|
DK2322631T3
(en)
*
|
2001-04-19 |
2015-01-12 |
Scripps Research Inst |
Methods and compositions for the production of orthogonal tRNA-aminoacyl-tRNA syntetasepar
|
|
US6964859B2
(en)
|
2001-10-16 |
2005-11-15 |
Massachusetts Institute Of Technology |
Suppressor tRNA system
|
|
US20030148391A1
(en)
*
|
2002-01-24 |
2003-08-07 |
Salafsky Joshua S. |
Method using a nonlinear optical technique for detection of interactions involving a conformational change
|
|
US7112435B1
(en)
|
2002-08-07 |
2006-09-26 |
Ambit Biosciences Corporation |
Uncoupling of DNA insert propagation and expression of protein for phage display
|
|
US20040038273A1
(en)
*
|
2002-06-17 |
2004-02-26 |
Whitehead Institute For Biomedical Research |
Bifunctional tRNA for in vitro selection
|
|
AU2003252153A1
(en)
*
|
2002-07-25 |
2004-02-16 |
Mds Proteomics Inc. |
Improved systems and methods for analysis of protein post-translational modification
|
|
US7897381B2
(en)
*
|
2002-08-07 |
2011-03-01 |
Ambit Biosciences Corporation |
Uncoupling of DNA insert propagation and expression of protein for phage display
|
|
US7833741B2
(en)
*
|
2002-08-07 |
2010-11-16 |
Ambit Biosciences Corporation |
Uncoupling of DNA insert propagation and expression of protein for phage display
|
|
US7563600B2
(en)
|
2002-09-12 |
2009-07-21 |
Combimatrix Corporation |
Microarray synthesis and assembly of gene-length polynucleotides
|
|
CA2500653A1
(en)
*
|
2002-10-16 |
2004-04-29 |
The Scripps Research Institute |
Glycoprotein synthesis
|
|
US7432092B2
(en)
|
2002-10-16 |
2008-10-07 |
The Scripps Research Institute |
Site specific incorporation of keto amino acids into proteins
|
|
EP1583816A4
(en)
*
|
2002-12-22 |
2007-06-13 |
Scripps Research Inst |
PROTEIN ARRAYS
|
|
ES2368941T3
(es)
|
2003-01-06 |
2011-11-23 |
Angiochem Inc. |
Angiopep-1, compuestos relacionados y utilizaciones correspondientes.
|
|
US7772188B2
(en)
|
2003-01-28 |
2010-08-10 |
Ironwood Pharmaceuticals, Inc. |
Methods and compositions for the treatment of gastrointestinal disorders
|
|
JP2006180701A
(ja)
*
|
2003-02-10 |
2006-07-13 |
Institute Of Physical & Chemical Research |
チロシルtRNA合成酵素の変異体及びその作製方法
|
|
KR101171397B1
(ko)
*
|
2003-04-17 |
2012-08-07 |
더 스크립스 리서치 인스티튜트 |
진핵 유전자 코드의 확장
|
|
AU2013201487B2
(en)
*
|
2003-04-17 |
2014-09-18 |
The Scripps Research Institute |
Expanding the eukaryotic genetic code
|
|
WO2004110964A2
(en)
*
|
2003-06-16 |
2004-12-23 |
Nuevolution A/S |
Encoded molecules by translation (emt)
|
|
CA2527877A1
(en)
|
2003-06-18 |
2005-01-13 |
The Scripps Research Institute |
Unnatural reactive amino acid genetic code additions
|
|
EP1658366A4
(en)
*
|
2003-07-07 |
2006-08-09 |
Scripps Research Inst |
COMPOSITIONS OF ORTHOGONAL GLUTAMYL-TRNA AND AMINOACYL-TRNA-SYNTHETASEPAARES AND THEIR USES
|
|
ES2301099T3
(es)
*
|
2003-07-07 |
2008-06-16 |
The Scripps Research Institute |
Composiciones de parejas ortogonales lisil-arnt y aminoacil-arnt sintetasa y usos de las mismas.
|
|
WO2005007870A2
(en)
*
|
2003-07-07 |
2005-01-27 |
The Scripps Research Institute |
COMPOSITIONS OF ORTHOGONAL LEUCYL-tRNA AND AMINOACYL-tRNA SYNTHETASE PAIRS AND USES THEREOF
|
|
EP1668114B1
(en)
*
|
2003-08-18 |
2009-11-04 |
The Regents of the University of California |
Polypeptide display libraries and methods of making and using thereof
|
|
DK1687401T3
(da)
|
2003-10-14 |
2013-02-04 |
Scripps Research Inst |
Sted-spicifik inkorporing af redoxaktive aminosyrer i protiener
|
|
WO2005072092A2
(en)
*
|
2003-12-12 |
2005-08-11 |
Conjugon, Inc. |
Systems for tightly regulated gene expression
|
|
EP1725251A4
(en)
*
|
2003-12-18 |
2009-07-01 |
Scripps Research Inst |
SELECTIVE PROCESSING OF 5-HYDROXYTRYPTOPHANE IN PROTEINS IN MAMMALIAN CELLS
|
|
US8778880B2
(en)
*
|
2004-02-02 |
2014-07-15 |
Ambrx, Inc. |
Human growth hormone modified at position 35
|
|
WO2005089110A2
(en)
*
|
2004-02-27 |
2005-09-29 |
President And Fellows Of Harvard College |
Polynucleotide synthesis
|
|
FR2868081A1
(fr)
*
|
2004-03-23 |
2005-09-30 |
Libragen Sa |
Methode d'identification de famille de voie metabolique par selection positive
|
|
US20050260711A1
(en)
*
|
2004-03-30 |
2005-11-24 |
Deepshikha Datta |
Modulating pH-sensitive binding using non-natural amino acids
|
|
EP1757686A4
(en)
*
|
2004-04-09 |
2008-03-12 |
Chugai Pharmaceutical Co Ltd |
Cell death inducer
|
|
US20050287639A1
(en)
*
|
2004-05-17 |
2005-12-29 |
California Institute Of Technology |
Methods of incorporating amino acid analogs into proteins
|
|
MXPA06013586A
(es)
*
|
2004-05-25 |
2007-11-09 |
Scripss Res Inst |
Incorporacion especifica del sitio de aminoacidos no naturales que contienen atomos pesados en proteinas para la determinacion de la estructura cristalina.
|
|
US20060008844A1
(en)
*
|
2004-06-17 |
2006-01-12 |
Avidia Research Institute |
c-Met kinase binding proteins
|
|
CN1968712B
(zh)
*
|
2004-06-18 |
2012-05-16 |
Ambrx公司 |
新颖抗原结合多肽和其用途
|
|
KR101699142B1
(ko)
*
|
2004-06-18 |
2017-01-23 |
암브룩스, 인코포레이티드 |
신규 항원-결합 폴리펩티드 및 이의 용도
|
|
PT1771474E
(pt)
|
2004-07-20 |
2010-05-03 |
Genentech Inc |
Inibidores de proteína 4 do tipo angiopoietina, combinações e sua utilização
|
|
US7638299B2
(en)
*
|
2004-07-21 |
2009-12-29 |
Ambrx, Inc. |
Biosynthetic polypeptides utilizing non-naturally encoded amino acids
|
|
ES2666693T3
(es)
|
2004-09-21 |
2018-05-07 |
The Scripps Research Institute |
Incorporación in vivo de alquinil aminoácidos a proteínas en eubacterias
|
|
WO2006036779A2
(en)
*
|
2004-09-22 |
2006-04-06 |
The Scripps Research Institute |
Site-specific labeling of proteins for nmr studies
|
|
CA2584984A1
(en)
*
|
2004-10-18 |
2006-04-27 |
Codon Devices, Inc. |
Methods for assembly of high fidelity synthetic polynucleotides
|
|
US20070122817A1
(en)
*
|
2005-02-28 |
2007-05-31 |
George Church |
Methods for assembly of high fidelity synthetic polynucleotides
|
|
WO2006045116A2
(en)
*
|
2004-10-20 |
2006-04-27 |
The Scripps Research Institute |
In vivo site-specific incorporation of n-acetyl-galactosamine amino acids in eubacteria
|
|
WO2006110182A2
(en)
*
|
2004-10-27 |
2006-10-19 |
The Scripps Research Institute |
Orthogonal translation components for the in vivo incorporation of unnatural amino acids
|
|
AU2011204773B2
(en)
*
|
2004-10-27 |
2012-02-02 |
The Scripps Research Institute |
Orthogonal translation components for the in vivo incorporation of unnatural amino acids
|
|
EP1814573B1
(en)
|
2004-10-29 |
2016-03-09 |
ratiopharm GmbH |
Remodeling and glycopegylation of fibroblast growth factor (fgf)
|
|
WO2006055898A2
(en)
*
|
2004-11-20 |
2006-05-26 |
Massachusetts Institute Of Technology |
Orthogonal suppressor trnas and aminoacyl-trna synthetases and uses thereof
|
|
WO2006054807A1
(ja)
*
|
2004-11-22 |
2006-05-26 |
Gifu University |
ミトコンドリア蛋白質を用いる、非天然アミノ酸を蛋白質に部位特異的に導入する方法及びtRNAの効率的調製方法
|
|
EP2284191A3
(en)
*
|
2004-12-22 |
2011-07-20 |
Ambrx, Inc. |
Process for the preparation of hGH
|
|
WO2006068802A2
(en)
|
2004-12-22 |
2006-06-29 |
Ambrx, Inc. |
COMPOSITIONS OF AMINOACYL-tRNA SYNTHETASE AND USES THEREOF
|
|
AU2013205030B2
(en)
*
|
2004-12-22 |
2016-05-12 |
Ambrx, Inc. |
Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
|
|
WO2006071840A2
(en)
*
|
2004-12-22 |
2006-07-06 |
Ambrx, Inc. |
Formulations of human growth hormone comprising a non-naturally encoded amino acid
|
|
MX2007007590A
(es)
|
2004-12-22 |
2007-12-10 |
Ambrx Inc |
Composiciones que contienen, metodos que involucran y usos de aminoacidos no naturales y polipeptidos.
