-04-13 Kwan Norman H Dental implant system and additional methods of attachment
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
CA2432438C (en) * 2001-01-09 2011-04-26 Microchips, Inc. Flexible microchip devices for ophthalmic and other applications
US9080146B2 (en) 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
US7709029B2 (en) * 2001-01-24 2010-05-04 Ada Foundation Calcium-containing restoration materials
SI1448246T2 (sl) * 2001-11-19 2015-12-31 Scil Technology Gmbh Postopek za proizvodnjo homogeno obložene naprave, ki ima osteoinduktivne in osteokonduktivne lastnosti
US7247609B2 (en) * 2001-12-18 2007-07-24 Universitat Zurich Growth factor modified protein matrices for tissue engineering
TW200400062A (en) 2002-04-03 2004-01-01 Mathys Medizinaltechnik Ag Kneadable, pliable bone replacement material
EP1523342B1 (de) 2002-04-29 2009-07-22 Biomet Deutschland GmbH Strukturierte komposite als matrix (scaffold) fur das tissue engineering von knochen
US7842300B2 (en) * 2002-07-31 2010-11-30 Dentsply International, Inc. Bone repair putty
US8876532B2 (en) 2002-07-31 2014-11-04 Dentsply International Inc. Bone repair putty
US7820638B2 (en) * 2002-08-09 2010-10-26 Arthrex, Inc. Method of applying hyaluronic acid to implant or graft to enhance lubricity and cellular density
US7598224B2 (en) 2002-08-20 2009-10-06 Biosurface Engineering Technologies, Inc. Dual chain synthetic heparin-binding growth factor analogs
US7166574B2 (en) * 2002-08-20 2007-01-23 Biosurface Engineering Technologies, Inc. Synthetic heparin-binding growth factor analogs
US8227411B2 (en) * 2002-08-20 2012-07-24 BioSurface Engineering Technologies, Incle FGF growth factor analogs
US7981862B2 (en) 2003-08-19 2011-07-19 Biosurface Engineering Technologies, Inc. Composition comprising BMP-2 amplifier/co-activator for enhancement of osteogenesis
CN100522241C (zh) 2002-09-10 2009-08-05 Scil技术股份有限公司 在低氧气浓度下用骨诱导蛋白包被的金属植入物
FR2850282B1 (fr) 2003-01-27 2007-04-06 Jerome Asius Implant injectable a base de ceramique pour le comblement de rides, depressions cutanees et cicatrices, et sa preparation
EP1608292A4 (en) * 2003-03-13 2007-10-31 Univ Rice William M INJECTABLE AND PRE-PRODUCED COMPOSITE MATERIAL AS A BONE REPLACEMENT AND METHOD FOR PRODUCING SUCH A BONE REPLACEMENT MATERIAL
WO2004098457A1 (en) * 2003-04-30 2004-11-18 Therics, Inc. Bone void filler and method of manufacture
US8029755B2 (en) 2003-08-06 2011-10-04 Angstrom Medica Tricalcium phosphates, their composites, implants incorporating them, and method for their production
US7955616B2 (en) * 2003-09-23 2011-06-07 Orthocon, Inc. Absorbable implants and methods for their use in hemostasis and in the treatment of osseous defects
WO2005065079A2 (en) * 2003-11-10 2005-07-21 Angiotech International Ag Medical implants and fibrosis-inducing agents
US20080227696A1 (en) * 2005-02-22 2008-09-18 Biosurface Engineering Technologies, Inc. Single branch heparin-binding growth factor analogs
DE602005023714D1 (de) * 2004-02-20 2010-11-04 Biosurface Eng Tech Inc Positiver modulator des knochenmorphogenetisches protein-2 (bmp-2)
US20070190101A1 (en) * 2004-03-31 2007-08-16 Chunlin Yang Flowable bone grafts
US7758896B2 (en) 2004-04-16 2010-07-20 University Of Massachusetts Porous calcium phosphate networks for synthetic bone material
WO2005114322A2 (en) 2004-05-12 2005-12-01 Massachusetts Institute Of Technology Manufacturing process, such as three-dimensional printing, including solvent vapor filming and the like
EP1604693A1 (en) 2004-06-09 2005-12-14 Scil Technology GmbH In situ forming scaffold, its manufacturing and use
US8012501B2 (en) 2004-06-10 2011-09-06 Synthes Usa, Llc Flexible bone composite
US9220595B2 (en) 2004-06-23 2015-12-29 Orthovita, Inc. Shapeable bone graft substitute and instruments for delivery thereof
US20060069436A1 (en) * 2004-09-30 2006-03-30 Depuy Spine, Inc. Trial disk implant
US20090088846A1 (en) 2007-04-17 2009-04-02 David Myung Hydrogel arthroplasty device
US7473678B2 (en) * 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
US8337873B2 (en) * 2004-10-22 2012-12-25 The Board Of Trustees Of The University Of Illinois Hollow and porous orthopaedic or dental implant that delivers a biological agent
JP4885866B2 (ja) 2004-10-25 2012-02-29 セロノヴァ バイオサイエンスィズ ジャーマニー ゲーエムベーハー 治療適用および／または診断適用のための充填可能なポリホスファゼン含有粒子、ならびにその調製方法および使用方法
US9114162B2 (en) 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
US20210299056A9 (en) 2004-10-25 2021-09-30 Varian Medical Systems, Inc. Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods
US9107850B2 (en) 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US20060110357A1 (en) * 2004-11-22 2006-05-25 Materna Peter A Bone putty composition that maintains granule suspension at reduced temperatures
JP4364245B2 (ja) * 2004-12-27 2009-11-11 オリンパス株式会社 医療機器の洗浄評価用汚物、及び洗浄評価用汚染方法
BRPI0606409A2 (pt) * 2005-01-06 2009-06-23 Kuros Biosurgery Ag matrizes suplementadas para o reparo de fraturas ósseas
US8575101B2 (en) 2005-01-06 2013-11-05 Kuros Biosurgery Ag Supplemented matrices for the repair of bone fractures
WO2006073711A2 (en) * 2005-01-06 2006-07-13 Kuros Biosurgery Ag Use of a matrix comprising a contrast agent in soft tissues
JP4975741B2 (ja) * 2005-05-26 2012-07-11 ジマー デンタル， インコーポレイテッド 人工歯科補装具
US8814567B2 (en) 2005-05-26 2014-08-26 Zimmer Dental, Inc. Dental implant prosthetic device with improved osseointegration and esthetic features
US7901650B2 (en) * 2005-06-22 2011-03-08 Skeletal Kinectics, LLC Porous beta-tricalcium phosphate and methods for producing the same
US20090062909A1 (en) * 2005-07-15 2009-03-05 Micell Technologies, Inc. Stent with polymer coating containing amorphous rapamycin
KR101406415B1 (ko) 2005-07-15 2014-06-19 미셀 테크놀로지즈, 인코포레이티드 제어된 형태의 약물 분말을 함유하는 중합체 코팅
KR100807108B1 (ko) * 2005-07-20 2008-02-26 주식회사 오스코텍 다공성의 β-인산삼칼슘 과립의 제조 방법
ITTO20050549A1 (it) 2005-08-03 2007-02-04 Consiglio Nazionale Ricerche Materiale composito iniettabile atto ad essere utilizzato come sostituto osseo
JP5438967B2 (ja) 2005-08-30 2014-03-12 ジマー デンタル， インコーポレイテッド 改良されたオッセオインテグレーションの特徴を有する歯科用インプラント
US8562346B2 (en) 2005-08-30 2013-10-22 Zimmer Dental, Inc. Dental implant for a jaw with reduced bone volume and improved osseointegration features
US8025903B2 (en) 2005-09-09 2011-09-27 Wright Medical Technology, Inc. Composite bone graft substitute cement and articles produced therefrom
