DE69416306T2 - Sphingoglycolipid und verwendung davon - Google Patents

Sphingoglycolipid und verwendung davon

Info

Publication number
DE69416306T2
DE69416306T2 DE69416306T DE69416306T DE69416306T2 DE 69416306 T2 DE69416306 T2 DE 69416306T2 DE 69416306 T DE69416306 T DE 69416306T DE 69416306 T DE69416306 T DE 69416306T DE 69416306 T2 DE69416306 T2 DE 69416306T2
Authority
DE
Germany
Prior art keywords
sphingoglycolipid
represent
relates
monosaccharide unit
specified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69416306T
Other languages
English (en)
Other versions
DE69416306D1 (de
Inventor
Tatsuo Higa
Takenori Natori
Yasuhiko Koezuka
Kazuhiro Motoki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kirin Pharma KK
Original Assignee
Kirin Brewery Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kirin Brewery Co Ltd filed Critical Kirin Brewery Co Ltd
Publication of DE69416306D1 publication Critical patent/DE69416306D1/de
Application granted granted Critical
Publication of DE69416306T2 publication Critical patent/DE69416306T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
DE69416306T 1993-04-15 1994-04-14 Sphingoglycolipid und verwendung davon Expired - Fee Related DE69416306T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8863093 1993-04-15
PCT/JP1994/000625 WO1994024142A1 (en) 1993-04-15 1994-04-14 Novel sphingoglycolipid and use thereof

Publications (2)

Publication Number Publication Date
DE69416306D1 DE69416306D1 (de) 1999-03-11
DE69416306T2 true DE69416306T2 (de) 1999-06-17

Family

ID=13948136

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69416306T Expired - Fee Related DE69416306T2 (de) 1993-04-15 1994-04-14 Sphingoglycolipid und verwendung davon

Country Status (11)

Country Link
US (1) US5780441A (de)
EP (1) EP0694558B1 (de)
JP (1) JP4020958B2 (de)
KR (1) KR100281265B1 (de)
CN (1) CN1045302C (de)
AT (1) ATE176237T1 (de)
AU (1) AU683653B2 (de)
CA (1) CA2160566C (de)
DE (1) DE69416306T2 (de)
TW (1) TW295588B (de)
WO (1) WO1994024142A1 (de)

