PE20171328A1 - Conjugados de acidos grasos y apelina sintetica con mayor vida media - Google Patents
Conjugados de acidos grasos y apelina sintetica con mayor vida mediaInfo
- Publication number
- PE20171328A1 PE20171328A1 PE2017001257A PE2017001257A PE20171328A1 PE 20171328 A1 PE20171328 A1 PE 20171328A1 PE 2017001257 A PE2017001257 A PE 2017001257A PE 2017001257 A PE2017001257 A PE 2017001257A PE 20171328 A1 PE20171328 A1 PE 20171328A1
- Authority
- PE
- Peru
- Prior art keywords
- conjugates
- heart failure
- fatty acid
- formula
- synthetic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Child & Adolescent Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
Abstract
La invencion proporciona un conjugado, o una sal farmaceuticamente aceptable del mismo, que comprende un polipeptido sintetico de Formula I: Q-R-P-R-L-C -H-K-G-P-(NIe)-C -F (I) o una amida o ester del mismo; y un acido graso seleccionado de: Formula I; en el que dicho acido graso esta unido covalentemente al extremo N-terminal del peptido a traves de una de sus funcionalidades de acido carboxilico, opcionalmente a traves de un enlazador de polietilenglicol; y en el que los dos aminoacidos de cisteina marcados con " " forman un enlace disulfuro entre las funcionalidades tiol de su cadena lateral. Los conjugados son agonistas del receptor APJ. La invencion tambien se refiere a un metodo para la fabrIcacion de los conjugados de la ·Invencion y sus usos terapeuticos, tales como el tratamiento o la prevencion de insuficiencia cardiaca aguda descompensada (ICAD), insuficiencia cardiaca cronica, hipertension pulmonar, fibrilacion atrial, sindrome de Brugada, taquicardia ventricular, aterosclerosis, hipertension, restenosis, enfermedades isquemicas cardiovasculares, cardiomiopatia, fibrosis cardiaca, arritmias, retencion de agua, diabetes (incluyendo diabetes gestacional), obesidad, enfermedad arterial periferica, accidentes cerebrovasculares, ataques isquemicos transitorios, lesiones cerebrales traumaticas, esclerosis lateral amiotrofica, quemaduras (incluyendo quemaduras de sol) y preeclampsia. La presente invencion proporciona ademas una combinacion de agentes farmacologicamente activos y una composicion farmaceutica
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562107040P | 2015-01-23 | 2015-01-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20171328A1 true PE20171328A1 (es) | 2017-09-12 |
Family
ID=55229773
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2017001257A PE20171328A1 (es) | 2015-01-23 | 2016-01-15 | Conjugados de acidos grasos y apelina sintetica con mayor vida media |
Country Status (22)
Country | Link |
---|---|
US (1) | US9931372B2 (es) |
EP (1) | EP3247405B1 (es) |
JP (1) | JP2018507187A (es) |
KR (1) | KR20170103970A (es) |
CN (1) | CN107406490A (es) |
AR (1) | AR104479A1 (es) |
AU (1) | AU2016209968B2 (es) |
BR (1) | BR112017014194A2 (es) |
CA (1) | CA2972871A1 (es) |
CO (1) | CO2017007244A2 (es) |
CR (1) | CR20170338A (es) |
CU (1) | CU20170093A7 (es) |
EA (1) | EA201791668A1 (es) |
IL (1) | IL253105A0 (es) |
MA (1) | MA41580A (es) |
