MX350954B - Derivados de maitansinoides novedosos con enlazador de peptido y conjugados de estos. - Google Patents
Derivados de maitansinoides novedosos con enlazador de peptido y conjugados de estos.Info
- Publication number
- MX350954B MX350954B MX2013015422A MX2013015422A MX350954B MX 350954 B MX350954 B MX 350954B MX 2013015422 A MX2013015422 A MX 2013015422A MX 2013015422 A MX2013015422 A MX 2013015422A MX 350954 B MX350954 B MX 350954B
- Authority
- MX
- Mexico
- Prior art keywords
- conjugates
- formula
- peptide linker
- novel
- maytansinoid derivatives
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 229940127089 cytotoxic agent Drugs 0.000 abstract 2
- 239000002254 cytotoxic agent Substances 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 231100000599 cytotoxic agent Toxicity 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
Classifications
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
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- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
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- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07—ORGANIC CHEMISTRY
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
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- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Transplantation (AREA)
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- Medicinal Preparation (AREA)
Abstract
La presente invención se refiere al conjugado novedoso de agente de unión a la célula y agente citotóxico con un enlazador peptídico y, más específicamente, a los conjugados de la fórmula (I). La invención también proporciona agentes citotóxicos novedosos de la fórmula (II), compuestos enlazadores representados por la fórmula (III) y compuestos de fármaco y enlazador representados por la fórmula (IV). La invención proporciona adicionalmente composiciones y métodos útiles para inhibir el crecimiento celular anormal o tratar un trastorno proliferativo en un mamífero usando los compuestos o conjugados de la invención.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161499548P | 2011-06-21 | 2011-06-21 | |
PCT/US2012/043488 WO2012177837A2 (en) | 2011-06-21 | 2012-06-21 | Novel maytansinoid derivatives with peptide linker and conjugates thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013015422A MX2013015422A (es) | 2014-09-22 |
MX350954B true MX350954B (es) | 2017-09-26 |
Family
ID=46889411
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013015422A MX350954B (es) | 2011-06-21 | 2012-06-21 | Derivados de maitansinoides novedosos con enlazador de peptido y conjugados de estos. |
Country Status (14)
Country | Link |
---|---|
US (2) | US9289512B2 (es) |
EP (1) | EP2723389A2 (es) |
JP (2) | JP6209159B2 (es) |
KR (1) | KR20140037208A (es) |
CN (1) | CN103648532A (es) |
AU (1) | AU2012272930B2 (es) |
BR (1) | BR112013032928A2 (es) |
CA (1) | CA2836927A1 (es) |
EA (2) | EA029797B1 (es) |
IL (2) | IL230043A (es) |
MX (1) | MX350954B (es) |
SG (2) | SG195172A1 (es) |
WO (1) | WO2012177837A2 (es) |
ZA (1) | ZA201308703B (es) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006012527A1 (en) | 2004-07-23 | 2006-02-02 | Endocyte, Inc. | Bivalent linkers and conjugates thereof |
CA2680535C (en) | 2007-03-14 | 2016-09-20 | Endocyte, Inc. | Binding ligand linked drug delivery conjugates of tubulysins |
US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
WO2009002993A1 (en) | 2007-06-25 | 2008-12-31 | Endocyte, Inc. | Conjugates containing hydrophilic spacer linkers |
CA2836927A1 (en) | 2011-06-21 | 2012-12-27 | Immunogen, Inc. | Novel maytansinoid derivatives with peptide linker and conjugates thereof |
WO2013126797A1 (en) | 2012-02-24 | 2013-08-29 | Purdue Research Foundation | Cholecystokinin b receptor targeting for imaging and therapy |
US20140080175A1 (en) | 2012-03-29 | 2014-03-20 | Endocyte, Inc. | Processes for preparing tubulysin derivatives and conjugates thereof |
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- 2012-06-21 CN CN201280030265.5A patent/CN103648532A/zh active Pending
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US20130029900A1 (en) | 2013-01-31 |
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CN103648532A (zh) | 2014-03-19 |
IL255475A (en) | 2018-02-28 |
MX2013015422A (es) | 2014-09-22 |
IL230043A (en) | 2017-11-30 |
JP2017197560A (ja) | 2017-11-02 |
EA201792652A2 (ru) | 2018-05-31 |
AU2012272930A1 (en) | 2013-04-18 |
WO2012177837A3 (en) | 2013-07-11 |
EA029797B1 (ru) | 2018-05-31 |
EA201490095A1 (ru) | 2014-05-30 |
WO2012177837A2 (en) | 2012-12-27 |
JP2014520156A (ja) | 2014-08-21 |
NZ618262A (en) | 2016-03-31 |
ZA201308703B (en) | 2016-03-30 |
JP6598821B2 (ja) | 2019-10-30 |
US20160263238A1 (en) | 2016-09-15 |
JP6209159B2 (ja) | 2017-10-04 |
CA2836927A1 (en) | 2012-12-27 |
SG195172A1 (en) | 2013-12-30 |
KR20140037208A (ko) | 2014-03-26 |
EP2723389A2 (en) | 2014-04-30 |
US9289512B2 (en) | 2016-03-22 |
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