PT2968284T - Derivados alquilamina de harmina para promoção de crescimento ósseo - Google Patents

Derivados alquilamina de harmina para promoção de crescimento ósseo

Info

Publication number
PT2968284T
PT2968284T PT147700520T PT14770052T PT2968284T PT 2968284 T PT2968284 T PT 2968284T PT 147700520 T PT147700520 T PT 147700520T PT 14770052 T PT14770052 T PT 14770052T PT 2968284 T PT2968284 T PT 2968284T
Authority
PT
Portugal
Prior art keywords
amine
alkyl
bone growth
promoting bone
harmine derivatives
Prior art date
Application number
PT147700520T
Other languages
English (en)
Original Assignee
Osteoqc Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osteoqc Inc filed Critical Osteoqc Inc
Publication of PT2968284T publication Critical patent/PT2968284T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/02—Formic acid
    • C07C53/06—Salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/265—Citric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
PT147700520T 2013-03-14 2014-03-14 Derivados alquilamina de harmina para promoção de crescimento ósseo PT2968284T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361785306P 2013-03-14 2013-03-14

Publications (1)

Publication Number Publication Date
PT2968284T true PT2968284T (pt) 2021-06-28

Family

ID=51569593

Family Applications (1)

Application Number Title Priority Date Filing Date
PT147700520T PT2968284T (pt) 2013-03-14 2014-03-14 Derivados alquilamina de harmina para promoção de crescimento ósseo

Country Status (16)

Country Link
US (3) US9540365B2 (pt)
EP (2) EP2968284B1 (pt)
JP (1) JP6721499B2 (pt)
CN (2) CN113416187A (pt)
CA (1) CA2899247C (pt)
DK (1) DK2968284T3 (pt)
ES (1) ES2875874T3 (pt)
HK (1) HK1218259A1 (pt)
HR (1) HRP20210931T1 (pt)
HU (1) HUE055455T2 (pt)
LT (1) LT2968284T (pt)
PL (1) PL2968284T3 (pt)
PT (1) PT2968284T (pt)
RS (1) RS62053B1 (pt)
SI (1) SI2968284T1 (pt)
WO (1) WO2014153203A2 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2899247C (en) * 2013-03-14 2023-04-04 Osteoqc Inc. Alkyl-amine harmine derivatives for promoting bone growth
US10092550B2 (en) 2014-10-21 2018-10-09 Ions Pharmaceutical S.À R.L. Therapeutic compositions containing curcumin, harmine, and isovanillin components, and methods of use thereof
US9907786B2 (en) 2014-10-21 2018-03-06 Ions Pharmaceutical S.À R.L. Therapeutic compositions containing harmine and isovanillin components, and methods of use thereof
US20160106721A1 (en) 2014-10-21 2016-04-21 Life Plus, LLC Human therapeutic agents
CN105837569B (zh) * 2016-04-29 2017-12-26 华南农业大学 一种骆驼蓬碱噁唑啉类化合物及其制备方法和应用
CN111936490A (zh) 2017-11-20 2020-11-13 西奈山伊坎医学院 激酶抑制剂化合物和组合物及使用方法
WO2019136320A1 (en) 2018-01-05 2019-07-11 Icahn School Of Medicine At Mount Sinai Method of increasing proliferation of pancreatic beta cells, treatment method, and composition
JP2021518413A (ja) * 2018-03-20 2021-08-02 アイカーン スクール オブ メディシン アット マウント サイナイ キナーゼ阻害剤化合物及び組成物ならびに使用方法
GB201810746D0 (en) 2018-06-29 2018-08-15 Mereo Biopharma 3 Ltd Use of sclerostin antagonist
CA3108714A1 (en) 2018-08-14 2020-02-20 Osteoqc Inc. Pyrrolo - dipyridine compounds
CA3109104A1 (en) * 2018-08-14 2020-02-20 Osteoqc Inc. Fluoro .beta.-carboline compounds
CN111773217A (zh) * 2020-06-18 2020-10-16 中国人民解放军空军军医大学 骆驼蓬碱在制备防治慢性肾脏病的药物中的应用