|
|
US8080391B2
(en)
*
|
2004-12-22 |
2011-12-20 |
Ambrx, Inc. |
Process of producing non-naturally encoded amino acid containing high conjugated to a water soluble polymer
|
|
PA8660701A1
(es)
|
2005-02-04 |
2006-09-22 |
Pfizer Prod Inc |
Agonistas de pyy y sus usos
|
|
US7723069B2
(en)
*
|
2005-04-05 |
2010-05-25 |
Yale University |
Site specific incorporation of phosphoserine into polypeptides using phosphoseryl-tRNA synthetase
|
|
EP1871795A4
(en)
|
2005-04-08 |
2010-03-31 |
Biogenerix Ag |
COMPOSITIONS AND METHOD FOR PRODUCING GLYCOSYLATION MUTANTS OF A PROTEASE-RESISTANT HUMAN GROWTH HORMONE
|
|
WO2006122224A1
(en)
*
|
2005-05-11 |
2006-11-16 |
Wayne State University |
Methods and compositions for the identification of antibiotics that are not susceptible to antibiotic resistance in pseudomonas aeruginosa
|
|
CA2609205A1
(en)
*
|
2005-06-03 |
2006-12-14 |
Ambrx, Inc. |
Improved human interferon molecules and their uses
|
|
MX2007015106A
(es)
*
|
2005-06-03 |
2008-02-15 |
Ambrx Inc |
Incorporacion de aminoacidos codificadores de manera no natural en proteinas.
|
|
CA2610987C
(en)
*
|
2005-06-10 |
2013-09-10 |
Chugai Seiyaku Kabushiki Kaisha |
Stabilizer for protein preparation comprising meglumine and use thereof
|
|
WO2007005053A1
(en)
*
|
2005-06-30 |
2007-01-11 |
Codon Devices, Inc. |
Hierarchical assembly methods for genome engineering
|
|
PL2233156T3
(pl)
|
2005-07-15 |
2013-09-30 |
Angiochem Inc |
Zastosowanie polipeptydów aprotyninowych jako nośników w koniugatach farmaceutycznych
|
|
DK1907545T3
(da)
*
|
2005-07-15 |
2011-02-07 |
Medical Res Council |
Sammensætninger og fremgangsmåder vedrørende orthogonale ribosom-mRNA-par
|
|
US8008453B2
(en)
|
2005-08-12 |
2011-08-30 |
Amgen Inc. |
Modified Fc molecules
|
|
WO2007021297A1
(en)
*
|
2005-08-18 |
2007-02-22 |
Ambrx, Inc. |
COMPOSITIONS OF tRNA AND USES THEREOF
|
|
US7666817B2
(en)
|
2005-08-31 |
2010-02-23 |
The Regents Of The University Of California |
Cellular libraries of peptide sequences (CLiPS) and methods of using the same
|
|
US8367588B2
(en)
*
|
2005-10-12 |
2013-02-05 |
The Scripps Research Institute |
Selective posttranslational modification of phage-displayed polypeptides
|
|
US20090018029A1
(en)
|
2005-11-16 |
2009-01-15 |
Ambrx, Inc. |
Methods and Compositions Comprising Non-Natural Amino Acids
|
|
ES2529065T3
(es)
*
|
2005-12-14 |
2015-02-16 |
Ambrx, Inc. |
Composiciones que contienen, procedimientos que implican y usos de aminoácidos no naturales y polipéptidos
|
|
AU2006330947B2
(en)
|
2005-12-22 |
2012-04-12 |
Pacific Biosciences Of California, Inc. |
Polymerases for nucleotide analogue incorporation
|
|
CA2632832A1
(en)
*
|
2005-12-30 |
2007-07-12 |
Ambrx, Inc. |
Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
|
|
JP2009523815A
(ja)
*
|
2006-01-19 |
2009-06-25 |
アンブルックス,インコーポレイテッド |
免疫原性が調節された非天然アミノ酸ポリペプチド
|
|
US20070178554A1
(en)
*
|
2006-02-01 |
2007-08-02 |
Nima Shiva |
Orthogonal Aminoacyl Synthetase-tRNA Pairs for Incorporating Unnatural Amino Acids Into Proteins
|
|
US20090081669A1
(en)
*
|
2006-02-01 |
2009-03-26 |
Encode Bio, Inc. |
Fluorescent Assays Using Orthogonal tRNA - Aminoacyl Synthetase Pairs
|
|
US7776535B2
(en)
|
2006-02-06 |
2010-08-17 |
Franklin And Marshall College |
Site-specific incorporation of fluorinated amino acids into proteins
|
|
EP1999259B1
(en)
|
2006-03-03 |
2014-06-25 |
California Institute of Technology |
Site-specific incorporation of amino acids into molecules
|
|
ES2432391T3
(es)
*
|
2006-03-09 |
2013-12-03 |
The Scripps Research Institute |
Sistema para la expresión de componentes de traducción ortogonales en células huésped eubacterianas
|
|
BRPI0709603A2
(pt)
|
2006-03-16 |
2011-07-19 |
Scripps Research Inst |
expressão de proteìnas geneticamente programada contendo o aminoácido não natural fenilselenocisteìna
|
|
US20080096819A1
(en)
|
2006-05-02 |
2008-04-24 |
Allozyne, Inc. |
Amino acid substituted molecules
|
|
WO2007130453A2
(en)
|
2006-05-02 |
2007-11-15 |
Allozyne, Inc. |
Non-natural amino acid substituted polypeptides
|
|
CA2652894A1
(en)
*
|
2006-05-23 |
2007-12-06 |
The Scripps Research Institute |
Genetically encoded fluorescent coumarin amino acids
|
|
CL2007001614A1
(es)
*
|
2006-06-09 |
2008-08-08 |
Novartis Ag |
Polipeptido que comprende una proteina del precursor del factor de crecimiento tipo insulina, igf-1 humana, en la cual la escision del peptido e mediante una proteasa se reduce a traves de la modificacion de la proteina del precursor; y su uso para t
|
|
WO2008001947A1
(en)
*
|
2006-06-28 |
2008-01-03 |
Riken |
MUTANT SepRS, AND METHOD FOR SITE-SPECIFIC INTRODUCTION OF PHOSPHOSERINE INTO PROTEIN BY USING THE SAME
|
|
EP2035554B1
(en)
*
|
2006-06-29 |
2013-04-24 |
The Board of Trustees of The Leland Stanford Junior University |
Cell-free synthesis of proteins containing unnatural amino acids
|
|
MX2009000487A
(es)
*
|
2006-07-13 |
2009-01-27 |
Chugai Pharmaceutical Co Ltd |
Inductor de muerte celular.
|
|
DK2064333T3
(da)
|
2006-09-08 |
2014-05-05 |
Ambrx Inc |
Suppressor-trna-transkription i hvirveldyrceller
|
|
AU2012203737B2
(en)
*
|
2006-09-08 |
2014-06-19 |
Ambrx, Inc. |
Modified human plasma polypeptide or Fc scaffolds and their uses
|
|
PT2061878E
(pt)
|
2006-09-08 |
2014-04-22 |
Ambrx Inc |
Supressor híbrido arnt para células de vertebrados
|
|
AU2013202770B2
(en)
*
|
2006-09-08 |
2015-08-20 |
Ambrx, Inc. |
Modified human plasma polypeptide or Fc scaffolds and their uses
|
|
DK2615108T3
(en)
|
2006-09-08 |
2017-01-30 |
Ambrx Inc |
Modified human plasma polypeptide or fc scaffolds and their applications
|
|
NZ574673A
(en)
*
|
2006-09-08 |
2012-02-24 |
Ambrx Inc |
Site specific incorporation of non-natural amino acids by vertebrate cells
|
|
EP2052083B1
(en)
*
|
2006-09-21 |
2014-01-08 |
The Scripps Research Institute |
Genetically programmed expression of selectively sulfated proteins in eubacteria
|
|
EP2069481A4
(en)
|
2006-10-18 |
2010-01-06 |
Scripps Research Inst |
GENETIC ASSEMBLY OF UNNATURAL AMINO ACIDS IN PROTEINS IN MAMMALIAN CELLS
|
|
KR101248252B1
(ko)
|
2006-11-28 |
2013-03-27 |
한올바이오파마주식회사 |
변형된 에리스로포이에틴 폴리펩티드와 이의 치료용 용도
|
|
EP1936340A1
(en)
*
|
2006-12-21 |
2008-06-25 |
Koninklijke Philips Electronics N.V. |
Sub wavelength aperture
|
|
WO2008103618A1
(en)
*
|
2007-02-22 |
2008-08-28 |
University Of Utah Research Foundation |
Synthesis of novel xylosides and potential uses thereof
|
|
CL2008000719A1
(es)
*
|
2007-03-12 |
2008-09-05 |
Univ Tokushima Chugai Seiyaku |
Agente terapeutico para cancer resistente a agentes quimioterapeuticos que comprende un anticuerpo que reconoce hla de clase i como ingrediente activo; composicion farmaceutica que comprende dicho anticuerpo; y metodo para tratar cancer resistente a
|
|
PL2068909T3
(pl)
|
2007-03-30 |
2012-09-28 |
Ambrx Inc |
Modyfikowane polipeptydy fgf-21 i ich zastosowanie
|
|
US8183037B2
(en)
*
|
2007-04-13 |
2012-05-22 |
The Salk Institute For Biological Studies |
Methods of genetically encoding unnatural amino acids in eukaryotic cells using orthogonal tRNA/synthetase pairs
|
|
EP2076533B1
(en)
|
2007-05-02 |
2014-10-08 |
Ambrx, Inc. |
Modified interferon beta polypeptides and their uses
|
|
US9365634B2
(en)
|
2007-05-29 |
2016-06-14 |
Angiochem Inc. |
Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
|
|
MX354786B
(es)
|
2007-06-04 |
2018-03-21 |
Synergy Pharmaceuticals Inc |
Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
|
|
US8969514B2
(en)
|
2007-06-04 |
2015-03-03 |
Synergy Pharmaceuticals, Inc. |
Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
|
