|
AU719434B2
(en)
|
1996-02-13 |
2000-05-11 |
Astrazeneca Ab |
Quinazoline derivatives as VEGF inhibitors
|
|
GB9603095D0
(en)
|
1996-02-14 |
1996-04-10 |
Zeneca Ltd |
Quinazoline derivatives
|
|
ES2169355T3
(es)
|
1996-03-05 |
2002-07-01 |
Astrazeneca Ab |
Derivados de 4-anilinoquinazolina.
|
|
GB9707800D0
(en)
|
1996-05-06 |
1997-06-04 |
Zeneca Ltd |
Chemical compounds
|
|
HRP970371A2
(en)
|
1996-07-13 |
1998-08-31 |
Kathryn Jane Smith |
Heterocyclic compounds
|
|
CN1252054C
(zh)
|
1996-09-25 |
2006-04-19 |
曾尼卡有限公司 |
抑制生长因子的作用的喹啉衍生物
|
|
GB9718972D0
(en)
|
1996-09-25 |
1997-11-12 |
Zeneca Ltd |
Chemical compounds
|
|
US6294532B1
(en)
|
1997-08-22 |
2001-09-25 |
Zeneca Limited |
Oxindolylquinazoline derivatives as angiogenesis inhibitors
|
|
RS49779B
(sr)
*
|
1998-01-12 |
2008-06-05 |
Glaxo Group Limited, |
Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze
|
|
US6288082B1
(en)
|
1998-09-29 |
2001-09-11 |
American Cyanamid Company |
Substituted 3-cyanoquinolines
|
|
US6297258B1
(en)
|
1998-09-29 |
2001-10-02 |
American Cyanamid Company |
Substituted 3-cyanoquinolines
|
|
HU230728B1
(hu)
|
1998-09-29 |
2017-12-28 |
Wyeth Holdings Llc |
Szubsztituált 3-cianokinolinok mint protein tirozin kinázok inhibitorai
|
|
HK1039126B
(en)
*
|
1998-10-08 |
2005-09-30 |
阿斯特拉曾尼卡有限公司 |
Quinazoline derivatives
|
|
UA71945C2
(en)
*
|
1999-01-27 |
2005-01-17 |
Pfizer Prod Inc |
Substituted bicyclic derivatives being used as anticancer agents
|
|
JP3270834B2
(ja)
|
1999-01-27 |
2002-04-02 |
ファイザー・プロダクツ・インク |
抗がん剤として有用なヘテロ芳香族二環式誘導体
|
|
MXPA01008182A
(es)
|
1999-02-10 |
2003-08-20 |
Astrazeneca Ab |
Derivados de quinazolina como inhibidores de angiotensina.
|
|
GB9904103D0
(en)
|
1999-02-24 |
1999-04-14 |
Zeneca Ltd |
Quinoline derivatives
|
|
GB9910580D0
(en)
|
1999-05-08 |
1999-07-07 |
Zeneca Ltd |
Chemical compounds
|
|
GB9910579D0
(en)
|
1999-05-08 |
1999-07-07 |
Zeneca Ltd |
Chemical compounds
|
|
CA2383546A1
(en)
|
1999-06-30 |
2001-01-04 |
William H. Parsons |
Src kinase inhibitor compounds
|
|
EP1194152A4
(en)
|
1999-06-30 |
2002-11-06 |
Merck & Co Inc |
Links to SRC kinase inhibition
|
|
US6329380B1
(en)
|
1999-06-30 |
2001-12-11 |
Merck & Co., Inc. |
SRC kinase inhibitor compounds
|
|
JP2003504363A
(ja)
|
1999-07-09 |
2003-02-04 |
グラクソ グループ リミテッド |
プロテインチロシンキナーゼ阻害剤としてのアニリノキナゾリン類
|
|
US6933299B1
(en)
|
1999-07-09 |
2005-08-23 |
Smithkline Beecham Corporation |
Anilinoquinazolines as protein tyrosine kinase inhibitors
|
|
US6432979B1
(en)
|
1999-08-12 |
2002-08-13 |
American Cyanamid Company |
Method of treating or inhibiting colonic polyps and colorectal cancer
|
|
WO2002049993A2
(en)
*
|
2000-09-29 |
2002-06-27 |
Neurogen Corporation |
High affinity small molecule c5a receptor modulators
|
|
EP1676845B1
(en)
|
1999-11-05 |
2008-06-11 |
AstraZeneca AB |
New quinazoline derivatives
|
|
UA74803C2
(uk)
|
1999-11-11 |
2006-02-15 |
Осі Фармасьютікалз, Інк. |
Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
|
|
UA75055C2
(uk)
*
|
1999-11-30 |
2006-03-15 |
Пфайзер Продактс Інк. |
Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі
|
|
US6638929B2
(en)
|
1999-12-29 |
2003-10-28 |
Wyeth |
Tricyclic protein kinase inhibitors
|
|
GB0002952D0
(en)
*
|
2000-02-09 |
2000-03-29 |
Pharma Mar Sa |
Process for producing kahalalide F compounds
|
|
DK1274692T3
(da)
|
2000-04-07 |
2006-10-30 |
Astrazeneca Ab |
Quinazolinforbindelser
|
|
UA73993C2
(uk)
|
2000-06-06 |
2005-10-17 |
Астразенека Аб |
Хіназолінові похідні для лікування пухлин та фармацевтична композиція
|
|
MXPA02012681A
(es)
*
|
2000-06-30 |
2003-04-25 |
Glaxo Group Ltd |
Compuestos de sales de ditosilato de quinazolina.
|
|
WO2002012226A1
(en)
|
2000-08-09 |
2002-02-14 |
Astrazeneca Ab |
Quinoline derivatives having vegf inhibiting activity
|
|
CA2419301C
(en)
|
2000-08-21 |
2009-12-08 |
Astrazeneca Ab |
Quinazoline derivatives
|
|
US6660731B2
(en)
|
2000-09-15 |
2003-12-09 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
ES2242771T5
(es)
|
2000-09-15 |
2011-10-14 |
Vertex Pharmaceuticals Incorporated |
Compuestos de pirazol útiles como inhibidores de proteína quinasas.
|
|
US7473691B2
(en)
|
2000-09-15 |
2009-01-06 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
HUP0302221A3
(en)
*
|
2000-09-20 |
2004-01-28 |
Merck Patent Gmbh |
4-amino-quinazolines
|
|
EP1318985A2
(en)
*
|
2000-09-20 |
2003-06-18 |
MERCK PATENT GmbH |
4-amino-quinazolines
|
|
AU2001292138A1
(en)
|
2000-10-13 |
2002-04-22 |
Astrazeneca Ab |
Quinazoline derivatives with anti-tumour activity
|
|
AU2001292137A1
(en)
|
2000-10-13 |
2002-04-22 |
Astrazeneca Ab |
Quinazoline derivatives
|
|
DE60134679D1
(de)
|
2000-10-20 |
2008-08-14 |
Eisai R&D Man Co Ltd |
Stickstoff enthaltende aromatische Heterozyklen
|
|
WO2002036570A1
(en)
|
2000-11-02 |
2002-05-10 |
Astrazeneca Ab |
4-substituted quinolines as antitumor agents
|
|
JP2004514718A
(ja)
|
2000-11-02 |
2004-05-20 |
アストラゼネカ アクチボラグ |
抗癌剤としての置換キノリン類
|
|
CN102250071A
(zh)
|
2000-12-21 |
2011-11-23 |
沃泰克斯药物股份有限公司 |
可用作蛋白激酶抑制剂的吡唑化合物
|
|
SV2007000775A
(es)
|
2001-01-05 |
2007-03-15 |
Pfizer |
Anticuerpos contra el receptor del factor de crecimiento similar a insulina
|
|
JP4458746B2
(ja)
*
|
2001-01-16 |
2010-04-28 |
グラクソ グループ リミテッド |
癌の治療方法
|
|
DK1370553T3
(da)
*
|
2001-03-23 |
2006-09-11 |
Bayer Corp |
Rho-kinase-inhibitorer
|
|
AR035792A1
(es)
*
|
2001-03-23 |
2004-07-14 |
Bayer Corp |
Compuestos de n-(4-quinazolinil)-n-(1h-indazol-5-il) amina, inhibidor de la rho-quinasa, su uso para la fabricacion de un medicamento y metodo para prepararlo
|
|
WO2002085895A1
(en)
|
2001-04-19 |
2002-10-31 |
Astrazeneca Ab |
Quinazoline derivatives
|
|
GB0112834D0
(en)
|
2001-05-25 |
2001-07-18 |
Smithkline Beecham Plc |
Medicaments
|
|
GB0112836D0
(en)
|
2001-05-25 |
2001-07-18 |
Smithkline Beecham Plc |
Medicaments
|
|
WO2003000194A2
(en)
|
2001-06-21 |
2003-01-03 |
Pfizer Inc. |
Thienopyridine and thienopyrimidine anticancer agents
|
|
US7829566B2
(en)
*
|
2001-09-17 |
2010-11-09 |
Werner Mederski |
4-amino-quinazolines
|
|
ATE423104T1
(de)
*
|
2001-11-03 |
2009-03-15 |
Astrazeneca Ab |
Quinazolin derivate als antitumor-mittel
|
|
GB0126433D0
(en)
*
|
2001-11-03 |
2002-01-02 |
Astrazeneca Ab |
Compounds
|
|
AR039067A1
(es)
|
2001-11-09 |
2005-02-09 |
Pfizer Prod Inc |
Anticuerpos para cd40
|
|
WO2003050108A1
(en)
|
2001-12-12 |
2003-06-19 |
Pfizer Products Inc. |
Salt forms of e-2-methoxy-n-(3-(4-(3-methyl-pyridin-3-yloxy)-phenylamino)-quinazolin-6-yl)-allyl)-acetamide, its preparation and its use against cancer
|
|
US6797825B2
(en)
|
2001-12-13 |
2004-09-28 |
Abbott Laboratories |
Protein kinase inhibitors
|
|
US20030187026A1
(en)
|
2001-12-13 |
2003-10-02 |
Qun Li |
Kinase inhibitors
|
|
AU2003202263A1
(en)
*
|
2002-01-10 |
2003-07-30 |
Bayer Healthcare Ag |
Roh-kinase inhibitors
|
|
EP1471910A2
(en)
*
|
2002-01-17 |
2004-11-03 |
Neurogen Corporation |
Substituted quinazolin-4-ylamine analogues as modulators of capsaicin receptors
|
|
WO2003062225A1
(en)
|
2002-01-23 |
2003-07-31 |
Bayer Pharmaceuticals Corporation |
Pyrimidine derivatives as rho-kinase inhibitors
|
|
ES2298497T3
(es)
|
2002-01-23 |
2008-05-16 |
Bayer Pharmaceuticals Corporation |
Inhibidores de quinasa rho.