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2688022A (en) * 1953-04-13 1954-08-31 Searle & Co 1-aminoalkyl-3-carbolines
US2767179A (en) * 1954-02-12 1956-10-16 Irwin Neisler And Company Quaternary ammonium salts of carboline derivatives
US2800474A (en) * 1956-03-26 1957-07-23 Searle & Co 9-(piperazinoalkyl) norharman derivatives
GB1268772A (en) * 1968-03-15 1972-03-29 Glaxo Lab Ltd NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME
US5344654A (en) 1988-04-08 1994-09-06 Stryker Corporation Prosthetic devices having enhanced osteogenic properties
US5324819A (en) 1988-04-08 1994-06-28 Stryker Corporation Osteogenic proteins
US5266683A (en) 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US5298852A (en) 1988-12-22 1994-03-29 Robert Bosch Gmbh Arrangement for and method of controlling a three-phase-generator in a vehicle
US5656593A (en) 1991-03-11 1997-08-12 Creative Biomolecules, Inc. Morphogen induced periodontal tissue regeneration
ATE238417T1 (de) 1991-11-04 2003-05-15 Inst Genetics Llc Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung
TW212798B (pt) 1991-11-25 1993-09-11 Takeda Pharm Industry Co Ltd
IT1255522B (it) 1992-09-24 1995-11-09 Ubaldo Conte Compressa per impiego terapeutico atta a cedere una o piu' sostanze attive con differenti velocita'
TW270114B (pt) * 1993-10-22 1996-02-11 Hoffmann La Roche
DE4435477A1 (de) 1994-10-04 1996-04-11 Bayer Ag Cycloalkano-indol- und -azaindol-derivate
DE4436190A1 (de) 1994-10-10 1996-04-11 Gerhard Prof Dr Bringmann Halogenierte ß-Carbolin-Derivate, Verfahren zu ihrer Herstellung und Verwendung dieser Substanzen zur Hemmung der Atmungskette
DE19613549A1 (de) 1996-04-04 1997-10-09 Bayer Ag Verfahren zur Herstellung von enantiomerenreinen Cycloalkano-indol- und azaindol-carbonsäuren und deren aktivierte Derivate
US5939039A (en) 1997-01-16 1999-08-17 Orthovita, Inc. Methods for production of calcium phosphate
WO1998034655A1 (en) 1997-02-07 1998-08-13 Stryker Corporation Matrix-free osteogenic devices, implants and methods of use thereof
US7041641B2 (en) 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
AU4919099A (en) 1998-07-11 2000-02-01 University Of Bristol, The Compounds having activity at imidazoline receptors
US6025538A (en) 1998-11-20 2000-02-15 Musculoskeletal Transplant Foundation Compound bone structure fabricated from allograft tissue
JP2002538205A (ja) 1999-03-10 2002-11-12 メルク エンド カムパニー インコーポレーテッド 性腺刺激ホルモン放出ホルモン拮抗薬としての６−アザインドール化合物
US20070060606A1 (en) 1999-10-07 2007-03-15 Robertson Harold A Compounds and methods for modulating phosphodiesterase 10A
EP1134221A1 (en) 2000-03-15 2001-09-19 Aventis Pharma Deutschland GmbH Substituted beta-carbolines as lkB kinase inhibitors
EP1209158A1 (en) 2000-11-18 2002-05-29 Aventis Pharma Deutschland GmbH Substituted beta-carbolines
BR0109161A (pt) 2000-03-15 2002-11-26 Aventis Pharma Gmbh Beta-carbolinas substituìdas com atividade de inibição de ikb-quinase
US20030082233A1 (en) 2000-12-01 2003-05-01 Lyons Karen M. Method and composition for modulating bone growth
EP1379268A1 (en) 2001-02-23 2004-01-14 Genetics Institute, LLC Chondrogenic potential of human bone marrow-derived cd105?+ cells by bmp
US6949251B2 (en) 2001-03-02 2005-09-27 Stryker Corporation Porous β-tricalcium phosphate granules for regeneration of bone tissue