|
US8293685B2
(en)
*
|
2007-07-26 |
2012-10-23 |
The Regents Of The University Of California |
Methods for enhancing bacterial cell display of proteins and peptides
|
|
CA2707840A1
(en)
*
|
2007-08-20 |
2009-02-26 |
Allozyne, Inc. |
Amino acid substituted molecules
|
|
US20110178029A1
(en)
*
|
2007-09-14 |
2011-07-21 |
Ambrx, Inc. |
Modified Human Apolipoprotein A-1 and Their Uses
|
|
EP2217700A4
(en)
*
|
2007-10-08 |
2011-02-16 |
Synthetic Genomics Inc |
SYSTEM AND METHOD FOR PRODUCING SYNTHETIC MICROORGANISMS CAPABLE OF TRANSLATING PROTEINS CONTAINING NON-STANDARD AMINO ACIDS
|
|
CA2703736A1
(en)
|
2007-10-25 |
2009-04-30 |
The Scripps Research Institute |
Genetic incorporation of 3-aminotyrosine into reductases
|
|
CA2704494A1
(en)
*
|
2007-11-02 |
2009-05-14 |
The Scripps Research Institute |
Directed evolution using proteins comprising unnatural amino acids
|
|
US20090148887A1
(en)
*
|
2007-11-02 |
2009-06-11 |
The Scripps Research Institute |
Genetically encoded boronate amino acid
|
|
PL2567709T3
(pl)
|
2007-11-02 |
2018-06-29 |
Novartis Ag |
Cząsteczki i sposoby modulowania białka związanego z receptorem dla lipoproteiny o niskiej gęstości 6 (LRP6)
|
|
WO2009064416A2
(en)
*
|
2007-11-15 |
2009-05-22 |
The Scripps Research Institute |
Genetic incorporation of an alpha-hydroxy acid into proteins to generate ester backbone linkages at defined sites
|
|
US8946148B2
(en)
|
2007-11-20 |
2015-02-03 |
Ambrx, Inc. |
Modified insulin polypeptides and their uses
|
|
EP2889370A1
(en)
|
2007-12-11 |
2015-07-01 |
The Scripps Research Institute |
In vivo unnatural amino acid expression in the methylotrophic yeast Pichia pastoris
|
|
CA2710683A1
(en)
|
2008-01-03 |
2009-07-16 |
Verenium Corporation |
Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them
|
|
EP2249853A4
(en)
|
2008-01-30 |
2012-12-26 |
Univ Indiana Res & Tech Corp |
ESTER BASED PEPTIDE PRODRUGS
|
|
US9938333B2
(en)
|
2008-02-08 |
2018-04-10 |
Ambrx, Inc. |
Modified leptin polypeptides and their uses
|
|
JP2011514322A
(ja)
*
|
2008-02-08 |
2011-05-06 |
ザ スクリプス リサーチ インスティチュート |
遺伝的にコードされる非天然アミノ酸による免疫寛容解除
|
|
WO2009117622A2
(en)
*
|
2008-03-19 |
2009-09-24 |
Ambrx, Inc. |
Modified fgf-23 polypeptides and their uses
|
|
WO2009117726A2
(en)
*
|
2008-03-21 |
2009-09-24 |
The Regents Of The University Of California |
High-sensitive fluorescent energy transfer assay using fluorescent amino acids and fluoresent proteins
|
|
SI2274008T1
(sl)
|
2008-03-27 |
2014-08-29 |
Zymogenetics, Inc. |
Sestavki in metode za zaviranje PDGFRBETA in VEGF-A
|
|
CA2720046C
(en)
|
2008-03-31 |
2018-07-24 |
Pacific Biosciences Of California, Inc. |
Generation of modified polymerases for improved accuracy in single molecule sequencing
|
|
CN102076713B
(zh)
|
2008-05-02 |
2015-03-25 |
诺华股份有限公司 |
改进的基于纤连蛋白的结合分子及其用途
|
|
CA2726917C
(en)
|
2008-06-04 |
2018-06-26 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
|
|
PT2310412T
(pt)
|
2008-06-20 |
2018-05-28 |
Novartis Ag |
Imunoglobulinas com agregação reduzida
|
|
WO2009158649A1
(en)
|
2008-06-26 |
2009-12-30 |
Atyr Pharma, Inc. |
Compositions and methods comprising glycyl-trna synthetases having non-canonical biological activities
|
|
MX344076B
(es)
|
2008-06-30 |
2016-12-05 |
Esbatech Alcon Biomed Res Unit |
Polipeptidos funcionalizados.
|
|
US8697074B2
(en)
|
2008-07-10 |
2014-04-15 |
Esbatech, An Alcon Biomedical Research Unit Llc |
Methods and compositions for enhanced delivery of macromolecules
|
|
EP2321341B1
(en)
|
2008-07-16 |
2017-02-22 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
|
|
PL2318029T3
(pl)
|
2008-07-23 |
2018-03-30 |
Elanco Us Inc. |
Zmodyfikowane polipeptydy bydlęcego G-CSF i ich zastosowania
|
|
US9182406B2
(en)
|
2008-08-04 |
2015-11-10 |
Biodesy, Inc. |
Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability
|
|
US20110195900A1
(en)
*
|
2008-08-19 |
2011-08-11 |
Ferring B.V. |
Peptidic pth receptor agonists
|
|
CA2738033C
(en)
|
2008-09-26 |
2019-11-26 |
Ambrx, Inc. |
Non-natural amino acid replication-dependent microorganisms and vaccines
|
|
US8278418B2
(en)
|
2008-09-26 |
2012-10-02 |
Ambrx, Inc. |
Modified animal erythropoietin polypeptides and their uses
|
|
EP2346906A4
(en)
|
2008-10-15 |
2013-04-24 |
Angiochem Inc |
CONJUGATES FROM GLP-1 AGONISTS AND THEIR USE
|
|
US8785151B2
(en)
|
2008-10-24 |
2014-07-22 |
Bernhard Geierstanger |
Biosynthetically generated pyrroline-carboxy-lysine and site specific protein modifications via chemical derivatization of pyrroline-carboxy-lysine and pyrrolysine residues
|
|
JP5759379B2
(ja)
|
2008-12-05 |
2015-08-05 |
アンジオケム インコーポレーテッド |
ニューロテンシンまたはニューロテンシンアナログおよびその使用
|
|
US20090197339A1
(en)
*
|
2008-12-10 |
2009-08-06 |
The Scripps Research Institute |
In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris
|
|
JP5959201B2
(ja)
|
2008-12-10 |
2016-08-02 |
ザ スクリプス リサーチ インスティテュート |
化学的に反応性の非天然アミノ酸を使用するキャリア−ペプチド接合体の製造
|
|
WO2010069074A1
(en)
|
2008-12-17 |
2010-06-24 |
Universite Du Quebec A Montreal |
Membrane type-1 matrix metalloprotein inhibitors and uses thereof
|
|
WO2010080606A1
(en)
|
2008-12-19 |
2010-07-15 |
Indiana University Research And Technology Corporation |
Insulin analogs
|
|
KR20110114568A
(ko)
*
|
2008-12-19 |
2011-10-19 |
인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 |
디펩티드 링크된 약효 물질
|
|
AU2009327418A1
(en)
|
2008-12-19 |
2010-06-24 |
Indiana University Research And Technology Corporation |
Amide based glucagon superfamily peptide prodrugs
|
|
CN102245624B
(zh)
|
2008-12-19 |
2016-08-10 |
印第安纳大学研究及科技有限公司 |
基于酰胺的胰岛素前药
|
|
WO2010096394A2
(en)
|
2009-02-17 |
2010-08-26 |
Redwood Biosciences, Inc. |
Aldehyde-tagged protein-based drug carriers and methods of use
|
|
WO2010099477A2
(en)
|
2009-02-27 |
2010-09-02 |
Atyr Pharma, Inc. |
Polypeptide structural motifs associated with cell signaling activity
|
|
WO2010120509A2
(en)
*
|
2009-03-31 |
2010-10-21 |
Atyr Pharma, Inc. |
Compositions and methods comprising aspartyl-trna synthetases having non-canonical biological activities
|
|
EP2421562B1
(en)
|
2009-04-20 |
2019-03-13 |
Angiochem Inc. |
Treatment of ovarian cancer using an anticancer agent conjugated to an angiopep-2 analog
|
|
AU2010247938B2
(en)
|
2009-05-11 |
2016-02-18 |
Pelican Technology Holdings, Inc. |
Production of recombinant proteins utilizing non-antibiotic selection methods and the incorporation of non-natural amino acids therein
|
|
EP2437785B1
(en)
|
2009-06-04 |
2015-02-25 |
Novartis AG |
METHODS FOR IDENTIFICATION OF SITES FOR IgG CONJUGATION
|
|
RU2012103240A
(ru)
|
2009-07-02 |
2013-08-10 |
Ангиокем Инк. |
Мультимерные пептидные конъюгаты и их применение
|
|
US10292956B2
(en)
|
2009-09-01 |
2019-05-21 |
Serbig Pharmaceutics Corp. |
Cancer starvation therapy
|
|
US20110054019A1
(en)
*
|
2009-09-01 |
2011-03-03 |
Pedro Anastacio Serrano-Ojeda |
Cancer Starvation Therapy
|
|
EP2311947A1
(en)
*
|
2009-10-14 |
2011-04-20 |
Ludwig-Maximilians-Universität München |
Protein synthesis via click chemistry
|
|
WO2011056502A1
(en)
|
2009-10-26 |
2011-05-12 |
Genentech, Inc. |
Bone morphogenetic protein receptor type ii compositions and methods of use
|
|
WO2011056497A1
(en)
|
2009-10-26 |
2011-05-12 |
Genentech, Inc. |
Activin receptor type iib compositions and methods of use
|
|
WO2011056494A1
(en)
|
2009-10-26 |
2011-05-12 |
Genentech, Inc. |
Activin receptor-like kinase-1 antagonist and vegfr3 antagonist combinations
|
|
WO2011051327A2
(en)
|
2009-10-30 |
2011-05-05 |
Novartis Ag |
Small antibody-like single chain proteins
|
|
WO2011051466A1
(en)
|
2009-11-02 |
2011-05-05 |
Novartis Ag |