MX (1) | MX2017009534A (es) |
PE (1) | PE20171328A1 (es) |
PH (1) | PH12017501112A1 (es) |
SG (1) | SG11201704758XA (es) |
TW (1) | TW201632197A (es) |
UY (1) | UY36523A (es) |
WO (1) | WO2016116842A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10588980B2 (en) | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
EP3684414A4 (en) * | 2017-09-19 | 2021-06-09 | Immunwork Inc. | PHARMACEUTICAL CONSTRUCTIONS WITH IMPROVED BINDING AFFINITY WITH ALBUMIN |
WO2019229242A1 (en) | 2018-05-31 | 2019-12-05 | Novo Nordisk A/S | Derivatives comprising an apelin analogue and uses thereof |
TW202304500A (zh) * | 2021-04-21 | 2023-02-01 | 瑞士商諾華公司 | 升糖素樣肽化合物 |
Family Cites Families (86)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2951135A1 (de) | 1979-12-19 | 1981-06-25 | Hoechst Ag, 6230 Frankfurt | Sulfonylharnstoffe, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung |
US4889861A (en) | 1982-12-21 | 1989-12-26 | Ciba-Geigy Corp. | Substituted imidazo[1,5-a]pyridine derivatives and other substituted bicyclic derivatives and their use as aromatase inhibitors |
US4617307A (en) | 1984-06-20 | 1986-10-14 | Ciba-Geigy Corporation | Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors |
DE3347565A1 (de) | 1983-12-30 | 1985-07-11 | Thomae Gmbh Dr K | Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
JPS6354321A (ja) | 1985-03-27 | 1988-03-08 | Ajinomoto Co Inc | 血糖降下剤 |
US5118666A (en) | 1986-05-05 | 1992-06-02 | The General Hospital Corporation | Insulinotropic hormone |
US5120712A (en) | 1986-05-05 | 1992-06-09 | The General Hospital Corporation | Insulinotropic hormone |
ATE164852T1 (de) | 1990-01-24 | 1998-04-15 | Douglas I Buckley | Glp-1-analoga verwendbar in der diabetesbehandlung |
AU654331B2 (en) | 1991-03-30 | 1994-11-03 | Kissei Pharmaceutical Co. Ltd. | Succinic acid compounds |
US5155100A (en) | 1991-05-01 | 1992-10-13 | Ciba-Geigy Corporation | Phosphono/biaryl substituted dipeptide derivatives |
RU2086544C1 (ru) | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
AU660930B2 (en) | 1991-06-21 | 1995-07-13 | Novo Nordisk A/S | (S)(+)-2-ethoxy-4-(N-(1-(2-piperidinophenyl)-3-methyl-1- butyl)aminocarbonylmethyl)benzoic acid |
JP2508949B2 (ja) | 1991-07-30 | 1996-06-19 | 味の素株式会社 | N−(トランス−4−イソプロピルシクロヘキシルカルボニル)−d−フェニルアラニンの結晶及びその製造法 |
EP0618803A4 (en) | 1991-12-19 | 1995-03-22 | Southwest Found Biomed Res | POLYPEPTIDE INHIBITING PROTEIN TRANSFER TO CHOLESTERYL ESTERS, ANTIBODIES AGAINST SYNTHETIC POLYPEPTIDE AND ANTI-ATHEROSCLEROSIS PROPHYLACTIC AND THERAPEUTIC TREATMENTS. |
WO1995004030A1 (en) * | 1993-08-02 | 1995-02-09 | Commonwealth Scientific And Industrial Research Organisation | Therapeutic compound - fatty acid conjugates |
IL111785A0 (en) | 1993-12-03 | 1995-01-24 | Ferring Bv | Dp-iv inhibitors and pharmaceutical compositions containing them |
US5705483A (en) | 1993-12-09 | 1998-01-06 | Eli Lilly And Company | Glucagon-like insulinotropic peptides, compositions and methods |
US5512549A (en) | 1994-10-18 | 1996-04-30 | Eli Lilly And Company | Glucagon-like insulinotropic peptide analogs, compositions, and methods of use |