|
|
US7268230B2
(en)
|
2002-02-01 |
2007-09-11 |
Astrazeneca Ab |
Quinazoline compounds
|
|
US7645878B2
(en)
*
|
2002-03-22 |
2010-01-12 |
Bayer Healthcare Llc |
Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof
|
|
US6924285B2
(en)
|
2002-03-30 |
2005-08-02 |
Boehringer Ingelheim Pharma Gmbh & Co. |
Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
|
|
JP2005534623A
(ja)
*
|
2002-04-08 |
2005-11-17 |
スミスクライン ビーチャム コーポレーション |
Ｅｒｂファミリーの阻害剤並びにｒａｆ及び／又はｒａｓ阻害剤を投与することを含む癌の治療法
|
|
UA77303C2
(en)
|
2002-06-14 |
2006-11-15 |
Pfizer |
Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use
|
|
MY141867A
(en)
|
2002-06-20 |
2010-07-16 |
Vertex Pharma |
Substituted pyrimidines useful as protein kinase inhibitors
|
|
GB0215823D0
(en)
|
2002-07-09 |
2002-08-14 |
Astrazeneca Ab |
Quinazoline derivatives
|
|
JP2005536486A
(ja)
|
2002-07-09 |
2005-12-02 |
アストラゼネカ アクチボラグ |
癌の処置に使用するためのキナゾリン誘導体
|
|
EP1521747B1
(en)
*
|
2002-07-15 |
2018-09-05 |
Symphony Evolution, Inc. |
Receptor-type kinase modulators and methods of use
|
|
CA2494061C
(en)
*
|
2002-07-31 |
2011-06-14 |
Wayne R. Danter |
Protein tyrosine kinase inhibitors
|
|
AU2003257078B2
(en)
|
2002-08-02 |
2010-04-01 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compositions useful as inhibitors of GSK-3
|
|
AU2003273675A1
(en)
*
|
2002-10-09 |
2004-05-04 |
Wayne R. Danter |
Protein tyrosine kinase inhibitors
|
|
GB0304367D0
(en)
*
|
2003-02-26 |
2003-04-02 |
Pharma Mar Sau |
Methods for treating psoriasis
|
|
GB0225579D0
(en)
|
2002-11-02 |
2002-12-11 |
Astrazeneca Ab |
Chemical compounds
|
|
ES2300619T3
(es)
|
2002-11-04 |
2008-06-16 |
Astrazeneca Ab |
Derivados de quinolina como inhibidores de src tirosina quinasa.
|
|
US7488823B2
(en)
|
2003-11-10 |
2009-02-10 |
Array Biopharma, Inc. |
Cyanoguanidines and cyanoamidines as ErbB2 and EGFR inhibitors
|
|
TW200418480A
(en)
*
|
2002-12-13 |
2004-10-01 |
Neurogen Corp |
2-substituted quinazolin-4-ylamine analogues
|
|
SI1585743T1
(sl)
|
2002-12-19 |
2007-08-31 |
Pfizer |
Spojine 2-(1H-indazol-6-ilamino)-benzamida kot inhibitorji protein-kinaz, uporabnih pri zdravljenju očesnih bolezni
|
|
AU2003285614B2
(en)
|
2002-12-20 |
2009-05-14 |
Pfizer Products, Inc. |
Pyrimidine derivatives for the treatment of abnormal cell growth
|
|
CN103265477B
(zh)
|
2003-02-26 |
2017-01-11 |
苏根公司 |
作为蛋白激酶抑制剂的氨基杂芳基化合物
|
|
JP4960085B2
(ja)
*
|
2003-03-19 |
2012-06-27 |
エクセリクシス， インク． |
Ｔｉｅ−２モジュレータと使用方法
|
|
GB0309850D0
(en)
|
2003-04-30 |
2003-06-04 |
Astrazeneca Ab |
Quinazoline derivatives
|
|
TWI328009B
(en)
|
2003-05-21 |
2010-08-01 |
Glaxo Group Ltd |
Quinoline derivatives as phosphodiesterase inhibitors
|
|
US8309562B2
(en)
|
2003-07-03 |
2012-11-13 |
Myrexis, Inc. |
Compounds and therapeutical use thereof
|
|
AU2004253967B2
(en)
*
|
2003-07-03 |
2010-02-18 |
Cytovia, Inc. |
4-arylamino-quinazolines as activators of caspases and inducers of apoptosis
|
|
AR045037A1
(es)
|
2003-07-10 |
2005-10-12 |
Aventis Pharma Sa |
Tetrahidro-1h-pirazolo [3,4-c] piridinas sustituidas, composiciones que las contienen y su utilizacion.
|
|
TW200510373A
(en)
*
|
2003-07-14 |
2005-03-16 |
Neurogen Corp |
Substituted quinolin-4-ylamine analogues
|
|
US7329664B2
(en)
*
|
2003-07-16 |
2008-02-12 |
Neurogen Corporation |
Substituted (7-pyridyl-4-phenylamino-quinazolin-2-yl)-methanol analogues
|
|
EP1653986A4
(en)
*
|
2003-08-01 |
2007-03-14 |
Smithkline Beecham Corp |
TREATMENT OF P95 ERBB2 EXPRESSIVE CARCINOMA
|
|
HN2004000285A
(es)
|
2003-08-04 |
2006-04-27 |
Pfizer Prod Inc |
ANTICUERPOS DIRIGIDOS A c-MET
|
|
US7501427B2
(en)
|
2003-08-14 |
2009-03-10 |
Array Biopharma, Inc. |
Quinazoline analogs as receptor tyrosine kinase inhibitors
|
|
DK1660090T3
(da)
|
2003-08-14 |
2012-12-17 |
Array Biopharma Inc |
Quinazolin-analoger som receptor-tyrosinkinase-inhibitorer
|
|
ATE412655T1
(de)
|
2003-08-29 |
2008-11-15 |
Pfizer |
Als neue antiangiogene mittel geeignete thienopyridinphenylacetamide und derivate davon
|
|
CA2537883A1
(en)
*
|
2003-09-09 |
2005-03-17 |
Neurogen Corporation |
Substituted bicyclic quinazolin-4-ylamine derivatives
|
|
GB0321066D0
(en)
*
|
2003-09-09 |
2003-10-08 |
Pharma Mar Sau |
New antitumoral compounds
|
|
AR045563A1
(es)
|
2003-09-10 |
2005-11-02 |
Warner Lambert Co |
Anticuerpos dirigidos a m-csf
|
|
MXPA06002964A
(es)
|
2003-09-16 |
2006-06-14 |
Astrazeneca Ab |
Derivados de quinazolina como inhibidores de cinasa de tirosina.
|
|
GB0322409D0
(en)
|
2003-09-25 |
2003-10-29 |
Astrazeneca Ab |
Quinazoline derivatives
|
|
ES2925655T3
(es)
*
|
2003-09-26 |
2022-10-19 |
Exelixis Inc |
Moduladores c-Met y métodos de uso
|
|
JP4303726B2
(ja)
|
2003-11-11 |
2009-07-29 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
ウレア誘導体およびその製造方法
|
|
US7511065B2
(en)
*
|
2003-11-12 |
2009-03-31 |
Eli Lilly And Company |
Mixed lineage kinase modulators
|
|
GB0326459D0
(en)
|
2003-11-13 |
2003-12-17 |
Astrazeneca Ab |
Quinazoline derivatives
|
|
WO2005051919A1
(en)
*
|
2003-11-26 |
2005-06-09 |
Pfizer Products Inc. |
Aminopyrazole derivatives as gsk-3 inhibitors
|
|
GB0330002D0
(en)
|
2003-12-24 |
2004-01-28 |
Astrazeneca Ab |
Quinazoline derivatives
|
|
EP1713781B1
(en)
|
2004-02-03 |
2008-11-05 |
AstraZeneca AB |
Quinazoline derivatives
|
|
AP2204A
(en)
|
2004-05-06 |
2011-02-07 |
Warner Lambert Co |
4-phenylamino-quinazolin-6-yl-amides.
|
|
CA2569404A1
(en)
*
|
2004-06-04 |
2005-12-22 |
Amphora Discovery Corporation |
Quinoline- and isoquinoline-based compounds exhibiting atp-utilizing enzyme inhibitory activity, and compositions, and uses thereof
|
|
CN101014365B
(zh)
|
2004-07-16 |
2011-04-13 |
辉瑞产品公司 |
使用抗-igf-1r抗体联合治疗非血液的恶性肿瘤
|
|
PL1786785T3
(pl)
|
2004-08-26 |
2010-08-31 |
Pfizer |
Enancjomerycznie czyste związki aminoheteroarylowe jako kinazy białkowe
|
|
WO2006031929A2
(en)
|
2004-09-15 |
2006-03-23 |
Janssen Pharmaceutica, N.V. |
Thiazolopyridine kinase inhibitors
|
|
ES2322175T3
(es)
|
2004-09-17 |
2009-06-17 |
EISAI R&D MANAGEMENT CO., LTD. |
Composicion medicinal con estabilidad mejorada y gelificacion reducida.
|
|
US20070054916A1
(en)
*
|
2004-10-01 |
2007-03-08 |
Amgen Inc. |
Aryl nitrogen-containing bicyclic compounds and methods of use
|
|
TW200621251A
(en)
|
2004-10-12 |
2006-07-01 |
Neurogen Corp |
Substituted biaryl quinolin-4-ylamine analogues
|
|
US7947676B2
(en)
|
2004-12-14 |
2011-05-24 |
Astrazeneca Ab |
Pyrazolo[3,4-d]pyrimidine compounds as antitumor agents
|
|
CA2592900A1
(en)
|
2005-01-03 |
2006-07-13 |
Myriad Genetics Inc. |
Nitrogen containing bicyclic compounds and therapeutical use thereof
|
|
US8258145B2
(en)
|
2005-01-03 |
2012-09-04 |
Myrexis, Inc. |
Method of treating brain cancer
|
|
US20090155247A1
(en)
*
|
2005-02-18 |
2009-06-18 |
Ashkenazi Avi J |
Methods of Using Death Receptor Agonists and EGFR Inhibitors
|
|
US20060188498A1
(en)
*
|
2005-02-18 |
2006-08-24 |
Genentech, Inc. |
Methods of using death receptor agonists and EGFR inhibitors
|
|
PL1854789T3
(pl)
|
2005-02-23 |
2014-03-31 |
Shionogi & Co |
Pochodna chinazoliny mająca aktywność hamowania kinazy tyrozynowej
|
|
WO2006105488A2
(en)
|
2005-03-31 |
2006-10-05 |
Agensys, Inc. |
Antibodies and related molecules that bind to 161p2f10b proteins
|
|
EP2444421A1
(en)
|
2005-04-26 |
2012-04-25 |
Pfizer Inc. |
P-Cadherin antibodies
|
|
GB0508715D0
(en)
*
|
2005-04-29 |
2005-06-08 |
Astrazeneca Ab |
Chemical compounds
|
|
US7579356B2
(en)
|
2005-05-04 |
2009-08-25 |
Janssen Pharmaceutica Nv |
Thia-tetraazaacenaphthylene kinase inhibitors
|
|
ATE465151T1
(de)
|
2005-07-27 |
2010-05-15 |
Hoffmann La Roche |
4-aryloxy-chinolin-derivate als 5-ht6-modulatoren
|
|
US9006240B2
(en)
|
2005-08-02 |
2015-04-14 |
Eisai R&D Management Co., Ltd. |
Method for assay on the effect of vascularization inhibitor
|
|
CN101517068B
(zh)
|
2005-09-07 |
2017-02-08 |
安进弗里蒙特公司 |
活化素受体样激酶‑1的人单克隆抗体
|
|
WO2007033196A1
(en)
*
|
2005-09-14 |
2007-03-22 |
Bristol-Myers Squibb Company |
Met kinase inhibitors
|
|
JP5055284B2
(ja)
|
2005-09-20 |
2012-10-24 |
オーエスアイ・フアーマシユーテイカルズ・エル・エル・シー |
インシュリン様成長因子−１受容体キナーゼ阻害剤に対する抗癌応答を予測する生物学的マーカー
|
|
WO2007034144A1
(en)
|
2005-09-20 |
2007-03-29 |
Astrazeneca Ab |
4- (ih-indazol-s-yl-amino)-quinazoline compounds as erbb receptor tyrosine kinase inhibitors for the treatment of cancer
|
|
GB0520475D0
(en)
*
|
2005-10-07 |
2005-11-16 |
Arrow Therapeutics Ltd |
Chemical compounds
|
|
AR056763A1
(es)
|
2005-11-03 |
2007-10-24 |
Vertex Pharma |
Aminopirimidinas sustituidas con tiazol o pirazol,utiles como agentes anticancer y composiciones farmaceuticas que las contienen.