Anti-idiotypic fibronectin-based binding molecules and uses thereof
|
|
EP2496944A2
(en)
|
2009-11-05 |
2012-09-12 |
Novartis AG |
Biomarkers predictive of progression of fibrosis
|
|
WO2011078987A1
(en)
|
2009-12-21 |
2011-06-30 |
Trustees Of Dartmouth College |
Recombinant prokaryotes and use thereof for production of o-glycosylated proteins
|
|
BR112012015461A2
(pt)
|
2009-12-21 |
2017-01-10 |
Ambrx Inc |
polipeptídeos de somatotropina boviina modificados e seus usos
|
|
US20120283172A1
(en)
|
2009-12-21 |
2012-11-08 |
Ambrx, Inc. |
Modified porcine somatotropin polypeptides and their uses
|
|
ES2802623T3
(es)
|
2010-01-27 |
2021-01-20 |
Massachusetts Inst Technology |
Agentes polipeptídicos técnicamente diseñados para la neutralización dirigida de amplio espectro de la gripe
|
|
WO2011092233A1
(en)
|
2010-01-29 |
2011-08-04 |
Novartis Ag |
Yeast mating to produce high-affinity combinations of fibronectin-based binders
|
|
BR112012019902A2
(pt)
|
2010-02-10 |
2019-09-24 |
Novartis Ag |
"método e compostos para o crescimento muscular"
|
|
US8674064B2
(en)
*
|
2010-03-03 |
2014-03-18 |
Onkologix Ltd |
Immunogenic compositions against human progastrin peptides
|
|
US8464858B2
(en)
*
|
2010-03-12 |
2013-06-18 |
Cabin Creek Inc. |
Conveyor belt scraper and system for the same
|
|
WO2011119771A2
(en)
*
|
2010-03-23 |
2011-09-29 |
The Salk Institute For Biological Studies |
Methods and compositions for detecting protein modifications
|
|
CN103118692A
(zh)
|
2010-04-26 |
2013-05-22 |
Atyr医药公司 |
与半胱氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
|
|
JP6240500B2
(ja)
|
2010-04-27 |
2017-11-29 |
エータイアー ファーマ, インコーポレイテッド |
スレオニルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
|
|
CA2797362C
(en)
|
2010-04-27 |
2020-12-08 |
Atyr Pharma, Inc. |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl trna synthetases
|
|
CN103097524B
(zh)
|
2010-04-28 |
2016-08-03 |
Atyr医药公司 |
与丙氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
|
|
AU2011248457B2
(en)
|
2010-04-29 |
2017-02-16 |
Pangu Biopharma Limited |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl tRNA synthetases
|
|
US8986680B2
(en)
|
2010-04-29 |
2015-03-24 |
Atyr Pharma, Inc. |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Asparaginyl tRNA synthetases
|
|
WO2011139988A2
(en)
|
2010-05-03 |
2011-11-10 |
Atyr Pharma, Inc. |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-trna synthetases
|
|
ES2623805T3
(es)
|
2010-05-03 |
2017-07-12 |
Atyr Pharma, Inc. |
Descubrimiento innovador de composiciones terapéuticas, de diagnóstico y de anticuerpos relacionadas con fragmentos de proteínas de fenilalanil-alfa-ARNt sintetasas
|
|
CN103096925A
(zh)
|
2010-05-03 |
2013-05-08 |
Atyr医药公司 |
与精氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
|
|
EP2566496B1
(en)
|
2010-05-03 |
2018-02-28 |
aTyr Pharma, Inc. |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-trna synthetases
|
|
EP2566492B1
(en)
|
2010-05-04 |
2016-10-26 |
aTyr Pharma, Inc. |
Innovative discovery of therapeutic compositions related to protein fragments of glutamyl-prolyl-trna synthetases
|
|
CN102985103A
(zh)
|
2010-05-04 |
2013-03-20 |
Atyr医药公司 |
与p38多-tRNA合成酶复合物相关的治疗、诊断和抗体组合物的创新发现
|
|
CA2799197C
(en)
|
2010-05-14 |
2019-10-29 |
Atyr Pharma, Inc. |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-trna synthetases
|
|
CA2799480C
(en)
|
2010-05-17 |
2020-12-15 |
Atyr Pharma, Inc. |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-trna synthetases
|
|
CA2800375C
(en)
|
2010-05-27 |
2021-03-09 |
Atyr Pharma, Inc. |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-trna synthetases
|
|
CN103118694B
(zh)
|
2010-06-01 |
2016-08-03 |
Atyr医药公司 |
与赖氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的发现
|
|
EP2584037B1
(en)
*
|
2010-06-16 |
2016-08-10 |
Riken |
Method for constructing recombinant bacterium for producing non-native protein, and utilization of same
|
|
WO2011159895A2
(en)
|
2010-06-16 |
2011-12-22 |
Indiana University Research And Technology Corporation |
Single chain insulin agonists exhibiting high activity at the insulin receptor
|
|
EP2588126A4
(en)
|
2010-06-24 |
2015-07-08 |
Univ Indiana Res & Tech Corp |
AMID-BASED GLUCAGON SUPERFAMILY PEPTIDE PRODRUGS
|
|
US8946147B2
(en)
|
2010-06-24 |
2015-02-03 |
Indiana University Research And Technology Corporation |
Amide-based insulin prodrugs
|
|
WO2012021249A2
(en)
|
2010-07-12 |
2012-02-16 |
Atyr Pharma, Inc. |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of histidyl-trna synthetases
|
|
KR102099730B1
(ko)
*
|
2010-07-12 |
2020-04-16 |
에이티와이알 파마, 인코포레이티드 |
아스파르틸trna 합성효소의 단백질 단편에 관련된 치료적, 진단적, 및 항체 조성물의 혁신적 발견
|
|
US8999321B2
(en)
|
2010-07-12 |
2015-04-07 |
Atyr Pharma, Inc. |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases
|
|
AU2011289831C1
(en)
|
2010-07-12 |
2017-06-15 |
Pangu Biopharma Limited |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases
|
|
EP3572091B1
(en)
|
2010-08-17 |
2023-12-13 |
Ambrx, Inc. |
Modified relaxin polypeptides and their uses
|
|
US9567386B2
(en)
|
2010-08-17 |
2017-02-14 |
Ambrx, Inc. |
Therapeutic uses of modified relaxin polypeptides
|
|
AU2011293294B2
(en)
|
2010-08-25 |
2016-03-24 |
Pangu Biopharma Limited |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Tyrosyl-tRNA synthetases
|
|
WO2012032181A2
(en)
|
2010-09-10 |
2012-03-15 |
Allozyne, Inc |
Novel antibody derivatives
|
|
US9616097B2
(en)
|
2010-09-15 |
2017-04-11 |
Synergy Pharmaceuticals, Inc. |
Formulations of guanylate cyclase C agonists and methods of use
|
|
AR083006A1
(es)
|
2010-09-23 |
2013-01-23 |
Lilly Co Eli |
Formulaciones para el factor estimulante de colonias de granulocitos (g-csf) bovino y variantes de las mismas
|
|
CA2812795C
(en)
|
2010-10-06 |
2021-08-31 |
Atyr Pharma, Inc. |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of tryptophanyl trna synthetases
|
|
WO2012048249A1
(en)
|
2010-10-07 |
2012-04-12 |
Yale University |
Site-specific incorporation of phosphoserine into proteins in escherichia coli
|
|
US9023791B2
(en)
|
2010-11-19 |
2015-05-05 |
Novartis Ag |
Fibroblast growth factor 21 mutations
|
|
US9540438B2
(en)
|
2011-01-14 |
2017-01-10 |
Redwood Bioscience, Inc. |
Aldehyde-tagged immunoglobulin polypeptides and methods of use thereof
|
|
ES2661095T3
(es)
|
2011-02-03 |
2018-03-27 |
European Molecular Biology Laboratory |
Aminoácidos no naturales que comprenden un grupo análogo de ciclooctinilo o trans-ciclooctenilo y usos de los mismos
|
|
US9428789B2
(en)
|
2011-03-21 |
2016-08-30 |
Biodesy, Inc. |
Classification of kinase inhibitors using nonlinear optical techniques
|
|
US20140249090A1
(en)
*
|
2011-04-01 |
2014-09-04 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaft e.V. |
Peptides and pharmaceutical compositions for use in the treatment by nasal administration of patients suffering from anxiety and sleep disorders
|
|
DK2694095T3
(en)
|
2011-04-05 |
2018-05-28 |
Longevity Biotech Inc |
COMPOSITIONS COMPREHENSIVE GLUCAGON ANALOGS AND METHODS FOR PREPARING AND USING THE SAME
|
|
EP2714685B1
(en)
|
2011-05-27 |
2016-10-19 |
Ambrx, Inc. |
Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives
|
|
KR102179369B1
(ko)
|
2011-05-27 |
2020-11-16 |
암브룩스, 인코포레이티드 |
비-천연 아미노산 연결된 돌라스타틴 유도체를 함유하는 조성물, 이를 수반하는 방법, 및 용도
|
|
WO2013009868A1
(en)
|
2011-07-11 |
2013-01-17 |
Yale University |
Compositions and methods for making selenocysteine containing polypeptides
|
|
US11788111B2
(en)
|
2011-07-11 |
2023-10-17 |
Yale University |
Compositions and methods for making selenocysteine containing polypeptides
|
|
US10876142B2
(en)
|