TW313568B (es) | 1994-12-20 | 1997-08-21 | Hoffmann La Roche | |
DE19616486C5 (de) | 1996-04-25 | 2016-06-30 | Royalty Pharma Collection Trust | Verfahren zur Senkung des Blutglukosespiegels in Säugern |
TW492957B (en) | 1996-11-07 | 2002-07-01 | Novartis Ag | N-substituted 2-cyanopyrrolidnes |
ATE383424T1 (de) | 1997-12-24 | 2008-01-15 | Takeda Pharmaceutical | Polypeptide, deren herstellung und verwendung |
WO1999043357A1 (en) * | 1998-02-25 | 1999-09-02 | Micrologix Biotech Inc. | Indolicidin and cationic peptides conjugated with polymers |
US6197786B1 (en) | 1998-09-17 | 2001-03-06 | Pfizer Inc | 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines |
GT199900147A (es) | 1998-09-17 | 1999-09-06 | 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas. | |
CO5150173A1 (es) | 1998-12-10 | 2002-04-29 | Novartis Ag | Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv |
US6544974B2 (en) | 1999-09-23 | 2003-04-08 | G.D. Searle & Co. | (R)-chiral halogenated substituted fused heterocyclic amino compounds useful for inhibiting cholesteryl ester transfer protein activity |
AU2001242749A1 (en) | 2000-03-23 | 2001-10-03 | Takeda Chemical Industries Ltd. | Peptide derivative |
AU2001273938B2 (en) | 2000-04-12 | 2005-03-03 | Novartis Ag | Novel medical use of aldosterone synthase inhibitors alone or in combination with ati-receptor antagonists |
DK2128246T3 (da) | 2001-04-19 | 2014-05-12 | Univ California | Fremgangsmåder og sammensætninger til fremstilling af ortogonale tRNA-aminoacyl-tRNA-syntetasepar. |
KR100913714B1 (ko) | 2001-11-08 | 2009-08-24 | 패시트 바이오테크 코포레이션 | Igg 항체의 안정한 액상 약학 제형물 |
AU2003232941A1 (en) | 2002-06-07 | 2003-12-22 | Glaxo Group Limited | N-mercaptoacyl phenyalanine derivatives, process for their preparation, and pharmaceutical compositions containing them |
DE60307483T2 (de) | 2002-08-07 | 2007-07-05 | Novartis Ag | Organische verbindungen als mittel zur behandlung von aldosteronbedingten zuständen |
ATE398124T1 (de) | 2002-11-18 | 2008-07-15 | Novartis Pharma Gmbh | Imidazoä1,5üa pyridin-derivate und methoden zur behandlung von krankheiten in verbindung mit aldosteron |
WO2004078777A2 (en) * | 2003-03-04 | 2004-09-16 | Biorexis Pharmaceutical Corporation | Dipeptidyl-peptidase protected proteins |
ES2308477T3 (es) | 2004-03-26 | 2008-12-01 | Eli Lilly And Company | Compuestos para el tratamiento de la dislipidemia. |
UA90269C2 (ru) | 2004-04-02 | 2010-04-26 | Мицубиси Танабе Фарма Корпорейшн | Тетрагидрохинолиновые производные и способ их получения |
TW200616623A (en) | 2004-05-28 | 2006-06-01 | Speedel Experimenta Ag | Organic compounds |
TW200611898A (en) | 2004-05-28 | 2006-04-16 | Speedel Experimenta Ag | Organic compounds |
TW200608978A (en) | 2004-05-28 | 2006-03-16 | Speedel Experimenta Ag | Organic compounds |
WO2006005726A2 (en) | 2004-07-09 | 2006-01-19 | Speedel Experimenta Ag | Heterocyclic compounds |
TW200716634A (en) | 2005-05-31 | 2007-05-01 | Speedel Experimenta Ag | Heterocyclic spiro-compounds |
TW200716636A (en) | 2005-05-31 | 2007-05-01 | Speedel Experimenta Ag | Heterocyclic spiro-compounds |
