DK3269809T3 - MODIFICERET AMINOACYL-tRNA-SYNTETASE OG ANVENDELSE DERAF - Google Patents

MODIFICERET AMINOACYL-tRNA-SYNTETASE OG ANVENDELSE DERAF Download PDF

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Publication number
DK3269809T3
DK3269809T3 DK16764874.0T DK16764874T DK3269809T3 DK 3269809 T3 DK3269809 T3 DK 3269809T3 DK 16764874 T DK16764874 T DK 16764874T DK 3269809 T3 DK3269809 T3 DK 3269809T3
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Denmark
Prior art keywords
trna synthetase
modified aminoacyl
aminoacyl
modified
trna
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DK16764874.0T
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English (en)
Inventor
Atsushi Ohta
Yusuke Yamagishi
Atsushi Matsuo
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Chugai Pharmaceutical Co Ltd
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Publication of DK3269809T3 publication Critical patent/DK3269809T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
DK16764874.0T 2015-03-13 2016-03-11 MODIFICERET AMINOACYL-tRNA-SYNTETASE OG ANVENDELSE DERAF DK3269809T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2015051202 2015-03-13
PCT/JP2016/057707 WO2016148044A1 (ja) 2015-03-13 2016-03-11 改変アミノアシルｔＲＮＡ合成酵素およびその用途

Publications (1)

Publication Number Publication Date
DK3269809T3 true DK3269809T3 (da) 2022-09-12

Family

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Family Applications (1)

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DK16764874.0T DK3269809T3 (da) 2015-03-13 2016-03-11 MODIFICERET AMINOACYL-tRNA-SYNTETASE OG ANVENDELSE DERAF

Country Status (6)

Country Link
US (2) US10815489B2 (da)
EP (2) EP3269809B1 (da)
JP (3) JP7020910B2 (da)
DK (1) DK3269809T3 (da)
HU (1) HUE059925T2 (da)
WO (1) WO2016148044A1 (da)

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JP7232758B2 (ja) 2017-06-09 2023-03-06 中外製薬株式会社 膜透過性の高い環状ペプチド化合物、及びこれを含むライブラリ
KR20230169447A (ko) 2017-06-09 2023-12-15 추가이 세이야쿠 가부시키가이샤 N-치환 아미노산을 포함하는 펩타이드의 합성 방법
US11492369B2 (en) 2017-12-15 2022-11-08 Chugai Seiyaku Kabushiki Kaisha Method for producing peptide, and method for processing bases
US20220002719A1 (en) * 2018-04-03 2022-01-06 The University Of Queensland Oligonucleotide-mediated sense codon reassignment
CN113056475A (zh) 2018-11-30 2021-06-29 中外制药株式会社 用于肽化合物或酰胺化合物的脱保护方法和在固相反应中的树脂脱除方法以及用于生产肽化合物的方法
US20230096766A1 (en) 2018-12-12 2023-03-30 Chugai Seiyaku Kabushiki Kaisha Amino acid having functional group capable of intermolecular hydrogen bonding, peptide compound containing same and method for production thereof
US20220325269A1 (en) * 2019-08-08 2022-10-13 Brickbio, Inc. Aminoacyl-trna synthetases and cell lines for site-specific incorporation of unnatural amino acids
EP4074829A4 (en) 2019-12-12 2024-01-10 Chugai Pharmaceutical Co Ltd METHOD FOR PRODUCING PEPTIDE CONTAINING NON-NATURAL AMINO ACID
EP4257978A1 (en) 2020-12-25 2023-10-11 Chugai Seiyaku Kabushiki Kaisha Method for screening for candidate molecule capable of forming complex in conjunction with plurality of target molecules

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ATE529509T1 (de) 1997-01-21 2011-11-15 Gen Hospital Corp Selektion von proteinen unter verwendung von rna- protein-fusionen
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AR030558A1 (es) 2000-04-19 2003-08-27 Schering Corp COMPUESTOS MACROCICLICOS, QUE INCLUYEN ENANTIOMEROS, ESTEROISOMEROS, ROTAMEROS Y TAUTOMEROS, SALES Y SOLVATOS FARMACEUTICAMENTE ACEPTABLES, COMPOSICIoN FARMACEUTICA, UN METODO PARA SU PREPARACION Y EL USO DE DICHOS COMPUESTOS PARA LA ELABORACION DE UN MEDICAMENTO, INHIBIDORES DE LA SERINA PROTEASA,
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WO2012074130A1 (ja) 2010-12-03 2012-06-07 国立大学法人東京大学 ペプチドライブラリーの製造方法、ペプチドライブラリー、及びスクリーニング方法
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JP6357154B2 (ja) 2013-08-05 2018-07-11 国立大学法人 東京大学 荷電性非タンパク質性アミノ酸含有ペプチドの製造方法
US10919938B2 (en) 2014-06-06 2021-02-16 Technische Universität München Modified cyclopentapeptides and uses thereof
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US20190338050A1 (en) 2016-03-03 2019-11-07 Chugai Seiyaku Kabushiki8 Kaisha Production method for noncyclic peptide-nucleic acid complex having, at n-terminal, amino acid with thiol group near amino group, library thereof, and cyclic peptide-nucleic acid complex library derived from same
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JP7232758B2 (ja) 2017-06-09 2023-03-06 中外製薬株式会社 膜透過性の高い環状ペプチド化合物、及びこれを含むライブラリ
KR20230169447A (ko) 2017-06-09 2023-12-15 추가이 세이야쿠 가부시키가이샤 N-치환 아미노산을 포함하는 펩타이드의 합성 방법

Also Published As

Publication number Publication date
JP7020910B2 (ja) 2022-02-16
EP3269809A4 (en) 2018-12-05
EP3269809B1 (en) 2022-07-27
EP4166664A1 (en) 2023-04-19
US10815489B2 (en) 2020-10-27
JPWO2016148044A1 (ja) 2017-12-28
JP2022061999A (ja) 2022-04-19
HUE059925T2 (hu) 2023-01-28
US20210087572A1 (en) 2021-03-25
WO2016148044A1 (ja) 2016-09-22
JP2023116605A (ja) 2023-08-22
US20180127761A1 (en) 2018-05-10
JP7292442B2 (ja) 2023-06-16
EP3269809A1 (en) 2018-01-17

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