ATE383424T1 - Polypeptide, deren herstellung und verwendung - Google Patents

Polypeptide, deren herstellung und verwendung

Info

Publication number
ATE383424T1
ATE383424T1 AT98961474T AT98961474T ATE383424T1 AT E383424 T1 ATE383424 T1 AT E383424T1 AT 98961474 T AT98961474 T AT 98961474T AT 98961474 T AT98961474 T AT 98961474T AT E383424 T1 ATE383424 T1 AT E383424T1
Authority
AT
Austria
Prior art keywords
function
polypeptides
production
aids
diseases
Prior art date
Application number
AT98961474T
Other languages
English (en)
Inventor
Shuji Hinuma
Kazuhiko Tatemoto
Masaki Hosoya
Yugo Habata
Ryo Fujii
Chieko Kitada
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Application granted granted Critical
Publication of ATE383424T1 publication Critical patent/ATE383424T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT98961474T 1997-12-24 1998-12-22 Polypeptide, deren herstellung und verwendung ATE383424T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP35395597 1997-12-24
JP3257798 1998-02-16
JP22085398 1998-08-04
JP27164598 1998-09-25

Publications (1)

Publication Number Publication Date
ATE383424T1 true ATE383424T1 (de) 2008-01-15

Family

ID=27459639

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98961474T ATE383424T1 (de) 1997-12-24 1998-12-22 Polypeptide, deren herstellung und verwendung

Country Status (9)