2011-07-11 |
2020-12-29 |
Yale University |
Compositions and methods for making selenocysteine containing polypeptides
|
|
US10240158B2
(en)
|
2011-07-11 |
2019-03-26 |
Yale University |
Compositions and methods for making selenocysteine containing polypeptides
|
|
CN102888387B
(zh)
*
|
2011-07-21 |
2015-03-18 |
中国科学院生物物理研究所 |
3-氯代酪氨酸翻译系统及其应用
|
|
EP2734621B1
(en)
|
2011-07-22 |
2019-09-04 |
President and Fellows of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
|
CN102925427B
(zh)
*
|
2011-08-08 |
2014-01-22 |
中国科学院生物物理研究所 |
丙烯酰赖氨酸翻译系统及其应用
|
|
US9714419B2
(en)
|
2011-08-09 |
2017-07-25 |
Atyr Pharma, Inc. |
PEGylated tyrosyl-tRNA synthetase polypeptides
|
|
UY34347A
(es)
|
2011-09-26 |
2013-04-30 |
Novartis Ag |
Proteínas de función dual para tratar trastornos metabólicos
|
|
WO2013068874A1
(en)
|
2011-11-11 |
2013-05-16 |
Pfizer Inc. |
Antibody-drug conjugates
|
|
WO2013086216A1
(en)
|
2011-12-06 |
2013-06-13 |
Atyr Pharma, Inc. |
Improved aspartyl-trna synthetases
|
|
WO2013086228A1
(en)
*
|
2011-12-06 |
2013-06-13 |
Atyr Pharma, Inc. |
Pegylated aspartyl-trna synthetase polypeptides
|
|
US9573987B2
(en)
|
2011-12-20 |
2017-02-21 |
Indiana University Research And Technology Corporation |
CTP-based insulin analogs for treatment of diabetes
|
|
HUE054006T2
(hu)
|
2011-12-28 |
2021-08-30 |
Chugai Pharmaceutical Co Ltd |
Eljárás peptid vegyület ciklizálására
|
|
EP2797959A4
(en)
|
2011-12-29 |
2015-08-26 |
Atyr Pharma Inc |
ASPARTYL-tRNA synthetase FC CONJUGATES
|
|
US9395358B2
(en)
|
2012-02-05 |
2016-07-19 |
Biodesy, Inc. |
Methods for detecting allosteric modulators of protein
|
|
AU2013221317B2
(en)
|
2012-02-16 |
2017-07-06 |
Pangu Biopharma Limited |
Histidyl-tRNA synthetases for treating autoimmune and inflammatory diseases
|
|
WO2013169377A1
(en)
|
2012-05-10 |
2013-11-14 |
Massachusetts Institute Of Technology |
Agents for influenza neutralization
|
|
KR102143664B1
(ko)
|
2012-06-07 |
2020-08-11 |
암브룩스, 인코포레이티드 |
전립선 특이적 막 항원 항체 약물 접합체
|
|
ES2718478T3
(es)
|
2012-06-08 |
2019-07-02 |
Sutro Biopharma Inc |
Anticuerpos que comprenden restos de aminoácidos no naturales de localización específica, métodos para su preparación y métodos para su uso
|
|
SG11201408494UA
(en)
|
2012-06-19 |
2015-02-27 |
Ambrx Inc |
Anti-cd70 antibody drug conjugates
|
|
DK2863955T3
(en)
|
2012-06-26 |
2017-01-23 |
Sutro Biopharma Inc |
MODIFIED FC PROTEINS, INCLUDING LOCATION-SPECIFIC NON-NATURAL AMINO ACID RESIDUES, CONJUGATES THEREOF, METHODS OF PRODUCING ITS AND PROCEDURES FOR USE THEREOF
|
|
CN103571804B
(zh)
*
|
2012-08-10 |
2015-08-12 |
中国科学院生物物理研究所 |
3-吡唑基酪氨酸翻译系统及其应用
|
|
WO2014031861A1
(en)
|
2012-08-22 |
2014-02-27 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Engineered anthrax lethal toxin for targeted delivery
|
|
WO2014035364A2
(en)
*
|
2012-08-27 |
2014-03-06 |
Empire Technology Development Llc |
Gelatin alkyd peptides and uses thereof
|
|
SG11201501464TA
(en)
|
2012-08-31 |
2015-03-30 |
Sutro Biopharma Inc |
Modified amino acids comprising an azido group
|
|
WO2014044873A1
(en)
|
2012-09-24 |
2014-03-27 |
Allozyne, Inc |
Amino acid derivatives
|
|
CN108383902A
(zh)
|
2012-09-26 |
2018-08-10 |
印第安纳大学研究及科技有限公司 |
胰岛素类似物二聚体
|
|
CN102875733B
(zh)
*
|
2012-10-25 |
2014-06-11 |
西安科技大学 |
具有仿细胞外层膜结构的纳米颗粒及其制备方法
|
|
US20140120116A1
(en)
|
2012-10-26 |
2014-05-01 |
The Chinese University Of Hong Kong |
Treatment of cancer using smad3 inhibitor
|
|
UY35144A
(es)
|
2012-11-20 |
2014-06-30 |
Novartis Ag |
Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
|
|
KR102182523B1
(ko)
|
2012-12-18 |
2020-11-25 |
노파르티스 아게 |
안정화된 인슐린-유사 성장 인자 폴리펩티드
|
|
JP2016507520A
(ja)
|
2013-01-23 |
2016-03-10 |
ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー |
安定化されたb型肝炎コアポリペプチド
|
|
JP6499591B2
(ja)
|
2013-02-25 |
2019-04-10 |
シナジー ファーマシューティカルズ インコーポレイテッド |
結腸洗浄において用いるためのグアニル酸シクラーゼ受容体アゴニスト
|
|
US9255255B2
(en)
|
2013-03-04 |
2016-02-09 |
The Board Of Trustees Of The Leland Stanford Junior University |
Synthesis of linear and branched polymers of polypeptides through direct conjugation
|
|
UY35368A
(es)
|
2013-03-08 |
2014-10-31 |
Irm Llc |
Péptidos y composiciones para el tratamiento de daño articular
|
|
WO2014158900A1
(en)
|
2013-03-14 |
2014-10-02 |
Indiana University Research And Technology Corporation |
Insulin-incretin conjugates
|
|
US11156608B2
(en)
|
2013-03-15 |
2021-10-26 |
The Trustees Of The University Of Pennsylvania |
Method for the site-specific covalent cross-linking of antibodies to surfaces
|
|
WO2014145718A2
(en)
|
2013-03-15 |
2014-09-18 |
Longevity Biotech, Inc. |
Peptides comprising non-natural amino acids and methods of making and using the same
|
|
JP2016514671A
(ja)
|
2013-03-15 |
2016-05-23 |
シナジー ファーマシューティカルズ インコーポレイテッド |
グアニル酸シクラーゼのアゴニストおよびその使用
|
|
ES2847383T3
(es)
|
2013-03-15 |
2021-08-03 |
Atyr Pharma Inc |
Conjugados de Fc-histidil-ARNt sintetasa
|
|
WO2014151200A2
(en)
|
2013-03-15 |
2014-09-25 |
Synergy Pharmaceuticals Inc. |
Compositions useful for the treatment of gastrointestinal disorders
|
|
EP2976362B1
(en)
|
2013-03-19 |
2019-10-23 |
Beijing Shenogen Pharma Group Ltd. |
Antibodies and methods for treating estrogen receptor-associated diseases
|
|
CN105764916B
(zh)
|
2013-06-05 |
2021-05-18 |
博士医疗爱尔兰有限公司 |
鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法
|
|
KR101568336B1
(ko)
|
2013-07-02 |
2015-11-12 |
서강대학교산학협력단 |
목적 단백질의 돌연변이체를 생성하는 세포, 상기 세포의 제조 방법, 및 상기 세포를 이용한 목적 단백질의 돌연변이체의 제조 방법
|
|
US9764039B2
(en)
|
2013-07-10 |
2017-09-19 |
Sutro Biopharma, Inc. |
Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use
|
|
US10005838B2
(en)
|
2013-07-19 |
2018-06-26 |
The Regents Of The University Of California |
Milk fat globule epidermal growth factor 8 regulates fatty acid uptake
|
|
PE20160991A1
(es)
|
2013-07-25 |
2016-10-15 |
Novartis Ag |
Bioconjugados de polipeptidos de apelina sintetica
|
|
TW201536814A
(zh)
|
2013-07-25 |
2015-10-01 |
Novartis Ag |
用於治療心臟衰竭之合成環狀多肽
|
|
US9163284B2
(en)
|
2013-08-09 |
2015-10-20 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a Cas9 nuclease
|
|
EP3492106B1
(en)
|
2013-08-09 |
2021-02-17 |
Ardelyx, Inc. |
Compounds and methods for inhibiting phosphate transport
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
WO2015031268A1
(en)
|
2013-08-26 |
2015-03-05 |
Arizona Board Of Regents On Behalf Of Arizona State University |
High affinity synbodies for influenza
|
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
|
US9340800B2
(en)
|
2013-09-06 |
2016-05-17 |
President And Fellows Of Harvard College |
Extended DNA-sensing GRNAS
|
|
US9322037B2
(en)
|
2013-09-06 |
2016-04-26 |
President And Fellows Of Harvard College |
Cas9-FokI fusion proteins and uses thereof
|
|
CA2926691A1
(en)
|
2013-10-10 |
2015-04-16 |
Synergy Pharmaceuticals, Inc. |
Agonists of guanylate cyclase useful for the treatment of opioid induced dysfunctions
|
|
WO2015054658A1
(en)
|
2013-10-11 |
2015-04-16 |
Sutro Biopharma, Inc. |
Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use
|
|
US20160235810A1
(en)
|
2013-10-18 |
2016-08-18 |
Novartis Ag |
Methods of treating diabetes and related disorders
|
|
US20150165054A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting caspase-9 point mutations
|
|
EP3094977B1
(en)
|
2014-01-14 |
2018-08-22 |
European Molecular Biology Laboratory |
Multiple cycloaddition reactions for labeling of molecules
|
|
WO2015120287A2
(en)
|
2014-02-06 |
2015-08-13 |
Yale University |
Compositions and methods of use thereof for making polypeptides with many instances of nonstandard amino acids
|
|
WO2015175375A1
(en)
|
