DE60132776D1 - Pyrimidine derivate und deren verwendung zur herstellung eines triazolo-pyrimidin carba nucleosids - Google Patents
Pyrimidine derivate und deren verwendung zur herstellung eines triazolo-pyrimidin carba nucleosidsInfo
- Publication number
- DE60132776D1 DE60132776D1 DE60132776T DE60132776T DE60132776D1 DE 60132776 D1 DE60132776 D1 DE 60132776D1 DE 60132776 T DE60132776 T DE 60132776T DE 60132776 T DE60132776 T DE 60132776T DE 60132776 D1 DE60132776 D1 DE 60132776D1
- Authority
- DE
- Germany
- Prior art keywords
- pyrimidine
- carba
- nucleoside
- manufacture
- triazolo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0013488.2A GB0013488D0 (en) | 2000-06-02 | 2000-06-02 | Chemical compound |
GB0013488 | 2000-06-02 | ||
SE0002102A SE0002102D0 (sv) | 2000-06-02 | 2000-06-06 | Chemical compound |
SE0002102 | 2000-06-06 | ||
PCT/SE2001/001241 WO2001092263A1 (en) | 2000-06-02 | 2001-05-31 | Novel triazolo pyrimidine compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60132776D1 true DE60132776D1 (de) | 2008-03-27 |
DE60132776T2 DE60132776T2 (de) | 2009-02-12 |
Family
ID=26244413
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60132776T Expired - Lifetime DE60132776T2 (de) | 2000-06-02 | 2001-05-31 | Pyrimidine derivate und deren verwendung zur herstellung eines triazolo-pyrimidin carba nucleosids |
Country Status (36)
Country | Link |
---|---|
US (6) | US7067663B2 (de) |
EP (1) | EP1299390B1 (de) |
JP (1) | JP4947870B2 (de) |
KR (2) | KR100802884B1 (de) |
CN (3) | CN1200940C (de) |
AR (1) | AR028605A1 (de) |
AT (1) | ATE386039T1 (de) |
AU (4) | AU6287601A (de) |
BG (1) | BG65866B1 (de) |
BR (1) | BR0111319A (de) |
CA (1) | CA2408914C (de) |
CY (1) | CY1108101T1 (de) |
CZ (3) | CZ303162B6 (de) |
DE (1) | DE60132776T2 (de) |
DK (1) | DK1299390T3 (de) |
EE (1) | EE05223B1 (de) |
ES (1) | ES2299487T3 (de) |
GB (1) | GB0013488D0 (de) |
HK (1) | HK1053122A1 (de) |
HU (1) | HU229281B1 (de) |
IL (3) | IL152776A0 (de) |
IS (1) | IS2600B (de) |
MX (2) | MXPA02011793A (de) |
MY (1) | MY131942A (de) |
NO (1) | NO324266B1 (de) |
NZ (1) | NZ522637A (de) |
PL (3) | PL211318B1 (de) |
PT (1) | PT1299390E (de) |
RU (1) | RU2295526C2 (de) |
SE (1) | SE0002102D0 (de) |
SI (1) | SI1299390T1 (de) |
SK (1) | SK286845B6 (de) |
TW (1) | TWI285203B (de) |
UA (1) | UA73182C2 (de) |
WO (1) | WO2001092263A1 (de) |
ZA (1) | ZA200209068B (de) |
Families Citing this family (85)
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GB0013407D0 (en) * | 2000-06-02 | 2000-07-26 | Astrazeneca Ab | Forms of a chemical compound |
SE0401001D0 (sv) * | 2004-03-31 | 2004-03-31 | Astrazeneca Ab | Chemical process |
SE0400873D0 (sv) * | 2004-03-31 | 2004-03-31 | Astrazeneca Ab | Chemical process |
GB0615619D0 (en) | 2006-08-05 | 2006-09-13 | Astrazeneca Ab | Chemical process for preparation of intermediates |
GB0615620D0 (en) | 2006-08-05 | 2006-09-13 | Astrazeneca Ab | A process for the preparation of optically active intermediates |