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ATE421881T1 (de) 1997-04-10 2009-02-15 Kyowa Hakko Kirin Co Ltd Nkt-zellenaktivatoren, die alpha-glycosylceramide enthalten
TW575420B (en) * 1997-09-22 2004-02-11 Kirin Brewery Composition for enhancing cellular immunogenicity comprising alpha-glycosylceramides
AU765809B2 (en) * 1998-02-12 2003-10-02 Emory University Sphingolipid derivatives and their methods of use
JPH11269189A (ja) * 1998-03-19 1999-10-05 Nissin Food Prod Co Ltd 免疫調節作用を有する化合物
JP4099267B2 (ja) * 1998-08-07 2008-06-11 株式会社紀文フードケミファ 乳化剤および乳化組成物
US7393652B2 (en) 2000-05-10 2008-07-01 The Trustees Of Columbia University In The City Of New York Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
US7718644B2 (en) 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
US7879840B2 (en) 2005-08-25 2011-02-01 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US8022058B2 (en) 2000-05-10 2011-09-20 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
WO2003009812A2 (en) * 2001-07-25 2003-02-06 New York University Use of glycosylceramides as adjuvants for vaccines against infections and cancer
CA2493690C (en) * 2002-06-13 2011-11-08 New York University Synthetic c-glycolipid and its use for treating cancer, infectious diseases and autoimmune diseases
US9809654B2 (en) 2002-09-27 2017-11-07 Vaccinex, Inc. Targeted CD1d molecules
US7544678B2 (en) 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
JP2007525165A (ja) 2003-03-07 2007-09-06 トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク タイプ１ライアノジン受容体に基づく方法
US7645873B2 (en) * 2003-03-20 2010-01-12 The Scripps Research Institute 6″-amino-6″-deoxygalactosylceramides
US7771726B2 (en) * 2003-10-08 2010-08-10 New York University Use of synthetic glycolipids as universal adjuvants for vaccines against cancer and infectious diseases
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
US20050222048A1 (en) * 2004-03-31 2005-10-06 The Research Foundation Of The City University Of New York Novel synthetic C-glycolipids, their synthesis and use to treat infections, cancer and autoimmune diseases
US8022043B2 (en) * 2004-08-27 2011-09-20 Albert Einstein College Of Medicine Of Yeshiva University Ceramide derivatives as modulators of immunity and autoimmunity
JP5226311B2 (ja) 2004-08-27 2013-07-03 アルバート アインシュタイン カレッジ オブ メディシン オブ イエシバ ユニバーシティ 免疫及び自己免疫の調節因子としてのセラミド誘導体
US8513008B2 (en) 2004-10-07 2013-08-20 Argos Therapeutics, Inc. Mature dendritic cell compositions and methods for culturing same
KR101243577B1 (ko) 2004-10-07 2013-03-20 아고스 쎄라퓨틱스, 인코포레이티드 성숙 수지상 세포 조성물 및 그의 배양 방법
DK1848813T3 (da) 2005-01-28 2013-07-15 Univ Brigham Young Aktivering af bakterielt glycolipid fra CD1D-begrænsede NKT-celler
US7704990B2 (en) 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
EP1776963A1 (de) 2005-10-19 2007-04-25 Gbf-Gesellschaft Für Biotechnologische Forschung Mbh Hexosylceramiden als Adjuvantien und ihre Verwendung in pharmazeutischen Zusammensetzungen
US20070231344A1 (en) * 2005-10-28 2007-10-04 The Brigham And Women's Hospital, Inc. Conjugate vaccines for non-proteinaceous antigens
EP2056842B1 (de) * 2006-04-07 2012-10-17 The Scripps Research Institute Modifiziertes galactosyl-ceramid zur behandlung von krebsartigen erkrankungen
WO2008005824A1 (en) * 2006-06-30 2008-01-10 The Scripps Research Institute Adjuvants and methods of use
JP5357782B2 (ja) 2007-02-21 2013-12-04 バクシネックス インコーポレーティッド 抗原負荷ＣＤ１ｄ分子によるＮＫＴ細胞活性の調節
US8916164B2 (en) * 2007-08-29 2014-12-23 Abivax Methods of enhancing adjuvaticity of vaccine compositions
EP2058011A1 (de) * 2007-11-07 2009-05-13 Wittycell NKT-Zellen aktivierende, kovalent gebundene Glykolipid-Antigene und/oder Arzneimittel
EP2060252A1 (de) 2007-11-19 2009-05-20 Wittycell Neue Formulierung von Galactosylceramid-Derivaten
EP2231145B1 (de) * 2007-12-05 2014-09-17 Wittycell Verwendung von glycosylceramiden für die verstärkung der immunantwort auf antigene
CA2739765A1 (en) * 2008-10-08 2010-04-15 Vincent Serra Vaccine composition for use against influenza
KR20110137290A (ko) * 2009-01-08 2011-12-22 알버트 아인슈타인 컬리지 오브 메디신 오브 예쉬바 유니버시티 세포벽 결합 세라미드 유사 당지질을 갖는 박테리아 백신 및 이의 용도
CN102355908B (zh) 2009-01-23 2014-09-24 德克萨斯大学系统评论委员会 纳米粒子制备的糖脂免疫抗原
US10813950B2 (en) 2010-12-02 2020-10-27 Riken Immunotherapy using allo-NKT cells, cells for immunotherapy in which alpha chain of t-cell receptor (TCR) gene has been rearranged to uniform Vα-Jα, and banking of NKT cells derived from said cells
EP2889039B1 (de) 2012-08-22 2017-11-08 Regimmune Corporation Präparat zur vorbeugung oder behandlung von typ-1-diabetes
CA2889858A1 (en) 2012-11-05 2014-05-08 Regimmune Corporation Immune-tolerance inducer
AU2013349706B2 (en) 2012-11-21 2019-08-22 Assistance Publique - Hopitaux De Paris Methods for determining the risk of acute graft versus host disease
US9371352B2 (en) 2013-02-08 2016-06-21 Vaccinex, Inc. Modified glycolipids and methods of making and using the same
CN106726875B (zh) * 2016-11-24 2019-05-21 晨光生物科技集团股份有限公司 一种含鞘糖脂类物质的提取物的制备方法
CA3201106A1 (en) 2020-12-04 2022-06-09 Yasuyuki Ishii Cd1d-ligand-compound-containing liposome preparation having improved pharmacokinetics