2014-05-13 |
2015-11-19 |
Short Jay M |
Conditionally active biological proteins
|
|
US10588980B2
(en)
|
2014-06-23 |
2020-03-17 |
Novartis Ag |
Fatty acids and their use in conjugation to biomolecules
|
|
CN112851790A
(zh)
|
2014-06-23 |
2021-05-28 |
诺华股份有限公司 |
位点特异性蛋白质修饰
|
|
US10316322B2
(en)
|
2014-07-02 |
2019-06-11 |
Sutro Biopharma, Inc. |
High growth capacity auxotrophic Escherichia coli and methods of use
|
|
CA2954791C
(en)
|
2014-07-14 |
2025-11-18 |
The Regents Of The University Of California |
CRISPR/CAS TRANSCRIPTIONAL MODULATION
|
|
CA2956224A1
(en)
|
2014-07-30 |
2016-02-11 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
|
KR20170044115A
(ko)
|
2014-09-03 |
2017-04-24 |
바이오아트라, 엘엘씨 |
동일한 진핵생물 세포 생산 숙주 내 조건부 활성 생체 단백질의 발견 및 제조
|
|
ES2822994T3
(es)
|
2014-09-24 |
2021-05-05 |
Univ Indiana Res & Tech Corp |
Conjugados de incretina-insulina
|
|
EP3197912B1
(en)
|
2014-09-24 |
2023-01-04 |
Indiana University Research & Technology Corporation |
Lipidated amide-based insulin prodrugs
|
|
WO2016073079A2
(en)
|
2014-09-26 |
2016-05-12 |
Yale University |
Compositions and methods for biocontainment of microorganisms
|
|
CN107108710B
(zh)
|
2014-10-24 |
2022-02-15 |
百时美施贵宝公司 |
修饰的fgf-21多肽及其用途
|
|
ES2986970T3
(es)
|
2014-12-04 |
2024-11-13 |
Celgene Corp |
Conjugados de biomoléculas
|
|
EP3237906B8
(en)
|
2014-12-23 |
2020-10-28 |
Bluelight Therapeutics, Inc. |
Attachment of proteins to interfaces for use in nonlinear optical detection
|
|
SE538541C2
(en)
*
|
2015-01-19 |
2016-09-13 |
Fogelstrand Per |
Method for preparing a biological sample for use in an immunolabeling process
|
|
CN107209176B
(zh)
|
2015-01-21 |
2020-08-14 |
克罗姆尼贡公司 |
免疫标记复合物的形成方法及用途
|
|
WO2016116842A1
(en)
|
2015-01-23 |
2016-07-28 |
Novartis Ag |
Synthetic apelin fatty acid conjugates with improved half-life
|
|
JP6886404B2
(ja)
|
2015-01-30 |
2021-06-16 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアThe Regents Of The University Of California |
初代造血細胞におけるタンパク質送達
|
|
US10815489B2
(en)
|
2015-03-13 |
2020-10-27 |
Chugai Seiyaku Kabushiki Kaisha |
Modified aminoacyl-tRNA synthetase and use thereof
|
|
US10483262B2
(en)
*
|
2015-05-15 |
2019-11-19 |
Taiwan Semiconductor Manufacturing Co., Ltd. |
Dual nitride stressor for semiconductor device and method of manufacturing
|
|
US10711273B2
(en)
|
2015-06-09 |
2020-07-14 |
National Institute Of Advanced Industrial Science And Technology |
Amino acid-modified nucleic acid and utilization thereof
|
|
CA2989400A1
(en)
|
2015-06-15 |
2016-12-22 |
Angiochem Inc. |
Ang1005 for the treatment of leptomeningeal carcinomatosis
|
|
ES2882355T3
(es)
|
2015-07-10 |
2021-12-01 |
Univ Hong Kong Science & Tech |
Composiciones para su uso en el tratamiento de afecciones neurodegenerativas y neuroinflamatorias
|
|
EP3359191A4
(en)
|
2015-10-05 |
2019-05-29 |
Merck Sharp & Dohme Corp. |
ANTIBODY PEPTIDE CONJUGATES WITH AGONISTEACTIVITY ON GLUCAGON RECEPTORS AND GLUCAGON-LIKE PEPTIDE-1
|
|
EP4434589A3
(en)
|
2015-10-23 |
2025-05-14 |
President and Fellows of Harvard College |
Evolved cas9 proteins for gene editing
|
|
WO2017109706A1
(en)
|
2015-12-22 |
2017-06-29 |
Novartis Ag |
Methods of treating or ameliorating metabolic disorders using growth differentiation factor 15 (gdf-15)
|
|
SG11201805255TA
(en)
|
2015-12-23 |
2018-07-30 |
Amgen Inc |
Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (gipr) in combination with glp-1 agonists
|
|
CN106929482A
(zh)
*
|
2015-12-31 |
2017-07-07 |
北京大学 |
定点突变的流感病毒、其活疫苗及其制备方法和应用
|
|
JP2019506383A
(ja)
|
2016-01-11 |
2019-03-07 |
シナジー ファーマシューティカルズ インコーポレイテッド |
潰瘍性大腸炎を治療するための製剤および方法
|
|
SG11201806419RA
(en)
|
2016-01-27 |
2018-08-30 |
Sutro Biopharma Inc |
Anti-cd74 antibody conjugates, compositions comprising anti-cd74 antibody conjugates and methods of using anti-cd74 antibody conjugates
|
|
CN109071634A
(zh)
|
2016-04-26 |
2018-12-21 |
R.P.谢勒技术有限责任公司 |
抗体偶联物及其制备和使用方法
|
|
WO2017196891A1
(en)
|
2016-05-09 |
2017-11-16 |
Biodesy, Inc. |
Methods and devices for detection of peripheral membrane protein interactions using nonlinear optical techniques
|
|
US11340218B2
(en)
|
2016-05-25 |
2022-05-24 |
Kromnigon Ab |
Method for preparing a biological sample for use in an immunolabeling process
|
|
AU2017283787B2
(en)
|
2016-06-15 |
2020-09-17 |
Novartis Ag |
Methods for treating disease using inhibitors of bone morphogenetic protein 6 (BMP6)
|
|
JP7231935B2
(ja)
|
2016-08-03 |
2023-03-08 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
アデノシン核酸塩基編集因子およびそれらの使用
|
|
US11661590B2
(en)
|
2016-08-09 |
2023-05-30 |
President And Fellows Of Harvard College |
Programmable CAS9-recombinase fusion proteins and uses thereof
|
|
WO2018039438A1
(en)
*
|
2016-08-24 |
2018-03-01 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
EP3309260A1
(en)
|
2016-10-14 |
2018-04-18 |
European Molecular Biology Laboratory |
Archaeal pyrrolysyl trna synthetases for orthogonal use
|
|
AU2017342543B2
(en)
|
2016-10-14 |
2024-06-27 |
President And Fellows Of Harvard College |
AAV delivery of nucleobase editors
|
|
CN117860868A
(zh)
|
2016-11-14 |
2024-04-12 |
诺华股份有限公司 |
用于治疗软骨损伤和关节炎的方法和组合物
|
|
EP3538546B1
(en)
|
2016-11-14 |
2025-01-08 |
Novartis AG |
Compositions, methods, and therapeutic uses related to fusogenic protein minion
|
|
KR20230052995A
(ko)
|
2016-12-19 |
2023-04-20 |
퀀텀-에스아이 인코포레이티드 |
시퀀싱 반응을 위한 중합 효소
|
|
WO2018119359A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Editing of ccr5 receptor gene to protect against hiv infection
|
|
DK3562503T3
(da)
|
2016-12-30 |
2025-05-26 |
Vaxcyte Inc |
Polypeptid-antigen-konjugater med ikke-naturlige aminosyrer
|
|
US11951165B2
(en)
|
2016-12-30 |
2024-04-09 |
Vaxcyte, Inc. |
Conjugated vaccine carrier proteins
|
|
JOP20190177A1
(ar)
|
2017-01-17 |
2019-07-16 |
Amgen Inc |
طريقة لعلاج أو تحسين اضطرابات أيضية باستخدام مساعدات مستقبل glp-1 مقترنة بمناهضات لمستقبل ببتيد مثبط معوي (gipr)
|
|
US12391971B2
(en)
|
2017-01-31 |
2025-08-19 |
Chugai Seiyaku Kabushiki Kaisha |
Method for synthesizing peptides in cell-free translation system
|
|
AU2018218280B2
(en)
|
2017-02-07 |
2024-10-17 |
The Regents Of The University Of California |
Gene therapy for haploinsufficiency
|
|
PE20191716A1
(es)
|
2017-02-08 |
2019-12-05 |
Bristol Myers Squibb Co |
Polipeptidos de relaxina modificada que comprenden un mejorador farmacocinetico y sus usos
|
|
CN110662556A
(zh)
|
2017-03-09 |
2020-01-07 |
哈佛大学的校长及成员们 |
癌症疫苗
|
|
US11898179B2
(en)
|
2017-03-09 |
2024-02-13 |
President And Fellows Of Harvard College |
Suppression of pain by gene editing
|
|
JP2020510439A
(ja)
|
2017-03-10 |
2020-04-09 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
シトシンからグアニンへの塩基編集因子
|
|
WO2018176009A1
(en)
|
2017-03-23 |
2018-09-27 |
President And Fellows Of Harvard College |
Nucleobase editors comprising nucleic acid programmable dna binding proteins
|
|
EP3381932A1
(en)
|
2017-03-28 |
2018-10-03 |
Technische Universität Berlin |
Modified mussel proteins, uses thereof and related compounds
|
|
ES2994451T3
(en)
|
2017-04-20 |
2025-01-24 |
Atyr Pharma Inc |
Compositions for treating lung inflammation
|
|
US11560566B2
(en)
|
2017-05-12 |
2023-01-24 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
|
|
SI3630977T1
(sl)
|
2017-06-02 |
2024-05-31 |
Ambrx, Inc. |
Postopki in sestavki za spodbujanje proizvodnje beljakovine, ki vsebuje nenaravno aminokislino
|
|
KR102744693B1
(ko)
|
2017-06-09 |
2024-12-18 |
추가이 세이야쿠 가부시키가이샤 |
N-치환 아미노산을 포함하는 펩타이드의 합성 방법
|
|
AU2018288854B2
(en)
|
2017-06-20 |
2025-06-26 |
Amgen Inc. |
Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (GIPR) in combination with GLP-1 agonists