EP2081433A2 (de) * | 2006-10-31 | 2009-07-29 | Janssen Pharmaceutica N.V. | Triazolpyrimidinderivate als adp-p2y12-rezeptorantagonisten |
TWI496776B (zh) * | 2007-11-15 | 2015-08-21 | Astrazeneca Ab | 製備(3aR,4S,6R,6aS)-6-胺基-2,2-二甲基四氫-3aH-環戊并[d][1,3]二氧雜環戊烯-4-醇之純非對映異構性之二苯甲醯-L-酒石酸鹽之方法 |
CN102149716A (zh) * | 2008-09-09 | 2011-08-10 | 阿斯利康(瑞典)有限公司 | 制备[1S-[1α,2α,3β(1S*,2R*),5β]]-3-[7-[2-(3,4-二氟苯基)-环丙氨基]-5-(丙硫基)-3H-1,2,3-三唑并[4,5-d]嘧啶-3-基]-5-(2-羟乙氧基)环戊烷-1,2-二醇的方法及其中间体 |
JP5580741B2 (ja) | 2008-09-19 | 2014-08-27 | 武田薬品工業株式会社 | 含窒素複素環化合物およびその用途 |
CA2694959A1 (en) * | 2009-03-02 | 2010-09-02 | Calera Corporation | Gas stream multi-pollutants control systems and methods |
CA2768043A1 (en) | 2009-07-27 | 2011-02-10 | Auspex Pharmaceuticals, Inc. | Cyclopropyl modulators of p2y12 receptor |
EP2305376A1 (de) | 2009-09-23 | 2011-04-06 | Lonza Ltd. | Prozess und Katalysator zur katalytischen Hydrierung von aromatischen und heteroaromatischen Nitroverbindungen |
US8859769B2 (en) | 2010-02-16 | 2014-10-14 | Actavis Group Ptc Ehf | Processes for preparing ticagrelor intermediate, 4,6-dichloro-5-nitro-2-(propylthio)pyrimidine |
CA2796504A1 (en) | 2010-04-20 | 2011-10-27 | Actavis Group Ptc Ehf | Novel process for preparing phenylcyclopropylamine derivatives using novel intermediates |
CN103003231A (zh) * | 2010-06-30 | 2013-03-27 | 阿特维斯集团公司 | 制备苯基环丙基胺衍生物的新方法及其用于制备替卡格雷的用途 |
WO2012063126A2 (en) | 2010-11-09 | 2012-05-18 | Actavis Group Ptc Ehf | Improved processes for preparing pure (3ar,4s,6r,6as)-6-amino-2,2-dimethyltetrahdro-3ah-cyclopenta[d] [1,3]-dioxol-4-ol and its key starting material |
CA2859743A1 (en) | 2010-12-20 | 2012-06-28 | Actavis Group Ptc Ehf | Novel processes for preparing triazolo[4,5-d]pyrimidine derivatives and intermediates thereof |
US9056838B2 (en) | 2011-04-06 | 2015-06-16 | Teva Pharmaceutical Industries Ltd. | Intermediates and processes for preparing Ticagrelor |
CN102731467B (zh) * | 2011-04-15 | 2015-12-16 | 博瑞生物医药(苏州)股份有限公司 | 替卡格雷的中间体及制备替卡格雷的方法 |
HUE027145T2 (en) * | 2011-05-13 | 2016-08-29 | Astrazeneca Ab | Process for the Preparation of Benzyl [(3aS, 4R, 6S, 6aR) -6-Hydroxy-2,2-dimethyltetrahydro-3aH-cyclopenta [d] [1,3] dioxol-4-yl] carbamate and intermediates of the process |
EP2721018A1 (de) | 2011-06-15 | 2014-04-23 | Actavis Group Ptc Ehf | Verbessertes verfahren zur herstellung von cyclopentylaminderivaten und zwischenprodukten davon |
US9221829B2 (en) | 2011-09-14 | 2015-12-29 | Lek Pharmaceuticals D.D. | Synthesis of triazolopyrimidine compounds |
EP2570405A1 (de) | 2011-09-14 | 2013-03-20 | LEK Pharmaceuticals d.d. | Synthese von Triazolpyrimidin-Verbindungen |
EP2586773A1 (de) | 2011-10-27 | 2013-05-01 | LEK Pharmaceuticals d.d. | Synthese von Triazolpyrimidin-Verbindungen |
CA2852652A1 (en) * | 2011-10-27 | 2013-05-02 | Lek Pharmaceuticals D.D. | Synthesis of triazolopyrimidine compounds |