|
|
CN101356171A
(zh)
|
2005-11-15 |
2009-01-28 |
阿雷生物药品公司 |
作为erbbi型受体酪氨酸激酶抑制剂用于治疗增殖性疾病的n4-苯基-喹唑啉-4-胺衍生物和相关化合物
|
|
BRPI0706412A2
(pt)
*
|
2006-01-11 |
2011-03-29 |
Arrow Therapeutics Ltd |
composto, uso de um composto, produto, composição farmacêutica, uso de um interferon ou um derivado de interferon, e, método de tratamento de um paciente sofrendo ou susceptìvel a infecção por flaviviridae
|
|
DE102006012251A1
(de)
*
|
2006-03-15 |
2007-11-08 |
Grünenthal GmbH |
Substituierte 4-Amino-chinazolin-Derivate und ihre Verwendung zur Herstellung von Arzneimitteln
|
|
MX2008013990A
(es)
|
2006-05-09 |
2009-01-29 |
Pfizer Prod Inc |
Derivados de cicloalquilamino acidos.
|
|
NL2000613C2
(nl)
|
2006-05-11 |
2007-11-20 |
Pfizer Prod Inc |
Triazoolpyrazinederivaten.
|
|
CA2652442C
(en)
|
2006-05-18 |
2014-12-09 |
Eisai R & D Management Co., Ltd. |
Antitumor agent for thyroid cancer
|
|
WO2008016123A1
(en)
*
|
2006-08-03 |
2008-02-07 |
Takeda Pharmaceutical Company Limited |
GSK-3β INHIBITOR
|
|
US20110053964A1
(en)
*
|
2006-08-22 |
2011-03-03 |
Roger Tung |
4-aminoquinazoline derivatives and methods of use thereof
|
|
WO2008024439A2
(en)
*
|
2006-08-22 |
2008-02-28 |
Concert Pharmaceuticals Inc. |
4-aminoquinazoline derivatives and methods of use thereof
|
|
EP2065372B1
(en)
|
2006-08-28 |
2012-11-28 |
Eisai R&D Management Co., Ltd. |
Antitumor agent for undifferentiated gastric cancer
|
|
ES2530438T3
(es)
|
2006-09-12 |
2015-03-02 |
Genentech Inc |
Procedimientos y composiciones para el diagnóstico y tratamiento del cáncer de pulmón utilizando el gen de KIT o KDR como marcador genético
|
|
MX2009003673A
(es)
*
|
2006-10-04 |
2009-04-22 |
Pfizer Prod Inc |
Derivados de piridido[4,3-d]pirimidin-4(3h)-ona como antagonistas de los receptores de calcio.
|
|
MX2009004700A
(es)
|
2006-11-06 |
2009-05-15 |
Supergen Inc |
Derivados de imidazo[1,2-b]piridazin y pirazolo[1,5-a] pirimidina y su uso como inhibidores de proteina cinasa.
|
|
EP1921070A1
(de)
|
2006-11-10 |
2008-05-14 |
Boehringer Ingelheim Pharma GmbH & Co. KG |
Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung
|
|
JP5571387B2
(ja)
|
2007-01-11 |
2014-08-13 |
クリティカル・アウトカム・テクノロジーズ・インコーポレイテッド |
癌の治療のための化合物および方法
|
|
JP5319306B2
(ja)
|
2007-01-29 |
2013-10-16 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
未分化型胃癌治療用組成物
|
|
EP2118075A1
(de)
|
2007-02-06 |
2009-11-18 |
Boehringer Ingelheim International GmbH |
Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
|
|
EP2137177B1
(en)
|
2007-04-05 |
2014-05-07 |
Amgen, Inc |
Aurora kinase modulators and method of use
|
|
EP2851091B1
(en)
|
2007-04-13 |
2017-12-27 |
Dana-Farber Cancer Institute, Inc. |
Methods for treating cancer resistant to ERBB therapeutics
|
|
JP4782239B2
(ja)
|
2007-04-18 |
2011-09-28 |
ファイザー・プロダクツ・インク |
異常細胞増殖治療のためのスルホニルアミド誘導体
|
|
NZ580884A
(en)
|
2007-05-02 |
2012-02-24 |
Vertex Pharma |
Thiazoles and pyrazoles useful as kinase inhibitors
|
|
CN101367794B
(zh)
*
|
2007-07-20 |
2013-07-10 |
上海恒瑞医药有限公司 |
喹唑啉类衍生物的制备方法及其在医药上的应用
|
|
WO2009012647A1
(fr)
*
|
2007-07-20 |
2009-01-29 |
Shanghai Hengrui Pharmaceutical Co., Ltd. |
Procédés de préparation de dérivés de quinazoline et leurs utilisations pharmaceutiques
|
|
AR067762A1
(es)
|
2007-07-31 |
2009-10-21 |
Vertex Pharma |
Proceso para preparar 5-fluoro-1h-pirazolo (3,4-b) piridin-3-amina y derivados de la misma
|
|
EP3330292A1
(en)
|
2007-08-21 |
2018-06-06 |
Amgen, Inc |
Human c-fms antigen binding proteins
|
|
HRP20130649T1
(hr)
|
2007-09-07 |
2013-08-31 |
Agensys, Inc. |
Protutijela i povezane molekule koje se vežu za 24p4c12 proteine
|
|
EP2207561A2
(en)
*
|
2007-10-19 |
2010-07-21 |
Pharma Mar, S.A. |
Improved antitumoral treatments
|
|
EP2220054A2
(en)
|
2007-10-29 |
2010-08-25 |
Natco Pharma Limited |
Novel 4-(tetrazol-5-yl)-quinazoline derivatives as anti cancer agents
|
|
CN101848895B
(zh)
|
2007-11-09 |
2013-10-23 |
卫材R&D管理有限公司 |
血管新生抑制物质和抗肿瘤性铂络合物的组合使用
|
|
WO2009067543A2
(en)
*
|
2007-11-19 |
2009-05-28 |
The Regents Of The University Of Colorado |
Treatment of histone deacetylase mediated disorders
|
|
US8466151B2
(en)
|
2007-12-26 |
2013-06-18 |
Critical Outcome Technologies, Inc. |
Compounds and method for treatment of cancer
|
|
TWI472339B
(zh)
|
2008-01-30 |
2015-02-11 |
Genentech Inc |
包含結合至ｈｅｒ２結構域ii之抗體及其酸性變異體的組合物
|
|
EP2252315A1
(en)
*
|
2008-01-30 |
2010-11-24 |
Pharma Mar, S.A. |
Improved antitumoral treatments
|
|
CN101939316B
(zh)
|
2008-02-07 |
2013-10-02 |
贝林格尔.英格海姆国际有限公司 |
螺环杂环化合物、含有所述化合物的药物、其用途及其制备方法
|
|
CN101965192A
(zh)
*
|
2008-03-07 |
2011-02-02 |
法马马有限公司 |
改善的抗肿瘤治疗
|
|
MX2010010151A
(es)
|
2008-03-20 |
2010-10-25 |
Amgen Inc |
Moduladores de cinasa aurora y metodo de uso.
|
|
WO2009126662A1
(en)
*
|
2008-04-08 |
2009-10-15 |
Syndax Pharmaceuticals, Inc. |
Administration of an inhibitor of hdac, an inhibitor of her-2, and a selective estrogen receptor modulator
|
|
WO2009137714A2
(en)
*
|
2008-05-07 |
2009-11-12 |
Teva Pharmaceutical Industries Ltd. |
Forms of lapatinib ditosylate and processes for preparation thereof
|
|
BRPI0912170A2
(pt)
|
2008-05-13 |
2015-10-13 |
Astrazeneca Ab |
composto, forma a, processo para a preparação da mesma, composição farmacêutica, uso de um composto, e, método para tratar um câncer em um animal de sangue quente
|
|
CN101584696A
(zh)
*
|
2008-05-21 |
2009-11-25 |
上海艾力斯医药科技有限公司 |
包含喹唑啉衍生物的组合物及制备方法、用途
|
|
CA2730890C
(en)
|
2008-07-17 |
2018-05-15 |
Critical Outcome Technologies Inc. |
Thiosemicarbazone inhibitor compounds and cancer treatment methods
|
|
US20100197915A1
(en)
*
|
2008-08-06 |
2010-08-05 |
Leonid Metsger |
Lapatinib intermediates
|
|
US8648191B2
(en)
|
2008-08-08 |
2014-02-11 |
Boehringer Ingelheim International Gmbh |
Cyclohexyloxy substituted heterocycles, pharmaceutical compositions containing these compounds and processes for preparing them
|
|
US9126935B2
(en)
|
2008-08-14 |
2015-09-08 |
Amgen Inc. |
Aurora kinase modulators and methods of use
|
|
US20100087459A1
(en)
*
|
2008-08-26 |
2010-04-08 |
Leonid Metsger |
Forms of lapatinib compounds and processes for the preparation thereof
|
|
BRPI0918496A2
(pt)
*
|
2008-09-02 |
2019-09-24 |
Novartis Ag |
composto inibidor bicíclico de quinase, uso do mesmo, composição farmacêutica e método para inibir a atividade da quinase pim em uma célula
|
|
WO2010027921A1
(en)
|
2008-09-03 |
2010-03-11 |
Vertex Pharmaceuticals Incorporated |
Co-crystals and pharmaceutical formulations comprising the same
|
|
TW201014860A
(en)
|
2008-09-08 |
2010-04-16 |
Boehringer Ingelheim Int |
New chemical compounds
|
|
JP5836125B2
(ja)
|
2008-10-16 |
2015-12-24 |
ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション |
高分子量メラノーマ関連抗原に対する完全ヒト抗体およびその使用
|
|
EP2349235A1
(en)
|
2008-11-07 |
2011-08-03 |
Triact Therapeutics, Inc. |
Use of catecholic butane derivatives in cancer therapy
|
|
KR20250123237A
(ko)
|
2009-01-16 |
2025-08-14 |
엑셀리시스, 인코포레이티드 |
암의 치료를 위한 ｎ-（４-｛〔６，７-비스（메틸옥시）퀴놀린-4-일〕옥시｝페닐）-ｎ＇-（４-플루오로페닐）사이클로프로판-1,1-디카르복사미드의 말산염 및 그 결정형
|
|
CN101787017A
(zh)
*
|
2009-01-23 |
2010-07-28 |
岑均达 |
光学纯喹唑啉类化合物
|
|
WO2010090764A1
(en)
|
2009-02-09 |
2010-08-12 |
Supergen, Inc. |
Pyrrolopyrimidinyl axl kinase inhibitors
|
|
WO2010099139A2
(en)
|
2009-02-25 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
Combination anti-cancer therapy
|
|
JP2012519170A
(ja)
|
2009-02-26 |
2012-08-23 |
オーエスアイ・ファーマシューティカルズ，エルエルシー |
生体内の腫瘍細胞のｅｍｔステータスをモニターするためのｉｎｓｉｔｕ法
|
|
WO2010099138A2
(en)
|
