IL159109A0 - Beta-amino tetrahydroimidazo (1,2-a) pyrazines and tetrahydrotriazolo (4,3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes - Google Patents

Beta-amino tetrahydroimidazo (1,2-a) pyrazines and tetrahydrotriazolo (4,3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes

Info

Publication number
IL159109A0
IL159109A0 IL15910902A IL15910902A IL159109A0 IL 159109 A0 IL159109 A0 IL 159109A0 IL 15910902 A IL15910902 A IL 15910902A IL 15910902 A IL15910902 A IL 15910902A IL 159109 A0 IL159109 A0 IL 159109A0
Authority
IL
Israel
Prior art keywords
pyrazines
tetrahydrotriazolo
diabetes
beta
prevention
Prior art date
Application number
IL15910902A
Other languages
English (en)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23172273&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL159109(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IL159109A0 publication Critical patent/IL159109A0/xx

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P5/00—Drugs for disorders of the endocrine system
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • A61P9/12—Antihypertensives

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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Ophthalmology & Optometry (AREA)
IL15910902A 2001-07-06 2002-07-05 Beta-amino tetrahydroimidazo (1,2-a) pyrazines and tetrahydrotriazolo (4,3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes IL159109A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30347401P 2001-07-06 2001-07-06
PCT/US2002/021349 WO2003004498A1 (en) 2001-07-06 2002-07-05 Beta-amino tetrahydroimidazo (1, 2-a) pyrazines and tetrahydrotrioazolo (4, 3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes

Publications (1)

Publication Number Publication Date
IL159109A0 true IL159109A0 (en) 2004-05-12

Family

ID=23172273

Family Applications (3)

Application Number Title Priority Date Filing Date
IL15910902A IL159109A0 (en) 2001-07-06 2002-07-05 Beta-amino tetrahydroimidazo (1,2-a) pyrazines and tetrahydrotriazolo (4,3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
IL159109A IL159109A (en) 2001-07-06 2003-11-27 Derivatives of 7- (3-amino-4-arylbutanoil) tetrahydroimidazole (A-2,1) pyrazine and tetrahydrotriazolo (3,4-A) pyrazine as inhibitors of dipeptidyl peptides and pharmaceutical preparations containing them
IL178307A IL178307A (en) 2001-07-06 2006-09-26 A medical composition comprising tetrahydrotriazolo [3,4–] a pyrazine

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL159109A IL159109A (en) 2001-07-06 2003-11-27 Derivatives of 7- (3-amino-4-arylbutanoil) tetrahydroimidazole (A-2,1) pyrazine and tetrahydrotriazolo (3,4-A) pyrazine as inhibitors of dipeptidyl peptides and pharmaceutical preparations containing them
IL178307A IL178307A (en) 2001-07-06 2006-09-26 A medical composition comprising tetrahydrotriazolo [3,4–] a pyrazine

Country Status (46)

Country Link
US (9) US6699871B2 (it)
EP (4) EP2292232B1 (it)
JP (1) JP3762407B2 (it)
KR (1) KR100606871B1 (it)
CN (2) CN1290848C (it)
AR (1) AR036114A1 (it)
AT (2) ATE321048T1 (it)
AU (1) AU2002320303B2 (it)
BE (1) BE2007C047I2 (it)
BG (1) BG108493A (it)
BR (1) BRPI0210866B8 (it)
CA (1) CA2450740C (it)
CR (1) CR7235A (it)
CY (3) CY2007019I2 (it)
DE (4) DE122008000046I1 (it)
DK (2) DK1625847T3 (it)
DO (1) DOP2002000438A (it)
EA (2) EA012701B1 (it)
EC (1) ECSP044935A (it)
ES (2) ES2259713T3 (it)
FR (2) FR07C0041I2 (it)
GE (2) GEP20063734B (it)
HK (1) HK1068882A1 (it)
HR (1) HRP20031098B1 (it)
HU (2) HU225695B1 (it)
IL (3) IL159109A0 (it)
IS (2) IS2218B (it)
JO (1) JO2230B1 (it)
LT (1) LTC1412357I2 (it)
LU (2) LUC91360I2 (it)
MA (1) MA27053A1 (it)
ME (1) ME00439B (it)
MX (1) MXPA04000018A (it)
MY (1) MY127961A (it)
NL (2) NL300287I2 (it)
NO (4) NO321999B1 (it)
NZ (1) NZ529833A (it)
PE (1) PE20030654A1 (it)
PL (1) PL196278B6 (it)
PT (2) PT1412357E (it)
RS (1) RS50737B (it)
SI (1) SI1412357T1 (it)
TW (1) TWI226331B (it)
UA (1) UA74912C2 (it)
WO (1) WO2003004498A1 (it)
ZA (1) ZA200309294B (it)

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US7544511B2 (en) * 1996-09-25 2009-06-09 Neuralstem Biopharmaceuticals Ltd. Stable neural stem cell line methods
US20030176357A1 (en) * 1998-10-06 2003-09-18 Pospisilik Andrew J. Dipeptidyl peptidase IV inhibitors and their uses for lowering blood pressure levels
DE69915514T2 (de) * 1998-12-31 2005-01-05 Société de Conseils de Recherches et d'Applications Scientifiques S.A.S. Prenyltransferase-inhibitoren
JP2004535433A (ja) 2001-06-20 2004-11-25 メルク　エンド　カムパニー　インコーポレーテッド 糖尿病治療用のジペプチジルペプチダーゼ阻害薬
CA2450475A1 (en) 2001-06-20 2003-01-03 Linda Brockunier Dipeptidyl peptidase inhibitors for the treatment of diabetes
CN1723196A (zh) 2001-06-27 2006-01-18 史密丝克莱恩比彻姆公司 作为二肽酶抑制剂的氟代吡咯烷
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JP4530852B2 (ja) * 2002-07-15 2010-08-25 メルク・シャープ・エンド・ドーム・コーポレイション 糖尿病治療のためのピペリジノピリミジンジペプチジルペプチダーゼ阻害剤
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FR07C0041I1 (it) 2007-10-19
PT1412357E (pt) 2006-07-31
EP2292232B1 (en) 2014-08-20
FR08C0033I2 (fr) 2010-12-31
ME00439B (me) 2011-12-20
ATE321048T1 (de) 2006-04-15
BE2007C047I2 (it) 2021-06-04
JO2230B1 (en) 2004-10-07
DK1412357T3 (da) 2006-07-17
CY1110784T1 (el) 2015-06-10
US20170348309A1 (en) 2017-12-07
ATE471148T1 (de) 2010-07-15
NO2007010I1 (no) 2007-09-17
CY2008014I2 (el) 2009-11-04
MXPA04000018A (es) 2004-05-21
DE60236767D1 (de) 2010-07-29
NO2020007I1 (no) 2020-03-19
US8440668B2 (en) 2013-05-14
EA200400153A1 (ru) 2004-06-24
US6699871B2 (en) 2004-03-02

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