HUP0302345A2 - Új triazolo-pirimidin-vegyületek, ezek intermedierjei és eljárás az előállításukra - Google Patents
Új triazolo-pirimidin-vegyületek, ezek intermedierjei és eljárás az előállításukraInfo
- Publication number
- HUP0302345A2 HUP0302345A2 HU0302345A HUP0302345A HUP0302345A2 HU P0302345 A2 HUP0302345 A2 HU P0302345A2 HU 0302345 A HU0302345 A HU 0302345A HU P0302345 A HUP0302345 A HU P0302345A HU P0302345 A2 HUP0302345 A2 HU P0302345A2
- Authority
- HU
- Hungary
- Prior art keywords
- intermediates
- preparation
- pyrimidine compounds
- triazolo pyrimidine
- novel triazolo
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title abstract 2
- YWBFPKPWMSWWEA-UHFFFAOYSA-O triazolopyrimidine Chemical class BrC1=CC=CC(C=2N=C3N=CN[N+]3=C(NCC=3C=CN=CC=3)C=2)=C1 YWBFPKPWMSWWEA-UHFFFAOYSA-O 0.000 title 1
- 239000012450 pharmaceutical intermediate Substances 0.000 abstract 1
- -1 pyrimidine compound Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
A találmány tárgyát az képletű, gyógyszerészeti intermedierkéntalkalmazható pirimidinvegyület, ennek előállítása, az előállításhozalkalmazható intermedierek képezik. Ó
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0013488.2A GB0013488D0 (en) | 2000-06-02 | 2000-06-02 | Chemical compound |
SE0002102A SE0002102D0 (sv) | 2000-06-02 | 2000-06-06 | Chemical compound |
PCT/SE2001/001241 WO2001092263A1 (en) | 2000-06-02 | 2001-05-31 | Novel triazolo pyrimidine compounds |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP0302345A2 true HUP0302345A2 (hu) | 2003-11-28 |
HUP0302345A3 HUP0302345A3 (en) | 2007-10-29 |
HU229281B1 HU229281B1 (en) | 2013-10-28 |
Family
ID=26244413
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0302345A HU229281B1 (en) | 2000-06-02 | 2001-05-31 | Novel triazolo pyrimidine compounds |
Country Status (36)
Country | Link |
---|---|
US (6) | US7067663B2 (hu) |
EP (1) | EP1299390B1 (hu) |
JP (1) | JP4947870B2 (hu) |
KR (2) | KR100802884B1 (hu) |
CN (3) | CN1200940C (hu) |
AR (1) | AR028605A1 (hu) |
AT (1) | ATE386039T1 (hu) |
AU (4) | AU6287601A (hu) |
BG (1) | BG65866B1 (hu) |
BR (1) | BR0111319A (hu) |
CA (1) | CA2408914C (hu) |
CY (1) | CY1108101T1 (hu) |
CZ (3) | CZ303162B6 (hu) |
DE (1) | DE60132776T2 (hu) |
DK (1) | DK1299390T3 (hu) |
EE (1) | EE05223B1 (hu) |
ES (1) | ES2299487T3 (hu) |
GB (1) | GB0013488D0 (hu) |
HK (1) | HK1053122A1 (hu) |
HU (1) | HU229281B1 (hu) |
IL (3) | IL152776A0 (hu) |
IS (1) | IS2600B (hu) |
MX (2) | MXPA02011793A (hu) |
MY (1) | MY131942A (hu) |
NO (1) | NO324266B1 (hu) |
NZ (1) | NZ522637A (hu) |
PL (3) | PL210375B1 (hu) |
PT (1) | PT1299390E (hu) |
RU (1) | RU2295526C2 (hu) |
SE (1) | SE0002102D0 (hu) |
SI (1) | SI1299390T1 (hu) |
SK (1) | SK286845B6 (hu) |
TW (1) | TWI285203B (hu) |
UA (1) | UA73182C2 (hu) |
WO (1) | WO2001092263A1 (hu) |
ZA (1) | ZA200209068B (hu) |
Families Citing this family (86)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0013407D0 (en) * | 2000-06-02 | 2000-07-26 | Astrazeneca Ab | Forms of a chemical compound |