ES2402651T3 (es) 2005-09-09 2013-05-07 Agnovos Healthcare, Llc Cemento sustituto de injerto óseo de material compuesto y artículos producidos del mismo
WO2007061889A2 (en) 2005-11-17 2007-05-31 Biomimetic Therapeutics, Inc. Maxillofacial bone augmentation using rhpdgf-bb and a biocompatible matrix
AU2006326271B2 (en) * 2005-12-14 2011-02-24 Scil Technology Gmbh A moldable biomaterial for bone regeneration
TWI316860B (en) 2005-12-29 2009-11-11 Ind Tech Res Inst Multi-layered matrix, method of tissue repair using the same and multi-layered implant prepared thereof
US7758803B2 (en) * 2006-01-11 2010-07-20 Jiang Chang Resorbable macroporous bioactive glass scaffold and method of manufacture
US10524916B2 (en) 2006-01-11 2020-01-07 Novabone Products, Llc Resorbable macroporous bioactive glass scaffold and method of manufacture
KR100739528B1 (ko) * 2006-02-03 2007-07-13 재단법인서울대학교산학협력재단 제1형 교원질 부착 유도 펩타이드가 고정된 골이식재 및 조직공학용 지지체
EP1991282B1 (en) 2006-02-09 2013-06-19 BioMimetic Therapeutics, LLC Compositions and methods for treating bone
CA2650542C (en) 2006-04-25 2016-09-13 Teleflex Medical Incorporated Calcium phosphate polymer composite and method
CA2996768C (en) 2006-04-26 2020-12-08 Micell Technologies, Inc. Coatings containing multiple drugs
EP2015789A1 (en) * 2006-04-27 2009-01-21 Queensland University of Technology Biodegradable implants for bone fusion and compositions therefor
DE102006026000B4 (de) * 2006-06-01 2015-01-15 Curasan Ag Patientenindividuelles Knochenaufbaumittel und Verfahren zu seiner Herstellung
US7820172B1 (en) 2006-06-01 2010-10-26 Biosurface Engineering Technologies, Inc. Laminin-derived multi-domain peptides
AU2007265379B9 (en) 2006-06-29 2014-05-29 Orthovita, Inc. Bioactive bone graft substitute
CA2656278C (en) 2006-06-30 2016-02-09 Biomimetic Therapeutics, Inc. Compositions and methods for treating rotator cuff injuries
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
EP3061791B1 (en) 2006-07-20 2019-01-16 OrbusNeich Medical, Inc. Bioabsorbable polymeric composition for a medical device
US7723291B2 (en) * 2006-07-27 2010-05-25 Warsaw Orthopedic, Inc. Release of BMP, bioactive agents and/or cells via a pump into a carrier matrix
US20080033322A1 (en) * 2006-07-31 2008-02-07 Femsuite, Llc Systems and methods for measuring cervical dilation
US20080051796A1 (en) * 2006-08-01 2008-02-28 Warsaw Orthopedic, Inc. Graft retention tack
US20080031914A1 (en) * 2006-08-02 2008-02-07 Drapeau Susan J Flowable biomaterial composition
US20060287654A1 (en) * 2006-08-11 2006-12-21 Jeffrey Posnick Implant securing device and method
GB0618963D0 (en) * 2006-09-26 2006-11-08 Ucl Business Plc Formulations and composites with reactive fillers
WO2008042909A2 (en) 2006-10-02 2008-04-10 Micell Technologies Inc. Surgical sutures having increased strength
DE102006048833A1 (de) * 2006-10-16 2008-04-17 Universität Rostock Behandlung von Osteoporose
US20080097618A1 (en) * 2006-10-18 2008-04-24 Kevin Charles Baker Deposition of calcium-phosphate (CaP) and calcium-phosphate with bone morphogenic protein (CaP+BMP) coatings on metallic and polymeric surfaces
US7959942B2 (en) 2006-10-20 2011-06-14 Orbusneich Medical, Inc. Bioabsorbable medical device with coating
EP2073754A4 (en) 2006-10-20 2012-09-26 Orbusneich Medical Inc BIOABSORBABLE POLYMER COMPOSITION AND MEDICAL DEVICE BACKGROUND
CA2667228C (en) 2006-10-23 2015-07-14 Micell Technologies, Inc. Holder for electrically charging a substrate during coating
US8106008B2 (en) 2006-11-03 2012-01-31 Biomimetic Therapeutics, Inc. Compositions and methods for arthrodetic procedures
US20100168868A1 (en) * 2006-11-30 2010-07-01 Nihon University Layered gradient material for biological use and method for producing the same
FI3345607T3 (fi) 2006-12-29 2022-11-30 Menetelmiä luun kasvun muuttamiseksi antamalla SOST- tai WISE-antagonistia tai antagonistia
US11426494B2 (en) 2007-01-08 2022-08-30 MT Acquisition Holdings LLC Stents having biodegradable layers
CN101711137B (zh) 2007-01-08 2014-10-22 米歇尔技术公司 具有可生物降解层的支架
FR2911508B1 (fr) * 2007-01-19 2012-11-09 Kasios Substitut osseux a base de ciment phosphocalcique
US20080195476A1 (en) * 2007-02-09 2008-08-14 Marchese Michael A Abandonment remarketing system
US9433516B2 (en) 2007-04-17 2016-09-06 Micell Technologies, Inc. Stents having controlled elution
CN101854962B (zh) * 2007-04-17 2015-12-16 米歇尔技术公司 具有生物降解性层的支架
WO2008148013A1 (en) 2007-05-25 2008-12-04 Micell Technologies, Inc. Polymer films for medical device coating
WO2009110917A1 (en) * 2007-06-07 2009-09-11 Osteotherapeutics, L.L.C. Bone cement compositions for use as growth factor carriers and methods of making same
US20090010990A1 (en) * 2007-06-20 2009-01-08 Little Marisa A Process for depositing calcium phosphate therapeutic coatings with controlled release rates and a prosthesis coated via the process
US20090062423A1 (en) * 2007-08-29 2009-03-05 Salumedica, Llc Orthopaedic cement mixtures with low weight percent polyvinyl alcohol (pva) solution
US20090061389A1 (en) 2007-08-30 2009-03-05 Matthew Lomicka Dental implant prosthetic device with improved osseointegration and shape for resisting rotation
US20090061002A1 (en) * 2007-09-05 2009-03-05 Venbrocks Rudolf A Calcium phospate based delivery of growth and differentiation factors to compromised bone
US7883511B2 (en) * 2007-09-12 2011-02-08 Fernyhough Jeffrey C Method and composition for use in reinforcing bone
US8052787B2 (en) * 2007-09-28 2011-11-08 National Taiwan University Bio-material and method of preparation thereof
ES2422259T3 (es) * 2008-02-07 2013-09-10 Biomimetic Therapeutics Inc Composiciones para la osteogénesis por distracción
US20090226668A1 (en) * 2008-03-10 2009-09-10 Ebi, L.P. Optimized surface for cellular proliferation and differentiation
US8685432B2 (en) * 2008-03-25 2014-04-01 University Of Utah Research Foundation Controlled release tissue graft combination biomaterials
JP5608160B2 (ja) 2008-04-17 2014-10-15 ミセル テクノロジーズ、インコーポレイテッド 生体吸収性の層を有するステント
US20110059149A1 (en) * 2008-06-16 2011-03-10 Little Marisa A Process for depositing calcium phosphate therapeutic coatings with different release rates and a prosthesis coated via the process
FR2932686B1 (fr) * 2008-06-23 2010-08-27 Centre Nat Rech Scient Combinaison de sang et de particules de ceramique de phosphates de calcium biphases.
FR2932687B1 (fr) * 2008-06-23 2010-09-17 Centre Nat Rech Scient Biomateriaux a base de phosphates de calcium.