TWI267378B (en) 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
WO2003070288A2 (en) 2001-10-12 2003-08-28 Inframat Corporation Coated implants and methods of coating implants
JP3646167B2 (ja) 2002-02-19 2005-05-11 独立行政法人産業技術総合研究所 フォスフォフォリンを含む複合生体材料
US7176322B2 (en) 2002-05-23 2007-02-13 Amgen Inc. Calcium receptor modulating agents
US20050085554A1 (en) 2003-06-26 2005-04-21 Hamann Mark T. Methods of treating disease through the administration of a manzamine analog or derivative
FI20031120A0 (fi) 2003-07-31 2003-07-31 Bci Bioabsorbable Concepts Ltd Monifunktionaalinen implanttilaite
US7189263B2 (en) 2004-02-03 2007-03-13 Vita Special Purpose Corporation Biocompatible bone graft material
US8071574B2 (en) 2005-02-22 2011-12-06 John Dennis Bobyn Implant improving local bone formation
KR101302279B1 (ko) 2005-09-08 2013-09-02 이데미쓰 고산 가부시키가이샤 유기 전계 발광 소자
US7390786B2 (en) 2005-12-21 2008-06-24 Wyeth Protein formulations with reduced viscosity and uses thereof
JP5080284B2 (ja) 2006-02-10 2012-11-21 株式会社エリナ 骨疾患の予防及び／又は治療用医薬組成物、その組成物を含有する機能性食品、健康食品及び医薬製剤、並びに歯根−歯周組織形成促進剤
US7812018B2 (en) * 2006-02-16 2010-10-12 Millennium Pharmaceuticals, Inc. Alpha carbolines and uses thereof
WO2009029625A1 (en) * 2007-08-27 2009-03-05 Kalypsys, Inc. 4- [heterocyclyl-methyl] -8-fluoro-quinolin-2-ones useful as nitric oxide synthase inhibitors
EP2227233B1 (en) * 2007-11-30 2013-02-13 Newlink Genetics Ido inhibitors
US8932557B2 (en) 2008-02-14 2015-01-13 Eli Lilly And Company Imaging agents for detecting neurological dysfunction
CN102015717A (zh) * 2008-03-28 2011-04-13 奥蒂瑞斯治疗公司 趋化因子受体调节剂
EP2151441A1 (en) 2008-08-06 2010-02-10 Julius-Maximilians-Universität Würzburg Beta-carbolin-derivates as substrates for an enzyme
US20100063085A1 (en) 2008-09-11 2010-03-11 University Court Of The University Of Dundee Method of treating learning impairment in down's syndrome subjects
US20100074939A1 (en) * 2008-09-25 2010-03-25 Osteogenex Inc. Harmine compounds for promoting bone growth
WO2010080756A2 (en) 2009-01-06 2010-07-15 Osteogenex, Inc. Harmine derivatives for reducing body weight
WO2010123583A2 (en) 2009-04-24 2010-10-28 University Of Tennessee Research Foundation 1-aryl or 1-heteroaryl-pyrido[b]indoles and uses thereof
US8927570B2 (en) 2009-04-24 2015-01-06 John K. Buolamwini 1-naphthyl-or 1-dihydroacenaphthenyl-pyrido[B]indoles and uses thereof in treating cancers
CN102844029A (zh) * 2009-12-28 2012-12-26 奥迪欧医药设备有限公司 用于治疗听力损伤和眩晕的β-咔啉
US20130231360A1 (en) * 2010-04-22 2013-09-05 The Brigham And Women S Hospital, Inc. Beta-Carbolines as Inhibitors of Haspin and DYRK Kinases
CA2803697A1 (en) 2010-06-25 2011-12-29 Facultes Universitaires Notre Dame De La Paix Beta carboline derivatives useful in the treatment of proliferative disorders
WO2012024433A2 (en) 2010-08-17 2012-02-23 Translational Genomics Research Institute Compounds that inhibit tau phosphorylation
CN102796124B (zh) 2011-05-26 2017-06-06 新疆华世丹药物研究有限责任公司 双β‑咔啉碱类化合物、其制法和其药物组合物与用途
US20130315965A1 (en) 2012-05-15 2013-11-28 OssiFi, Inc. Harmine derivatives for promoting bone growth
CA2899247C (en) * 2013-03-14 2023-04-04 Osteoqc Inc. Alkyl-amine harmine derivatives for promoting bone growth
WO2018024643A1 (en) 2016-08-02 2018-02-08 Ucb Biopharma Sprl 9h-pyrrolo-dipyridine derivatives

