ATE383424T1 - POLYPEPTIDES, THEIR PRODUCTION AND USE - Google Patents

POLYPEPTIDES, THEIR PRODUCTION AND USE

Info

Publication number
ATE383424T1
ATE383424T1 AT98961474T AT98961474T ATE383424T1 AT E383424 T1 ATE383424 T1 AT E383424T1 AT 98961474 T AT98961474 T AT 98961474T AT 98961474 T AT98961474 T AT 98961474T AT E383424 T1 ATE383424 T1 AT E383424T1
Authority
AT
Austria
Prior art keywords
function
polypeptides
production
aids
diseases
Prior art date
Application number
AT98961474T
Other languages
German (de)
Inventor
Shuji Hinuma
Kazuhiko Tatemoto
Masaki Hosoya
Yugo Habata
Ryo Fujii
Chieko Kitada
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Application granted granted Critical
Publication of ATE383424T1 publication Critical patent/ATE383424T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

This invention relates to a novel polypeptide involving in the modulation of central nervous system function, circulatory function, immune function, gastrointestinal function, metabolic function, reproductive function, etc., it can be used as a drug for treating or preventing a variety of diseases, e.g. HIV infection or AIDS (acquired immune deficiency syndrome) or the like.
AT98961474T 1997-12-24 1998-12-22 POLYPEPTIDES, THEIR PRODUCTION AND USE ATE383424T1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP35395597 1997-12-24
JP3257798 1998-02-16
JP22085398 1998-08-04
JP27164598 1998-09-25

Publications (1)

Publication Number Publication Date
ATE383424T1 true ATE383424T1 (en) 2008-01-15

Family

ID=27459639

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98961474T ATE383424T1 (en) 1997-12-24 1998-12-22 POLYPEPTIDES, THEIR PRODUCTION AND USE

Country Status (9)