US8231387B2 (en) 2008-07-02 2012-07-31 Zimmer, Inc. Porous implant with non-porous threads
US8562348B2 (en) 2008-07-02 2013-10-22 Zimmer Dental, Inc. Modular implant with secured porous portion
US9095396B2 (en) 2008-07-02 2015-08-04 Zimmer Dental, Inc. Porous implant with non-porous threads
US8899982B2 (en) 2008-07-02 2014-12-02 Zimmer Dental, Inc. Implant with structure for securing a porous portion
US20120209396A1 (en) 2008-07-07 2012-08-16 David Myung Orthopedic implants having gradient polymer alloys
EP2313122B1 (en) 2008-07-17 2019-03-06 Micell Technologies, Inc. Drug delivery medical device
GB0813659D0 (en) * 2008-07-25 2008-09-03 Smith & Nephew Fracture putty
EP2323670A4 (en) 2008-08-05 2013-12-25 Biomimedica Inc POLYURETHANE-GEPPROPFTE HYDROGELE
US20110106170A1 (en) * 2008-08-14 2011-05-05 Doerr Timothy E Tack for spine fixation
WO2010019928A2 (en) * 2008-08-14 2010-02-18 Doerr Timothy E Tack for spine fixation
KR20110067035A (ko) 2008-09-09 2011-06-20 바이오미메틱 세라퓨틱스, 인크. 건 및 인대 손상의 치료를 위한 혈소판-유래 성장 인자 조성물 및 방법
US20100114314A1 (en) 2008-11-06 2010-05-06 Matthew Lomicka Expandable bone implant
JP4392460B1 (ja) * 2008-11-13 2010-01-06 株式会社カタリメディック 芳香族炭化水素の残留量が低いリン酸カルシウム多孔体
US9320761B2 (en) 2008-12-18 2016-04-26 Vivex Biomedical, Inc. Bone induction system and methods
US8834913B2 (en) 2008-12-26 2014-09-16 Battelle Memorial Institute Medical implants and methods of making medical implants
AU2010221089A1 (en) * 2009-03-05 2011-09-15 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods for the treatment of osteochondral defects
JP2012522589A (ja) 2009-04-01 2012-09-27 ミシェル テクノロジーズ，インコーポレイテッド 被覆ステント
US20100266691A1 (en) * 2009-04-15 2010-10-21 Battelle Memorial Institute Agents and Methods to Stimulate Bone Healing
US9707058B2 (en) 2009-07-10 2017-07-18 Zimmer Dental, Inc. Patient-specific implants with improved osseointegration
EP2453834A4 (en) 2009-07-16 2014-04-16 Micell Technologies Inc MEDICAL DEVICE DISPENSING MEDICINE
JP2012533373A (ja) * 2009-07-23 2012-12-27 プロゲンティックス・オーソバイオロジー・ベー・フェー 注入及び成形可能な骨誘導性セラミック材料
US8529933B2 (en) * 2009-07-27 2013-09-10 Warsaw Orthopedic, Inc. Biphasic calcium phosphate cement for drug delivery
US8653029B2 (en) * 2009-07-30 2014-02-18 Warsaw Orthopedic, Inc. Flowable paste and putty bone void filler
TWI457146B (zh) * 2009-08-28 2014-10-21 Univ Kaohsiung Medical 藥物緩釋系統及其製備方法
US20110224410A1 (en) 2009-09-17 2011-09-15 Hile David Buffers for Controlling the pH of Bone Morphogenetic Proteins
WO2011063152A1 (en) * 2009-11-18 2011-05-26 Affinergy, Inc. Methods and compositions for soft tissue repair
US8602782B2 (en) 2009-11-24 2013-12-10 Zimmer Dental, Inc. Porous implant device with improved core
CA2781518C (en) * 2009-11-25 2016-08-23 Healionics Corporation Granules of porous biocompatible materials
CA2785038A1 (en) 2009-12-22 2011-07-21 Stryker Corporation Bmp-7 variants with reduced immunogenicity
US9163212B2 (en) * 2010-01-25 2015-10-20 Warsaw Orthopedic, Inc. Osteogenic cell delivery matrix
EP2531140B1 (en) 2010-02-02 2017-11-01 Micell Technologies, Inc. Stent and stent delivery system with improved deliverability
US8338498B2 (en) * 2010-02-18 2012-12-25 Doctors Research Group, Inc. Polymeric bone defect filler
US20110201704A1 (en) * 2010-02-18 2011-08-18 Doctors Research Group, Inc. Polymeric bone defect filler
CN107080834A (zh) 2010-02-22 2017-08-22 生物模拟治疗有限责任公司 用于治疗腱病的血小板衍生生长因子组合物和方法
US9144629B2 (en) 2010-03-03 2015-09-29 Novabone Products, Llc Ionically crosslinked materials and methods for production
WO2015147923A1 (en) 2010-03-03 2015-10-01 Novabone Products, Llc Kit for delivering bone grafting materials
WO2011109581A1 (en) 2010-03-03 2011-09-09 Novabone Products, Llc Devices and methods for the regeneration of bony defects
US8795762B2 (en) 2010-03-26 2014-08-05 Battelle Memorial Institute System and method for enhanced electrostatic deposition and surface coatings
US10232092B2 (en) 2010-04-22 2019-03-19 Micell Technologies, Inc. Stents and other devices having extracellular matrix coating
WO2011137231A1 (en) * 2010-04-29 2011-11-03 Warsaw Orthopedic, Inc. Flowable ceramic putty
DK2569342T3 (da) 2010-05-11 2022-04-19 Howmedica Osteonics Corp Multivalente organofosformetalforbindelser og interpenetrerende polymerklæbemiddelnetværkssammensætninger og fremgangsmåder
TWI579007B (zh) 2010-07-02 2017-04-21 艾格諾福斯保健公司 骨再生材料之用途
EP2593039B1 (en) 2010-07-16 2022-11-30 Micell Technologies, Inc. Drug delivery medical device
US20130217829A1 (en) 2010-08-27 2013-08-22 David Myung "hydrophobic and hydrophilic interpenetrating polymer networks derived from hydrophobic polymers and methods of preparing the same"
US8877221B2 (en) * 2010-10-27 2014-11-04 Warsaw Orthopedic, Inc. Osteoconductive matrices comprising calcium phosphate particles and statins and methods of using the same
CN101991880A (zh) * 2010-11-08 2011-03-30 中国人民解放军军事医学科学院基础医学研究所 由复合msc的plga/tcp和msc组成的制剂及其应用
US10329327B2 (en) * 2010-12-06 2019-06-25 Massachusetts Institute Of Technology Tricalcium phosphate binding peptides and uses thereof
US8551525B2 (en) 2010-12-23 2013-10-08 Biostructures, Llc Bone graft materials and methods
MY169686A (en) * 2011-01-27 2019-05-13 Sirim Berhad A method of converting limestone into tri-calcium phosphate and tetra-calcium phosphate powder simultaneously
WO2012105224A1 (ja) * 2011-01-31 2012-08-09 オリンパス株式会社 ワクチン・アジュバント
US20140030338A1 (en) 2011-03-03 2014-01-30 Spineart Sa Product
WO2012123028A1 (en) 2011-03-16 2012-09-20 Kuros Biosurgery Ag Pharmaceutical formulation for use in spinal fusion
US8765189B2 (en) 2011-05-13 2014-07-01 Howmedica Osteonic Corp. Organophosphorous and multivalent metal compound compositions and methods
EP2529764A1 (de) * 2011-05-31 2012-12-05 Curasan AG Biologisch degradierbares kompositmaterial
WO2012166819A1 (en) 2011-05-31 2012-12-06 Micell Technologies, Inc. System and process for formation of a time-released, drug-eluting transferable coating
CA2841360A1 (en) 2011-07-15 2013-01-24 Micell Technologies, Inc. Drug delivery medical device