Also Published As

Publication number Publication date
CN105120863B (zh) 2021-06-04
HRP20210931T1 (hr) 2021-09-03
HK1218259A1 (zh) 2017-02-10
EP3915987C0 (en) 2023-12-13
EP3915987B1 (en) 2023-12-13
CA2899247C (en) 2023-04-04
HUE055455T2 (hu) 2021-11-29
JP6721499B2 (ja) 2020-07-15
SI2968284T1 (sl) 2021-08-31
DK2968284T3 (da) 2021-06-14
EP2968284B1 (en) 2021-04-21
EP3915987A1 (en) 2021-12-01
LT2968284T (lt) 2021-07-12
JP2016519082A (ja) 2016-06-30
US10501457B2 (en) 2019-12-10
US20140288068A1 (en) 2014-09-25
EP2968284A2 (en) 2016-01-20
CA2899247A1 (en) 2014-09-25
RS62053B1 (sr) 2021-07-30
PL2968284T3 (pl) 2021-09-27
CN105120863A (zh) 2015-12-02
ES2875874T3 (es) 2021-11-11
WO2014153203A2 (en) 2014-09-25
US20200172538A1 (en) 2020-06-04
US11267814B2 (en) 2022-03-08
US20170298059A1 (en) 2017-10-19
WO2014153203A3 (en) 2014-11-13
CN113416187A (zh) 2021-09-21
EP2968284A4 (en) 2016-08-17
US9540365B2 (en) 2017-01-10

Similar Documents

Publication Publication Date Title
HK1218259A1 (zh) 促進骨生長的烷基胺駱駝蓬碱衍生物
IL243599A0 (en) surgical implant
IL240398A0 (en) surgical implant
IL240349A0 (en) surgical implant
IL240534A0 (en) surgical implant
EP2950303A4 (en) PEDAL HOLDER FOR ELECTROPHONE INSTRUMENTS
EP2961764A4 (en) PROCESS FOR THE PRODUCTION OF TUBULYSINES
IL264738B (en) graft
HK1203857A1 (en) Method for preparing biological tissue
GB201322237D0 (en) Surgical reamer
SG11201505498YA (en) Method for preparing polybutene
PL3062718T3 (pl) Implant do osteotomii
SG10201708498VA (en) Method for generating extended sequence reads
KR101391404B9 (ko) 골신장기
EP2970037A4 (en) PROCESS FOR THE PREPARATION OF ALKYLFURANES
EP3533412C0 (en) ENHANCED DISINTEGRABLE BONE IMPLANTS
GB201313526D0 (en) Orthopaedic Apparatus
EP2870929C0 (en) Surgical attachment device
HK1212353A1 (en) Method for preparing coumestrol or coumestrin
ZA201504764B (en) Method for measuring bone loss rate
IL242897A0 (en) A process for the preparation of pyridylpyrazole compounds and their derivatives from pyridylhydrazine
GB201307817D0 (en) Bone Growth Scaffold
EP2993166A4 (en) PROCESS FOR PURIFYING DIMETHYL SULFOXIDE
IL239993A0 (en) Process for preparing 5-fluoro-1-methyl-3-difluoromethyl-h1-pyrazole-4-carbaldehyde
ZA201405667B (en) Growing apparatus