SE0401001D0 (sv) * | 2004-03-31 | 2004-03-31 | Astrazeneca Ab | Chemical process |
SE0400873D0 (sv) * | 2004-03-31 | 2004-03-31 | Astrazeneca Ab | Chemical process |
GB0615619D0 (en) | 2006-08-05 | 2006-09-13 | Astrazeneca Ab | Chemical process for preparation of intermediates |
GB0615620D0 (en) | 2006-08-05 | 2006-09-13 | Astrazeneca Ab | A process for the preparation of optically active intermediates |
CA2668180A1 (en) | 2006-10-31 | 2008-05-08 | Janssen Pharmaceutica N.V. | Triazolopyrimidine derivatives as adp p2y12 receptor antagonists |
TWI496776B (zh) * | 2007-11-15 | 2015-08-21 | Astrazeneca Ab | 製備(3aR,4S,6R,6aS)-6-胺基-2,2-二甲基四氫-3aH-環戊并[d][1,3]二氧雜環戊烯-4-醇之純非對映異構性之二苯甲醯-L-酒石酸鹽之方法 |
SG196805A1 (en) * | 2008-09-09 | 2014-02-13 | Astrazeneca Ab | A process for preparing [1s- [1-alpha, 2-alpha, 3-beta (1s*, 2r*) 5-beta] ] -3- [7- [2- (3, 4-dif luorophenyl) -cyclopropylamino] - 5- (propylthio) -3h-1, 2, 3-triazolo [4, 5-d] pyrimidin-3-yl] -5- (2- hydroxyethoxy) cyclopentane-1, 2-diol and to its intermediates |
EP2336105B9 (en) | 2008-09-19 | 2014-09-17 | Takeda Pharmaceutical Company Limited | Nitrogen-containing heterocyclic compound and use of same |
US8883104B2 (en) * | 2009-03-02 | 2014-11-11 | Calera Corporation | Gas stream multi-pollutants control systems and methods |
WO2011017108A2 (en) | 2009-07-27 | 2011-02-10 | Auspex Pharmaceuticals, Inc. | Cyclopropyl modulators of p2y12 receptor |
EP2305376A1 (en) | 2009-09-23 | 2011-04-06 | Lonza Ltd. | Process and catalyst for the catalytic hydrogenation of aromatic and heteroaromatic nitro compounds |
US8859769B2 (en) | 2010-02-16 | 2014-10-14 | Actavis Group Ptc Ehf | Processes for preparing ticagrelor intermediate, 4,6-dichloro-5-nitro-2-(propylthio)pyrimidine |
CA2796504A1 (en) | 2010-04-20 | 2011-10-27 | Actavis Group Ptc Ehf | Novel process for preparing phenylcyclopropylamine derivatives using novel intermediates |
EP2588441A2 (en) * | 2010-06-30 | 2013-05-08 | Actavis Group Ptc Ehf | Novel processes for the preparation of phenylcyclopropylamine derivatives and use thereof for preparing ticagrelor |
WO2012063126A2 (en) | 2010-11-09 | 2012-05-18 | Actavis Group Ptc Ehf | Improved processes for preparing pure (3ar,4s,6r,6as)-6-amino-2,2-dimethyltetrahdro-3ah-cyclopenta[d] [1,3]-dioxol-4-ol and its key starting material |
CN103429576A (zh) | 2010-12-20 | 2013-12-04 | 阿特维斯集团公司 | 制备三唑并[4,5-d]嘧啶衍生物及其中间体的新方法 |
BR112013025680A2 (pt) | 2011-04-06 | 2017-01-03 | Teva Pharma | Novos intermediários e processos para preparar ticagrelor |
CN102731467B (zh) * | 2011-04-15 | 2015-12-16 | 博瑞生物医药(苏州)股份有限公司 | 替卡格雷的中间体及制备替卡格雷的方法 |
PL2707363T3 (pl) * | 2011-05-13 | 2016-02-29 | Astrazeneca Ab | Sposób wytwarzania [(3aS,4R,6S,6aR)-6-hydroksy-2,2- dimetylotetrahydro-3aH-cyklopenta[d][1,3]dioksol]-4-ilo]karbaminianu benzylu i związki pośrednie w tym sposobie |
EP2721018A1 (en) | 2011-06-15 | 2014-04-23 | Actavis Group Ptc Ehf | Improved process for preparing cyclopentylamine derivatives and intermediates thereof |