TWI449546B (zh) * 2011-09-07 2014-08-21 Ind Tech Res Inst 應用於軟硬組織修復與再生之生醫材料
WO2013052105A2 (en) 2011-10-03 2013-04-11 Biomimedica, Inc. Polymeric adhesive for anchoring compliant materials to another surface
US9381112B1 (en) 2011-10-06 2016-07-05 William Eric Sponsell Bleb drainage device, ophthalmological product and methods
US10188772B2 (en) 2011-10-18 2019-01-29 Micell Technologies, Inc. Drug delivery medical device
AU2012340699A1 (en) 2011-11-21 2014-06-19 Biomimedica, Inc. Systems, devices, and methods for anchoring orthopaedic implants to bone
US8632489B1 (en) 2011-12-22 2014-01-21 A. Mateen Ahmed Implantable medical assembly and methods
EP2793961A4 (en) * 2011-12-23 2015-06-24 Skeletal Kinetics Llc Porous calcium phosphate granule and process for its preparation and use
CN102552986B (zh) * 2012-02-28 2013-12-18 河南科技大学 一种用金属致孔剂制备多孔骨水泥的方法
US10207027B2 (en) 2012-06-11 2019-02-19 Globus Medical, Inc. Bioactive bone graft substitutes
KR101345805B1 (ko) * 2012-09-04 2014-01-03 주식회사 바이오알파 인산칼슘계 주입 및 자기경화형의 다공성 골이식재 및 거대기공을 생성시키기 위한 첨가제 적용방법
WO2014123978A2 (en) 2013-02-05 2014-08-14 University Of Utah Research Foundation Implantable devices for bone or joint defects
EP2967803B1 (en) 2013-03-12 2023-12-27 Micell Technologies, Inc. Bioabsorbable biomedical implants
CN113416187B (zh) 2013-03-14 2024-07-19 奥斯菲治疗有限公司 促进骨生长的烷基胺骆驼蓬碱衍生物
KR101443814B1 (ko) * 2013-03-28 2014-09-30 주식회사 바이오알파 골 이식재 조성물 및 이의 제조방법
EP2996629B1 (en) 2013-05-15 2021-09-22 Micell Technologies, Inc. Bioabsorbable biomedical implants
US11229789B2 (en) 2013-05-30 2022-01-25 Neurostim Oab, Inc. Neuro activator with controller
JP2016523125A (ja) 2013-05-30 2016-08-08 グラハム エイチ． クリーシー 局所神経性刺激
US9168114B2 (en) 2013-10-17 2015-10-27 B & D Dental Corp. Method of making a dental prosthesis
US9539286B2 (en) 2013-10-18 2017-01-10 Globus Medical, Inc. Bone grafts including osteogenic stem cells, and methods relating to the same
US9486483B2 (en) 2013-10-18 2016-11-08 Globus Medical, Inc. Bone grafts including osteogenic stem cells, and methods relating to the same
WO2015081087A1 (en) * 2013-11-26 2015-06-04 The Trustees Of Columbia University In The City Of New York Core-centered granule composed of micro-structure body
TWI651103B (zh) 2013-12-13 2019-02-21 萊特醫技股份有限公司 多相骨移植替代材料
CN104771782A (zh) * 2014-01-10 2015-07-15 东莞博捷生物科技有限公司 一种骨修复用材料β-磷酸三钙及其制备方法
US9579421B2 (en) 2014-02-07 2017-02-28 Globus Medical Inc. Bone grafts and methods of making and using bone grafts
US9463264B2 (en) 2014-02-11 2016-10-11 Globus Medical, Inc. Bone grafts and methods of making and using bone grafts
EP3134372B1 (en) 2014-04-24 2019-12-04 OssDsign AB Methods of forming a porous ceramic shaped article
ES2881626T3 (es) * 2014-05-30 2021-11-30 Univ New York State Res Found Composiciones y procedimientos para favorecer la formación ósea
CN106535948A (zh) * 2014-07-18 2017-03-22 Mt奥塞有限责任公司 由金属材料或金属合金制造的可生物相容的颗粒材料以及所述颗粒在椎骨成形术中的使用
EP3203930B1 (en) * 2014-10-06 2020-05-13 Proxy Biomedical Inc. Tissue integration devices and methods of making the same
AU2015374114B2 (en) 2014-12-29 2018-07-26 Bioventus, Llc Systems and methods for improved delivery of osteoinductive molecules in bone repair
CN104644455B (zh) * 2015-01-26 2017-10-27 华南理工大学 一种生物玻璃‑海藻酸钠复合生物材料及试剂盒和应用
US11077301B2 (en) 2015-02-21 2021-08-03 NeurostimOAB, Inc. Topical nerve stimulator and sensor for bladder control
US11426489B2 (en) 2015-06-10 2022-08-30 Globus Medical, Inc. Biomaterial compositions, implants, and methods of making the same
US10016529B2 (en) 2015-06-10 2018-07-10 Globus Medical, Inc. Biomaterial compositions, implants, and methods of making the same
US11077228B2 (en) 2015-08-10 2021-08-03 Hyalex Orthopaedics, Inc. Interpenetrating polymer networks
JP2018019944A (ja) * 2016-08-04 2018-02-08 国立大学法人 名古屋工業大学 生分解性繊維からなる骨再生用材料、及び骨再生用材料を製造するための方法
WO2017203331A1 (en) 2016-05-27 2017-11-30 Universität Bern Composition and methods for bone tissue engineering
CN106620859A (zh) * 2016-11-19 2017-05-10 华南理工大学 一种生物活性玻璃复合支架及其制备方法
WO2018190687A1 (ko) 2017-04-14 2018-10-18 한국기계연구원 구형 세라믹 과립의 제조방법
WO2018190688A1 (ko) * 2017-04-14 2018-10-18 한국기계연구원 유무기 복합 과립 및 이의 제조방법
EP3678602A4 (en) 2017-09-08 2021-10-06 Pioneer Surgical Technology, Inc. DISC IMPLANTS, INSTRUMENTS AND PROCEDURES
USD907771S1 (en) 2017-10-09 2021-01-12 Pioneer Surgical Technology, Inc. Intervertebral implant
US10953225B2 (en) 2017-11-07 2021-03-23 Neurostim Oab, Inc. Non-invasive nerve activator with adaptive circuit
CN108144113A (zh) * 2018-02-12 2018-06-12 华南理工大学 一种生物活性玻璃多孔骨修复体材料及其制备方法
US11103618B2 (en) 2018-02-22 2021-08-31 Warsaw Orthopedic, Inc. Demineralized bone matrix having improved handling characteristics
US12220500B2 (en) * 2018-04-13 2025-02-11 University Of Virginia Patent Foundation Compositions and methods for preparing and using non-immunogenic fast annealing microporous annealed particle hydrogels
US10869950B2 (en) 2018-07-17 2020-12-22 Hyalex Orthopaedics, Inc. Ionic polymer compositions
ES3004565T3 (en) 2018-08-14 2025-03-12 Ossifi Therapeutics Llc Pyrrolo - dipyridine compounds for the treatment of bone loss
JP7695496B2 (ja) 2018-08-14 2025-06-19 オシフィ セラピューティクス リミティド ライアビリティ カンパニー フルオロβ－カルボリン化合物
CN113166202B (zh) 2018-10-12 2024-09-13 治疗调适公司 包括β-磷酸三钙-结合序列的多肽及其用途
WO2020118011A1 (en) 2018-12-06 2020-06-11 Alexion Pharmaceuticals, Inc. Anti-alk2 antibodies and uses thereof
RU2705084C1 (ru) * 2019-03-29 2019-11-01 Федеральное государственное бюджетное учреждение науки Институт металлургии и материаловедения им. А.А. Байкова Российской академии наук (ИМЕТ РАН) Способ получения пористых материалов из альгината натрия и поливинилпирролидона, содержащих фосфаты кальция
WO2020264214A1 (en) 2019-06-26 2020-12-30 Neurostim Technologies Llc Non-invasive nerve activator with adaptive circuit
US12599696B2 (en) 2019-07-26 2026-04-14 Warsaw Orthopedic, Inc. Hydratable and flowable implantable compositions and methods of making and using them
