IL173625A - Coupler connectors for cell and methanesinoid and methods for using them - Google Patents
Coupler connectors for cell and methanesinoid and methods for using themInfo
- Publication number
- IL173625A IL173625A IL173625A IL17362506A IL173625A IL 173625 A IL173625 A IL 173625A IL 173625 A IL173625 A IL 173625A IL 17362506 A IL17362506 A IL 17362506A IL 173625 A IL173625 A IL 173625A
- Authority
- IL
- Israel
- Prior art keywords
- methods
- same
- binding agent
- cell binding
- maytansinoid conjugates
- Prior art date
Links
- 239000011230 binding agent Substances 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
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- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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- C—CHEMISTRY; METALLURGY
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- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50990103P | 2003-10-10 | 2003-10-10 | |
US10/960,602 US8088387B2 (en) | 2003-10-10 | 2004-10-08 | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
PCT/US2004/030917 WO2005037992A2 (en) | 2003-10-10 | 2004-10-12 | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
Publications (2)
Publication Number | Publication Date |
---|---|
IL173625A0 IL173625A0 (en) | 2006-07-05 |
IL173625A true IL173625A (en) | 2016-07-31 |
Family
ID=34467962
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL173625A IL173625A (en) | 2003-10-10 | 2006-02-09 | Coupler connectors for cell and methanesinoid and methods for using them |
IL214788A IL214788A0 (en) | 2003-10-10 | 2011-08-22 | Cell binding agent maytansinoid conjugates and methods for using the same |
IL235253A IL235253B (en) | 2003-10-10 | 2014-10-21 | Active esters of maytansinoid thioether compounds |
IL246605A IL246605A (en) | 2003-10-10 | 2016-07-05 | Coupler connectors for cell and methanesinoid and methods for using them |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL214788A IL214788A0 (en) | 2003-10-10 | 2011-08-22 | Cell binding agent maytansinoid conjugates and methods for using the same |
IL235253A IL235253B (en) | 2003-10-10 | 2014-10-21 | Active esters of maytansinoid thioether compounds |
IL246605A IL246605A (en) | 2003-10-10 | 2016-07-05 | Coupler connectors for cell and methanesinoid and methods for using them |
Country Status (26)
Country | Link |
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US (10) | US8088387B2 (OSRAM) |
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