Family Cites Families (23)

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US4598051A (en) * 1980-03-12 1986-07-01 The Regents Of The University Of California Liposome conjugates and diagnostic methods therewith
US4806466A (en) * 1981-10-29 1989-02-21 The Regents Of The University Of California Cell agglutination reagent comprising conjugates of antibody covalently bound to liposomes
IT1168205B (it) * 1983-07-21 1987-05-20 Wellcome Italia Derivato di monsialo ganglioside dotato di attivita' antibatterica, antifungina ed antitumorale, composizioni che lo contengono e procedimento per la loro preparazione
EP0146810A3 (de) * 1983-12-05 1987-05-13 Solco Basel AG Verfahren zur Herstellung von Sphingosinderivaten
JPS6157594A (ja) * 1984-08-30 1986-03-24 Suntory Ltd ガラクトスフインゴ脂質及びその製造法
DK17885D0 (da) * 1985-01-14 1985-01-14 Karlsson Karl Anders Antiviralt middel
JPS6239597A (ja) * 1985-08-13 1987-02-20 ソルコ　バ−ゼル　アクチエンゲゼルシヤフト スフインゴシン誘導体の製造方法
JPH07116209B2 (ja) * 1986-04-11 1995-12-13 メクト株式会社 シアロシルセラミド類及びその製造方法
US4990603A (en) * 1986-07-04 1991-02-05 Mect Corporation Sialic acid derivatives and process therefor
US4937232A (en) * 1986-09-15 1990-06-26 Duke University Inhibition of protein kinase C by long-chain bases
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US5041441A (en) * 1988-04-04 1991-08-20 The Regents Of The University Of Michigan Method of chemotherapy using 1-phenyl-2-decanoylamino-3-morpholino-1-propanol
US5073543A (en) * 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
DE3840044A1 (de) * 1988-11-27 1990-06-07 Behringwerke Ag Glykosphingolipide mit kopplungsfaehiger gruppe im sphingoidanteil, ihre herstellung und verwendung
US5028715A (en) * 1989-02-06 1991-07-02 Southwest Research Institute Radioprotective agents and their method of manufacture
EP0425821B1 (de) * 1989-09-29 1994-08-10 Ajinomoto Co., Inc. Verwendung von Human-ADF (=Adult T-cell leukemia-derived factor) zur Herstellung von Medikamenten
JP3068910B2 (ja) * 1990-11-08 2000-07-24 麒麟麦酒株式会社 新規スフィンゴ糖脂質、その製造法および使用
JPH06145189A (ja) * 1991-01-23 1994-05-24 Kitasato Inst:The スフィンゴ糖脂質
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US5567684A (en) * 1994-09-14 1996-10-22 The Regents Of The University Of California Synthetic ganglioside derivatives

Also Published As

Publication number Publication date
AU6513094A (en) 1994-11-08
CA2160566A1 (en) 1994-10-27
WO1994024142A1 (en) 1994-10-27
CA2160566C (en) 2004-07-13
JP4020958B2 (ja) 2007-12-12
DE69416306D1 (de) 1999-03-11
CN1045302C (zh) 1999-09-29
AU683653B2 (en) 1997-11-20
ATE176237T1 (de) 1999-02-15
EP0694558A4 (de) 1996-08-21
KR100281265B1 (ko) 2001-02-01
EP0694558A1 (de) 1996-01-31
CN1124963A (zh) 1996-06-19
EP0694558B1 (de) 1999-01-27
US5780441A (en) 1998-07-14
TW295588B (de) 1997-01-11

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: KIRIN PHARMA KABUSHIKI KAISHA, SHIBUYA, TOKYO, JP

8339 Ceased/non-payment of the annual fee