US11311647B2 (en) * 2019-07-26 2022-04-26 Warsaw Orthopedic, Inc. Implantable calcium phosphate compositions and methods
KR102196242B1 (ko) 2020-03-31 2020-12-30 (주)메드파크 골 이식재 조성물 및 이의 제조방법
TWI739485B (zh) * 2019-08-19 2021-09-11 喜樂醫療器材股份有限公司 止血方法
US11793452B2 (en) 2019-10-03 2023-10-24 Johnson & Johnson Consumer Inc. Method of visualizing and quantifying remineralization
WO2021126921A1 (en) 2019-12-16 2021-06-24 Neurostim Solutions, Llc Non-invasive nerve activator with boosted charge delivery
US10786597B1 (en) 2020-03-24 2020-09-29 Secada Medical Llc Methods of producing an osteoinductive calcium phosphate material for bone grafting
AU2021254751B2 (en) 2020-04-15 2025-01-30 Theradaptive, Inc. Compositions and methods for targeted therapeutic delivery to bone
US11083557B1 (en) 2020-05-01 2021-08-10 Secada Medical Llc Bone graft containment system
US11896736B2 (en) 2020-07-13 2024-02-13 Globus Medical, Inc Biomaterial implants and methods of making the same
US12383246B2 (en) 2020-10-12 2025-08-12 Abbott Cardiovascular Systems, Inc. Vessel closure device with improved safety and tract hemostasis
AU2022378270B2 (en) * 2021-11-01 2025-01-02 Lg Chem, Ltd. Composite filler, and product using the same
CN116806160A (zh) * 2021-11-01 2023-09-26 株式会社Lg化学 复合填料和使用其的产品
CN116492450B (zh) * 2023-06-25 2023-10-10 朗肽生物制药股份有限公司 重组人碱性成纤维细胞生长因子口腔凝胶及其制备方法

Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60142857A (ja) * 1983-12-29 1985-07-29 住友セメント株式会社 骨セメント組成物
JPS6179462A (ja) * 1984-09-25 1986-04-23 ティーディーケイ株式会社 多孔質人工骨材料
US4596574A (en) * 1984-05-14 1986-06-24 The Regents Of The University Of California Biodegradable porous ceramic delivery system for bone morphogenetic protein
JPS62254764A (ja) * 1986-04-18 1987-11-06 メルク・パテント・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング インプラント材料用リン酸三カルシウム
JPH02182261A (ja) * 1989-01-06 1990-07-16 Olympus Optical Co Ltd 生体用セラミクス部材の製造方法
JPH07206489A (ja) * 1991-11-22 1995-08-08 Maria G Boltong りん酸カルシウムセメント組成物、その製造方法、及びその使用方法
JPH07291723A (ja) * 1994-03-02 1995-11-07 Advance Co Ltd α−リン酸三カルシウムセラミック及びその製造方法
JPH07291759A (ja) * 1994-04-27 1995-11-07 Ngk Spark Plug Co Ltd 多孔質セラミックスの製造方法
WO1997045147A1 (en) * 1996-05-28 1997-12-04 1218122 Ontario Inc. Resorbable implant biomaterial made of condensed calcium phosphate particles
JPH10158075A (ja) * 1996-11-25 1998-06-16 Advance Co Ltd セラミックスの製造方法
WO1998041246A2 (en) * 1997-03-20 1998-09-24 Stryker Corporation Osteogenic devices and methods of use thereof for repair of bone
JPH10314295A (ja) * 1997-03-14 1998-12-02 Asahi Optical Co Ltd 骨補填材及びその製造方法
JP2000508911A (ja) * 1996-04-19 2000-07-18 オシリス セラピューティクス，インコーポレイテッド 間葉幹細胞を用いる骨の再生および増強
JP2000202017A (ja) * 1999-01-20 2000-07-25 Ruian Pharmaceutic Co Ltd 骨充填剤材料とその製造方法
WO2001013970A1 (de) * 1999-08-26 2001-03-01 Gerontocare Gmbh Resorbierbares knochenersatz- und knochenaufbaumaterial
WO2001066163A1 (en) * 2000-03-10 2001-09-13 Technology Finance Corporation (Proprietary) Limited Including a body of non-resorbable bioactive material implant

Family Cites Families (172)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6306297B1 (en) 1968-07-08 2001-10-23 Asahi Kogaku Kogyo Kabushiki Kaisha Packing material for liquid chromatography and process for producing the same
DE2242867C3 (de) 1972-08-31 1975-09-25 Battelle-Institut E.V., 6000 Frankfurt Verfahren zur Herstellung implantierbarer, keramischer Knochenersatz-, Knochenverbund- oder Prothesenverankerung swerkstoffe
DE2620890C3 (de) 1976-05-12 1987-09-10 Battelle-Institut eV, 6000 Frankfurt Plastische Masse auf der Basis von gesinterten Calciumphosphaten für implantierbare Knochenersatz-, Knochenverbund- oder Prothesenverankerungswerkstoffe
DE2905878A1 (de) 1979-02-16 1980-08-28 Merck Patent Gmbh Implantationsmaterialien und verfahren zu ihrer herstellung
JPS56166843A (en) 1980-05-28 1981-12-22 Mitsubishi Mining & Cement Co Filler for bone broken section and void section
DK154260C (da) 1981-02-20 1989-05-22 Mundipharma Gmbh Fremgangsmaade til fremstilling af et knogleimplantat af braendt tricalciumphosphat, specielt til udfyldning af hulrum eller til sammensaetning af knogledele efter fraktur.
DE3106917C2 (de) 1981-02-25 1984-04-05 Schuett Und Grundei Gmbh Medizintechnische Fabrikation, 2400 Luebeck Verfahren zur Herstellung eines Implantates als Knochenersatz
DE3224265C2 (de) 1982-06-28 1987-01-08 S + G Implants GmbH, 2400 Lübeck Verfahren zur Herstellung eines Implantates als Knochenersatz
DE3239033A1 (de) * 1982-10-21 1984-04-26 Dr. C. Otto & Co Gmbh, 4630 Bochum Porosiertes, insbesonder feuerfestes keramisches erzeugnis sowie verfahren zu seiner herstellung
JPS59101145A (ja) 1982-11-30 1984-06-11 日本特殊陶業株式会社 薬液含浸多孔質セラミツクス
JPS59131346A (ja) 1983-01-17 1984-07-28 日本特殊陶業株式会社 薬液含浸多孔質セラミツクスの製造法
JPS59135053A (ja) 1983-01-20 1984-08-03 日本特殊陶業株式会社 薬液含浸繊維質セラミツクス
US4911720A (en) 1983-03-10 1990-03-27 Collier John P Particular surface replacement prosthesis
JPS59171546A (ja) 1983-03-18 1984-09-28 日本特殊陶業株式会社 代替骨用充填材
DE3325111A1 (de) 1983-07-12 1985-01-24 Merck Patent Gmbh, 6100 Darmstadt Implantationsmaterialien
NL8402158A (nl) 1983-07-09 1985-02-01 Sumitomo Cement Co Poreus keramisch materiaal en werkwijze voor de bereiding daarvan.
JPS6021763A (ja) 1983-07-15 1985-02-04 ティーディーケイ株式会社 人工骨材料
JPS6090880A (ja) 1983-10-25 1985-05-22 住友セメント株式会社 リン酸カルシウム多孔体およびその製造方法
US4563489A (en) 1984-02-10 1986-01-07 University Of California Biodegradable organic polymer delivery system for bone morphogenetic protein
JPS60142857U (ja) 1984-02-29 1985-09-21 日本電気株式会社 デイスク収納容器応動型デイスク取り出し装置
DE3414924A1 (de) 1984-04-19 1985-10-31 Klaus Dr.med. Dr.med.habil. 8000 München Draenert Beschichtetes verankerungsteil fuer implantate
JPS6131163A (ja) 1984-07-23 1986-02-13 京セラ株式会社 セラミツク製生体補綴材とその製造方法
NL8402534A (nl) 1984-08-17 1986-03-17 Gerrit Johannes Brinks Materiaal, geschikt voor toepassing als implantatiemateriaal bij mens en dier ter vervanging van afwezig botweefsel, alsmede werkwijze ter bereiding van het materiaal.
