HRP970473B1 - 6-0-substituted ketolides having antibacterial activity - Google Patents

6-0-substituted ketolides having antibacterial activity

Info

Publication number
HRP970473B1
HRP970473B1 HR970473A HRP970473A HRP970473B1 HR P970473 B1 HRP970473 B1 HR P970473B1 HR 970473 A HR970473 A HR 970473A HR P970473 A HRP970473 A HR P970473A HR P970473 B1 HRP970473 B1 HR P970473B1
Authority
HR
Croatia
Prior art keywords
substituted
alkyl
aryl
heteroaryl
group
Prior art date
Application number
HR970473A
Other languages
English (en)
Croatian (hr)
Inventor
Sun Or Yat
T. Chu Daniel
Ma Zhenkun
J. Plattner Jacob
F. Clark Richard
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27107953&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP970473(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/888,350 external-priority patent/US5866549A/en
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of HRP970473A2 publication Critical patent/HRP970473A2/hr
Publication of HRP970473B1 publication Critical patent/HRP970473B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cephalosporin Compounds (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
HR970473A 1996-09-04 1997-09-03 6-0-substituted ketolides having antibacterial activity HRP970473B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70777696A 1996-09-04 1996-09-04
US08/888,350 US5866549A (en) 1996-09-04 1997-07-03 6-O-substituted ketolides having antibacterial activity

Publications (2)

Publication Number Publication Date
HRP970473A2 HRP970473A2 (en) 1998-08-31
HRP970473B1 true HRP970473B1 (en) 2007-02-28

Family

ID=27107953

Family Applications (5)

Application Number Title Priority Date Filing Date
HR970473A HRP970473B1 (en) 1996-09-04 1997-09-03 6-0-substituted ketolides having antibacterial activity
HRP20060277AA HRP20060277B1 (hr) 1996-09-04 2006-08-11 6-0-supstituirani ketolidi antibakterijskog djelovanja
HRP20060275AA HRP20060275B1 (hr) 1996-09-04 2006-08-11 6-0-supstituirani ketolidi antibakterijskog djelovanja
HRP20060278AA HRP20060278B1 (hr) 1996-09-04 2006-08-11 6-0-supstituirani ketolidi antibakterijskog djelovanja
HRP20060276AA HRP20060276B1 (hr) 1996-09-04 2006-08-11 6-0-supstituirani ketolidi antibakterijskog djelovanja

Family Applications After (4)

Application Number Title Priority Date Filing Date
HRP20060277AA HRP20060277B1 (hr) 1996-09-04 2006-08-11 6-0-supstituirani ketolidi antibakterijskog djelovanja
HRP20060275AA HRP20060275B1 (hr) 1996-09-04 2006-08-11 6-0-supstituirani ketolidi antibakterijskog djelovanja
HRP20060278AA HRP20060278B1 (hr) 1996-09-04 2006-08-11 6-0-supstituirani ketolidi antibakterijskog djelovanja
HRP20060276AA HRP20060276B1 (hr) 1996-09-04 2006-08-11 6-0-supstituirani ketolidi antibakterijskog djelovanja

Country Status (28)