2009-02-27 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
|
US8465912B2
(en)
|
2009-02-27 |
2013-06-18 |
OSI Pharmaceuticals, LLC |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
|
JP2012519281A
(ja)
|
2009-02-27 |
2012-08-23 |
オーエスアイ・ファーマシューティカルズ，エルエルシー |
間葉様腫瘍細胞またはその生成を阻害する薬剤を同定するための方法
|
|
US20100222381A1
(en)
|
2009-02-27 |
2010-09-02 |
Hariprasad Vankayalapati |
Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors
|
|
JP2012520893A
(ja)
|
2009-03-18 |
2012-09-10 |
オーエスアイ・ファーマシューティカルズ，エルエルシー |
Ｅｇｆｒ阻害薬及びｉｇｆ−１ｒ阻害剤の投与を含む組み合わせ癌治療
|
|
ES2572728T3
(es)
|
2009-03-20 |
2016-06-02 |
F. Hoffmann-La Roche Ag |
Anticuerpos anti-HER biespecíficos
|
|
EP2270002A1
(en)
|
2009-06-18 |
2011-01-05 |
Vereniging voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek en Patiëntenzorg |
Quinazoline derivatives as histamine H4-receptor inhibitors for use in the treatment of inflammatory disorders
|
|
NZ597379A
(en)
|
2009-06-29 |
2014-04-30 |
Agios Pharmaceuticals Inc |
Therapeutic compounds and compositions
|
|
RU2012103492A
(ru)
|
2009-07-02 |
2013-08-10 |
Ньюджен Терапьютикс, Инк. |
Содержащие фосфор соединения хиназолина и способы применения
|
|
UA108618C2
(uk)
|
2009-08-07 |
2015-05-25 |
|
Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку
|
|
AU2010285740C1
(en)
|
2009-08-19 |
2016-03-17 |
Eisai R&D Management Co., Ltd. |
Quinoline derivative-containing pharmaceutical composition
|
|
HUE029098T2
(en)
|
2009-08-21 |
2017-02-28 |
Novartis Ag |
To treat lapatinib cancer
|
|
WO2011027249A2
(en)
|
2009-09-01 |
2011-03-10 |
Pfizer Inc. |
Benzimidazole derivatives
|
|
SG178592A1
(en)
|
2009-09-03 |
2012-04-27 |
Bristol Myers Squibb Co |
Quinazolines as potassium ion channel inhibitors
|
|
CN102030742B
(zh)
|
2009-09-28 |
2013-06-19 |
齐鲁制药有限公司 |
作为酪氨酸激酶抑制剂的4-(取代苯胺基)喹唑啉衍生物
|
|
KR20120103587A
(ko)
|
2009-11-12 |
2012-09-19 |
제넨테크, 인크. |
수상돌기 소극 밀도를 증진시키는 방법
|
|
EP2510110A1
(en)
|
2009-11-13 |
2012-10-17 |
Pangaea Biotech S.L. |
Molecular biomarkers for predicting response to tyrosine kinase inhibitors in lung cancer
|
|
WO2011079231A1
(en)
*
|
2009-12-23 |
2011-06-30 |
Gatekeeper Pharmaceutical, Inc. |
Compounds that modulate egfr activity and methods for treating or preventing conditions therewith
|
|
CN102108079B
(zh)
*
|
2009-12-25 |
2014-10-01 |
齐鲁制药有限公司 |
作为酪氨酸激酶抑制剂的4-(取代苯胺基)喹唑啉衍生物
|
|
TW201129565A
(en)
|
2010-01-12 |
2011-09-01 |
Hoffmann La Roche |
Tricyclic heterocyclic compounds, compositions and methods of use thereof
|
|
CN102153544B
(zh)
*
|
2010-02-12 |
2015-04-29 |
上海阳帆医药科技有限公司 |
一类酪氨酸激酶抑制剂的制备及用途
|
|
JP5745283B2
(ja)
|
2010-02-12 |
2015-07-08 |
ファイザー・インク |
８−フルオロ−２−｛４−［（メチルアミノ）メチル］フェニル｝−１，３，４，５−テトラヒドロ−６Ｈ−アゼピノ［５，４，３−ｃｄ］インドール−６−オンの塩および多形体
|
|
CN102892779B
(zh)
|
2010-02-18 |
2016-12-21 |
基因泰克公司 |
神经调节蛋白拮抗剂及其在治疗癌症中的用途
|
|
AU2011223643A1
(en)
|
2010-03-03 |
2012-06-28 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
|
WO2011109584A2
(en)
|
2010-03-03 |
2011-09-09 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
|
CA2793024A1
(en)
|
2010-03-17 |
2011-09-22 |
F. Hoffmann-La Roche Ag |
Imidazopyridine compounds, compositions and methods of use
|
|
AU2011232219B2
(en)
*
|
2010-03-23 |
2016-02-04 |
Scinopharm Taiwan, Ltd. |
Process and intermediates for preparing lapatinib
|
|
EP2552915B1
(en)
|
2010-04-01 |
2017-07-19 |
Critical Outcome Technologies Inc. |
Compounds for the treatment of hiv
|
|
WO2011130654A1
(en)
|
2010-04-16 |
2011-10-20 |
Genentech, Inc. |
Fox03a as predictive biomarker for pi3k/akt kinase pathway inhibitor efficacy
|
|
CN104689314B
(zh)
|
2010-06-16 |
2018-02-02 |
高等教育联邦系统-匹兹堡大学 |
内质蛋白的抗体及其用途
|
|
ES2573515T3
(es)
|
2010-06-25 |
2016-06-08 |
Eisai R&D Management Co., Ltd. |
Agente antitumoral que emplea compuestos con efecto inhibitorio de cinasas combinados
|
|
RU2013114360A
(ru)
|
2010-08-31 |
2014-10-10 |
Дженентек, Инк. |
Биомаркеры и способы лечения
|
|
CA2812087A1
(en)
|
2010-09-15 |
2012-03-22 |
F. Hoffmann-La Roche Ag |
Azabenzothiazole compounds, compositions and methods of use
|
|
ES2543151T3
(es)
|
2010-10-20 |
2015-08-17 |
Pfizer Inc |
Derivados de 2-piridina como moduladores del receptor Smoothened
|
|
JP2013542966A
(ja)
|
2010-11-19 |
2013-11-28 |
エフ．ホフマン−ラ ロシュ アーゲー |
ピラゾロピリジンならびにｔｙｋ２阻害剤としてのピラゾロピリジン及びそれらの使用
|
|
CN102552271B
(zh)
*
|
2010-12-09 |
2014-08-06 |
中国科学院上海药物研究所 |
一类喹唑啉类化合物在制备抗黄病毒科病毒的药物中的用途
|
|
EP2468883A1
(en)
|
2010-12-22 |
2012-06-27 |
Pangaea Biotech S.L. |
Molecular biomarkers for predicting response to tyrosine kinase inhibitors in lung cancer
|
|
WO2012085176A1
(en)
|
2010-12-23 |
2012-06-28 |
F. Hoffmann-La Roche Ag |
Tricyclic pyrazinone compounds, compositions and methods of use thereof as janus kinase inhibitors
|
|
US9134297B2
(en)
|
2011-01-11 |
2015-09-15 |
Icahn School Of Medicine At Mount Sinai |
Method and compositions for treating cancer and related methods
|
|
WO2012116040A1
(en)
|
2011-02-22 |
2012-08-30 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors in hepatocellular carcinoma
|
|
EP2492688A1
(en)
|
2011-02-23 |
2012-08-29 |
Pangaea Biotech, S.A. |
Molecular biomarkers for predicting response to antitumor treatment in lung cancer
|
|
SG10201913982WA
(en)
|
2011-03-04 |
2020-03-30 |
Newgen Therapeutics Inc |
Alkyne Substituted Quinazoline Compound And Methods Of Use
|
|
BR112013022307A2
(pt)
|
2011-03-04 |
2020-09-24 |
Glaxosmithkline Intellectual Property (No. 2) Limited |
aminoquinolinas como inibidores de quinase
|
|
US10952415B2
(en)
|
2011-03-09 |
2021-03-23 |
Richard G. Pestell |
Prostate cancer cell lines, gene signatures and uses thereof
|
|
CN103648500B
(zh)
|
2011-03-17 |
2016-05-04 |
宾夕法尼亚大学理事会 |
双功能酶制钳型分子的方法和用途
|
|
US9295676B2
(en)
|
2011-03-17 |
2016-03-29 |
The Trustees Of The University Of Pennsylvania |
Mutation mimicking compounds that bind to the kinase domain of EGFR
|
|
WO2012129145A1
(en)
|
2011-03-18 |
2012-09-27 |
OSI Pharmaceuticals, LLC |
Nscle combination therapy
|
|
US9150644B2
(en)
|
2011-04-12 |
2015-10-06 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Human monoclonal antibodies that bind insulin-like growth factor (IGF) I and II
|
|
JP6021805B2
(ja)
|
2011-04-18 |
2016-11-09 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
腫瘍治療剤
|
|
ES2724801T3
(es)
|
2011-04-19 |
2019-09-16 |
Pfizer |
Combinaciones de anticuerpos anti-4-1BB y anticuerpos inductores de ADCC para el tratamiento del cáncer
|
|
WO2012149014A1
(en)
|
2011-04-25 |
2012-11-01 |
OSI Pharmaceuticals, LLC |
Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment
|
|
CN102918029B
(zh)
|
2011-05-17 |
2015-06-17 |
江苏康缘药业股份有限公司 |
4-苯胺-6-丁烯酰胺-7-烷醚喹唑啉衍生物及其制备方法和用途
|
|
EP3444363B1
(en)
|
2011-06-03 |
2020-11-25 |
Eisai R&D Management Co., Ltd. |
Biomarkers for prediciting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds
|
|
WO2013007765A1
(en)
|
2011-07-13 |
2013-01-17 |
F. Hoffmann-La Roche Ag |
Fused tricyclic compounds for use as inhibitors of janus kinases
|
|
WO2013007768A1
(en)
|
2011-07-13 |
2013-01-17 |
F. Hoffmann-La Roche Ag |
Tricyclic heterocyclic compounds, compositions and methods of use thereof as jak inhibitors
|
|
PT3409278T
(pt)
|
2011-07-21 |
2020-12-18 |
Sumitomo Dainippon Pharma Oncology Inc |
Inibidores de proteína cinase heterocíclicos
|
|
CA2843499A1
(en)
|
2011-08-12 |
2013-02-21 |
F. Hoffmann-La Roche Ag |
Indazole compounds, compositions and methods of use
|
|
MX2014001766A
(es)
|
2011-08-17 |
2014-05-01 |
Genentech Inc |
Anticuerpos de neuregulina y sus usos.