TW200716105A (en) | 2005-05-31 | 2007-05-01 | Speedel Experimenta Ag | Imidazole compounds |
GT200600381A (es) | 2005-08-25 | 2007-03-28 | Compuestos organicos | |
US8673848B2 (en) | 2012-01-27 | 2014-03-18 | Novartis Ag | Synthetic apelin mimetics for the treatment of heart failure |
TW200804378A (en) | 2005-12-09 | 2008-01-16 | Speedel Experimenta Ag | Organic compounds |
DK1962886T4 (da) | 2005-12-20 | 2022-05-02 | Bristol Myers Squibb Co | Stabile proteinformuleringer |
WO2007116908A1 (ja) | 2006-04-04 | 2007-10-18 | Taiyo Nippon Sanso Corporation | メタン分離方法、メタン分離装置及びメタン利用システム |
TW200808813A (en) | 2006-04-12 | 2008-02-16 | Speedel Experimenta Ag | Imidazo compounds |
TW200808812A (en) | 2006-04-12 | 2008-02-16 | Speedel Experimenta Ag | Imidazo compounds |
US8232403B2 (en) | 2006-05-10 | 2012-07-31 | Novartis Ag | Bicyclic derivatives as CETP inhibitors |
EP1886695A1 (en) | 2006-06-27 | 2008-02-13 | Speedel Experimenta AG | Pharmaceutical combination of an aldosterone synthase inhibitor and a glucocorticoid receptor antagonist or a cortisol synthesis inhibitor or a corticotropin releasing factor antagonist |
KR101149274B1 (ko) | 2006-07-20 | 2012-05-29 | 노파르티스 아게 | Cετρ 억제제로서의 아미노-피페리딘 유도체 |
WO2008027284A1 (en) | 2006-08-25 | 2008-03-06 | Novartis Ag | Fused imidazole derivatives for the treatment of disorders mediated by aldosterone synthase and/or 11-beta-hydroxylase and/or aromatase |
US7825093B2 (en) * | 2006-10-25 | 2010-11-02 | Amgen Inc. | Methods of using OSK1 peptide analogs |
EP2121652A1 (en) | 2006-12-18 | 2009-11-25 | Novartis AG | 4-imidazolyl-1,2,3,4-tetrahydroquinoline derivatives and their use as aldosterone/11-beta-hydroxylase inhibitors |
JP2010513560A (ja) | 2006-12-18 | 2010-04-30 | ノバルティス アーゲー | 1−置換イミダゾール誘導体およびアルドステロン合成阻害剤としてのその使用 |
KR20090091817A (ko) | 2006-12-18 | 2009-08-28 | 노파르티스 아게 | 알도스테론 신타제 억제제로서의 이미다졸 |
AR066691A1 (es) | 2007-03-29 | 2009-09-09 | Speedel Experimenta Ag | Compuestos espiro heterociclicos derivados de imidazol. composiciones farmaceuticas. |
TWI448284B (zh) | 2007-04-24 | 2014-08-11 | Theravance Inc | 雙效抗高血壓劑 |
US7834041B2 (en) | 2007-09-07 | 2010-11-16 | Theravance, Inc. | Dual-acting antihypertensive agents |
PE20090982A1 (es) | 2007-11-05 | 2009-08-13 | Novartis Ag | Derivados de piperidina como inhibidores de la proteina de transferencia de colesteril-ester (cetp) |
EP2229356B1 (en) | 2007-12-03 | 2011-10-12 | Novartis AG | 1,2-disubstituted-4-benzylamino-pyrrolidine derivatives as cetp inhibitors useful for the treatment of diseases such as hyperli pidemia or arteriosclerosis |
JP2011518884A (ja) | 2008-04-29 | 2011-06-30 | セラヴァンス, インコーポレーテッド | 二重活性抗高血圧剤 |
AR072297A1 (es) | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
CN102112157B (zh) * | 2008-08-06 | 2013-05-29 | 诺沃-诺迪斯克保健股份有限公司 | 具有延长的体内效能的缀合蛋白 |
KR101316159B1 (ko) | 2008-10-24 | 2013-10-15 | 아이알엠 엘엘씨 | 생합성적으로 생성된 피롤린-카르복시-리신, 및 피롤린-카르복시-리신 및 피롤리신 잔기의 화학적 유도체화를 통한 부위 특이적 단백질 변형 |
CN102203117A (zh) * | 2008-11-04 | 2011-09-28 | 安科治疗公司 | Apj受体化合物 |