Country Link
US (4) US6028181A (ja)
EP (5) EP1291351B1 (ja)
JP (1) JP4597274B2 (ja)
KR (5) KR100523679B1 (ja)
CN (4) CN100441591C (ja)
AT (5) ATE296307T1 (ja)
BG (1) BG63547B1 (ja)
BR (1) BR9711661A (ja)
CA (1) CA2263972C (ja)
CZ (1) CZ300106B6 (ja)
DE (5) DE69733422T2 (ja)
DK (5) DK0929563T3 (ja)
ES (5) ES2242811T3 (ja)
HK (1) HK1021537A1 (ja)
HR (5) HRP970473B1 (ja)
HU (1) HU230166B1 (ja)
ID (1) ID19406A (ja)
IL (1) IL128681A0 (ja)
NO (1) NO314230B1 (ja)
NZ (1) NZ334274A (ja)
PL (1) PL188173B1 (ja)
PT (5) PT1291352E (ja)
RO (1) RO121473B1 (ja)
RU (1) RU2192427C2 (ja)
SI (1) SI20023B (ja)
SK (5) SK285534B6 (ja)
TR (1) TR199901127T2 (ja)
WO (1) WO1998009978A1 (ja)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495348B1 (en) 1993-10-07 2002-12-17 Regents Of The University Of Minnesota Mitomycin biosynthetic gene cluster
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
ES2199524T3 (es) 1998-04-24 2004-02-16 Pfizer Products Inc. Derivados 9a,11b-deshidro de 9-oxima-3-ceto-6-o-metileritromicina.
US6265202B1 (en) 1998-06-26 2001-07-24 Regents Of The University Of Minnesota DNA encoding methymycin and pikromycin
JP4573925B2 (ja) * 1998-07-09 2010-11-04 アベンティス・ファーマ・ソシエテ・アノニム 新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用
FR2792637B1 (fr) * 1999-04-26 2001-06-01 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2780977B1 (fr) * 1998-07-09 2000-09-01 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2785612A1 (fr) * 1998-11-10 2000-05-12 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
JP4043191B2 (ja) 1998-11-03 2008-02-06 ファイザー・プロダクツ・インク 新規なマクロライド抗生物質
SK13162001A3 (sk) * 1999-03-15 2001-12-03 Abbott Laboratories 6-o-substituované makrolidy majúce antibakteriálnu aktivitu
US6939861B2 (en) 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
ATE340183T1 (de) 1999-04-16 2006-10-15 Kosan Biosciences Inc Antiinfektiöse makrolidderivate
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6420535B1 (en) * 1999-06-07 2002-07-16 Abbott Laboratories 6-O-carbamate ketolide derivatives
ATE250076T1 (de) * 1999-06-07 2003-10-15 Abbott Lab 6-o-carbamat ketolide derivate
US6417366B2 (en) * 1999-06-24 2002-07-09 Abbott Laboratories Preparation of quinoline-substituted carbonate and carbamate derivatives
US6437106B1 (en) 1999-06-24 2002-08-20 Abbott Laboratories Process for preparing 6-o-substituted erythromycin derivatives
EP1101769A3 (en) 1999-11-18 2001-10-24 Pfizer Products Inc. Nitrogen containing erythromycin derivatives
US6472372B1 (en) 2000-12-06 2002-10-29 Ortho-Mcneil Pharmaceuticals, Inc. 6-O-Carbamoyl ketolide antibacterials
WO2003004509A2 (en) * 2001-07-03 2003-01-16 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
CN1589277A (zh) 2001-09-17 2005-03-02 奥索-麦克尼尔药品公司 6－o－氨基甲酸酯－11,12－内酯－酮内酯抗菌剂
US6673774B2 (en) * 2001-12-03 2004-01-06 Enanta Pharmaceuticals, Inc. 11-O-substituted macrolides and their descladinose derivatives
US6825170B2 (en) 2001-12-05 2004-11-30 Ortho-Mcneil Pharmaceutical, Inc. 6-O-acyl ketolide antibacterials
US20030162729A1 (en) * 2002-02-13 2003-08-28 Zhenkun Ma Macrolides with activity against methicillin-resistant staphylococcus aureus
US6831068B2 (en) * 2002-02-13 2004-12-14 Abbott Laboratories Macrolide antibacterial compounds
MXPA04007883A (es) * 2002-02-13 2004-11-26 Abbott Lab Compuestos antimicrobianos de macrolido.
JP4625637B2 (ja) 2002-02-22 2011-02-02 シャイア エルエルシー 活性物質送達系及び活性物質を保護し投与する方法
US6995143B2 (en) 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
US7910558B2 (en) * 2002-05-13 2011-03-22 Enanta Pharmaceuticals, Inc. Bridged macrocyclic compounds and processes for the preparation thereof
US6841664B2 (en) * 2002-07-25 2005-01-11 Enanra Pharmaceuticals, Inc. 6,11-4-carbon bridged ketolides
US7273853B2 (en) * 2002-05-13 2007-09-25 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
JP2005531603A (ja) * 2002-05-31 2005-10-20 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ３−デスクラジノシル−６−ｏ−カルバモイルおよび６−ｏ−カルボノイルマクロライド抗菌剤
WO2004078771A1 (ja) * 2003-03-07 2004-09-16 Taisho Pharmaceutical Co., Ltd. ２－フルオロ－６－ｏ－置換ケトライド誘導体
US7601695B2 (en) 2003-03-10 2009-10-13 Optimer Pharmaceuticals, Inc. Antibacterial agents
US7163924B2 (en) * 2003-04-25 2007-01-16 Chiron Corporation Ketolide derivatives
US6790835B1 (en) * 2003-06-05 2004-09-14 Enanta Pharmaceuticals, Inc. Bicyclic macrolide derivatives
US20040254126A1 (en) * 2003-06-05 2004-12-16 Yao-Ling Qiu 11-12 Bicyclic erythromycin derivatives
EP1670808A1 (en) * 2003-09-12 2006-06-21 Chiron Corporation Antimicrobial derivatives
