IL173625A - Coupler connectors for cell and methanesinoid and methods for using them - Google Patents

Coupler connectors for cell and methanesinoid and methods for using them

Info

Publication number
IL173625A
IL173625A IL173625A IL17362506A IL173625A IL 173625 A IL173625 A IL 173625A IL 173625 A IL173625 A IL 173625A IL 17362506 A IL17362506 A IL 17362506A IL 173625 A IL173625 A IL 173625A
Authority
IL
Israel
Prior art keywords
methods
same
binding agent
cell binding
maytansinoid conjugates
Prior art date
Application number
IL173625A
Other languages
English (en)
Hebrew (he)
Other versions
IL173625A0 (en
Original Assignee
Immunogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34467962&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL173625(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Immunogen Inc filed Critical Immunogen Inc
Publication of IL173625A0 publication Critical patent/IL173625A0/en
Publication of IL173625A publication Critical patent/IL173625A/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/6803Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68033Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a maytansine
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    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3092Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
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    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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IL173625A 2003-10-10 2006-02-09 Coupler connectors for cell and methanesinoid and methods for using them IL173625A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50990103P 2003-10-10 2003-10-10
US10/960,602 US8088387B2 (en) 2003-10-10 2004-10-08 Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
PCT/US2004/030917 WO2005037992A2 (en) 2003-10-10 2004-10-12 Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates

Publications (2)

Publication Number Publication Date
IL173625A0 IL173625A0 (en) 2006-07-05
IL173625A true IL173625A (en) 2016-07-31

Family

ID=34467962

Family Applications (4)

Application Number Title Priority Date Filing Date
IL173625A IL173625A (en) 2003-10-10 2006-02-09 Coupler connectors for cell and methanesinoid and methods for using them
IL214788A IL214788A0 (en) 2003-10-10 2011-08-22 Cell binding agent maytansinoid conjugates and methods for using the same
IL235253A IL235253B (en) 2003-10-10 2014-10-21 Active esters of maytansinoid thioether compounds
IL246605A IL246605A (en) 2003-10-10 2016-07-05 Coupler connectors for cell and methanesinoid and methods for using them

Family Applications After (3)

Application Number Title Priority Date Filing Date
IL214788A IL214788A0 (en) 2003-10-10 2011-08-22 Cell binding agent maytansinoid conjugates and methods for using the same
IL235253A IL235253B (en) 2003-10-10 2014-10-21 Active esters of maytansinoid thioether compounds
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ES2404304T3 (es) 2013-05-27
BRPI0415448A (pt) 2006-12-05
NZ545195A (en) 2010-07-30
IL235253B (en) 2018-04-30
NO2016001I2 (no) 2016-01-26
CY2014002I2 (el) 2020-05-29
NO337458B1 (no) 2016-04-18
BE2013C075I2 (OSRAM) 2023-12-18
EP2612682A3 (en) 2013-09-25
DK1689846T3 (da) 2013-05-06
HUS1300075I1 (hu) 2014-02-28
WO2005037992A3 (en) 2009-04-23
CN103223174A (zh) 2013-07-31
AU2004282491A1 (en) 2005-04-28
CY1113984T1 (el) 2016-07-27
EP2596804A2 (en) 2013-05-29
EP1689846B1 (en) 2013-03-27
US8685920B2 (en) 2014-04-01
CN108578710B (zh) 2021-11-19
EP1689846A4 (en) 2010-08-04
FR13C0068I2 (fr) 2014-04-11
JP2014177463A (ja) 2014-09-25
CN107198778A (zh) 2017-09-26
AU2010212291B2 (en) 2012-05-24
US20080114153A1 (en) 2008-05-15
JP2022068295A (ja) 2022-05-09
US8088387B2 (en) 2012-01-03
LU92336I2 (fr) 2014-02-17
EP2596804A3 (en) 2013-09-18
KR20120034800A (ko) 2012-04-12
JP2016135786A (ja) 2016-07-28
US20120226025A1 (en) 2012-09-06
CY2014002I1 (el) 2020-05-29
NZ583844A (en) 2011-06-30
US20170226220A1 (en) 2017-08-10
US20080171865A1 (en) 2008-07-17
HK1244452A1 (zh) 2018-08-10
KR20140033003A (ko) 2014-03-17
EA200600752A1 (ru) 2007-08-31
US20110281856A1 (en) 2011-11-17
US20210261683A1 (en) 2021-08-26
AU2004282491B2 (en) 2010-12-23
AU2004282491C1 (en) 2011-06-30
CN108578710A (zh) 2018-09-28
US20080145374A1 (en) 2008-06-19
SI1689846T1 (en) 2013-06-28
IL246605A (en) 2017-08-31
KR20060130552A (ko) 2006-12-19
CA2542128C (en) 2022-01-11
FR13C0068I1 (OSRAM) 2014-01-17
JP2020189854A (ja) 2020-11-26
BRPI0415448A8 (pt) 2019-08-13
CA2542128A1 (en) 2005-04-28
ECSP066461A (es) 2007-05-30
IL173625A0 (en) 2006-07-05
KR20130102649A (ko) 2013-09-17
KR101476082B1 (ko) 2014-12-23
US20140154804A1 (en) 2014-06-05
EP2596803A3 (en) 2013-09-11
PL1689846T3 (pl) 2013-07-31
JP5926759B2 (ja) 2016-05-25
JP2017200934A (ja) 2017-11-09
IL214788A0 (en) 2011-11-30
AU2010212291C1 (en) 2012-11-29
US8563509B2 (en) 2013-10-22
LU92336I9 (OSRAM) 2019-01-16
EP2612682A2 (en) 2013-07-10

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