WO2010130796A1 (en) | 2009-05-15 | 2010-11-18 | Novartis Ag | Aryl pyridine as aldosterone synthase inhibitors |
EA201101672A1 (ru) | 2009-05-28 | 2012-06-29 | Новартис Аг | Замещенные производные аминомасляной кислоты в качестве ингибиторов неприлизина |
BRPI1011657A2 (pt) | 2009-05-28 | 2019-04-16 | Novartis Ag | derivados aminopropiônicos substituídos como inibidores de neprilisina |
US9345661B2 (en) | 2009-07-31 | 2016-05-24 | Genentech, Inc. | Subcutaneous anti-HER2 antibody formulations and uses thereof |
JO2967B1 (en) | 2009-11-20 | 2016-03-15 | نوفارتس ايه جي | Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors |
TWI508737B (zh) * | 2010-01-22 | 2015-11-21 | 諾佛 儂迪克股份有限公司 | 具有延長的活體內功效的生長激素 |
TW201138808A (en) | 2010-05-03 | 2011-11-16 | Bristol Myers Squibb Co | Serum albumin binding molecules |
CA2797089A1 (en) | 2010-05-13 | 2011-11-17 | Indiana University Research And Technology Corporation | Glucagon superfamily peptides exhibiting g protein-coupled receptor activity |
US20140142049A1 (en) | 2011-03-11 | 2014-05-22 | Zhiqiang Jia | Pegylated apelin and uses thereof |
CA2860740A1 (en) * | 2012-01-09 | 2013-07-18 | Anchor Therapeutics, Inc. | Apj receptor compounds |
ES2875957T3 (es) | 2012-12-20 | 2021-11-11 | Amgen Inc | Agonistas del receptor APJ y usos de los mismos |
AU2014236451B2 (en) | 2013-03-14 | 2018-08-09 | Regeneron Pharmaceuticals, Inc. | Apelin fusion proteins and uses thereof |
MX2016001020A (es) * | 2013-07-25 | 2016-08-03 | Novartis Ag | Polipeptidos ciclicos para el tratamiento de insuficiencia cardiaca. |
US9340582B2 (en) * | 2013-07-25 | 2016-05-17 | Novartis Ag | Bioconjugates of synthetic apelin polypeptides |
CA2951391C (en) | 2014-06-10 | 2021-11-02 | Amgen Inc. | Apelin polypeptides |
US10588980B2 (en) * | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
WO2016102648A1 (en) | 2014-12-23 | 2016-06-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Metabolically stable apelin analogs in the treatment of disease mediated by the apelin receptor |
-
2016
- 2016-01-15 AU AU2016209968A patent/AU2016209968B2/en not_active Ceased
- 2016-01-15 CN CN201680006640.0A patent/CN107406490A/zh active Pending
- 2016-01-15 SG SG11201704758XA patent/SG11201704758XA/en unknown
- 2016-01-15 EP EP16701560.1A patent/EP3247405B1/en active Active
- 2016-01-15 PE PE2017001257A patent/PE20171328A1/es not_active Application Discontinuation
- 2016-01-15 MA MA041580A patent/MA41580A/fr unknown
- 2016-01-15 JP JP2017538728A patent/JP2018507187A/ja active Pending
- 2016-01-15 EA EA201791668A patent/EA201791668A1/ru unknown
- 2016-01-15 WO PCT/IB2016/050206 patent/WO2016116842A1/en active Application Filing
- 2016-01-15 KR KR1020177022999A patent/KR20170103970A/ko unknown
- 2016-01-15 BR BR112017014194A patent/BR112017014194A2/pt not_active IP Right Cessation
- 2016-01-15 CR CR20170338A patent/CR20170338A/es unknown
- 2016-01-15 MX MX2017009534A patent/MX2017009534A/es unknown
- 2016-01-15 US US14/996,418 patent/US9931372B2/en active Active
- 2016-01-15 CU CUP2017000093A patent/CU20170093A7/es unknown
- 2016-01-15 CA CA2972871A patent/CA2972871A1/en not_active Abandoned