|
|
TWI547494B
(zh)
|
2011-08-18 |
2016-09-01 |
葛蘭素史克智慧財產發展有限公司 |
作為激酶抑制劑之胺基喹唑啉類
|
|
BR112014004762A2
(pt)
|
2011-08-31 |
2018-06-19 |
Genentech Inc |
métodos de determinação da sensibilidade de crescimento de célula tumoral á inibição por um inibidor de quinase de egfr, de identificação de um paciente com câncer que provavelmente irá se beneficiar do tratamento com um inibidor de efgr, de tratamento de um câncer em um paciente, de seleção de uma terapia para um paciente com câncer e de determinação de superexpressão de gene erbb2 em uma célula
|
|
KR20140082710A
(ko)
|
2011-09-20 |
2014-07-02 |
에프. 호프만-라 로슈 아게 |
이미다조피리딘 화합물, 조성물 및 사용 방법
|
|
CA2847540C
(en)
|
2011-09-22 |
2016-05-17 |
Pfizer Inc. |
Pyrrolopyrimidine and purine derivatives
|
|
SG11201400996SA
(en)
|
2011-09-30 |
2014-04-28 |
Genentech Inc |
Diagnostic methylation markers of epithelial or mesenchymal phenotype and response to egfr kinase inhibitor in tumours or tumour cells
|
|
WO2013050725A1
(en)
|
2011-10-04 |
2013-04-11 |
King's College London |
Ige anti -hmw-maa antibody
|
|
WO2013060881A1
(en)
|
2011-10-27 |
2013-05-02 |
Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patientenzorg |
Pyridopyrimidines and their therapeutic use
|
|
BR112014011115A2
(pt)
|
2011-11-08 |
2017-06-13 |
Pfizer |
métodos para tratamento de distúrbios inflamatórios usando anticorpos anti-m-csf
|
|
CN106987620A
(zh)
|
2011-11-30 |
2017-07-28 |
霍夫曼-拉罗奇有限公司 |
癌症中的erbb3突变
|
|
EP2796451B1
(en)
|
2011-12-20 |
2018-08-01 |
Wei Qian |
Heterocycle amido alkyloxy substituted quinazoline derivative and use thereof
|
|
RU2014135224A
(ru)
|
2012-01-31 |
2016-03-27 |
Смитклайн Бичем (Корк) Лимитед |
Способ лечения злокачественных опухолей
|
|
AR090263A1
(es)
|
2012-03-08 |
2014-10-29 |
Hoffmann La Roche |
Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma
|
|
JP2015514710A
(ja)
|
2012-03-27 |
2015-05-21 |
ジェネンテック， インコーポレイテッド |
Ｈｅｒ３阻害剤に関する診断及び治療
|
|
JP2015512425A
(ja)
|
2012-04-03 |
2015-04-27 |
ノバルティス アーゲー |
チロシンキナーゼ阻害剤との組合せ製品及びそれらの使用
|
|
WO2013152252A1
(en)
|
2012-04-06 |
2013-10-10 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
|
WO2013173312A1
(en)
|
2012-05-14 |
2013-11-21 |
Pestell Richard G |
Using modulators of ccr5 for treating cancer
|
|
WO2013190089A1
(en)
|
2012-06-21 |
2013-12-27 |
Pangaea Biotech, S.L. |
Molecular biomarkers for predicting outcome in lung cancer
|
|
AR092530A1
(es)
|
2012-09-13 |
2015-04-22 |
Glaxosmithkline Llc |
Compuesto de amino-quinolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento
|
|
AR092529A1
(es)
|
2012-09-13 |
2015-04-22 |
Glaxosmithkline Llc |
Compuesto de aminoquinazolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento
|
|
US9394257B2
(en)
|
2012-10-16 |
2016-07-19 |
Tolero Pharmaceuticals, Inc. |
PKM2 modulators and methods for their use
|
|
US9260426B2
(en)
|
2012-12-14 |
2016-02-16 |
Arrien Pharmaceuticals Llc |
Substituted 1H-pyrrolo [2, 3-b] pyridine and 1H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors
|
|
BR112015009004A8
(pt)
|
2012-12-21 |
2021-07-20 |
Eisai R&D Man Co Ltd |
forma amorfa de derivado de quinolina e método de produção da mesma
|
|
TWI630203B
(zh)
|
2013-02-21 |
2018-07-21 |
葛蘭素史克智慧財產發展有限公司 |
做為激酶抑制劑的喹唑啉類
|
|
JP2016509045A
(ja)
|
2013-02-22 |
2016-03-24 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
がんを治療し、薬剤耐性を防止する方法
|
|
EP2961412A4
(en)
|
2013-02-26 |
2016-11-09 |
Triact Therapeutics Inc |
CANCER THERAPY
|
|
US9468681B2
(en)
|
2013-03-01 |
2016-10-18 |
California Institute Of Technology |
Targeted nanoparticles
|
|
WO2014138364A2
(en)
|
2013-03-06 |
2014-09-12 |
Genentech, Inc. |
Methods of treating and preventing cancer drug resistance
|
|
MX2015011898A
(es)
|
2013-03-13 |
2016-05-05 |
Genentech Inc |
Compuestos de pirazolo y usos de los mismos.
|
|
ES2738493T3
(es)
|
2013-03-14 |
2020-01-23 |
Tolero Pharmaceuticals Inc |
Inhibidores de JAK2 y ALK2 y métodos para su uso
|
|
CA2903480A1
(en)
|
2013-03-14 |
2014-09-25 |
Genentech, Inc. |
Combinations of a mek inhibitor compound with an her3/egfr inhibitor compound and methods of use
|
|
WO2014153030A2
(en)
|
2013-03-14 |
2014-09-25 |
Genentech, Inc. |
Methods of treating cancer and preventing cancer drug resistance
|
|
MX2015011899A
(es)
|
2013-03-15 |
2016-05-05 |
Genentech Inc |
Metodos para el tratamiento de cáncer y prevención de resistencia a los fármacos para el cáncer.
|
|
WO2014147246A1
(en)
|
2013-03-21 |
2014-09-25 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Method and pharmaceutical composition for use in the treatment of chronic liver diseases associated with a low hepcidin expression
|
|
US9206188B2
(en)
|
2013-04-18 |
2015-12-08 |
Arrien Pharmaceuticals Llc |
Substituted pyrrolo[2,3-b]pyridines as ITK and JAK inhibitors
|
|
US10517861B2
(en)
|
2013-05-14 |
2019-12-31 |
Eisai R&D Management Co., Ltd. |
Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
|
|
TW201605896A
(zh)
|
2013-08-30 |
2016-02-16 |
安美基股份有限公司 |
Gitr抗原結合蛋白
|
|
CA2922925A1
(en)
|
2013-09-05 |
2015-03-12 |
Genentech, Inc. |
Antiproliferative compounds
|
|
US9381246B2
(en)
|
2013-09-09 |
2016-07-05 |
Triact Therapeutics, Inc. |
Cancer therapy
|
|
TW201605857A
(zh)
|
2013-10-03 |
2016-02-16 |
赫孚孟拉羅股份公司 |
Ｃｄｋ８之醫療性抑制劑及其用途
|
|
WO2015051304A1
(en)
|
2013-10-04 |
2015-04-09 |
Aptose Biosciences Inc. |
Compositions, biomarkers and their use in treatment of cancer
|
|
CA2925598A1
(en)
|
2013-10-18 |
2015-04-23 |
Genentech, Inc. |
Anti-rspo antibodies and methods of use
|
|
CN103554091B
(zh)
*
|
2013-11-05 |
2016-05-18 |
沈阳工业大学 |
喹唑啉衍生物及其制备方法和用途
|
|
UA115388C2
(uk)
|
2013-11-21 |
2017-10-25 |
Пфайзер Інк. |
2,6-заміщені пуринові похідні та їх застосування в лікуванні проліферативних захворювань
|
|
ES2750236T3
(es)
*
|
2013-12-09 |
2020-03-25 |
UCB Biopharma SRL |
Derivados heteroaromáticos bicíclicos condensados como moduladores de la actividad del TNF
|
|
KR20240017102A
(ko)
|
2013-12-17 |
2024-02-06 |
제넨테크, 인크. |
Pd-1 축 결합 길항제 및 탁산을 이용한 암 치료 방법
|
|
BR112016013963A2
(pt)
|
2013-12-17 |
2017-10-10 |
Genentech Inc |
terapia de combinação compreendendo agonistas de ligação de ox40 e antagonistas de ligação do eixo de pd-1
|
|
WO2015148531A1
(en)
|
2014-03-24 |
2015-10-01 |
Genentech, Inc. |
Cancer treatment with c-met antagonists and correlation of the latter with hgf expression
|
|
KR20160146747A
(ko)
|
2014-03-31 |
2016-12-21 |
제넨테크, 인크. |
항혈관신생제 및 ox40 결합 효능제를 포함하는 조합 요법
|
|
EP3126394B1
(en)
|
2014-03-31 |
2019-10-30 |
F.Hoffmann-La Roche Ag |
Anti-ox40 antibodies and methods of use
|
|
WO2015155624A1
(en)
|
2014-04-10 |
2015-10-15 |
Pfizer Inc. |
Dihydropyrrolopyrimidine derivatives
|
|
WO2015156674A2
(en)
|
2014-04-10 |
2015-10-15 |
Stichting Het Nederlands Kanker Instituut |
Method for treating cancer
|
|
KR20160149256A
(ko)
|
2014-04-30 |
2016-12-27 |
화이자 인코포레이티드 |
시클로알킬-결합된 디헤테로사이클 유도체
|
|
WO2016001789A1
(en)
|
2014-06-30 |
2016-01-07 |
Pfizer Inc. |
Pyrimidine derivatives as pi3k inhibitors for use in the treatment of cancer
|
|
EP3473271B1
(en)
|
2014-07-31 |
2022-07-20 |
The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services |
Human monoclonal antibodies against epha4 and their use
|
|
JP6659554B2
(ja)
|
2014-08-28 |
2020-03-04 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
高純度キノリン誘導体およびその製造方法
|
|
JP6814730B2
(ja)
|
2014-09-05 |
2021-01-20 |
ジェネンテック， インコーポレイテッド |
治療用化合物およびその使用
|
|
JP2017529358A
(ja)
|
2014-09-19 |
2017-10-05 |
ジェネンテック， インコーポレイテッド |
がんの処置のためのｃｂｐ／ｅｐ３００阻害剤およびｂｅｔ阻害剤の使用
|
|
JP6783230B2
(ja)
|
2014-10-10 |
2020-11-11 |
ジェネンテック， インコーポレイテッド |
ヒストンデメチラーゼのインヒビターとしてのピロリドンアミド化合物
|
|
JP2017536347A
(ja)
|
2014-10-17 |
2017-12-07 |
ノバルティス アーゲー |
セリチニブとｅｇｆｒ阻害剤の組合せ
|
|
MX2017005750A
(es)
|
2014-11-03 |
2017-12-15 |
Genentech Inc |
Ensayos para detectar subgrupos inmunes de células t y sus métodos de uso.
