JP2000508911A - 間葉幹細胞を用いる骨の再生および増強 - Google Patents
間葉幹細胞を用いる骨の再生および増強Info
- Publication number
- JP2000508911A JP2000508911A JP9538185A JP53818597A JP2000508911A JP 2000508911 A JP2000508911 A JP 2000508911A JP 9538185 A JP9538185 A JP 9538185A JP 53818597 A JP53818597 A JP 53818597A JP 2000508911 A JP2000508911 A JP 2000508911A
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- bone
- bmp
- msc
- cells
- composition
- Prior art date
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.骨形成増強を必要とする個体に分離ヒト間葉幹細胞を媒体と共に前記個体に 投与し、その媒体はそれから骨形成を生成するのに十分な範囲でその幹細胞の骨 形成系列への分化を支持することを特徴とする骨形成を増強するための一つの方 法。 2.請求の範囲第1項記載の方法であって、ここで媒体が多孔セラミックあるは 再吸収性バイオポリマーであることを特徴とする方法。 3.請求の範囲第2項記載の方法であって、ここでセラミックがヒドロキシアパ タイト、β−リン酸トリカルシウムおよびその組合せよりなるグループから選択 されることを特徴とする方法。 4.請求の範囲第2項記載の方法であって、ここでセラミックが微粒子の形態に あることを特徴とする方法。 5.請求の範囲第2項記載の方法であって、ここでセラミックが構造的に安定し た三次元移植片であることを特徴とする方法。 6.請求の範囲第5項記載の方法であって、ここで構造的に安定した三次元移植 片が立方体、円筒、ブロックでありあるいは解剖学的形態の形にあることを特徴 とする方法。 7.請求の範囲第2項記載の方法であって、ここで吸収性バイオポリマーがゼラ チン、コラーゲンおよびセルロースよりなるグループから選択されることを特徴 とする方法。 8.請求の範囲第7項記載の方法であって、ここで媒体がパウダー、スポンジ、 条片、フィルム、ゲルあるいはウェブであ り、もしくは立方体、円筒あるいはブロックの形態もしくは解剖学的形態の形に ある構造的に安定した三次元移植片であることを特徴とする方法。 9.請求の範囲第7項記載の方法であって、ここでゼラチンがウシ皮膚誘導ゼラ チンであることを特徴とする方法。 10.請求の範囲第1項記載の方法であって、それが更にその間葉幹細胞の骨形 成系列への分化を誘導しあるいは加速する少くとも1個の生物活性因子を前記個 体に投与することを含むことを特徴とする方法。 11.請求の範囲第2項記載の方法であって、それが更にその間葉幹細胞の骨形 成系列への分化を誘導しあるいは加速する少くとも1個の生物活性因子を前記個 体に投与することを含むことを特徴とする方法。 12.請求の範囲第7項記載の方法であって、それが更にその間葉幹細胞の骨形 成系列への分化を誘導しあるいは加速する少くとも1個の生物活性因子を前記個 体に投与することを含むことを特徴とする方法。 13.請求の範囲第10項記載の方法であって、ここで細胞が生体外で生物活性 因子と接触されることを特徴とする方法。 14.請求の範囲第11項記載の方法であって、ここで細胞が生体外で生物活性 因子と接触されることを特徴とする方法。 15.請求の範囲第12項記載の方法であって、ここで細胞が生体外で生物活性 因子と接触されることを特徴とする方法。 16.請求の範囲第13項記載の方法であって、ここでそれから骨形成を生成す るのに十分な範囲でそのような幹細胞の骨形 成系列への分化を支持する基質と接触する時に、その細胞が生物活性因子と接触 されることを特徴とする方法。 17.請求の範囲第14項記載の方法であって、ここでそれから骨形成を生成す るのに十分な範囲でそのような幹細胞の骨形成系列への分化を支持する基質と接 触する時に、その細胞が生物活性因子と接触されることを特徴とする方法。 18.請求の範囲第15項記載の方法であって、ここでそれから骨形成を生成す るのに十分な範囲でそのような幹細胞の骨形成系列への分化を支持する基質と接 触する時に、その細胞が生物活性因子と接触されることを特徴とする方法。 19.請求の範囲第10項記載の方法であって、ここで生物活性因子が合成グル ココルチコイドであることを特徴とする方法。 20.請求の範囲第11項記載の方法であって、ここで生物活性因子が合成グル ココルチコイドであることを特徴とする方法。 21.請求の範囲第12項記載の方法であって、ここで生物活性因子が合成グル ココルチコイドであることを特徴とする方法。 22.請求の範囲第19項記載の方法であって、ここで合成グルココルチコイド がデキサメタゾンであることを特徴とする方法。 23.請求の範囲第20項記載の方法であって、ここで合成グルココルチコイド がデキサメタゾンであることを特徴とする方法。 24.請求の範囲第21項記載の方法であって、ここで合成グルココルチコイド がデキサメタゾンであることを特徴とする方法。 25.請求の範囲第10項記載の方法であって、ここで生物活性因子が骨形態形 成タンパク質であることを特徴とする方法。 26.請求の範囲第11項記載の方法であって、ここで生物活性因子が骨形態形 成タンパク質であることを特徴とする方法。 27.請求の範囲第12項記載の方法であって、ここで生物活性因子が骨形態形 成タンパク質であることを特徴とする方法。 28.請求の範囲第25項記載の方法であって、ここで骨形態形成タンパク質が 筋肉内、静脈内、髄内あるいは関節内注射に適した液あるいは半固体担体の中に あることを特徴とする方法。 29.請求の範囲第26項記載の方法であって、ここで骨形態形成タンパク質が 筋肉内、静脈内、髄内あるいは関節内注射に適した液あるいは半固体担体の中に あることを特徴とする方法。 30.請求の範囲第27項記載の方法であって、ここで骨形態形成タンパク質が 筋肉内、静脈内、髄内あるいは関節内注射に適した液あるいは半固体担体の中に あることを特徴とする方法。 31.請求の範囲第25項記載の方法であって、ここで骨形態形成タンパク質が BMP−2、BMP−3、BMP−4、BMP−6およびBMP−7よりなるグ ループから選択されることを特徴とする方法。 