SG10201605041VA - Novel maytansinoid derivatives with peptide linker and conjugates thereof - Google Patents
Novel maytansinoid derivatives with peptide linker and conjugates thereofInfo
- Publication number
- SG10201605041VA SG10201605041VA SG10201605041VA SG10201605041VA SG10201605041VA SG 10201605041V A SG10201605041V A SG 10201605041VA SG 10201605041V A SG10201605041V A SG 10201605041VA SG 10201605041V A SG10201605041V A SG 10201605041VA SG 10201605041V A SG10201605041V A SG 10201605041VA
- Authority
- SG
- Singapore
- Prior art keywords
- conjugates
- peptide linker
- maytansinoid derivatives
- novel maytansinoid
- novel
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
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- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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- A61K47/6863—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from stomach or intestines cancer cell
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- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
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- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
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- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
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Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161499548P | 2011-06-21 | 2011-06-21 |
Publications (1)
Publication Number | Publication Date |
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SG10201605041VA true SG10201605041VA (en) | 2016-08-30 |
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Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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SG2013087556A SG195172A1 (en) | 2011-06-21 | 2012-06-21 | Novel maytansinoid derivatives with peptide linker and conjugates thereof |
SG10201605041VA SG10201605041VA (en) | 2011-06-21 | 2012-06-21 | Novel maytansinoid derivatives with peptide linker and conjugates thereof |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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SG2013087556A SG195172A1 (en) | 2011-06-21 | 2012-06-21 | Novel maytansinoid derivatives with peptide linker and conjugates thereof |
Country Status (14)
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US (2) | US9289512B2 (en) |
EP (1) | EP2723389A2 (en) |
JP (2) | JP6209159B2 (en) |
KR (1) | KR20140037208A (en) |
CN (1) | CN103648532A (en) |
AU (1) | AU2012272930B2 (en) |
BR (1) | BR112013032928A2 (en) |
CA (1) | CA2836927A1 (en) |
EA (2) | EA029797B1 (en) |
IL (2) | IL230043A (en) |
MX (1) | MX350954B (en) |
SG (2) | SG195172A1 (en) |
WO (1) | WO2012177837A2 (en) |
ZA (1) | ZA201308703B (en) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006012527A1 (en) | 2004-07-23 | 2006-02-02 | Endocyte, Inc. | Bivalent linkers and conjugates thereof |
NZ599239A (en) | 2007-03-14 | 2013-10-25 | Endocyte Inc | Binding ligand linked drug delivery conjugates of tubulysins |
AU2008268432B2 (en) | 2007-06-25 | 2015-01-15 | Endocyte, Inc. | Conjugates containing hydrophilic spacer linkers |
US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
BR112013032928A2 (en) | 2011-06-21 | 2017-01-24 | Immunogen Inc | "peptide-binding maytansinoid derivatives and conjugates thereof, pharmaceutical composition comprising and use thereof" |
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