GB0327720D0 (en) 2003-11-28 2003-12-31 Biotica Tech Ltd Erythromycins and process for their preparation
US7414030B2 (en) * 2004-01-07 2008-08-19 Enanta Pharmaceuticals, Inc. 6-11 Bicyclic erythromycin derivatives
US7265094B2 (en) * 2004-01-09 2007-09-04 Enanta Pharmaceuticals, Inc. 9N-substituted 6-11 bicyclic erythromycin derivatives
US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
BRPI0514381A (pt) * 2004-07-30 2008-06-10 Palumed Sa compostos hìbridos de aminoquinolina-antibiótico, composições farmacêuticas, método de preparação e uso destes
FR2874922A1 (fr) * 2004-07-30 2006-03-10 Palumed Sa Molecules hybrides qa ou q est une aminoquinoleine et a est un residu antibiotique, leur synthese et leurs utilisations en tant qu'agent antibacterien
TW200635600A (en) * 2004-12-13 2006-10-16 Enanta Pharm Inc Tetracyclic bicyclolides
PT1836211E (pt) 2004-12-21 2010-04-08 Pfizer Prod Inc Macrólidos
US20060252710A1 (en) * 2005-05-04 2006-11-09 Guoqiang Wang 6-11 Bridged oxime erythromycin derivatives
US7517859B2 (en) * 2005-05-04 2009-04-14 Enanta Pharmaceuticals, Inc. Spirocyclic bicyclolides
US7384922B2 (en) * 2005-05-04 2008-06-10 Enanta Pharmaceuticals, Inc. 6-11 bridged oxime erythromycin derivatives
EP1985620A4 (en) 2006-02-07 2012-08-15 Taisho Pharmaceutical Co Ltd COMPOUND 10a-AZALIDE
EP2056844A4 (en) 2006-08-24 2010-11-24 Wockhardt Research Center NEW MACROLIDS AND KETOLIDS WITH ANTIMICROBIAL EFFECT
US8293715B2 (en) 2007-08-06 2012-10-23 Taisho Pharmaceutical Co., Ltd. 10a-Azalide compound crosslinked at 10a- and 12-positions
US8354383B2 (en) * 2007-09-17 2013-01-15 Enanta Pharmaceuticals, Inc. 6,11-bridged biaryl macrolides
NZ584159A (en) * 2007-09-17 2012-08-31 Enanta Pharm Inc 6,11-bridged biaryl macrolides
US8273720B2 (en) * 2007-09-17 2012-09-25 Enanta Pharmaceuticals, Inc. 6,11-bicyclolides: bridged biaryl macrolide derivatives
CN101917850B (zh) * 2007-10-25 2016-01-13 森普拉制药公司 大环内酯类抗菌剂的制备方法
TW200946109A (en) * 2008-05-09 2009-11-16 Enanta Pharm Inc Anti-bacterial activity of 9-hydroxy derivatives 6, 11-bicyclolides
JPWO2009139181A1 (ja) 2008-05-15 2011-09-15 大正製薬株式会社 ４員環構造を有する１０ａ−アザライド化合物
ES2565083T3 (es) 2008-10-24 2016-03-31 Cempra Pharmaceuticals, Inc. Biodefensas usando macrólidos que contienen triazol
KR101566053B1 (ko) 2009-05-27 2015-11-04 욱크하르트 리미티드 항균 활성을 갖는 케톨라이드
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
CN108310000A (zh) 2009-09-10 2018-07-24 森普拉制药公司 治疗疟疾、结核病和mac疾病的方法
CN103080122A (zh) 2010-03-22 2013-05-01 森普拉制药公司 大环内脂的结晶形式及其用途
RU2608390C2 (ru) 2010-05-20 2017-01-18 Семпра Фармасьютикалз, Инк. Способы получения макролидов и кетолидов, и промежуточных соединений для их получения
US8796474B1 (en) 2010-08-23 2014-08-05 Rutgers, The State University Of New Jersey Macrolide compounds and methods and intermediates useful for their preparation
KR20130120458A (ko) 2010-09-10 2013-11-04 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
EP3216798A3 (en) 2010-12-09 2017-10-25 Wockhardt Limited Ketolide compounds
AR085286A1 (es) * 2011-02-21 2013-09-18 Taisho Pharmaceutical Co Ltd Derivado de macrolido sustituido en la posicion c-4
US9206214B2 (en) 2011-03-01 2015-12-08 Wockhardt Ltd. Process for preparation of ketolide intermediates
US8993739B2 (en) 2011-03-22 2015-03-31 Wockhardt Ltd. Process for preparation of ketolide compounds
CN102766181A (zh) * 2011-05-06 2012-11-07 上海医药工业研究院 6-o-取代的红霉素衍生物的制备方法
CN102766089A (zh) * 2011-05-06 2012-11-07 上海医药工业研究院 3-(3-喹啉基)-2-丙烯-1-卤代物及其制备方法
KR20140139083A (ko) 2012-03-27 2014-12-04 셈프라 파마슈티컬스, 인크. 마크롤라이드계 항생제를 투여하기 위한 비경구 제제
JP5857008B2 (ja) * 2012-08-20 2016-02-10 大正製薬株式会社 Ｃ−４”位置換マクロライド誘導体を含有する医薬
GB201217310D0 (en) 2012-09-27 2012-11-14 C10 Pharma As Compounds
JP6426696B2 (ja) 2013-03-14 2018-11-21 センプラ ファーマシューティカルズ，インコーポレイテッド 呼吸器疾患の治療のための方法および製剤
AU2014233240B2 (en) 2013-03-15 2018-08-09 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
AR102810A1 (es) 2014-08-18 2017-03-29 Taisho Pharmaceutical Co Ltd Derivado de macrólido sustituido en la posición c-4
JP2019533669A (ja) 2016-10-04 2019-11-21 バイオファーマティ ソシエテ アノニム 抗菌活性を有するケトライド
EP3589327A4 (en) * 2017-03-03 2022-04-06 Synovo GmbH NOVEL ANTI-INFECTION AND ANTI-INFLAMMATORY COMPOUNDS
CN109942653B (zh) * 2019-02-27 2021-06-25 北京理工大学 一种红霉素衍生物及其制备方法
CA3163337A1 (en) * 2019-12-02 2021-06-10 AliquantumRx, Inc. Salts and polymorphs of cethromycin for the treatment of disease salts and polymorphs of cethromycin
CN113817008B (zh) * 2021-07-15 2023-05-23 湖州师范学院 新型琥珀酰基十六元大环内酯的制备方法及用途