WO2013037942A1 (en) | 2011-09-14 | 2013-03-21 | Lek Pharmaceuticals D.D. | Synthesis of triazolopyrimidine compounds |
EP2570405A1 (en) | 2011-09-14 | 2013-03-20 | LEK Pharmaceuticals d.d. | Synthesis of Triazolopyrimidine Compounds |
EP2586773A1 (en) | 2011-10-27 | 2013-05-01 | LEK Pharmaceuticals d.d. | Synthesis of Triazolopyrimidine Compounds |
PL2771326T4 (pl) * | 2011-10-27 | 2018-06-29 | Lek Pharmaceuticals D.D. | Synteza związków triazolopirymidynowych |
AU2012343928A1 (en) | 2011-11-30 | 2014-05-29 | Actavis Group Ptc Ehf | Novel crystalline form of ticagrelor and process for the preparation thereof |
CN104114542B (zh) | 2011-12-23 | 2017-11-14 | 力奇制药公司 | 三唑并嘧啶化合物的合成 |
EP2628721A1 (en) | 2012-02-20 | 2013-08-21 | LEK Pharmaceuticals d.d. | Synthesis of 2-(3,4-difluorophenyl)cyclopropanecarboxylic acid |
CN104603098B (zh) * | 2012-03-30 | 2016-06-29 | 桑多斯股份公司 | 2-(3,4-二氟苯基)环丙胺衍生物和盐的合成 |
EP2644590A1 (en) | 2012-03-30 | 2013-10-02 | LEK Pharmaceuticals d.d. | Synthesis of 2-(3,4-difluorophenyl)cyclopropanamine derivatives and salts |
EP2834247A4 (en) | 2012-04-05 | 2016-03-30 | Reddys Lab Ltd Dr | PREPARATION OF TICAGRELOR |
WO2013163892A1 (en) * | 2012-05-02 | 2013-11-07 | Sunshine Lake Pharma Co., Ltd. | Novel triazolo pyrimidine compounds and a process of preparation thereof |
CN102659815B (zh) * | 2012-05-04 | 2013-07-17 | 开原亨泰制药股份有限公司 | 一种制备选择性抗凝血药替卡格雷及其中间体的方法 |
CN102675321B (zh) * | 2012-05-11 | 2014-12-10 | 上海皓元化学科技有限公司 | 一种替卡格雷的制备方法 |
EP2666771A1 (en) | 2012-05-24 | 2013-11-27 | LEK Pharmaceuticals d.d. | Synthesis of Aminocyclopentanetriol Derivatives |
WO2014023681A1 (en) * | 2012-08-06 | 2014-02-13 | Enantia, S.L. | A process for the preparation of an intermediate for a triazolopyrimidine carbonucleoside |
CN103588674B (zh) * | 2012-08-14 | 2015-02-11 | 上海医药工业研究院 | 一种具有光学活性的环丙烷酰阱化合物、其制备和应用 |
CN103626743B (zh) * | 2012-08-23 | 2018-06-08 | 广东东阳光药业有限公司 | 替卡格雷的新型中间体及其制备方法 |
CN102875537A (zh) * | 2012-09-10 | 2013-01-16 | 常州制药厂有限公司 | 一种新的抗血栓药物的制备方法 |
WO2014083139A1 (en) | 2012-11-29 | 2014-06-05 | Actavis Group Ptc Ehf | Novel amorphous form of ticagrelor |
US20150322071A1 (en) * | 2012-12-06 | 2015-11-12 | Brightgene Bio-Medical Technology (Suzhou) Co., Ltd | Process for preparing triazole pyrimidine compounds and intermediates thereof |
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CN103848834B (zh) * | 2012-12-06 | 2017-09-22 | 博瑞生物医药(苏州)股份有限公司 | 一种制备替卡格雷的方法及其中间体 |
WO2014102830A1 (en) | 2012-12-31 | 2014-07-03 | Megafine Pharma (P) Ltd. | A process for preparation of ticagrelor and intermediates thereof |
CN103936767B (zh) * | 2013-01-23 | 2016-08-03 | 上海医药工业研究院 | 一种制备化合物(1r,2s,6s,7s)-4,4-二甲基-9-苯甲基-3,5,8-三氧杂-9-氮杂三环[5.2.1.02.6]葵烷的方法 |
CZ307217B6 (cs) | 2013-03-14 | 2018-04-04 | Zentiva, K.S. | Zlepšený způsob výroby a nové intermediáty syntézy ticagreloru |
ITMI20130487A1 (it) | 2013-03-29 | 2014-09-30 | Chemo Res S L | Alchilazione selettiva di ciclopentilalcoli |
CN104098553B (zh) | 2013-04-10 | 2017-11-28 | 江苏恒瑞医药股份有限公司 | 替格瑞洛的中间体及其制备方法和替格瑞洛的制备方法 |