32.請求の範囲第26項記載の方法であって、ここで骨形態形成タンパク質が BMP−2、BMP−3、BMP−4、BMP−6およびBMP−7よりなるグ ループから選択されることを特徴とする方法。 33.請求の範囲第27項記載の方法であって、ここで骨形態形成タンパク質が BMP−2、BMP−3、BMP−4、BMP−6およびBMP−7よりなるグ ループから選択されることを特徴とする方法。 34.骨形成を増強する一つの組成物であって、その組成物が少くとも1個の新 鮮骨髄および分離間葉幹細胞と組み合わされた多孔セラミックを含むことを特徴 とする骨形成を増強する組成物。 35.請求の範囲第34項記載の組成物であって、ここで多孔セラミックが微粒 子形態にあることを特徴とする組成物。 36.請求の範囲第34項記載の組成物であって、ここで多孔セラミックが構造 的に安定した三次元移植片であることを特徴とする組成物。 37.骨形成を増強する一つの組成物であって、その組成物が少くとも1個の新 鮮骨髄および分離間葉幹細胞と組み合わされたゼラチン、セルロースおよびコラ ーゲンよりなるグループから選択される再吸収性バイオポリマーを含むことを特 徴とする骨形成を増強する組成物。 38.請求の範囲第37項記載の組成物であって、ここで再吸収性バイオポリマ ーが微粒子形態であることを特徴とする組成物。 39.請求の範囲第37項記載の組成物であって、ここで再吸収性バイオポリマ ーがスポンジ、条片、フィルム、ゲルあるいはウェブもしくは構造的に安定した 三次元移植片であることを特徴とする組成物。 40.それを必要とする個体に骨形成を増強するための一つの方法であって、前 記個体に請求の範囲第34項に記載の組成物の骨形成増強量を投与することを含 むことを特徴とする方法。 41.それを必要とする個体に骨形成を増強するための一つの方法であって、前 記個体に請求の範囲第35項に記載の組成物の骨形成増強量を投与することを含 むことを特徴とする方法。 42.それを必要とする個体に骨形成を増強するための一つの方法であって、前 記個体に請求の範囲第36項に記載の組成物の骨形成増強量を投与することを含 むことを特徴とする方法。 43.それを必要とする個体に骨形成を増強するための一つの方法であって、前 記個体に請求の範囲第37項に記載の組成物の骨形成増強量を投与することを含 むことを特徴とする方法。 44.それを必要とする個体に骨形成を増強するための一つの方法であって、前 記個体に請求の範囲第38項に記載の組成物の骨形成増強量を投与することを含 むことを特徴とする方法。 45.それを必要とする個体に骨形成を増強するための一つの方法であって、前 記個体に請求の範囲第39項に記載の組成物の骨形成増強量を投与することを含 むことを特徴とする方法。
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PCT/US1997/006433 WO1997040137A1 (en) | 1996-04-19 | 1997-04-17 | Regeneration and augmentation of bone using mesenchymal stem cells |
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US1624596A (en) | 1920-12-24 | 1927-04-12 | Western Electric Co | Signaling method and system |
US2983896A (en) | 1958-09-10 | 1961-05-09 | Continental Connector Corp | Multiple electrical connector with selectively positionable polarizing member |
US5486359A (en) * | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
JPH05339167A (ja) * | 1991-08-08 | 1993-12-21 | Hajime Ogushi | 骨形成補助剤 |
EP1002538A3 (en) * | 1992-06-25 | 2000-07-19 | SCHEER, David | Stem cell and lymphocyte storage |
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JP2004505747A (ja) * | 2000-08-22 | 2004-02-26 | ジンテーズ アクチエンゲゼルシャフト クール | 骨代用材料 |
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Also Published As
Publication number | Publication date |
---|---|
US6863900B2 (en) | 2005-03-08 |
WO1997040137A1 (en) | 1997-10-30 |
AU2462297A (en) | 1997-11-12 |
EP0906415B1 (en) | 2009-08-19 |
AU731468B2 (en) | 2001-03-29 |
EP2311471A2 (en) | 2011-04-20 |
ATE439849T1 (de) | 2009-09-15 |
DE69739540D1 (de) | 2009-10-01 |
CA2251983A1 (en) | 1997-10-30 |
ES2329953T3 (es) | 2009-12-02 |
EP0906415A4 (en) | 2005-12-21 |
US6541024B1 (en) | 2003-04-01 |
JP2006158975A (ja) | 2006-06-22 |
CA2251983C (en) | 2003-12-16 |
EP0906415A1 (en) | 1999-04-07 |
EP2311471A3 (en) | 2013-05-15 |
EP2105138A2 (en) | 2009-09-30 |
US20030031695A1 (en) | 2003-02-13 |
EP2105138A3 (en) | 2013-06-05 |
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