BR112014013085A2 (pt) | 2011-11-30 | 2017-06-13 | Actavis Group Ptc Ehf | forma cristalina do ticagrelor, processo para a preparação da forma cristalina do ticagrelor, composição farmacêutica e processo para preparar uma composição farmacêutica |
IN2014KN01491A (de) | 2011-12-23 | 2015-10-23 | Lek Pharmaceuticals | |
EP2628721A1 (de) | 2012-02-20 | 2013-08-21 | LEK Pharmaceuticals d.d. | Synthese von 2-(3,4-difluorphenyl)cyclopropancarboxylsäure |
EP2644590A1 (de) | 2012-03-30 | 2013-10-02 | LEK Pharmaceuticals d.d. | Synthese von 2-(3,4-difluorphenyl)cyclopropanamin-Derivaten und -Salzen |
WO2013144295A1 (en) | 2012-03-30 | 2013-10-03 | Sandoz Ag | Synthesis of 2-(3,4-difluorophenyl)cyclopropanamine derivatives and salts |
US9233966B2 (en) | 2012-04-05 | 2016-01-12 | Dr. Reddy's Laboratories Limited | Preparation of ticagrelor |
WO2013163892A1 (en) * | 2012-05-02 | 2013-11-07 | Sunshine Lake Pharma Co., Ltd. | Novel triazolo pyrimidine compounds and a process of preparation thereof |
CN102659815B (zh) * | 2012-05-04 | 2013-07-17 | 开原亨泰制药股份有限公司 | 一种制备选择性抗凝血药替卡格雷及其中间体的方法 |
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EP2666771A1 (de) | 2012-05-24 | 2013-11-27 | LEK Pharmaceuticals d.d. | Synthese von Aminocyclopentanetriol-Derivaten |
US20150152114A1 (en) * | 2012-08-06 | 2015-06-04 | Enantia, S.L. | Process for the preparation of an intermediate for a triazolopyrimidine carbonucleoside |
CN103588674B (zh) * | 2012-08-14 | 2015-02-11 | 上海医药工业研究院 | 一种具有光学活性的环丙烷酰阱化合物、其制备和应用 |
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CN102875537A (zh) * | 2012-09-10 | 2013-01-16 | 常州制药厂有限公司 | 一种新的抗血栓药物的制备方法 |
WO2014083139A1 (en) | 2012-11-29 | 2014-06-05 | Actavis Group Ptc Ehf | Novel amorphous form of ticagrelor |
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EP0946561B1 (de) * | 1996-12-20 | 2002-02-13 | AstraZeneca AB | Triazolo(4,5-d)pyrimidinyl-derivate und ihre verwendung als medikamente |
SE9702773D0 (sv) * | 1997-07-22 | 1997-07-22 | Astra Pharma Prod | Novel compounds |
AR017014A1 (es) * | 1997-07-22 | 2001-08-22 | Astrazeneca Ab | Compuestos de triazolo [4,5-d]pirimidina, composiciones farmaceuticas, uso de los mismos para preparar medicamentos y procesos para la preparacionde dichos compuestos |
CA2316264A1 (en) * | 1998-02-17 | 1999-08-19 | Brian Springthorpe | Novel triazolo(4,5-d)pyrimidine compounds |
TWI229674B (en) | 1998-12-04 | 2005-03-21 | Astra Pharma Prod | Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses |
CZ20002947A3 (cs) * | 1999-02-05 | 2000-11-15 | Astrazeneca Uk Limited | Nové triazolo(4,5-d)pyrimidiny, způsob jejich přípravy a farmaceutický prostředek, který je obsahuje |
SE9904129D0 (sv) | 1999-11-15 | 1999-11-15 | Astra Pharma Prod | Novel compounds |
GB0013407D0 (en) * | 2000-06-02 | 2000-07-26 | Astrazeneca Ab | Forms of a chemical compound |
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2000
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