CN103275056B (zh) * | 2013-05-24 | 2015-06-17 | 浙江普洛医药科技有限公司 | 一种替卡格雷中间体的制备方法 |
WO2014195861A2 (en) * | 2013-06-04 | 2014-12-11 | Dr. Reddy’S Laboratories Limited | Preparation of ticagrelor |
CN104230818B (zh) * | 2013-06-06 | 2018-01-12 | 郝聪梅 | 替卡格雷中间体的改进制备方法 |
WO2014206187A1 (zh) * | 2013-06-24 | 2014-12-31 | 苏州明锐医药科技有限公司 | 替卡格雷及其中间体的制备方法 |
CN103275087A (zh) * | 2013-06-28 | 2013-09-04 | 南京工业大学 | 一种三氮唑并嘧啶类衍生物及其制备方法 |
CN104059069B (zh) * | 2013-08-22 | 2016-08-10 | 北京康立生医药技术开发有限公司 | 一种替卡格雷的制备方法 |
CN104592237A (zh) * | 2013-10-31 | 2015-05-06 | 徐州万邦金桥制药有限公司 | 一种抗凝血药替格瑞洛的合成方法 |
CN103588750B (zh) * | 2013-11-07 | 2014-11-26 | 苏州明锐医药科技有限公司 | 替卡格雷中间体的制备方法 |
CN103588712B (zh) * | 2013-11-08 | 2016-06-08 | 南京欧信医药技术有限公司 | 一种嘧啶类化合物及其制备方法、和应用 |
CZ2013866A3 (cs) | 2013-11-08 | 2015-05-20 | Zentiva, K.S. | Způsob výroby a nová krystalická forma intermediátu syntézy ticagreloru |
CN104710425B (zh) * | 2013-12-16 | 2019-06-14 | 石药集团中奇制药技术(石家庄)有限公司 | 一种替格瑞洛新结晶及其制备方法 |
CN104744424B (zh) * | 2013-12-27 | 2018-12-25 | 博瑞生物医药(苏州)股份有限公司 | 一种替卡格雷中间体的制备方法 |
CN103923020A (zh) * | 2014-04-02 | 2014-07-16 | 黄河三角洲京博化工研究院有限公司 | 一种2-丙硫基-4,6-二氯-5-氨基嘧啶的制备方法 |
CN103992323B (zh) * | 2014-04-18 | 2017-03-29 | 南通常佑药业科技有限公司 | 一种替格瑞洛的制备方法 |
WO2015162630A1 (en) | 2014-04-25 | 2015-10-29 | Anlon Chemical Research Organization | Novel processes for preparing triazolo [4,5-d]- pyrimidines, including ticagrelor, vianew intermediates and new route of synthesis. |
WO2015193165A1 (en) | 2014-06-18 | 2015-12-23 | Flamma Spa | Process for the preparation of triazolo[4,5-d] pyrimidine cyclopentane compounds |
WO2016001851A1 (en) * | 2014-07-02 | 2016-01-07 | Dr. Reddy's Laboratories Limited | Preparation of ticagrelor |
CN104193748A (zh) * | 2014-08-14 | 2014-12-10 | 严白双 | 一种替卡格雷的合成方法 |
WO2016030704A1 (en) * | 2014-08-30 | 2016-03-03 | Cipla Limited | Solid form of intermediate of ticagrelor |
CN105801583A (zh) * | 2014-12-31 | 2016-07-27 | 徐州万邦金桥制药有限公司 | 一种替格瑞洛的纯化方法 |
WO2016116942A1 (en) | 2015-01-20 | 2016-07-28 | Anlon Chemical Research Organization | Novel pharmaceutical compounds comprising ticagrelor with salts of aspirin |
WO2016117852A2 (ko) * | 2015-01-22 | 2016-07-28 | 동아에스티 주식회사 | 티카그렐러 제조방법 및 이를 위한 신규한 중간체 |
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CN105153167B (zh) * | 2015-09-06 | 2017-09-19 | 惠州信立泰药业有限公司 | 一种替格瑞洛结晶及含有该结晶的药物组合物 |
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WO2017072790A1 (en) * | 2015-10-26 | 2017-05-04 | Avra Laboratories Pvt. Ltd. | An improved process for synthesis of ticagrelor |
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EP3919497A1 (en) | 2020-06-04 | 2021-12-08 | Zaklady Farmaceutyczne Polpharma S.A. | Process for the preparation of ticagrelor |
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Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3040406A1 (de) * | 1980-10-27 | 1982-05-27 | Degussa Ag, 6000 Frankfurt | Verfahren zur gewinnung von n-tert-alkylaminen und ameisensaeureestern |
GB8916477D0 (en) | 1989-07-19 | 1989-09-06 | Glaxo Group Ltd | Chemical process |