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR960000434B1 (ko) * 1986-12-17 1996-01-06 다이쇼 세이야꾸 가부시끼가이샤 에리스로마이신 a유도체 및 그의 제조 방법
EP0553353A1 (en) * 1990-10-15 1993-08-04 Taisho Pharmaceutical Co. Ltd 2'-modified erythromycin or derivative thereof
IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of the history of erythromycin
WO1992009614A1 (fr) * 1990-11-28 1992-06-11 Taisho Pharmaceutical Co., Ltd. Derive de 6-o-methylerythromycine a
WO1993013663A1 (en) * 1992-01-17 1993-07-22 Abbott Laboratories Method of directing biosynthesis of specific polyketides
US5523399A (en) * 1991-12-27 1996-06-04 Taisho Pharmaceutical Co., Ltd. 5-O-desosaminylerythronolide derivatives
CA2093303C (en) * 1992-04-09 1998-11-24 Abraham Araya Aluminosilicates
ATE145212T1 (de) * 1992-04-22 1996-11-15 Taisho Pharmaceutical Co Ltd 5-0-desosaminylerythronolide a derivate
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2702480B1 (fr) * 1993-03-09 1995-04-28 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2713226B1 (fr) * 1993-12-03 1996-01-05 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2718450B1 (fr) * 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2719587B1 (fr) * 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2732023B1 (fr) * 1995-03-22 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2732684B1 (fr) * 1995-04-06 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2738571B1 (fr) * 1995-09-11 1997-10-17 Roussel Uclaf Nouveaux derives de la 5-0-desosaminyl 6-0-methyl- erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs
US6274715B1 (en) * 1995-11-08 2001-08-14 Abbott Laboratories Tricyclic erythromycin derivatives
ES2218604T3 (es) * 1995-11-08 2004-11-16 Abbott Laboratories Derivados triciclicos de eritromicina.
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
AU4472797A (en) * 1996-10-31 1998-05-22 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
US6171807B1 (en) * 1996-11-13 2001-01-09 Associates Of Cape Cod, Inc. Detection and quantitation of endotoxin by fluorescence polarization

