HK1053122A1 - Pyrimidine compounds and their use in the preparation of a triazolo-pyrimidine carba nucleoside - Google Patents

Pyrimidine compounds and their use in the preparation of a triazolo-pyrimidine carba nucleoside

Info

Publication number
HK1053122A1
HK1053122A1 HK03105490A HK03105490A HK1053122A1 HK 1053122 A1 HK1053122 A1 HK 1053122A1 HK 03105490 A HK03105490 A HK 03105490A HK 03105490 A HK03105490 A HK 03105490A HK 1053122 A1 HK1053122 A1 HK 1053122A1
Authority
HK
Hong Kong
Prior art keywords
pyrimidine
preparation
carba
triazolo
nucleoside
Prior art date
Application number
HK03105490A
Other languages
English (en)
Inventor
Larsson Ulf
Magnusson Mattias
Musil Tibor
Palmgren Andreas
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26244413&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1053122(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of HK1053122A1 publication Critical patent/HK1053122A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HK03105490A 2000-06-02 2003-07-30 Pyrimidine compounds and their use in the preparation of a triazolo-pyrimidine carba nucleoside HK1053122A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0013488.2A GB0013488D0 (en) 2000-06-02 2000-06-02 Chemical compound
SE0002102A SE0002102D0 (sv) 2000-06-02 2000-06-06 Chemical compound
PCT/SE2001/001241 WO2001092263A1 (en) 2000-06-02 2001-05-31 Novel triazolo pyrimidine compounds

Publications (1)

Publication Number Publication Date
HK1053122A1 true HK1053122A1 (en) 2003-10-10

Family

ID=26244413

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03105490A HK1053122A1 (en) 2000-06-02 2003-07-30 Pyrimidine compounds and their use in the preparation of a triazolo-pyrimidine carba nucleoside

Country Status (36)

Country Link
US (6) US7067663B2 (hu)
EP (1) EP1299390B1 (hu)
JP (1) JP4947870B2 (hu)
KR (2) KR100814229B1 (hu)
CN (3) CN101143864A (hu)
AR (1) AR028605A1 (hu)
AT (1) ATE386039T1 (hu)
AU (4) AU2001262876B2 (hu)
BG (1) BG65866B1 (hu)
BR (1) BR0111319A (hu)
CA (1) CA2408914C (hu)
CY (1) CY1108101T1 (hu)
CZ (3) CZ302645B6 (hu)
DE (1) DE60132776T2 (hu)
DK (1) DK1299390T3 (hu)
EE (1) EE05223B1 (hu)
ES (1) ES2299487T3 (hu)
GB (1) GB0013488D0 (hu)
HK (1) HK1053122A1 (hu)
HU (1) HU229281B1 (hu)
IL (3) IL152776A0 (hu)
IS (1) IS2600B (hu)
MX (2) MXPA02011793A (hu)
MY (1) MY131942A (hu)
NO (1) NO324266B1 (hu)
NZ (1) NZ522637A (hu)
PL (3) PL212128B1 (hu)
PT (1) PT1299390E (hu)
RU (1) RU2295526C2 (hu)
SE (1) SE0002102D0 (hu)
SI (1) SI1299390T1 (hu)
SK (1) SK286845B6 (hu)
TW (1) TWI285203B (hu)
UA (1) UA73182C2 (hu)
WO (1) WO2001092263A1 (hu)
ZA (1) ZA200209068B (hu)

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CN105198864B (zh) * 2015-10-21 2018-11-06 华仁药业股份有限公司 一种环戊基嘧啶化合物的无溶剂制备方法
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CN105669681A (zh) * 2016-04-11 2016-06-15 成都华宇制药有限公司 一种替格瑞洛的合成方法
CN106543191B (zh) * 2016-10-28 2019-03-01 天津红日药业股份有限公司 一种替格瑞洛制备工艺
CN107337675A (zh) * 2017-06-03 2017-11-10 湖南天济草堂制药股份有限公司 一种制备替格瑞洛的改进方法
CN107382953A (zh) * 2017-07-25 2017-11-24 安徽诺全药业有限公司 一种制备多取代环戊烷衍生物的方法
CN108689984B (zh) * 2018-05-02 2019-09-20 淮阴工学院 一种替格瑞洛中间体的生物合成方法及其中间体
CN110894184B (zh) * 2019-11-25 2022-02-18 安徽一帆香料有限公司 一种基于绿色环保的替格瑞洛中间体的制备方法
EP3919497A1 (en) 2020-06-04 2021-12-08 Zaklady Farmaceutyczne Polpharma S.A. Process for the preparation of ticagrelor
CN112457316B (zh) * 2020-11-05 2022-04-12 南通常佑药业科技有限公司 一种应用连续流反应技术制备替卡格雷高级中间体的方法
CN112724119B (zh) * 2020-12-30 2022-05-03 江苏恒沛药物科技有限公司 一种替卡格雷关键中间体的合成方法
CN115160320B (zh) * 2022-06-27 2024-05-07 南通常佑药业科技有限公司 一种手性嘧啶并三唑类替格瑞洛的制备方法
CN115785058B (zh) * 2022-12-09 2024-05-03 广州康瑞泰药业有限公司 一种合成替格瑞洛五元环中间体的方法
CN116535384A (zh) * 2023-04-17 2023-08-04 重庆普佑生物医药有限公司 替卡格雷中间体的制备方法

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Also Published As

Publication number Publication date
CZ302645B6 (cs) 2011-08-10
EE05223B1 (et) 2009-10-15
PL392726A1 (pl) 2010-12-06
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