|
|
EP3215637B1
(en)
|
2014-11-03 |
2019-07-03 |
F. Hoffmann-La Roche AG |
Methods and biomarkers for predicting efficacy and valuation of an ox40 agonist treatment
|
|
WO2016073282A1
(en)
|
2014-11-06 |
2016-05-12 |
Genentech, Inc. |
Combination therapy comprising ox40 binding agonists and tigit inhibitors
|
|
EP3218376B1
(en)
|
2014-11-10 |
2019-12-25 |
Genentech, Inc. |
Bromodomain inhibitors and uses thereof
|
|
MA40943A
(fr)
|
2014-11-10 |
2017-09-19 |
Constellation Pharmaceuticals Inc |
Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines
|
|
MA40940A
(fr)
|
2014-11-10 |
2017-09-19 |
Constellation Pharmaceuticals Inc |
Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines
|
|
SG11201703605QA
(en)
|
2014-11-17 |
2017-06-29 |
Genentech Inc |
Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists
|
|
US9763922B2
(en)
|
2014-11-27 |
2017-09-19 |
Genentech, Inc. |
Therapeutic compounds and uses thereof
|
|
CA3081443A1
(en)
|
2014-12-15 |
2016-06-23 |
The Regents Of The University Of Michigan |
Small molecule inhibitors of egfr and pi3k
|
|
EP3233829B1
(en)
|
2014-12-18 |
2019-08-14 |
Pfizer Inc |
Pyrimidine and triazine derivatives and their use as axl inhibitors
|
|
SG11201704707PA
(en)
|
2014-12-23 |
2017-07-28 |
Genentech Inc |
Compositions and methods for treating and diagnosing chemotherapy-resistant cancers
|
|
EP3699290A1
(en)
|
2014-12-24 |
2020-08-26 |
F. Hoffmann-La Roche AG |
Therapeutic, diagnostic, and prognostic methods for cancer
|
|
CN107208138A
(zh)
|
2014-12-30 |
2017-09-26 |
豪夫迈·罗氏有限公司 |
用于癌症预后和治疗的方法和组合物
|
|
EP3242872B1
(en)
|
2015-01-09 |
2019-07-03 |
Genentech, Inc. |
(piperidin-3-yl)(naphthalen-2-yl)methanone derivatives and related compounds as inhibitors of the histone demethylase kdm2b for the treatment of cancer
|
|
JP6889661B2
(ja)
|
2015-01-09 |
2021-06-18 |
ジェネンテック， インコーポレイテッド |
４，５−ジヒドロイミダゾール誘導体およびヒストンジメチラーゼ（ｋｄｍ２ｂ）インヒビターとしてのその使用
|
|
WO2016112298A1
(en)
|
2015-01-09 |
2016-07-14 |
Genentech, Inc. |
Pyridazinone derivatives and their use in the treatment of cancer
|
|
EP3250571B1
(en)
|
2015-01-29 |
2022-11-30 |
Genentech, Inc. |
Therapeutic compounds and uses thereof
|
|
WO2016123387A1
(en)
|
2015-01-30 |
2016-08-04 |
Genentech, Inc. |
Therapeutic compounds and uses thereof
|
|
LT3263106T
(lt)
|
2015-02-25 |
2024-01-10 |
Eisai R&D Management Co., Ltd. |
Chinolino darinių kartumo sumažinimo būdas
|
|
MA41598A
(fr)
|
2015-02-25 |
2018-01-02 |
Constellation Pharmaceuticals Inc |
Composés thérapeutiques de pyridazine et leurs utilisations
|
|
AU2015384801B2
(en)
|
2015-03-04 |
2022-01-06 |
Eisai R&D Management Co., Ltd. |
Combination of a PD-1 antagonist and a VEGFR/FGFR/RET tyrosine kinase inhibitor for treating cancer
|
|
EP3280736A1
(en)
|
2015-04-07 |
2018-02-14 |
F. Hoffmann-La Roche AG |
Antigen binding complex having agonistic activity and methods of use
|
|
HK1251655A1
(zh)
|
2015-04-20 |
2019-02-01 |
Tolero Pharmaceuticals, Inc. |
通过线粒体分析预测对阿伏西地的应答
|
|
CN107709344B
(zh)
|
2015-05-01 |
2022-07-15 |
共晶制药股份有限公司 |
用于治疗黄病毒科病毒和癌症的核苷类似物
|
|
HRP20201900T4
(hr)
|
2015-05-12 |
2024-06-07 |
F. Hoffmann - La Roche Ag |
Terapeutski i dijagnostički postupci kod raka
|
|
EP4086264B1
(en)
|
2015-05-18 |
2023-10-25 |
Sumitomo Pharma Oncology, Inc. |
Alvocidib prodrugs having increased bioavailability
|
|
IL294138A
(en)
|
2015-05-29 |
2022-08-01 |
Genentech Inc |
Therapeutic and diagnostic methods for cancer
|
|
US20170000885A1
(en)
|
2015-06-08 |
2017-01-05 |
Genentech, Inc. |
Methods of treating cancer using anti-ox40 antibodies and pd-1 axis binding antagonists
|
|
CA2985483A1
(en)
|
2015-06-08 |
2016-12-15 |
Genentech, Inc. |
Methods of treating cancer using anti-ox40 antibodies
|
|
AU2016279474B2
(en)
|
2015-06-16 |
2021-09-09 |
Eisai R&D Management Co., Ltd. |
Anticancer agent
|
|
IL256080B2
(en)
|
2015-06-17 |
2025-06-01 |
Genentech Inc |
Methods of treating locally advanced or metastatic breast cancers using pd-1 axis binding antagonists and taxanes
|
|
CN111643479B
(zh)
|
2015-07-01 |
2023-10-27 |
加州理工学院 |
基于阳离子粘酸聚合物的递送系统
|
|
WO2017009751A1
(en)
|
2015-07-15 |
2017-01-19 |
Pfizer Inc. |
Pyrimidine derivatives
|
|
US10568887B2
(en)
|
2015-08-03 |
2020-02-25 |
Tolero Pharmaceuticals, Inc. |
Combination therapies for treatment of cancer
|
|
SG11201801083UA
(en)
|
2015-08-20 |
2018-03-28 |
Eisai R&D Man Co Ltd |
Tumor therapeutic agent
|
|
ES2862727T3
(es)
|
2015-08-26 |
2021-10-07 |
Fundacion Del Sector Publico Estatal Centro Nac De Investigaciones Oncologicas Carlos Iii F S P Cnio |
Compuestos tricíclicos condensados como inhibidores de proteínas quinasas
|
|
NZ739750A
(en)
|
2015-09-25 |
2019-11-29 |
Genentech Inc |
Anti-tigit antibodies and methods of use
|
|
AU2016333987A1
(en)
|
2015-10-05 |
2018-05-10 |
Ny State Psychiatric Institute |
Activators of autophagic flux and phospholipase D and clearance of protein aggregates including tau and treatment of proteinopathies
|
|
WO2017096165A1
(en)
|
2015-12-03 |
2017-06-08 |
Agios Pharmaceuticals, Inc. |
Mat2a inhibitors for treating mtap null cancer
|
|
WO2017106647A1
(en)
|
2015-12-16 |
2017-06-22 |
Genentech, Inc. |
Process for the preparation of tricyclic pi3k inhibitor compounds and methods for using the same for the treatment of cancer
|
|
EP3400246B1
(en)
|
2016-01-08 |
2020-10-21 |
H. Hoffnabb-La Roche Ag |
Methods of treating cea-positive cancers using pd-1 axis binding antagonists and anti-cea/anti-cd3 bispecific antibodies
|
|
KR20180119632A
(ko)
|
2016-02-29 |
2018-11-02 |
제넨테크, 인크. |
암에 대한 치료 및 진단 방법
|
|
CN107141293B
(zh)
|
2016-03-01 |
2022-09-23 |
上海医药集团股份有限公司 |
一种含氮杂环化合物、制备方法、中间体、组合物和应用
|
|
SG11201807596YA
(en)
|
2016-03-08 |
2018-10-30 |
Janssen Biotech Inc |
Gitr antibodies, methods, and uses
|
|
EP3865511A1
(en)
|
2016-04-14 |
2021-08-18 |
F. Hoffmann-La Roche AG |
Anti-rspo3 antibodies and methods of use
|
|
WO2017180581A1
(en)
|
2016-04-15 |
2017-10-19 |
Genentech, Inc. |
Diagnostic and therapeutic methods for cancer
|
|
CN109154613A
(zh)
|
2016-04-15 |
2019-01-04 |
豪夫迈·罗氏有限公司 |
用于监测和治疗癌症的方法
|
|
EP3443120A2
(en)
|
2016-04-15 |
2019-02-20 |
H. Hoffnabb-La Roche Ag |
Methods for monitoring and treating cancer
|
|
JP7160688B2
(ja)
|
2016-05-24 |
2022-10-25 |
ジェネンテック， インコーポレイテッド |
Ｃｂｐ／ｅｐ３００の複素環式インヒビターおよびがんの処置におけるそれらの使用
|
|
JP7014736B2
(ja)
|
2016-05-24 |
2022-02-01 |
ジェネンテック， インコーポレイテッド |
がんの処置のためのピラゾロピリジン誘導体
|
|
JP2019527037A
(ja)
|
2016-06-08 |
2019-09-26 |
ジェネンテック， インコーポレイテッド |
がんのための診断及び治療方法
|
|
IL264161B2
(en)
|
2016-07-14 |
2025-06-01 |
Scholar Rock Inc |
Tgfb antibodies, methods, and uses
|
|
WO2018027204A1
(en)
|
2016-08-05 |
2018-02-08 |
Genentech, Inc. |
Multivalent and multiepitopic anitibodies having agonistic activity and methods of use
|
|
WO2018029124A1
(en)
|
2016-08-08 |
2018-02-15 |
F. Hoffmann-La Roche Ag |
Therapeutic and diagnostic methods for cancer
|
|
JP7579056B2
(ja)
|
2016-10-06 |
2024-11-07 |
ジェネンテック， インコーポレイテッド |
がんのための治療方法及び診断方法
|
|
CN110267678A
(zh)
|
2016-10-29 |
2019-09-20 |
霍夫曼-拉罗奇有限公司 |
抗mic抗体和使用方法
|
|
US11279694B2
(en)
|
2016-11-18 |
2022-03-22 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Alvocidib prodrugs and their use as protein kinase inhibitors
|
|
MX2019007332A
(es)
|
2016-12-19 |
2019-11-18 |
Tolero Pharmaceuticals Inc |
Péptidos indicadores y métodos para caracterizar sensibilidad.
|
|
EA201991528A1
(ru)
|
2016-12-22 |
2020-01-16 |
Эмджен Инк. |
БЕНЗИЗОТИАЗОЛЬНЫЕ, ИЗОТИАЗОЛО[3,4-b]ПИРИДИНОВЫЕ, ХИНАЗОЛИНОВЫЕ, ФТАЛАЗИНОВЫЕ, ПИРИДО[2,3-d]ПИРИДАЗИНОВЫЕ И ПИРИДО[2,3-d]ПИРИМИДИНОВЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ G12C KRAS ДЛЯ ЛЕЧЕНИЯ РАКА ЛЕГКОГО, РАКА ПОДЖЕЛУДОЧНОЙ ЖЕЛЕЗЫ ИЛИ КОЛОРЕКТАЛЬНОГО РАКА
|
|
CN110072528B
(zh)
|
2017-02-08 |
2022-04-26 |
卫材R&D管理有限公司 |
治疗肿瘤的药物组合物
|
|
EP3589754B1
(en)
|
2017-03-01 |
2023-06-28 |
F. Hoffmann-La Roche AG |
Diagnostic and therapeutic methods for cancer
|
|
AU2018250875A1
(en)
|
2017-04-13 |
2019-10-03 |
F. Hoffmann-La Roche Ag |
An interleukin-2 immunoconjugate, a CD40 agonist, and optionally a PD-1 axis binding antagonist for use in methods of treating cancer
|
|
KR20200013644A
(ko)
|
2017-05-16 |
2020-02-07 |
에자이 알앤드디 매니지먼트 가부시키가이샤 |
간세포 암종의 치료
|
|
JOP20190272A1
(ar)
|
2017-05-22 |
2019-11-21 |
Amgen Inc |
مثبطات kras g12c وطرق لاستخدامها
|
|
CA3069469A1
(en)
|
2017-07-21 |
2019-01-24 |
Genentech, Inc. |
Therapeutic and diagnostic methods for cancer
|
|
AU2018316343B2
(en)
|
2017-08-11 |
2025-06-12 |
Genentech, Inc. |
Anti-CD8 antibodies and uses thereof
|
|
US11578074B2
(en)
|
2017-09-01 |
2023-02-14 |
Shanghai Pharmaceuticals Holding Cd., Ltd. |
Nitrogenous heterocyclic compound, preparation method, intermediate, composition, and application
|
|
ES2985118T3
(es)
|
2017-09-08 |
2024-11-04 |
Amgen Inc |
Inhibidores de KRAS G12C y métodos de uso de los mismos
|
|
KR102811888B1
(ko)
|
2017-09-08 |
2025-05-27 |
에프. 호프만-라 로슈 아게 |
암의 진단 및 치료 방법
|
|
JP7196160B2
(ja)
|
2017-09-12 |
2022-12-26 |
スミトモ ファーマ オンコロジー， インコーポレイテッド |
Ｍｃｌ－１阻害剤アルボシジブを用いた、ｂｃｌ－２阻害剤に対して非感受性である癌の治療レジメン
|
|
WO2019075367A1
(en)
|
2017-10-13 |
2019-04-18 |
Tolero Pharmaceuticals, Inc. |
PKM2 ACTIVATORS IN COMBINATION WITH OXYGEN REACTIVE SPECIES FOR THE TREATMENT OF CANCER
|
|
EP3710001B1
(en)
|
2017-10-27 |
2025-06-18 |
University Of Virginia Patent Foundation |
Compounds and methods for regulating, limiting, or inhibiting avil expression
|
|
ES2984919T3
(es)
|
2017-11-06 |
2024-10-31 |
Hoffmann La Roche |
Procedimientos diagnósticos y terapéuticos para el cáncer
|
|
JP2021506974A
(ja)
|
2017-12-18 |
2021-02-22 |
スターングリーン、インク． |
チロシンキナーゼ阻害剤として有用なピリミジン化合物
|
|
JP7236164B2
(ja)
|
2018-01-15 |
2023-03-09 |
エピアクシス セラピューティクス プロプライエタリー リミテッド |
治療法に対する応答を予測する薬剤及び方法
|
|
KR20200135313A
(ko)
|
2018-02-26 |
2020-12-02 |
제넨테크, 인크. |
항-tigit 및 항-pd-l1 길항제 항체에 의한 치료를 위한 투약
|
|
EP3788038B1
(en)
|
2018-05-04 |
2023-10-11 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
|
CA3099118A1
(en)
|
2018-05-04 |
2019-11-07 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
|
MA52564A
(fr)
|
2018-05-10 |
2021-03-17 |
Amgen Inc |
Inhibiteurs de kras g12c pour le traitement du cancer
|
|
CN112771177A
(zh)
|
2018-05-21 |
2021-05-07 |
纳米线科技公司 |
分子基因标签及其使用方法
|
|
MX2020012731A
(es)
|
2018-06-01 |
2021-02-22 |
Amgen Inc |
Inhibidores de kras g12c y metodos para su uso.