|
|
CA3263567A1
(en)
|
2017-06-21 |
2025-10-30 |
Amgen Inc. |
Method of treating or ameliorating metabolic disorders using antagonistic binding proteins for gastric inhibitory peptide receptor (gipr)/glp-1 receptor agonist fusion proteins
|
|
TW202426655A
(zh)
|
2017-07-11 |
2024-07-01 |
美商新索思股份有限公司 |
非天然核苷酸之導入及其方法
|
|
KR101956042B1
(ko)
*
|
2017-07-13 |
2019-03-08 |
서강대학교산학협력단 |
표적 단백질 내 l-디하이드록시페닐알라닌의 도입 방법
|
|
EP3658588A1
(en)
|
2017-07-26 |
2020-06-03 |
Sutro Biopharma, Inc. |
Methods of using anti-cd74 antibodies and antibody conjugates in treatment of t-cell lymphoma
|
|
US11732274B2
(en)
|
2017-07-28 |
2023-08-22 |
President And Fellows Of Harvard College |
Methods and compositions for evolving base editors using phage-assisted continuous evolution (PACE)
|
|
MA49767A
(fr)
|
2017-08-03 |
2021-05-26 |
Synthorx Inc |
Conjugués de cytokine pour le traitement de maladies auto-immunes
|
|
WO2019139645A2
(en)
|
2017-08-30 |
2019-07-18 |
President And Fellows Of Harvard College |
High efficiency base editors comprising gam
|
|
CA3074839A1
(en)
|
2017-09-07 |
2019-03-14 |
Cue Biopharma, Inc. |
T-cell modulatory multimeric polypeptide with conjugation sites and methods of use thereof
|
|
KR20200051802A
(ko)
|
2017-09-18 |
2020-05-13 |
서트로 바이오파마, 인크. |
항-엽산 수용체 알파 항체 접합체 및 이의 용도
|
|
KR20200121782A
(ko)
|
2017-10-16 |
2020-10-26 |
더 브로드 인스티튜트, 인코퍼레이티드 |
아데노신 염기 편집제의 용도
|
|
CN111479819B
(zh)
|
2017-12-15 |
2024-06-14 |
中外制药株式会社 |
制备肽的方法和处理碱的方法
|
|
US12406749B2
(en)
|
2017-12-15 |
2025-09-02 |
The Broad Institute, Inc. |
Systems and methods for predicting repair outcomes in genetic engineering
|
|
AU2019263303A1
(en)
|
2018-05-01 |
2020-12-24 |
Ambrx, Inc. |
A method for optimizing antibody expression
|
|
US12157760B2
(en)
|
2018-05-23 |
2024-12-03 |
The Broad Institute, Inc. |
Base editors and uses thereof
|
|
WO2019237119A1
(en)
|
2018-06-08 |
2019-12-12 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
New compositions and detection methods for onchocerca volvulus infection
|
|
US12522807B2
(en)
|
2018-07-09 |
2026-01-13 |
The Broad Institute, Inc. |
RNA programmable epigenetic RNA modifiers and uses thereof
|
|
US20210356377A1
(en)
*
|
2018-09-07 |
2021-11-18 |
Medimmune, Llc |
Methods Of Cell Selection
|
|
DK3849614T3
(da)
|
2018-09-11 |
2024-02-26 |
Ambrx Inc |
Interleukin-2-polypeptidkonjugater og anvendelser deraf
|
|
US20220047716A1
(en)
|
2018-09-17 |
2022-02-17 |
Sutro Biopharma, Inc. |
Combination therapies with anti-folate receptor antibody conjugates
|
|
WO2020082057A1
(en)
|
2018-10-19 |
2020-04-23 |
Ambrx, Inc. |
Interleukin-10 polypeptide conjugates, dimers thereof, and their uses
|
|
WO2020092453A1
(en)
|
2018-10-29 |
2020-05-07 |
The Broad Institute, Inc. |
Nucleobase editors comprising geocas9 and uses thereof
|
|
US11325978B2
(en)
|
2018-11-06 |
2022-05-10 |
The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services |
Compositions and methods for treating beta-globinopathies
|
|
KR102841441B1
(ko)
|
2018-11-07 |
2025-07-31 |
추가이 세이야쿠 가부시키가이샤 |
O-치환 세린 유도체의 제조 방법
|
|
CN113056475B
(zh)
|
2018-11-30 |
2024-09-24 |
中外制药株式会社 |
用于肽化合物或酰胺化合物的脱保护方法和在固相反应中的树脂脱除方法以及用于生产肽化合物的方法
|
|
WO2020154500A1
(en)
|
2019-01-23 |
2020-07-30 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
CA3127689A1
(en)
|
2019-02-06 |
2020-08-13 |
Synthorx, Inc. |
Il-2 conjugates and methods of use thereof
|
|
AU2020223031B2
(en)
|
2019-02-12 |
2024-08-29 |
Ambrx, Inc. |
Compositions containing, methods and uses of antibody-TLR agonist conjugates
|
|
EP3696189A1
(en)
|
2019-02-14 |
2020-08-19 |
European Molecular Biology Laboratory |
Means and methods for preparing engineered target proteins by genetic code expansion in a target protein selective manner
|
|
JP7495420B2
(ja)
|
2019-02-20 |
2024-06-04 |
ノヴォ ノルディスク アー/エス |
アミノアシル-tRNA合成酵素およびこの使用
|
|
CN113785058B
(zh)
*
|
2019-03-04 |
2024-12-24 |
得克萨斯A&M大学系统 |
制作和利用琥珀专性的噬菌体展示文库的方法
|
|
JP7472101B2
(ja)
|
2019-03-15 |
2024-04-22 |
中外製薬株式会社 |
芳香族アミノ酸誘導体の製造方法
|
|
MX2021011426A
(es)
|
2019-03-19 |
2022-03-11 |
Broad Inst Inc |
Metodos y composiciones para editar secuencias de nucleótidos.
|
|
WO2020214842A1
(en)
|
2019-04-17 |
2020-10-22 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
WO2020227105A1
(en)
|
2019-05-03 |
2020-11-12 |
Sutro Biopharma, Inc. |
Anti-bcma antibody conjugates
|
|
US12258304B2
(en)
|
2019-05-20 |
2025-03-25 |
Albert Einstein College Of Medicine |
Compounds and methods for treatment of bacterial infections
|
|
WO2020245321A1
(en)
|
2019-06-04 |
2020-12-10 |
Institut Curie |
METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
|
|
US12139708B2
(en)
|
2019-06-07 |
2024-11-12 |
Massachusetts Institute Of Technology |
Frameshift suppressor tRNA compositions and methods of use
|
|
US12534465B2
(en)
|
2019-06-10 |
2026-01-27 |
Sutro Biopharma, Inc. |
5H-pyrrolo[3,2-d]pyrimidine-2,4-diamino compounds and antibody conjugates thereof
|
|
US20220259202A1
(en)
|
2019-06-17 |
2022-08-18 |
Sutro Biopharma, Inc. |
1-(4-(aminomethyl)benzyl)-2-butyl-2h-pyrazolo[3,4-c]quinolin-4-amine derivatives and related compounds as toll-like receptor (tlr) 7/8 agonists, as well as antibody drug conjugates thereof for use in cancer therapy and diagnosis
|
|
JP2022539560A
(ja)
|
2019-06-28 |
2022-09-12 |
クアンタム-エスアイ インコーポレイテッド |
配列決定反応のための重合酵素
|
|
WO2021072129A2
(en)
|
2019-10-08 |
2021-04-15 |
Trustees Of Boston College |
Proteins containing multiple, different unnatural amino acids and methods of making and using such proteins
|
|
TW202128996A
(zh)
*
|
2019-10-10 |
2021-08-01 |
美商史基普研究協會 |
用於活體內合成非天然多肽的組合物及方法
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
KR20220080101A
(ko)
*
|
2019-10-15 |
2022-06-14 |
트러스티스 오브 보스톤 칼리지 |
향상된 비천연 아미노산 혼입을 위한 키메라 열안정성 아미노아실-tRNA 합성효소
|
|
US11149280B2
(en)
|
2019-10-29 |
2021-10-19 |
Yale University |
Engineering organisms resistant to viruses and horizontally transferred genetic elements
|
|
WO2021092162A1
(en)
*
|
2019-11-05 |
2021-05-14 |
Aditya Kunjapur |
Biosynthesis of para-nitro-l-phenylalanine
|
|
BR112022007535A2
(pt)
|
2019-11-07 |
2022-07-12 |
Chugai Pharmaceutical Co Ltd |
Composto peptídico cíclico tendo ação inibitória de kras
|
|
WO2021136223A1
(en)
|
2019-12-31 |
2021-07-08 |
Beijing Ql Biopharmaceutical Co., Ltd. |
Fusion proteins of glp-1 and gdf15 and conjugates thereof
|
|
EP4084819A1
(en)
|
2020-01-03 |
2022-11-09 |
The United States of America, as represented by the Secretary, Department of Health and Human Services |
Tnap locally administered for promoting periodontal health
|
|
CN115322794B
(zh)
|
2020-01-11 |
2025-09-19 |
北京质肽生物医药科技有限公司 |
Glp-1和fgf21的融合蛋白的缀合物
|
|
WO2021165968A1
(en)
*
|
2020-02-20 |
2021-08-26 |
B. G. Negev Technologies And Applications Ltd., At Ben-Gurion University |
Mutant aminoacyl-trna synthetases
|
|
EP3868882A1
(en)
|
2020-02-21 |
2021-08-25 |
European Molecular Biology Laboratory |
Archaeal pyrrolysyl trna synthetases for orthogonal use
|
|
US20230095053A1
(en)
|
2020-03-03 |
2023-03-30 |
Sutro Biopharma, Inc. |
Antibodies comprising site-specific glutamine tags, methods of their preparation and methods of their use
|
|
MX2022011163A
(es)
|
2020-03-11 |
2022-10-18 |
Ambrx Inc |
Conjugados de polipeptidos de interleucina-2 y sus usos.
|
|
CN111302975A
(zh)
*
|
2020-03-30 |
2020-06-19 |
滨海吉尔多肽有限公司 |
一种n-叔丁氧羰基-o-烯丙基-l-酪氨酸的制备方法
|
|
IL297329A
(en)
|
2020-04-22 |
2022-12-01 |
Merck Sharp & Dohme Llc |
Dimeric interleukin-2 beta gamma receptor-biased human interleukin-2 conjugates conjugated to soluble non-peptide polymers.