US4629464A (en) 1984-09-25 1986-12-16 Tdk Corporation Porous hydroxyapatite material for artificial bone substitute
JPS61127658A (ja) 1984-11-26 1986-06-14 セントラル硝子株式会社 多孔体リン酸カルシウム系セラミツクの製造法
US5522894A (en) 1984-12-14 1996-06-04 Draenert; Klaus Bone replacement material made of absorbable beads
US4636526A (en) 1985-02-19 1987-01-13 The Dow Chemical Company Composites of unsintered calcium phosphates and synthetic biodegradable polymers useful as hard tissue prosthetics
US5034352A (en) 1985-06-25 1991-07-23 Lifecore Biomedical, Inc. Calcium phosphate materials
US4693986A (en) 1985-06-25 1987-09-15 Orthomatrix, Inc. Ceramic process and products
US4645503A (en) 1985-08-27 1987-02-24 Orthomatrix Inc. Moldable bone-implant material
CA1279175C (en) 1985-12-31 1991-01-22 Ronald L. Salsbury Ceramic processing and products
JPS62158175A (ja) 1986-01-07 1987-07-14 住友大阪セメント株式会社 代替骨用多孔質セラミツク成形体およびその製造方法
JPH0655219B2 (ja) 1986-03-04 1994-07-27 住友セメント株式会社 義肢取付具
US4830994A (en) 1986-03-31 1989-05-16 The Dow Chemical Company Greenware binder
US4777153A (en) 1986-05-06 1988-10-11 Washington Research Foundation Process for the production of porous ceramics using decomposable polymeric microspheres and the resultant product
JPS62281953A (ja) 1986-05-28 1987-12-07 旭光学工業株式会社 骨補填材
JPS6346171A (ja) 1986-06-06 1988-02-27 旭光学工業株式会社 生体内留置医療用具の支持体
US4839215A (en) 1986-06-09 1989-06-13 Ceramed Corporation Biocompatible particles and cloth-like article made therefrom
US6432919B1 (en) 1986-07-01 2002-08-13 Genetics Institute, Inc. Bone morphogenetic protein-3 and compositions
US5939388A (en) 1986-07-01 1999-08-17 Rosen; Vicki A. Methods of administering BMP-5 compositions
JP2508654B2 (ja) 1986-08-14 1996-06-19 富士ゼロックス株式会社 電子写真用感光体
JPS6346167A (ja) 1986-08-14 1988-02-27 株式会社明電舎 多孔質体の製造方法
JPS63125259A (ja) 1986-11-14 1988-05-28 旭光学工業株式会社 リン酸カルシウム系多孔質骨補填材
US4737411A (en) 1986-11-25 1988-04-12 University Of Dayton Controlled pore size ceramics particularly for orthopaedic and dental applications
JPS63159313A (ja) 1986-12-24 1988-07-02 Olympus Optical Co Ltd 治療用薬剤
CA1325327C (en) 1987-01-20 1993-12-21 Kenji Saita Process for production of porous ceramic article
US4861733A (en) 1987-02-13 1989-08-29 Interpore International Calcium phosphate bone substitute materials
JP2608721B2 (ja) 1987-05-12 1997-05-14 旭光学工業株式会社 リン酸カルシウム系材料の製造方法
JP2572606B2 (ja) 1987-09-14 1997-01-16 旭光学工業株式会社 表面多孔質なリン酸カルシウム系セラミックスの製造法
JP2702953B2 (ja) 1988-01-30 1998-01-26 オリンパス光学工業株式会社 薬液含浸セラミックス
JP3058174B2 (ja) * 1988-09-20 2000-07-04 旭光学工業株式会社 多孔質セラミックス及びその製造用乾燥体並びにそれらの製造方法
US5171720A (en) * 1988-09-20 1992-12-15 Asahi Kogaku Kogyo K.K. Porous ceramic sinter and process for producing same
US5207710A (en) 1988-09-29 1993-05-04 Collagen Corporation Method for improving implant fixation
US5258029A (en) 1988-09-29 1993-11-02 Collagen Corporation Method for improving implant fixation
US5059388A (en) 1988-10-06 1991-10-22 Sumitomo Cement Co., Ltd. Process for manufacturing sintered bodies
US5106626A (en) 1988-10-11 1992-04-21 International Genetic Engineering, Inc. Osteogenic factors
US5055307A (en) 1988-12-29 1991-10-08 Asahi Kagaku Kogyo Kabushiki Kaisha Slow release drug delivery granules and process for production thereof
US5135394A (en) 1989-01-06 1992-08-04 Olympus Optical Co., Ltd. Extraction cavity filling member and a manufacturing method thereof
SE9000650L (sv) 1989-02-28 1990-08-29 Asahi Optical Co Ltd Separation av celler eller virus
US5422340A (en) 1989-09-01 1995-06-06 Ammann; Arthur J. TGF-βformulation for inducing bone growth
US5152791A (en) 1989-12-07 1992-10-06 Olympus Optical Co., Ltd. Prosthetic artificial bone having ceramic layers of different porosity
US5011495A (en) 1990-02-16 1991-04-30 The United States Of America As Represented By The Secretary Of The Army Unique bone regeneration tricalcium phosphate
US5492697A (en) 1990-03-05 1996-02-20 Board Of Regents, Univ. Of Texas System Biodegradable implant for fracture nonunions
US5164187A (en) 1990-04-05 1992-11-17 Norian Corporation Hydroxyapatite prosthesis coatings
US5263985A (en) 1990-08-14 1993-11-23 Pfizer Hospital Products Group, Inc. Bone growth stimulator
US6080801A (en) 1990-09-13 2000-06-27 Klaus Draenert Multi-component material and process for its preparation
DE4033343A1 (de) 1990-10-19 1992-04-23 Draenert Klaus Werkstoff als ausgangsmaterial zur herstellung von knochenzement und verfahren zu seiner herstellung
US6350462B1 (en) 1990-12-26 2002-02-26 Olympus Optical Co., Ltd. Hollow porous ceramic carrier for embedding in patient for sustained medicament release and method of preparation thereof
JP2922667B2 (ja) * 1991-04-26 1999-07-26 京セラ株式会社 徐放性薬剤含有セラミックス多孔体
DE4120325A1 (de) 1991-06-20 1992-12-24 Merck Patent Gmbh Implantatwerkstoff
JP3351525B2 (ja) 1991-06-21 2002-11-25 ジェネティックス・インスティテュート・インコーポレイテッド 骨形成性蛋白医薬処方物
DE4121043A1 (de) 1991-06-26 1993-01-07 Merck Patent Gmbh Knochenersatzmaterial mit fgf
DE4133877C1 (enExample) 1991-10-12 1993-05-19 S + G Implants Gmbh, 2400 Luebeck, De
US5338356A (en) 1991-10-29 1994-08-16 Mitsubishi Materials Corporation Calcium phosphate granular cement and method for producing same
US5306303A (en) 1991-11-19 1994-04-26 The Medical College Of Wisconsin, Inc. Bone induction method
JP3191963B2 (ja) 1991-12-26 2001-07-23 株式会社日立製作所 変圧器鉄心の組立方法及び組立装置並びに変圧器鉄心
SE469653B (sv) 1992-01-13 1993-08-16 Lucocer Ab Poroest implantat
ZA93506B (en) 1992-02-11 1994-05-11 Bristol Myers Squibb Co Soft tissue augmentation material
US7060287B1 (en) 1992-02-11 2006-06-13 Bioform Inc. Tissue augmentation material and method
US6537574B1 (en) 1992-02-11 2003-03-25 Bioform, Inc. Soft tissue augmentation material
WO1993020859A1 (en) 1992-04-20 1993-10-28 Board Of Regents Of The University Of Washington Sustained release compositions for delivery of growth factors
DE4216496C2 (de) 1992-05-19 1994-09-22 Werner Prof Dr Med Sattel Verwendung eines Plombenkörpers zum Einsetzen in eine Knochenhöhle, insbesondere in den Markraum eines Röhrenknochens
US6303297B1 (en) 1992-07-17 2001-10-16 Incyte Pharmaceuticals, Inc. Database for storage and analysis of full-length sequences
AU671721B2 (en) 1993-01-12 1996-09-05 Genentech Inc. Tgf-beta formulation for inducing bone growth
GB9300746D0 (en) 1993-01-15 1993-03-03 Univ Southampton Prosthesis
JP3231135B2 (ja) 1993-04-16 2001-11-19 日本特殊陶業株式会社 生体インプラント材料及びその製造方法
US5492440A (en) * 1993-05-18 1996-02-20 U.S. Philips Corporation Apparatus for movement of an object
US5581176A (en) * 1993-05-24 1996-12-03 North American Philips Corporation Analog autonomous test bus framework for testing integrated circuits on a printed circuit board
US5964745A (en) * 1993-07-02 1999-10-12 Med Usa Implantable system for cell growth control
US5385887A (en) 1993-09-10 1995-01-31 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
US5531794A (en) 1993-09-13 1996-07-02 Asahi Kogaku Kogyo Kabushiki Kaisha Ceramic device providing an environment for the promotion and formation of new bone
CH686518A5 (de) 1993-10-05 1996-04-15 Asahi Optical Co Ltd Granulares Polymerkomposit, Herstellungsverfahren fur dieses und diagnostische Mittel.