Also Published As

Publication number Publication date
RO121473B1 (ro) 2007-06-29
RU2192427C2 (ru) 2002-11-10
PT1291352E (pt) 2005-09-30
ES2242812T3 (es) 2005-11-16
CN100441591C (zh) 2008-12-10
PT1291350E (pt) 2005-09-30
JP4597274B2 (ja) 2010-12-15
KR100568455B1 (ko) 2006-04-07
DE69733439D1 (de) 2005-07-07
ES2242983T3 (es) 2005-11-16
TR199901127T2 (xx) 1999-07-21
DE69733369D1 (de) 2005-06-30
CN1680420A (zh) 2005-10-12
PL188173B1 (pl) 2004-12-31
EP1291353B1 (en) 2005-06-01
KR100523679B1 (ko) 2005-10-26
SK285535B6 (sk) 2007-03-01
SI20023A (sl) 2000-02-29
BR9711661A (pt) 1999-08-24
JP2001500855A (ja) 2001-01-23
ATE296832T1 (de) 2005-06-15
EP1291352A1 (en) 2003-03-12
ATE296308T1 (de) 2005-06-15
CN1237183A (zh) 1999-12-01
HRP20060275B1 (hr) 2014-04-11
EP1291351B1 (en) 2005-07-13
HRP20060277B1 (hr) 2014-04-11
DE69733439T2 (de) 2006-05-04
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ES2244716T3 (es) 2005-12-16
DE69733369T2 (de) 2006-01-26
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PL332009A1 (en) 1999-08-16
US6147197A (en) 2000-11-14
HRP20060277A2 (en) 2007-10-31
CZ68599A3 (cs) 1999-08-11
HUP9902869A3 (en) 2001-04-28
NO991022D0 (no) 1999-03-02
WO1998009978A1 (en) 1998-03-12
KR20050044815A (ko) 2005-05-12
DK1291353T3 (da) 2005-10-03
SK285536B6 (sk) 2007-03-01
BG63547B1 (bg) 2002-04-30
DK1291350T3 (da) 2005-09-26
HRP20060276A2 (en) 2007-10-31
DE69733370T2 (de) 2006-02-02
CN100460415C (zh) 2009-02-11
ID19406A (id) 1998-07-09
ATE296307T1 (de) 2005-06-15
AU4178097A (en) 1998-03-26
EP0929563A1 (en) 1999-07-21
BG103292A (en) 1999-12-30
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KR20050043993A (ko) 2005-05-11
PT1291351E (pt) 2005-11-30
HUP9902869A2 (hu) 2000-02-28
EP1291351A1 (en) 2003-03-12
DE69733723T2 (de) 2006-04-20
KR100576988B1 (ko) 2006-05-10
HRP20060276B1 (hr) 2014-04-25
AU729348B2 (en) 2001-02-01
EP1291353A1 (en) 2003-03-12
ES2242813T3 (es) 2005-11-16
CZ300106B6 (cs) 2009-02-11
CN1680418A (zh) 2005-10-12
SK285534B6 (sk) 2007-03-01
HK1021537A1 (en) 2000-06-16
KR20000068435A (ko) 2000-11-25
CA2263972A1 (en) 1998-03-12
US6075133A (en) 2000-06-13
DK1291352T3 (da) 2005-09-19
PT1291353E (pt) 2005-10-31
US6028181A (en) 2000-02-22
HRP970473A2 (en) 1998-08-31
NO991022L (no) 1999-05-03
DK1291351T3 (da) 2005-10-24
DE69733370D1 (de) 2005-06-30
CA2263972C (en) 2008-01-29
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HU230166B1 (hu) 2015-09-28
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NO314230B1 (no) 2003-02-17
IL128681A0 (en) 2000-01-31
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EP1291352B1 (en) 2005-05-25
NZ334274A (en) 2001-02-23
DE69733422T2 (de) 2006-05-04
SK286181B6 (sk) 2008-04-07
PT929563E (pt) 2005-10-31
USRE39591E1 (en) 2007-04-24
DE69733422D1 (de) 2005-07-07
EP1291350A1 (en) 2003-03-12
SK28699A3 (en) 2000-03-13
ATE299508T1 (de) 2005-07-15
EP1291350B1 (en) 2005-05-25
KR100610043B1 (ko) 2006-08-08
ES2242811T3 (es) 2005-11-16
HRP20060278B1 (hr) 2014-04-11
ATE296831T1 (de) 2005-06-15
KR20050043994A (ko) 2005-05-11
KR20050044816A (ko) 2005-05-12
CN1273475C (zh) 2006-09-06

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