|
|
EP4268898A3
(en)
|
2018-06-11 |
2024-01-17 |
Amgen Inc. |
Kras g12c inhibitors for treating cancer
|
|
EP3807276B1
(en)
|
2018-06-12 |
2025-12-10 |
Amgen Inc. |
Kras g12c inhibitors encompassing a piperazine ring and use thereof in the treatment of cancer
|
|
WO2019241327A1
(en)
|
2018-06-13 |
2019-12-19 |
California Institute Of Technology |
Nanoparticles for crossing the blood brain barrier and methods of treatment using the same
|
|
SG11202012446UA
(en)
|
2018-06-23 |
2021-01-28 |
Genentech Inc |
Methods of treating lung cancer with a pd-1 axis binding antagonist, a platinum agent, and a topoisomerase ii inhibitor
|
|
EP3823611A1
(en)
|
2018-07-18 |
2021-05-26 |
Genentech, Inc. |
Methods of treating lung cancer with a pd-1 axis binding antagonist, an antimetabolite, and a platinum agent
|
|
US11040038B2
(en)
|
2018-07-26 |
2021-06-22 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Methods for treating diseases associated with abnormal ACVR1 expression and ACVR1 inhibitors for use in the same
|
|
CN112805267B
(zh)
|
2018-09-03 |
2024-03-08 |
豪夫迈·罗氏有限公司 |
用作tead调节剂的甲酰胺和磺酰胺衍生物
|
|
CA3111401A1
(en)
|
2018-09-19 |
2020-03-26 |
Genentech, Inc. |
Therapeutic and diagnostic methods for bladder cancer
|
|
AU2019342133B8
(en)
|
2018-09-21 |
2025-08-07 |
Genentech, Inc. |
Diagnostic methods for triple-negative breast cancer
|
|
EP3860608A1
(en)
|
2018-10-04 |
2021-08-11 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Egfr inhibitors for treating keratodermas
|
|
AU2019362972A1
(en)
|
2018-10-17 |
2021-05-20 |
The University Of Queensland |
Epigenetic biomarker and uses therefor
|
|
AU2019361983A1
(en)
|
2018-10-18 |
2021-05-20 |
Genentech, Inc. |
Diagnostic and therapeutic methods for sarcomatoid kidney cancer
|
|
JP7516029B2
(ja)
|
2018-11-16 |
2024-07-16 |
アムジエン・インコーポレーテツド |
Ｋｒａｓ ｇ１２ｃ阻害剤化合物の重要な中間体の改良合成法
|
|
JP7377679B2
(ja)
|
2018-11-19 |
2023-11-10 |
アムジエン・インコーポレーテツド |
がん治療のためのｋｒａｓｇ１２ｃ阻害剤及び１種以上の薬学的に活性な追加の薬剤を含む併用療法
|
|
JP7454572B2
(ja)
|
2018-11-19 |
2024-03-22 |
アムジエン・インコーポレーテツド |
Ｋｒａｓ ｇ１２ｃ阻害剤及びその使用方法
|
|
AU2019391097B2
(en)
|
2018-12-04 |
2025-07-03 |
Sumitomo Pharma America, Inc. |
CDK9 inhibitors and polymorphs thereof for use as agents for treatment of cancer
|
|
JP2022515198A
(ja)
|
2018-12-19 |
2022-02-17 |
アレイ バイオファーマ インコーポレイテッド |
ＦＧＦＲチロシンキナーゼの阻害剤としての置換ピラゾロ［１，５－ａ］ピリジン化合物
|
|
US12351571B2
(en)
|
2018-12-19 |
2025-07-08 |
Array Biopharma Inc. |
Substituted quinoxaline compounds as inhibitors of FGFR tyrosine kinases
|
|
MX419368B
(es)
|
2018-12-20 |
2025-01-14 |
Amgen Inc |
Heteroarilamidas utiles como inhibidores de kif18a
|
|
KR102875569B1
(ko)
|
2018-12-20 |
2025-10-23 |
암젠 인크 |
Kif18a 억제제
|
|
US12459932B2
(en)
|
2018-12-20 |
2025-11-04 |
Amgen Inc. |
KIF18A inhibitors
|
|
US12441736B2
(en)
|
2018-12-20 |
2025-10-14 |
Amgen Inc. |
KIF18A inhibitors
|
|
EP3921443A1
(en)
|
2019-02-08 |
2021-12-15 |
F. Hoffmann-La Roche AG |
Diagnostic and therapeutic methods for cancer
|
|
NZ778055A
(en)
|
2019-02-12 |
2025-11-28 |
Sumitomo Pharma America Inc |
Formulations comprising heterocyclic protein kinase inhibitors
|
|
US20220146495A1
(en)
|
2019-02-27 |
2022-05-12 |
Epiaxis Therapeutics Pty Ltd |
Methods and agents for assessing t-cell function and predicting response to therapy
|
|
CA3130695A1
(en)
|
2019-02-27 |
2020-09-03 |
Genentech, Inc. |
Dosing for treatment with anti-tigit and anti-cd20 or anti-cd38 antibodies
|
|
WO2020180768A1
(en)
|
2019-03-01 |
2020-09-10 |
Revolution Medicines, Inc. |
Bicyclic heteroaryl compounds and uses thereof
|
|
EP3930845A1
(en)
|
2019-03-01 |
2022-01-05 |
Revolution Medicines, Inc. |
Bicyclic heterocyclyl compounds and uses thereof
|
|
JP2022525149A
(ja)
|
2019-03-20 |
2022-05-11 |
スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド |
ベネトクラクスが失敗した急性骨髄性白血病（ａｍｌ）の処置
|
|
EP3941463A1
(en)
|
2019-03-22 |
2022-01-26 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Compositions comprising pkm2 modulators and methods of treatment using the same
|
|
WO2020223233A1
(en)
|
2019-04-30 |
2020-11-05 |
Genentech, Inc. |
Prognostic and therapeutic methods for colorectal cancer
|
|
MX2021013222A
(es)
|
2019-05-03 |
2022-01-06 |
Genentech Inc |
Metodos para tratar el cancer con un anticuerpo anti-pd-l1.
|
|
EP3738593A1
(en)
|
2019-05-14 |
2020-11-18 |
Amgen, Inc |
Dosing of kras inhibitor for treatment of cancers
|
|
KR20250159270A
(ko)
|
2019-05-21 |
2025-11-10 |
암젠 인크 |
고체 상태 형태
|
|
CN112300279A
(zh)
|
2019-07-26 |
2021-02-02 |
上海复宏汉霖生物技术股份有限公司 |
针对抗cd73抗体和变体的方法和组合物
|
|
WO2021026099A1
(en)
|
2019-08-02 |
2021-02-11 |
Amgen Inc. |
Kif18a inhibitors
|
|
EP4007752B1
(en)
|
2019-08-02 |
2025-09-24 |
Amgen Inc. |
Kif18a inhibitors
|
|
WO2021026101A1
(en)
|
2019-08-02 |
2021-02-11 |
Amgen Inc. |
Kif18a inhibitors
|
|
WO2021026100A1
(en)
|
2019-08-02 |
2021-02-11 |
Amgen Inc. |
Pyridine derivatives as kif18a inhibitors
|
|
EP4025608A1
(en)
|
2019-09-04 |
2022-07-13 |
F. Hoffmann-La Roche AG |
Cd8 binding agents and uses thereof
|
|
CR20220127A
(es)
|
2019-09-27 |
2022-05-27 |
Genentech Inc |
Administración de dosis para tratamiento con anticuerpos antagonistas anti-tigit y anti-pd-l1
|
|
MX2022004656A
(es)
|
2019-10-24 |
2022-05-25 |
Amgen Inc |
Derivados de piridopirimidina utiles como inhibidores de kras g12c y kras g12d en el tratamiento del cancer.
|
|
EP4051674A1
(en)
|
2019-10-29 |
2022-09-07 |
F. Hoffmann-La Roche AG |
Bifunctional compounds for the treatment of cancer
|
|
PH12022550988A1
(en)
|
2019-11-04 |
2023-10-09 |
Revolution Medicines Inc |
Ras inhibitors
|
|
CN114901366A
(zh)
|
2019-11-04 |
2022-08-12 |
锐新医药公司 |
Ras抑制剂
|
|
KR20220109408A
(ko)
|
2019-11-04 |
2022-08-04 |
레볼루션 메디슨즈, 인크. |
Ras 억제제
|
|
IL292458A
(en)
|
2019-11-06 |
2022-06-01 |
Genentech Inc |
Diagnostic and treatment methods for the treatment of hematological cancer
|
|
CN112778217B
(zh)
*
|
2019-11-08 |
2024-01-26 |
沈阳化工研究院有限公司 |
一种喹唑啉类化合物及其应用
|
|
WO2021092115A1
(en)
|
2019-11-08 |
2021-05-14 |
Revolution Medicines, Inc. |
Bicyclic heteroaryl compounds and uses thereof
|
|
EP4058435A1
(en)
|
2019-11-13 |
2022-09-21 |
Genentech, Inc. |
Therapeutic compounds and methods of use
|
|
AR120457A1
(es)
|
2019-11-14 |
2022-02-16 |
Amgen Inc |
Síntesis mejorada del compuesto inhibidor de g12c de kras
|
|
CA3161156A1
(en)
|
2019-11-14 |
2021-05-20 |
Amgen Inc. |
Improved synthesis of kras g12c inhibitor compound
|
|
WO2021108683A1
(en)
|
2019-11-27 |
2021-06-03 |
Revolution Medicines, Inc. |
Covalent ras inhibitors and uses thereof
|
|
EP4072584B1
(en)
|
2019-12-13 |
2026-01-28 |
Genentech, Inc. |
Anti-ly6g6d antibodies and methods of use
|
|
CA3164995A1
(en)
|
2019-12-20 |
2021-06-24 |
Erasca, Inc. |
Tricyclic pyridones and pyrimidones
|
|
WO2021142026A1
(en)
|
2020-01-07 |
2021-07-15 |
Revolution Medicines, Inc. |
Shp2 inhibitor dosing and methods of treating cancer
|
|
TW202142230A
(zh)
|
2020-01-27 |
2021-11-16 |
美商建南德克公司 |
用於以抗ｔｉｇｉｔ拮抗體抗體治療癌症之方法
|
|
WO2021194481A1
(en)
|
2020-03-24 |
2021-09-30 |
Genentech, Inc. |
Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies
|
|
WO2021155006A1
(en)
|
2020-01-31 |
2021-08-05 |
Les Laboratoires Servier Sas |
Inhibitors of cyclin-dependent kinases and uses thereof
|
|
WO2021177980A1
(en)
|
2020-03-06 |
2021-09-10 |
Genentech, Inc. |
Combination therapy for cancer comprising pd-1 axis binding antagonist and il6 antagonist
|
|
JP2023520515A
(ja)
|
2020-04-03 |
2023-05-17 |
ジェネンテック， インコーポレイテッド |
がんに対する治療方法及び診断方法
|
|
JP2023523450A
(ja)
|
2020-04-28 |
2023-06-05 |
ジェネンテック， インコーポレイテッド |
非小細胞肺がん免疫療法のための方法及び組成物
|
|
KR20230025691A
(ko)
|
2020-06-16 |
2023-02-22 |
제넨테크, 인크. |
삼중 음성 유방암을 치료하기 위한 방법과 조성물
|
|
AU2021293507A1
(en)
|
2020-06-18 |
2023-02-02 |
F. Hoffmann-La Roche Ag |
Treatment with anti-TIGIT antibodies and PD-1 axis binding antagonists
|
|
MX2022016355A
(es)
|
2020-06-18 |
2023-04-03 |
Revolution Medicines Inc |
Metodos para retardar, prevenir, y tratar la resistencia adquirida a inhibidores de ras.