AU699913B2 (en) * 1993-11-10 1998-12-17 Henry M. Jackson Foundation For The Advancement Of Military Medicine Compositions and method for stimulating antibody release by B lymphocytes
FR2715853B1 (fr) 1994-02-08 1996-04-26 Centre Nat Rech Scient Composition pour bio-matériau; procédé de préparation.
US5962427A (en) 1994-02-18 1999-10-05 The Regent Of The University Of Michigan In vivo gene transfer methods for wound healing
US5626861A (en) * 1994-04-01 1997-05-06 Massachusetts Institute Of Technology Polymeric-hydroxyapatite bone composite
US5707968A (en) * 1994-05-26 1998-01-13 Abbott Laboratories Inhibition of attachment of H.influenzae to human cells
US5639402A (en) * 1994-08-08 1997-06-17 Barlow; Joel W. Method for fabricating artificial bone implant green parts
US5520923A (en) 1994-09-19 1996-05-28 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
US5707962A (en) 1994-09-28 1998-01-13 Gensci Regeneration Sciences Inc. Compositions with enhanced osteogenic potential, method for making the same and therapeutic uses thereof
US6180606B1 (en) 1994-09-28 2001-01-30 Gensci Orthobiologics, Inc. Compositions with enhanced osteogenic potential, methods for making the same and uses thereof
DE4435680A1 (de) 1994-10-06 1996-04-11 Merck Patent Gmbh Poröse Knochenersatzmaterialien
US5741329A (en) 1994-12-21 1998-04-21 Board Of Regents, The University Of Texas System Method of controlling the pH in the vicinity of biodegradable implants
US6376573B1 (en) 1994-12-21 2002-04-23 Interpore International Porous biomaterials and methods for their manufacture
US6599515B1 (en) * 1995-01-16 2003-07-29 Baxter International Inc. Fibrin porous structure
US5641502A (en) 1995-06-07 1997-06-24 United States Surgical Corporation Biodegradable moldable surgical material
EP0842209B1 (en) 1995-07-28 2006-10-11 Genzyme Corporation Multiblock biodegradable hydrogels for use as controlled release agents for drugs and tissue treatment agents
US5776193A (en) 1995-10-16 1998-07-07 Orquest, Inc. Bone grafting matrix
US6048964A (en) * 1995-12-12 2000-04-11 Stryker Corporation Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
JP3600676B2 (ja) 1996-01-29 2004-12-15 ペンタックス株式会社 生体内可溶性複合体粒子
ATE273723T1 (de) 1996-02-29 2004-09-15 Bioactive Bone Substitute Oy A Osteogene vorrichtungen und methode zur herstellung derselben
US5792477A (en) 1996-05-07 1998-08-11 Alkermes Controlled Therapeutics, Inc. Ii Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent
US6051247A (en) 1996-05-30 2000-04-18 University Of Florida Research Foundation, Inc. Moldable bioactive compositions
FR2749756B1 (fr) 1996-06-14 1998-09-11 Bioland Procede de preparation d'un materiau composite implantable, materiau obtenu, implant comprenant ce materiau et kit de mise en oeuvre
GB2354518B (en) 1996-10-04 2001-06-13 Dytech Corp Ltd A porous ceramic body composed of bonded particles
US6037519A (en) * 1997-10-20 2000-03-14 Sdgi Holdings, Inc. Ceramic fusion implants and compositions
FI105159B (fi) 1996-10-25 2000-06-30 Biocon Ltd Kirurginen implantaatti, väline tai sen osa
US5866155A (en) 1996-11-20 1999-02-02 Allegheny Health, Education And Research Foundation Methods for using microsphere polymers in bone replacement matrices and composition produced thereby
FR2758988B1 (fr) 1997-02-05 2000-01-21 S H Ind Procede d'elaboration de substituts osseux synthetiques d'architecture poreuse parfaitement maitrisee
US5914121A (en) * 1997-02-12 1999-06-22 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Formation of human bone in vivo using ceramic powder and human marrow stromal fibroblasts
DE69823955T2 (de) 1997-03-04 2005-06-16 Technology Finance Corp. (Pty.) Ltd., Sandton Als knochenimplantat geeignetes erzeugnis
US6210612B1 (en) 1997-03-31 2001-04-03 Pouvair Corporation Method for the manufacture of porous ceramic articles
CA2285430C (en) 1997-04-01 2008-11-18 Cap Biotechnology, Inc. Calcium phosphate microcarriers and microspheres
DE69821510T2 (de) 1997-04-24 2004-06-24 Takeda Chemical Industries, Ltd. Mit apatit beschichtete feste zusammensetzung
JP3490864B2 (ja) 1997-06-02 2004-01-26 ペンタックス株式会社 セラミックス球状顆粒の製造方法
US6136029A (en) 1997-10-01 2000-10-24 Phillips-Origen Ceramic Technology, Llc Bone substitute materials
US6296667B1 (en) 1997-10-01 2001-10-02 Phillips-Origen Ceramic Technology, Llc Bone substitutes
ATE224213T1 (de) 1997-10-21 2002-10-15 Augmentec Ag Implantat aus resorbierbaren phosphatglas
US20010014667A1 (en) * 1998-01-05 2001-08-16 Chen Charles C. Compositions with enhanced osteogenic potential, methods for making the same and therapeutic uses thereof
US6063117A (en) 1998-01-22 2000-05-16 Perry; Arthur C. Porous orbital implant structure
US6030635A (en) 1998-02-27 2000-02-29 Musculoskeletal Transplant Foundation Malleable paste for filling bone defects
JPH11276468A (ja) 1998-03-27 1999-10-12 Sumitomo Osaka Cement Co Ltd 骨塩定量用ファントム
JP3360810B2 (ja) 1998-04-14 2003-01-07 ペンタックス株式会社 骨補填材の製造方法
US6027744A (en) 1998-04-24 2000-02-22 University Of Massachusetts Medical Center Guided development and support of hydrogel-cell compositions
US6281257B1 (en) 1998-04-27 2001-08-28 The Regents Of The University Of Michigan Porous composite materials
US6261322B1 (en) 1998-05-14 2001-07-17 Hayes Medical, Inc. Implant with composite coating
AU766735B2 (en) * 1998-09-15 2003-10-23 Isotis N.V. Osteoinduction
GB9820874D0 (en) 1998-09-26 1998-11-18 Smith & Nephew Melt-mouldable composites
US6165486A (en) 1998-11-19 2000-12-26 Carnegie Mellon University Biocompatible compositions and methods of using same
JP2002532160A (ja) 1998-12-17 2002-10-02 ケンブリッジ サイエンティフィック， インコーポレイテッド 皮質骨同種移植片の順序付けられた組み込み
US6194006B1 (en) 1998-12-30 2001-02-27 Alkermes Controlled Therapeutics Inc. Ii Preparation of microparticles having a selected release profile
US6383519B1 (en) 1999-01-26 2002-05-07 Vita Special Purpose Corporation Inorganic shaped bodies and methods for their production and use
ES2209820T3 (es) 1999-02-04 2004-07-01 Sdgi Holdings, Inc. Composiciones esponjosas osteogenicas altamente mineralizadas, y usos de las mismas.