IE902671A1 (en) * | 1989-07-24 | 1991-02-27 | Glaxo Group Ltd | Cyclopentane derivatives |
US5654285A (en) | 1991-04-06 | 1997-08-05 | Astra Pharmaceuticals Limited | ADP and ATP analogues, process for making and administration to inhibit ADP-induced platelet aggregation |
ATE127808T1 (de) * | 1991-04-06 | 1995-09-15 | Fisons Plc | Atp-analogen. |
US5817672A (en) * | 1991-12-06 | 1998-10-06 | Hoechst Marion Roussel, Inc. | Trans cyclopentanyl purine analogs useful as immunosuppressants |
IL122814A (en) * | 1995-07-11 | 2001-04-30 | Astrazeneca Ab | Acid 1 - [1, 2, 3, - Triazolo [4, 5, - [d pyrimidine - 3 - il] Ribo - the photopornorone, converted in positions 5 and 7 and its analogues, their preparation and pharmaceutical preparations containing them |
AU5501598A (en) * | 1996-12-20 | 1998-07-17 | Astra Pharmaceuticals Limited | Triazolo{4,5-(d)}pyrimidinyl derivatives and their use as medicaments |
SE9702773D0 (sv) * | 1997-07-22 | 1997-07-22 | Astra Pharma Prod | Novel compounds |
TW530058B (en) * | 1997-07-22 | 2003-05-01 | Astra Pharma Prod | Triazolo [4,5-d]pyrimidine compounos and their use and process for preparation |
JP2002503663A (ja) * | 1998-02-17 | 2002-02-05 | アストラゼネカ ユーケイ リミテッド | 新規のトリアゾロ(4,5−d)ピリミジン化合物 |
TWI229674B (en) * | 1998-12-04 | 2005-03-21 | Astra Pharma Prod | Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses |
CZ20002947A3 (cs) * | 1999-02-05 | 2000-11-15 | Astrazeneca Uk Limited | Nové triazolo(4,5-d)pyrimidiny, způsob jejich přípravy a farmaceutický prostředek, který je obsahuje |
SE9904129D0 (sv) | 1999-11-15 | 1999-11-15 | Astra Pharma Prod | Novel compounds |
GB0013407D0 (en) * | 2000-06-02 | 2000-07-26 | Astrazeneca Ab | Forms of a chemical compound |
-
2000
- 2000-06-02 GB GBGB0013488.2A patent/GB0013488D0/en not_active Ceased
- 2000-06-06 SE SE0002102A patent/SE0002102D0/xx unknown
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2001
- 2001-05-22 AR ARP010102431A patent/AR028605A1/es active IP Right Grant
- 2001-05-22 TW TW090112235A patent/TWI285203B/zh not_active IP Right Cessation
- 2001-05-31 UA UA20021210810A patent/UA73182C2/uk unknown
- 2001-05-31 MY MYPI20012586A patent/MY131942A/en unknown
- 2001-05-31 PL PL359183A patent/PL210375B1/pl unknown
- 2001-05-31 PT PT01937111T patent/PT1299390E/pt unknown
- 2001-05-31 KR KR1020027016378A patent/KR100802884B1/ko active IP Right Grant
- 2001-05-31 JP JP2002500876A patent/JP4947870B2/ja not_active Expired - Lifetime
- 2001-05-31 CA CA002408914A patent/CA2408914C/en not_active Expired - Lifetime
- 2001-05-31 CN CNB018105645A patent/CN1200940C/zh not_active Ceased
- 2001-05-31 ES ES01937111T patent/ES2299487T3/es not_active Expired - Lifetime
- 2001-05-31 AU AU6287601A patent/AU6287601A/xx active Pending
- 2001-05-31 BR BR0111319-4A patent/BR0111319A/pt not_active Application Discontinuation
- 2001-05-31 SI SI200130817T patent/SI1299390T1/sl unknown
- 2001-05-31 RU RU2002135596/04A patent/RU2295526C2/ru not_active IP Right Cessation