Country Link
US (3) US6492324B1 (en)
EP (1) EP1040189B1 (en)
KR (1) KR20010033601A (en)
CN (1) CN1283228A (en)
AT (1) ATE383424T1 (en)
AU (1) AU1685499A (en)
CA (1) CA2313246A1 (en)
DE (1) DE69838986T2 (en)
WO (1) WO1999033976A1 (en)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999046383A1 (en) * 1998-03-13 1999-09-16 Brown University Research Foundation Human n-type calcium channel isoform and uses thereof
AU5759399A (en) * 1998-09-25 2000-04-17 Takeda Chemical Industries Ltd. Peptide derivative
EP1138772A4 (en) * 1998-12-11 2005-04-06 Takeda Chemical Industries Ltd Process for producing apelin
CN1419563A (en) * 2000-03-23 2003-05-21 武田药品工业株式会社 Peptide derivative
DE10138569A1 (en) * 2001-08-06 2003-04-30 Bayer Ag Regulation of the APJ receptor
WO2003063892A1 (en) * 2002-01-29 2003-08-07 Takeda Chemical Industries, Ltd. Use of apelin
EP2404676A1 (en) 2002-12-30 2012-01-11 The Regents of the University of California Microfluidic Control Structures
DE602004030425D1 (en) 2003-02-28 2011-01-20 Takeda Pharmaceutical ANTI TGR23-2 LIGAND ANTIBODIES AND THEIR USES
ATE471722T1 (en) * 2003-03-12 2010-07-15 Univ Arizona State METHOD FOR REGULATING ANGIOGENESIS USING APELIN COMPOSITIONS
US7947280B2 (en) * 2003-05-22 2011-05-24 The Board Of Trustees Of The Leland Stanford Junior University Apelin and uses thereof
WO2006019193A1 (en) * 2004-08-20 2006-02-23 Takeda Pharmaceutical Company Limited Use of inhibitor and promoter
US20060045880A1 (en) * 2004-08-23 2006-03-02 Krieg Paul A Methods for modulating angiogenesis and apoptosis with apelin compositions
US8673848B2 (en) 2012-01-27 2014-03-18 Novartis Ag Synthetic apelin mimetics for the treatment of heart failure
CA2634363A1 (en) 2005-12-20 2007-06-28 Takeda Pharmaceutical Company Limited Novel application of apelin
US20090324610A1 (en) * 2006-04-25 2009-12-31 Kyushu Univeristy, National University Corporation Gene associated with arteriosclerotic disease, and use thereof
WO2009033740A2 (en) * 2007-09-11 2009-03-19 Mondobiotech Laboratories Ag Use of a peptide as a therapeutic agent
US8946382B2 (en) * 2009-02-27 2015-02-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Apelin peptides and methods of use
GB201012603D0 (en) * 2010-07-27 2010-09-08 Ucb Pharma Sa Protein purification
WO2013050441A1 (en) 2011-10-05 2013-04-11 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical composition for inhibiting or preventing platelet aggregation
JP6082402B2 (en) 2011-11-28 2017-02-15 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル Pharmaceutical composition for use in the treatment of dysfunction associated with aging
UY35144A (en) 2012-11-20 2014-06-30 Novartis Ag APELINE SYNTHETIC LINEAR MIMETICS FOR THE CARDIAC INSUFFICIENCY TREATMENT
US8921307B2 (en) 2012-11-20 2014-12-30 Novartis Ag Synthetic linear apelin mimetics for the treatment of heart failure
CN105026423A (en) 2013-03-14 2015-11-04 瑞泽恩制药公司 Apelin fusion proteins and uses thereof
TW201536814A (en) 2013-07-25 2015-10-01 Novartis Ag Synthetic cyclic polypeptides for the treatment of heart failure
MX2016001021A (en) 2013-07-25 2016-08-03 Novartis Ag Bioconjugates of synthetic apelin polypeptides.
US10155811B2 (en) 2013-11-20 2018-12-18 Regeneron Pharmaceuticals, Inc. APLNR modulators and uses thereof
US10588980B2 (en) 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules
SG11201609706VA (en) 2014-06-23 2017-01-27 Novartis Ag Site specific protein modifications
EP3206707B1 (en) 2014-10-13 2020-12-02 University of Maryland, Baltimore Fc-ela-32 and its use in the treatment of cardiac conditions
BR112017014194A2 (en) 2015-01-23 2018-01-09 Novartis Ag synthetic apelin fatty acid conjugates with improved half life
US10426818B2 (en) * 2015-03-24 2019-10-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Method and pharmaceutical composition for use in the treatment of diabetes
WO2017140684A2 (en) 2016-02-15 2017-08-24 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of post-operative cognitive dysfunction
EP3228630A1 (en) 2016-04-07 2017-10-11 IMBA-Institut für Molekulare Biotechnologie GmbH Combination of an apelin antagonist and an angiogenesis inhibitor for the treatment of cancer
CN108376608B (en) * 2018-02-10 2020-11-06 青岛大学 Magnetic nano particle and application thereof in preparing magnetic solid phase carrier
CN110655577A (en) * 2018-06-13 2020-01-07 鸿运华宁（杭州）生物医药有限公司 APJ antibody and fusion protein thereof with Elabela, and pharmaceutical composition and application thereof
CN109575117B (en) * 2018-12-14 2021-09-21 昆明积大制药股份有限公司 Preparation method of [ Pyr1] -apelin-13
WO2024023034A1 (en) 2022-07-25 2024-02-01 Institut National de la Santé et de la Recherche Médicale Use of apelin for the treatment of lymphedema

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2118372T3 (en) * 1992-11-17 1998-09-16 Icos Corp NEW RECEIVERS SEVEN TRANSMEMBRANA V28.
CA2232733A1 (en) * 1995-09-20 1997-03-27 Orikkalapat Prem Das Yeast receptor and g-protein fusion protein

Also Published As

Publication number Publication date
US7799533B2 (en) 2010-09-21
US20030092618A1 (en) 2003-05-15
US7410776B2 (en) 2008-08-12
US20090075334A1 (en) 2009-03-19
EP1040189B1 (en) 2008-01-09
WO1999033976A1 (en) 1999-07-08
CN1283228A (en) 2001-02-07
DE69838986D1 (en) 2008-02-21
KR20010033601A (en) 2001-04-25
EP1040189A1 (en) 2000-10-04
CA2313246A1 (en) 1999-07-08
DE69838986T2 (en) 2009-01-08
AU1685499A (en) 1999-07-19
US6492324B1 (en) 2002-12-10

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