Country Link
US (3) US6492324B1 (de)
EP (1) EP1040189B1 (de)
KR (1) KR20010033601A (de)
CN (1) CN1283228A (de)
AT (1) ATE383424T1 (de)
AU (1) AU1685499A (de)
CA (1) CA2313246A1 (de)
DE (1) DE69838986T2 (de)
WO (1) WO1999033976A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2378977T3 (es) * 1998-03-13 2012-04-19 Brown University Research Foundation Isoforma del canal de calcio del tipo N humano y usos de la misma
AU5759399A (en) * 1998-09-25 2000-04-17 Takeda Chemical Industries Ltd. Peptide derivative
EP1138772A4 (de) * 1998-12-11 2005-04-06 Takeda Chemical Industries Ltd Verfahren zur herstellung von apelin
KR20020081466A (ko) * 2000-03-23 2002-10-26 다케다 야쿠힌 고교 가부시키가이샤 펩티드 유도체
DE10138569A1 (de) * 2001-08-06 2003-04-30 Bayer Ag Regulation des APJ-Rezeptors
WO2003063892A1 (en) * 2002-01-29 2003-08-07 Takeda Chemical Industries, Ltd. Use of apelin
WO2004061085A2 (en) 2002-12-30 2004-07-22 The Regents Of The University Of California Methods and apparatus for pathogen detection and analysis
EP1598369B1 (de) * 2003-02-28 2010-12-08 Takeda Pharmaceutical Company Limited Anti tgr23-2 ligand antikörper und deren verwendungen
EP1613348B1 (de) * 2003-03-12 2010-06-23 The Arizona Board of Regents on Behalf of the University of Arizona Verfahren zur regulierung von angiogenese mit apelin-zusammensetzungen
US7947280B2 (en) * 2003-05-22 2011-05-24 The Board Of Trustees Of The Leland Stanford Junior University Apelin and uses thereof
WO2006019193A1 (ja) * 2004-08-20 2006-02-23 Takeda Pharmaceutical Company Limited 阻害剤・促進剤の用途
WO2006023893A2 (en) * 2004-08-23 2006-03-02 Arizona Board Of Regents On Behalf Of The University Of Arizona Methods for modulating angiogenesis and apoptosis with apelin compositions
US8673848B2 (en) 2012-01-27 2014-03-18 Novartis Ag Synthetic apelin mimetics for the treatment of heart failure
WO2007072980A1 (ja) 2005-12-20 2007-06-28 Takeda Pharmaceutical Company Limited アペリンの新規用途
WO2007123233A1 (ja) 2006-04-25 2007-11-01 Kyushu University, National University Corporation 動脈硬化性疾患関連遺伝子、およびその利用
EP2187910A2 (de) * 2007-09-11 2010-05-26 Mondobiotech Laboratories AG Verwendung von band 3 protein (824-829) und/oder melanozyten-stimulierendem hormonfreisetzungs, hemmendem faktor als therapeutisches mittel bei der behandlung von infektionen mit pseudomonas aeruginosa
US8946382B2 (en) * 2009-02-27 2015-02-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Apelin peptides and methods of use
GB201012603D0 (en) * 2010-07-27 2010-09-08 Ucb Pharma Sa Protein purification
WO2013050441A1 (en) 2011-10-05 2013-04-11 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical composition for inhibiting or preventing platelet aggregation
WO2013079487A1 (en) 2011-11-28 2013-06-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Pharmaceutical composition for use in the treatment of dysfunction associated with aging
US8921307B2 (en) 2012-11-20 2014-12-30 Novartis Ag Synthetic linear apelin mimetics for the treatment of heart failure
UY35144A (es) 2012-11-20 2014-06-30 Novartis Ag Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
JP6525951B2 (ja) * 2013-03-14 2019-06-05 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． アペリン融合タンパク質およびその使用
PE20160991A1 (es) 2013-07-25 2016-10-15 Novartis Ag Bioconjugados de polipeptidos de apelina sintetica
TW201536814A (zh) 2013-07-25 2015-10-01 Novartis Ag 用於治療心臟衰竭之合成環狀多肽
EA201691027A1 (ru) 2013-11-20 2016-12-30 Ридженерон Фармасьютикалз, Инк. Модуляторы aplnr и их применение
CN112851790A (zh) 2014-06-23 2021-05-28 诺华股份有限公司 位点特异性蛋白质修饰
US10588980B2 (en) 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules
US10463716B2 (en) 2014-10-13 2019-11-05 University Of Maryland, Baltimore Methods for treating cardiovascular dysfunction and improving fluid homeostasis with Elabela peptide hormone
WO2016116842A1 (en) 2015-01-23 2016-07-28 Novartis Ag Synthetic apelin fatty acid conjugates with improved half-life
ES2805743T3 (es) 2015-03-24 2021-02-15 Inst Nat Sante Rech Med Método y composición farmacéutica para uso en el tratamiento de la diabetes
EP3416688B1 (de) 2016-02-15 2022-08-17 INSERM - Institut National de la Santé et de la Recherche Médicale Apelin zur verwendung bei der behandlung von postoperativer kognitiver dysfunktion
EP3228630A1 (de) 2016-04-07 2017-10-11 IMBA-Institut für Molekulare Biotechnologie GmbH Kombination eines apelin-antagonisten und angiogeneseinhibitor zur behandlung von krebs
CN108376608B (zh) * 2018-02-10 2020-11-06 青岛大学 一种磁性纳米粒子及其制备磁性固相载体的用途
CN110655577A (zh) 2018-06-13 2020-01-07 鸿运华宁（杭州）生物医药有限公司 APJ抗体及其与Elabela的融合蛋白质，以及其药物组合物和应用
CN109575117B (zh) * 2018-12-14 2021-09-21 昆明积大制药股份有限公司 [Pyr1]-apelin-13的制备方法
WO2024023034A1 (en) 2022-07-25 2024-02-01 Institut National de la Santé et de la Recherche Médicale Use of apelin for the treatment of lymphedema
CN115920057A (zh) * 2023-01-03 2023-04-07 中国科学院合肥物质科学研究院 靶向aplnr蛋白棕榈酰化修饰的多肽及其在癌痛治疗中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5759804A (en) * 1992-11-17 1998-06-02 Icos Corporation Isolated nucleic acid encoding seven transmembrane receptors
CA2232733A1 (en) * 1995-09-20 1997-03-27 Orikkalapat Prem Das Yeast receptor and g-protein fusion protein

Also Published As

Publication number Publication date
US20030092618A1 (en) 2003-05-15
EP1040189A1 (de) 2000-10-04
EP1040189B1 (de) 2008-01-09
WO1999033976A1 (en) 1999-07-08
DE69838986T2 (de) 2009-01-08
US6492324B1 (en) 2002-12-10
US7799533B2 (en) 2010-09-21
US20090075334A1 (en) 2009-03-19
DE69838986D1 (de) 2008-02-21
CN1283228A (zh) 2001-02-07
US7410776B2 (en) 2008-08-12
CA2313246A1 (en) 1999-07-08
KR20010033601A (ko) 2001-04-25
AU1685499A (en) 1999-07-19

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