- 2001-05-31 SK SK1683-2002A patent/SK286845B6/sk not_active IP Right Cessation
- 2001-05-31 EP EP01937111A patent/EP1299390B1/en not_active Expired - Lifetime
- 2001-05-31 CZ CZ20100462A patent/CZ303162B6/cs not_active IP Right Cessation
- 2001-05-31 DE DE60132776T patent/DE60132776T2/de not_active Expired - Lifetime
- 2001-05-31 AT AT01937111T patent/ATE386039T1/de active
- 2001-05-31 PL PL392726A patent/PL212128B1/pl unknown
- 2001-05-31 AU AU2001262876A patent/AU2001262876B2/en not_active Expired
- 2001-05-31 CN CNA2007101528077A patent/CN101143864A/zh active Pending
- 2001-05-31 DK DK01937111T patent/DK1299390T3/da active
- 2001-05-31 WO PCT/SE2001/001241 patent/WO2001092263A1/en active Application Filing
- 2001-05-31 EE EEP200200669A patent/EE05223B1/xx unknown
- 2001-05-31 US US10/275,560 patent/US7067663B2/en not_active Expired - Lifetime
- 2001-05-31 NZ NZ522637A patent/NZ522637A/en unknown
- 2001-05-31 MX MXPA02011793A patent/MXPA02011793A/es active IP Right Grant
- 2001-05-31 PL PL392725A patent/PL211318B1/pl not_active IP Right Cessation
- 2001-05-31 CZ CZ20023919A patent/CZ302645B6/cs not_active IP Right Cessation
- 2001-05-31 CZ CZ20100616A patent/CZ302644B6/cs not_active IP Right Cessation
- 2001-05-31 IL IL15277601A patent/IL152776A0/xx unknown
- 2001-05-31 CN CNB2005100594528A patent/CN100354268C/zh not_active Expired - Fee Related
- 2001-05-31 KR KR1020077028366A patent/KR100814229B1/ko active Protection Beyond IP Right Term
- 2001-05-31 HU HU0302345A patent/HU229281B1/hu unknown
-
2002
- 2002-11-07 ZA ZA200209068A patent/ZA200209068B/en unknown
- 2002-11-11 IL IL152776A patent/IL152776A/en active IP Right Grant
- 2002-11-14 IS IS6614A patent/IS2600B/is unknown
- 2002-11-28 BG BG107333A patent/BG65866B1/bg unknown
- 2002-11-28 MX MX2013006281A patent/MX336939B/es unknown
- 2002-11-28 NO NO20025719A patent/NO324266B1/no not_active IP Right Cessation
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2003
- 2003-07-30 HK HK03105490A patent/HK1053122A1/xx not_active IP Right Cessation
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2005
- 2005-10-24 US US11/255,838 patent/US20060041132A1/en not_active Abandoned
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2006
- 2006-11-02 US US11/591,464 patent/US7381828B2/en not_active Expired - Lifetime
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2007
- 2007-02-16 AU AU2007200776A patent/AU2007200776B2/en not_active Expired
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2008
- 2008-04-09 CY CY20081100388T patent/CY1108101T1/el unknown
- 2008-04-28 US US12/149,145 patent/US20080234481A1/en not_active Abandoned
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2009
- 2009-09-10 US US12/585,285 patent/US20100004444A1/en not_active Abandoned
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2010
- 2010-02-09 AU AU2010200461A patent/AU2010200461B2/en not_active Ceased
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2011
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