|
|
US12351850B2
(en)
|
2020-04-30 |
2025-07-08 |
Sutro Biopharma, Inc. |
Methods of producing full-length antibodies using E. coli
|
|
TW202207988A
(zh)
|
2020-05-05 |
2022-03-01 |
美商建南德克公司 |
用於酪胺酸酶媒介的位點特異性蛋白質結合的系統及方法
|
|
WO2021226558A1
(en)
|
2020-05-08 |
2021-11-11 |
The Broad Institute, Inc. |
Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence
|
|
CN115835904A
(zh)
|
2020-05-22 |
2023-03-21 |
武田药品工业有限公司 |
用于治疗和诊断冠状病毒疾病并发症的adamts13组合物和方法
|
|
AU2021327396A1
(en)
|
2020-08-20 |
2023-03-23 |
Ambrx, Inc. |
Antibody-TLR agonist conjugates, methods and uses thereof
|
|
TWI899326B
(zh)
*
|
2020-09-14 |
2025-10-01 |
美商蘇特羅生物製藥公司 |
使用無細胞蛋白質合成系統來大規模生產抗體之方法
|
|
JP2023545684A
(ja)
|
2020-09-30 |
2023-10-31 |
ベイジン キューエル バイオファーマシューティカル カンパニー,リミテッド |
ポリペプチドコンジュゲートおよび使用の方法
|
|
EP4313163A1
(en)
|
2021-04-03 |
2024-02-07 |
Ambrx, Inc. |
Anti-her2 antibody-drug conjugates and uses thereof
|
|
US20230016731A1
(en)
*
|
2021-05-21 |
2023-01-19 |
The Regents Of The University Of California |
Affinity purification sequencing
|
|
CA3222359A1
(en)
|
2021-07-09 |
2023-01-12 |
Bright Peak Therapeutics Ag |
Conjugates of checkpoint inhibitors with il-2, and uses thereof
|
|
AU2022307460A1
(en)
|
2021-07-09 |
2024-01-04 |
Bright Peak Therapeutics Ag |
Checkpoint inhibitors conjugated to il-2, and uses thereof
|
|
US20230201364A1
(en)
|
2021-07-09 |
2023-06-29 |
Bright Peak Therapeutics Ag |
Antibody conjugates and manufacture thereof
|
|
US20230303649A1
(en)
|
2021-07-09 |
2023-09-28 |
Bright Peak Therapeutics Ag |
Modified il-2 polypeptides for treatment of inflammatory and autoimmune diseases
|
|
US20230201365A1
(en)
|
2021-07-09 |
2023-06-29 |
Bright Peak Therapeutics Ag |
Modified cd20 antibodies and uses thereof
|
|
CN118339280A
(zh)
|
2021-09-06 |
2024-07-12 |
维拉克萨生物技术有限责任公司 |
用于真核生物中遗传密码子扩展的新型氨酰tRNA合成酶变体
|
|
WO2023044431A2
(en)
*
|
2021-09-17 |
2023-03-23 |
Absci Corporation |
Composition of transfer rnas and use in production of proteins containing non-standard amino acids
|
|
US20240384267A1
(en)
|
2021-09-20 |
2024-11-21 |
The Broad Institute, Inc. |
Compositions and methods for multiplex decoding of quadruplet codons
|
|
IL312221A
(en)
|
2021-10-20 |
2024-06-01 |
Synthekine Inc |
Heterodimeric fc cytokines and uses thereof
|
|
WO2023081167A2
(en)
|
2021-11-02 |
2023-05-11 |
The Regents Of The University Of California |
P-selectin mutants and modulation of integrin-mediated signaling
|
|
DK4186529T3
(da)
|
2021-11-25 |
2025-08-25 |
Veraxa Biotech Gmbh |
Forbedrede antistof-payload-konjugater (apc) fremstillet ved stedspecifik konjugering ved hjælp af genetisk kodeudvidelse
|
|
KR20240105469A
(ko)
|
2021-11-25 |
2024-07-05 |
베락사 바이오테크 게엠베하 |
유전자 코드 확장을 이용하는 부위-특이적 접합에 의해 제조되는 개선된 항체-페이로드 접합체 (apc)
|
|
WO2023104941A1
(en)
|
2021-12-08 |
2023-06-15 |
European Molecular Biology Laboratory |
Hydrophilic tetrazine-functionalized payloads for preparation of targeting conjugates
|
|
US20250092106A1
(en)
|
2022-01-25 |
2025-03-20 |
The Regents Of The University Of California |
Vegf mutants and modulation of integrin-mediated signaling
|
|
EP4482531A1
(en)
|
2022-02-23 |
2025-01-01 |
Bright Peak Therapeutics AG |
Immune antigen specific il-18 immunocytokines and uses thereof
|
|
US20240132563A1
(en)
|
2022-02-23 |
2024-04-25 |
Bright Peak Therapeutics Ag |
Bifunctional cytokine compositions
|
|
EP4323413A4
(en)
|
2022-03-30 |
2025-10-15 |
Beijing Ql Biopharmaceutical Co Ltd |
LIQUID PHARMACEUTICAL COMPOSITIONS OF POLYPEPTIDE CONJUGATES AND METHODS OF USE THEREOF
|
|
EP4547284A1
(en)
|
2022-06-30 |
2025-05-07 |
Sutro Biopharma, Inc. |
Anti-ror1 antibodies and antibody conjugates, compositions comprising anti-ror1 antibodies or antibody conjugates, and methods of making and using anti-ror1 antibodies and antibody conjugates
|
|
CN116376851A
(zh)
*
|
2022-08-25 |
2023-07-04 |
凯莱英医药集团(天津)股份有限公司 |
氨酰tRNA合酶突变体及其应用
|
|
NL2033185B1
(en)
|
2022-09-29 |
2024-04-08 |
Stichting Vu |
Compounds for rna stabilisation and delivery
|
|
CN120344270A
(zh)
|
2022-10-07 |
2025-07-18 |
Ambrx 公司 |
药物接头及其抗体缀合物
|
|
WO2024091824A1
(en)
|
2022-10-26 |
2024-05-02 |
Ada Forsyth Institute, Inc. |
Differentiation and reprogramming of chondrocyte
|
|
CN120380161A
(zh)
*
|
2022-12-31 |
2025-07-25 |
康码(上海)生物科技有限公司 |
一种用于插入非天然氨基酸的体外无细胞蛋白质合成体系、方法及应用
|
|
WO2024150175A1
(en)
|
2023-01-11 |
2024-07-18 |
Bright Peak Therapeutics Ag |
Conditionally activated proteins and methods of use
|
|
KR20250134670A
(ko)
|
2023-01-16 |
2025-09-11 |
암브룩스, 인코포레이티드 |
항-cd70 항체-약물 접합체
|
|
WO2024178310A1
(en)
|
2023-02-23 |
2024-08-29 |
Ambrx, Inc. |
Trop2-directed antibody-drug conjugates and uses thereof
|
|
WO2024211306A1
(en)
|
2023-04-03 |
2024-10-10 |
Sutro Biopharma, Inc. |
Rf1 ko e. coli strains
|
|
AR131133A1
(es)
|
2023-05-24 |
2025-02-19 |
Ambrx Inc |
INTERFERÓN l BOVINO PEGILADO Y MÉTODOS DE USO DEL MISMO
|
|
CN121646574A
(zh)
|
2023-07-27 |
2026-03-10 |
维拉克萨生物技术有限责任公司 |
亲水性反式环辛烯(hyTCO)化合物、含有该化合物的构建体和缀合物
|
|
WO2025041055A1
(en)
|
2023-08-22 |
2025-02-27 |
Ambrx, Inc. |
Anti-psma adc conjugate compositions and methods of use thereof
|
|
US20250197467A1
(en)
|
2023-08-23 |
2025-06-19 |
Bright Peak Therapeutics Ag |
Activatable il-18 immunocytokines and uses thereof
|
|
WO2025041102A1
(en)
|
2023-08-23 |
2025-02-27 |
Bright Peak Therapeutics Ag |
Targeted immune activation with il-18 immunocytokines
|
|
US12540197B2
(en)
|
2023-10-13 |
2026-02-03 |
Sutro Biopharma, Inc. |
Anti-tissue factor antibodies and antibody conjugates, compositions comprising anti-tissue factor antibodies or antibody conjugates, and methods of making and using anti-tissue factor antibodies and antibody conjugates
|
|
WO2025080711A1
(en)
|
2023-10-13 |
2025-04-17 |
Sutro Biopharma, Inc. |
Dual payload antibody drug conjugates
|
|
WO2025176699A1
(en)
|
2024-02-20 |
2025-08-28 |
LenioBio GmbH |
A system and method for cell-free unnatural amino acid incorporation
|
|
WO2025184315A1
(en)
|
2024-02-29 |
2025-09-04 |
Amgen Inc. |
Glucagon receptor agonists, conjugated to glucose-dependent insulinotropic polypeptide antibodies
|
|
WO2025199030A1
(en)
|
2024-03-18 |
2025-09-25 |
Amgen Inc. |
Glp-1 receptor agonists and their medical use
|
|
EP4644408A1
(en)
|
2024-04-19 |
2025-11-05 |
The Chinese University of Hong Kong Office of Research and Knowledge Transfer Services (ORKTS) |
Polyethylenimine-modified cry proteins and their use
|
|
WO2025257695A1
(en)
|
2024-06-10 |
2025-12-18 |
Università Degli Studi Di Torino |
Growth factor-free stem cell expansion and differentiation
|
|
WO2025257694A1
(en)
|
2024-06-10 |
2025-12-18 |
Università Degli Studi Di Torino |
Cell differentiation through multimodal tuning of gene expression
|
|
WO2026043823A2
(en)
|
2024-08-19 |
2026-02-26 |
Sutro Biopharma, Inc. |
Antibodies comprising site-specific non-natural amino acid residues, methods of preparation and uses thereof
|