|
|
US11787775B2
(en)
|
2020-07-24 |
2023-10-17 |
Genentech, Inc. |
Therapeutic compounds and methods of use
|
|
EP4189121A1
(en)
|
2020-08-03 |
2023-06-07 |
Genentech, Inc. |
Diagnostic and therapeutic methods for lymphoma
|
|
EP4196612A1
(en)
|
2020-08-12 |
2023-06-21 |
Genentech, Inc. |
Diagnostic and therapeutic methods for cancer
|
|
CA3187757A1
(en)
|
2020-09-03 |
2022-03-24 |
Ethan AHLER |
Use of sos1 inhibitors to treat malignancies with shp2 mutations
|
|
IL301298A
(en)
|
2020-09-15 |
2023-05-01 |
Revolution Medicines Inc |
Indole derivatives as RAS inhibitors in cancer therapy
|
|
EP4217071A1
(en)
|
2020-09-23 |
2023-08-02 |
Erasca, Inc. |
Tricyclic pyridones and pyrimidones
|
|
CA3193952A1
(en)
|
2020-10-05 |
2022-04-14 |
Bernard Martin Fine |
Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
|
|
WO2022133345A1
(en)
|
2020-12-18 |
2022-06-23 |
Erasca, Inc. |
Tricyclic pyridones and pyrimidones
|
|
JP2024501995A
(ja)
|
2020-12-22 |
2024-01-17 |
メカニスティク・セラピューティクス・エルエルシー |
Ｅｇｆｒ及び／又はｐｉ３ｋ阻害剤としての置換アミノベンジルヘテロアリール化合物
|
|
AU2021409816A1
(en)
|
2020-12-22 |
2023-07-06 |
Qilu Regor Therapeutics Inc. |
Sos1 inhibitors and uses thereof
|
|
CA3210553A1
(en)
|
2021-02-12 |
2022-08-18 |
F. Hoffmann-La Roche Ag |
Bicyclic tetrahydroazepine derivatives for the treatment of cancer
|
|
AR125787A1
(es)
|
2021-05-05 |
2023-08-16 |
Revolution Medicines Inc |
Inhibidores de ras
|
|
AR125782A1
(es)
|
2021-05-05 |
2023-08-16 |
Revolution Medicines Inc |
Inhibidores de ras
|
|
WO2022235866A1
(en)
|
2021-05-05 |
2022-11-10 |
Revolution Medicines, Inc. |
Covalent ras inhibitors and uses thereof
|
|
JP2024520457A
(ja)
|
2021-05-25 |
2024-05-24 |
エラスカ・インコーポレイテッド |
硫黄含有ヘテロ芳香族三環式ｋｒａｓ阻害剤
|
|
WO2022266206A1
(en)
|
2021-06-16 |
2022-12-22 |
Erasca, Inc. |
Kras inhibitor conjugates
|
|
TW202321261A
(zh)
|
2021-08-10 |
2023-06-01 |
美商伊瑞斯卡公司 |
選擇性ｋｒａｓ抑制劑
|
|
AR127308A1
(es)
|
2021-10-08 |
2024-01-10 |
Revolution Medicines Inc |
Inhibidores ras
|
|
US12275745B2
(en)
|
2021-11-24 |
2025-04-15 |
Genentech, Inc. |
Therapeutic compounds and methods of use
|
|
US12110276B2
(en)
|
2021-11-24 |
2024-10-08 |
Genentech, Inc. |
Pyrazolo compounds and methods of use thereof
|
|
CN119212994A
(zh)
|
2021-12-17 |
2024-12-27 |
建新公司 |
作为shp2抑制剂的吡唑并吡嗪化合物
|
|
EP4227307A1
(en)
|
2022-02-11 |
2023-08-16 |
Genzyme Corporation |
Pyrazolopyrazine compounds as shp2 inhibitors
|
|
JP2025509217A
(ja)
|
2022-03-07 |
2025-04-11 |
アムジエン・インコーポレーテツド |
４－メチル－２－プロパン－２－イル－ピリジン－３－カルボニトリルを調製するための方法
|
|
WO2023172940A1
(en)
|
2022-03-08 |
2023-09-14 |
Revolution Medicines, Inc. |
Methods for treating immune refractory lung cancer
|
|
IL315770A
(en)
|
2022-04-01 |
2024-11-01 |
Genentech Inc |
Dosage for treatment with bispecific anti-FCRH5/anti-CD3 antibodies
|
|
AU2022458320A1
(en)
|
2022-05-11 |
2024-11-28 |
Genentech, Inc. |
Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
|
|
IL317449A
(en)
|
2022-06-07 |
2025-02-01 |
Genentech Inc |
Method for determining the efficacy of a lung cancer treatment comprising an anti-PD-L1 antagonist and an anti-TIGIT antibody-antagonist
|
|
CN120504682A
(zh)
|
2022-06-10 |
2025-08-19 |
锐新医药公司 |
大环ras抑制剂
|
|
JP2025523020A
(ja)
|
2022-07-13 |
2025-07-17 |
ジェネンテック， インコーポレイテッド |
抗ＦｃＲＨ５／抗ＣＤ３二重特異性抗体による処置のための投与
|
|
IL318252A
(en)
|
2022-07-19 |
2025-03-01 |
Genentech Inc |
Dosage for treatment with bispecific anti-FCRH5/anti-CD3 antibodies
|
|
CN119677732A
(zh)
|
2022-08-11 |
2025-03-21 |
豪夫迈·罗氏有限公司 |
双环四氢氮杂䓬衍生物
|
|
CN119677733A
(zh)
|
2022-08-11 |
2025-03-21 |
豪夫迈·罗氏有限公司 |
双环四氢硫氮杂䓬衍生物
|
|
JP2025526683A
(ja)
|
2022-08-11 |
2025-08-15 |
エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト |
二環式テトラヒドロチアゼピン誘導体
|
|
JP2025526727A
(ja)
|
2022-08-11 |
2025-08-15 |
エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト |
二環式テトラヒドロチアゼピン誘導体
|
|
JP2025536257A
(ja)
|
2022-10-14 |
2025-11-05 |
ブラック ダイアモンド セラピューティクス，インコーポレイティド |
イソキノリンまたは６－ａｚａ－キノリン誘導体を使用してがんを治療する方法
|
|
WO2024085242A2
(en)
|
2022-10-21 |
2024-04-25 |
Kawasaki Institute Of Industrial Promotion |
Non-fouling or super stealth vesicle
|
|
WO2024091991A1
(en)
|
2022-10-25 |
2024-05-02 |
Genentech, Inc. |
Therapeutic and diagnostic methods for multiple myeloma
|
|
WO2024173842A1
(en)
|
2023-02-17 |
2024-08-22 |
Erasca, Inc. |
Kras inhibitors
|
|
KR20250164828A
(ko)
|
2023-03-30 |
2025-11-25 |
레볼루션 메디슨즈, 인크. |
Ras gtp 가수분해 유도를 위한 조성물 및 이의 용도
|
|
CN121263418A
(zh)
|
2023-04-07 |
2026-01-02 |
锐新医药公司 |
大环ras抑制剂
|
|
KR20260005904A
(ko)
|
2023-04-07 |
2026-01-12 |
레볼루션 메디슨즈, 인크. |
매크로사이클릭 ras 억제제
|
|
CN121100123A
(zh)
|
2023-04-14 |
2025-12-09 |
锐新医药公司 |
Ras抑制剂的结晶形式
|
|
TW202448897A
(zh)
|
2023-04-14 |
2024-12-16 |
美商銳新醫藥公司 |
Ｒａｓ抑制劑之結晶形式、含有其之組合物及其使用方法
|
|
TW202508595A
(zh)
|
2023-05-04 |
2025-03-01 |
美商銳新醫藥公司 |
用於ｒａｓ相關疾病或病症之組合療法
|
|
TW202448949A
(zh)
|
2023-05-05 |
2024-12-16 |
美商建南德克公司 |
用抗ｆｃｒｈ５／抗ｃｄ３雙特異性抗體進行治療之給藥
|
|
WO2024254455A1
(en)
|
2023-06-08 |
2024-12-12 |
Genentech, Inc. |
Macrophage signatures for diagnostic and therapeutic methods for lymphoma
|
|
WO2025024257A1
(en)
|
2023-07-21 |
2025-01-30 |
Genentech, Inc. |
Diagnostic and therapeutic methods for cancer
|
|
US20250049810A1
(en)
|
2023-08-07 |
2025-02-13 |
Revolution Medicines, Inc. |
Methods of treating a ras protein-related disease or disorder
|
|
WO2025049277A1
(en)
|
2023-08-25 |
2025-03-06 |
Genentech, Inc. |
Methods and compositions for treating non-small cell lung cancer comprising an anti-tigit antagonist antibody and a pd-1 axis binding antagonist
|
|
WO2025080946A2
(en)
|
2023-10-12 |
2025-04-17 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
TW202542151A
(zh)
|
2023-12-22 |
2025-11-01 |
美商銳格醫藥有限公司 |
Ｓｏｓ１抑制劑及其用途
|
|
WO2025171296A1
(en)
|
2024-02-09 |
2025-08-14 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2025240847A1
(en)
|
2024-05-17 |
2025-11-20 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2025255438A1
(en)
|
2024-06-07 |
2025-12-11 |
Revolution Medicines, Inc. |
Methods of treating a ras protein-related disease or disorder
|
|
WO2025265060A1
(en)
|
2024-06-21 |
2025-12-26 |
Revolution Medicines, Inc. |
Therapeutic compositions and methods for managing treatment-related effects
|
|
WO2026006747A1
(en)
|
2024-06-28 |
2026-01-02 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2026015796A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026015790A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026015825A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Use of ras inhibitor for treating pancreatic cancer
|
|
WO2026015801A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|