- 2016-01-20 UY UY0001036523A patent/UY36523A/es not_active Application Discontinuation
- 2016-01-22 TW TW105102112A patent/TW201632197A/zh unknown
- 2016-01-22 AR ARP160100180A patent/AR104479A1/es unknown
-
2017
- 2017-06-15 PH PH12017501112A patent/PH12017501112A1/en unknown
- 2017-06-22 IL IL253105A patent/IL253105A0/en unknown
- 2017-07-19 CO CONC2017/0007244A patent/CO2017007244A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
CU20170093A7 (es) | 2017-09-06 |
MX2017009534A (es) | 2018-04-10 |
MA41580A (fr) | 2017-11-29 |
AR104479A1 (es) | 2017-07-26 |
PH12017501112A1 (en) | 2017-11-27 |
JP2018507187A (ja) | 2018-03-15 |
BR112017014194A2 (pt) | 2018-01-09 |
WO2016116842A1 (en) | 2016-07-28 |
KR20170103970A (ko) | 2017-09-13 |
EA201791668A1 (ru) | 2017-11-30 |
WO2016116842A9 (en) | 2016-12-08 |
SG11201704758XA (en) | 2017-08-30 |
CA2972871A1 (en) | 2016-07-28 |
AU2016209968A1 (en) | 2017-07-20 |
AU2016209968B2 (en) | 2018-11-29 |
EP3247405A1 (en) | 2017-11-29 |
UY36523A (es) | 2016-08-31 |
EP3247405B1 (en) | 2019-07-17 |
US20160213743A1 (en) | 2016-07-28 |
IL253105A0 (en) | 2017-08-31 |
CN107406490A (zh) | 2017-11-28 |
TW201632197A (zh) | 2016-09-16 |
US9931372B2 (en) | 2018-04-03 |
CR20170338A (es) | 2017-09-12 |
CO2017007244A2 (es) | 2017-10-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CU20140097A7 (es) | Miméticos de apelina sintéticos para el tratamiento de insuficiencia | |
BR112016001376A2 (pt) | bioconjugados de polipeptídeos de apelin sintéticos | |
CU20160013A7 (es) | Polipéptidos cíclicos para el tratamiento de la insuficiencia cardíaca | |
PE20171328A1 (es) | Conjugados de acidos grasos y apelina sintetica con mayor vida media | |
UY35144A (es) | Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca | |
CY1123307T1 (el) | Πρωτεϊνες συγχωνευσης fgf21 μακρας δρασης και φαρμακευτικες συνθεσεις που τις περιλαμβανουν | |
JP2016527249A5 (es) | ||
NZ704604A (en) | Nep inhibitors for treating diseases characterized by atrial enlargement or remodeling | |
Alfieri et al. | Angiopoietin-1 regulates microvascular reactivity and protects the microcirculation during acute endothelial dysfunction: role of eNOS and VE-cadherin | |
UY33288A (es) | Derivados de indolina inhibidores de la proteina quinasa r del reticulo endoplasmatico | |
AR079706A1 (es) | Composiciones, metodos para el tratamiento de enfermedades oculares relacionadas con la angiogenesis y uso | |
JP2021169531A (ja) | 炎症を処置するための化合物および方法 | |
JP2018507187A5 (es) | ||
WO2016084935A1 (ja) | Iii型コラーゲン産生促進剤 | |
AR059980A1 (es) | Metodos de tratamiento con inhibidores de la proteina de transferencia de ester de colesterol (cetp) | |
TN2016000029A1 (en) | Bioconjugates of synthetic apelin polypeptides | |
JP2017502089A5 (es) | ||
CA3049727A1 (en) | An agent for promoting angiogenesis and methods and uses thereof | |
US20180271820A1 (en) | Methods of treating heart failure | |
JP2014524435A5 (es) | ||
ECSP993240A (es) | Preparaciones de combinacion farmaceutica |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application declared void or lapsed |