CA2362046A1 (en) * 1999-02-04 2000-08-10 Sdgi Holdings, Inc. Osteogenic paste compositions and uses thereof
US6656489B1 (en) * 1999-02-10 2003-12-02 Isotis N.V. Scaffold for tissue engineering cartilage having outer surface layers of copolymer and ceramic material
EP1027897B1 (en) 1999-02-10 2005-04-13 IsoTis N.V. Cartillage tissue engineering
WO2000050104A1 (de) 1999-02-25 2000-08-31 Degradable Solutions Ag Biodegradierbare, poröse formkörper
JP2000262608A (ja) 1999-03-12 2000-09-26 Mitsubishi Materials Corp 複合型骨充填材
JP3400740B2 (ja) 1999-04-13 2003-04-28 東芝セラミックス株式会社 リン酸カルシウム系多孔質焼結体およびその製造方法
US6667049B2 (en) * 1999-06-14 2003-12-23 Ethicon, Inc. Relic process for producing bioresorbable ceramic tissue scaffolds
ES2327026T3 (es) 1999-07-08 2009-10-23 Cap Biotechnology, Inc. Estructuras que contienen calcio y procedimientos de fabricacion y uso de las mismas.
JP4358374B2 (ja) 1999-08-10 2009-11-04 日本特殊陶業株式会社 生体インプラント材の製造方法
JP4365485B2 (ja) 1999-08-19 2009-11-18 株式会社アドバンス 多孔質リン酸カルシウムセラミックスの製造方法
WO2001029189A2 (en) 1999-10-15 2001-04-26 Mount Sinai Hospital Synthetic substrate for tissue formation
EP1220693B1 (en) 1999-10-15 2004-12-08 Genetics Institute, LLC Formulations for delivery of osteogenic proteins
US6451059B1 (en) 1999-11-12 2002-09-17 Ethicon, Inc. Viscous suspension spinning process for producing resorbable ceramic fibers and scaffolds
US6479418B2 (en) 1999-12-16 2002-11-12 Isotis N.V. Porous ceramic body
AU3242201A (en) 1999-12-16 2001-06-25 Isotis N.V. Porous ceramic body
DE29922585U1 (de) 1999-12-22 2000-07-20 Biovision GmbH, 98693 Ilmenau Temporärer Knochendefektfüller
AU4234901A (en) * 2000-01-28 2001-08-07 Dot Dunnschicht Und Oberflache Inorganic resorbable bone substitute material and production method
WO2001054746A2 (en) 2000-01-31 2001-08-02 Advanced Research And Technology Institute, Inc. Composite biomaterial including anisometric calcium phosphate reinforcement particles
US20020022885A1 (en) * 2000-05-19 2002-02-21 Takahiro Ochi Biomaterial
US9387094B2 (en) * 2000-07-19 2016-07-12 Warsaw Orthopedic, Inc. Osteoimplant and method of making same
DE60116103T2 (de) 2000-08-04 2006-08-24 Orthogem Ltd., Wollaton Poröse synthetische knochenimplantate und verfahren zu deren herstellung
GB0020610D0 (en) 2000-08-21 2000-10-11 Dytech Corp Ltd Uses of porous carriers
US7045125B2 (en) 2000-10-24 2006-05-16 Vita Special Purpose Corporation Biologically active composites and methods for their production and use
US20020114795A1 (en) * 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
JP2004533276A (ja) 2001-01-25 2004-11-04 リジェネレーション テクノロジーズ インク． 注射可能な多孔性骨グラフト材料
US20020115742A1 (en) * 2001-02-22 2002-08-22 Trieu Hai H. Bioactive nanocomposites and methods for their use
US7122057B2 (en) * 2001-04-12 2006-10-17 Therics, Llc Method and apparatus for engineered regenerative biostructures such as hydroxyapatite substrates for bone healing applications
ES2424614T3 (es) 2001-05-01 2013-10-07 Amedica Corporation Injerto óseo radiolúcido
WO2010063119A1 (en) 2008-12-04 2010-06-10 Tajinder Manku Multi-transport mode devices having improved data throughput

Patent Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60142857A (ja) * 1983-12-29 1985-07-29 住友セメント株式会社 骨セメント組成物
US4596574A (en) * 1984-05-14 1986-06-24 The Regents Of The University Of California Biodegradable porous ceramic delivery system for bone morphogenetic protein
JPS6179462A (ja) * 1984-09-25 1986-04-23 ティーディーケイ株式会社 多孔質人工骨材料
JPS62254764A (ja) * 1986-04-18 1987-11-06 メルク・パテント・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング インプラント材料用リン酸三カルシウム
JPH02182261A (ja) * 1989-01-06 1990-07-16 Olympus Optical Co Ltd 生体用セラミクス部材の製造方法
JPH07206489A (ja) * 1991-11-22 1995-08-08 Maria G Boltong りん酸カルシウムセメント組成物、その製造方法、及びその使用方法
JPH07291723A (ja) * 1994-03-02 1995-11-07 Advance Co Ltd α−リン酸三カルシウムセラミック及びその製造方法
JPH07291759A (ja) * 1994-04-27 1995-11-07 Ngk Spark Plug Co Ltd 多孔質セラミックスの製造方法
JP2000508911A (ja) * 1996-04-19 2000-07-18 オシリス セラピューティクス，インコーポレイテッド 間葉幹細胞を用いる骨の再生および増強
WO1997045147A1 (en) * 1996-05-28 1997-12-04 1218122 Ontario Inc. Resorbable implant biomaterial made of condensed calcium phosphate particles
JPH10158075A (ja) * 1996-11-25 1998-06-16 Advance Co Ltd セラミックスの製造方法
JPH10314295A (ja) * 1997-03-14 1998-12-02 Asahi Optical Co Ltd 骨補填材及びその製造方法
WO1998041246A2 (en) * 1997-03-20 1998-09-24 Stryker Corporation Osteogenic devices and methods of use thereof for repair of bone
JP2000202017A (ja) * 1999-01-20 2000-07-25 Ruian Pharmaceutic Co Ltd 骨充填剤材料とその製造方法
WO2001013970A1 (de) * 1999-08-26 2001-03-01 Gerontocare Gmbh Resorbierbares knochenersatz- und knochenaufbaumaterial
WO2001066163A1 (en) * 2000-03-10 2001-09-13 Technology Finance Corporation (Proprietary) Limited Including a body of non-resorbable bioactive material implant

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014510763A (ja) * 2011-04-11 2014-05-01 インデュース バイオロジクス インコーポレイテッド 増殖因子の多相放出を行うためのシステムおよび方法
JP2022545185A (ja) * 2019-08-20 2022-10-26 セラダプティブ インク 骨インプラントにおける係留可能なタンパク質の送達のための材料
JP7588136B2 (ja) 2019-08-20 2024-11-21 セラダプティブ インク 骨インプラントにおける係留可能なタンパク質の送達のための材料

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