DE69416306D1 - Sphingoglycolipid und verwendung davon - Google Patents

Sphingoglycolipid und verwendung davon

Info

Publication number
DE69416306D1
DE69416306D1 DE69416306T DE69416306T DE69416306D1 DE 69416306 D1 DE69416306 D1 DE 69416306D1 DE 69416306 T DE69416306 T DE 69416306T DE 69416306 T DE69416306 T DE 69416306T DE 69416306 D1 DE69416306 D1 DE 69416306D1
Authority
DE
Germany
Prior art keywords
sphingoglycolipid
represent
relates
monosaccharide unit
specified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69416306T
Other languages
English (en)
Other versions
DE69416306T2 (de
Inventor
Tatsuo Higa
Takenori Natori
Yasuhiko Koezuka
Kazuhiro Motoki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kirin Pharma KK
Original Assignee
Kirin Brewery Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kirin Brewery Co Ltd filed Critical Kirin Brewery Co Ltd
Publication of DE69416306D1 publication Critical patent/DE69416306D1/de
Application granted granted Critical
Publication of DE69416306T2 publication Critical patent/DE69416306T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69416306T 1993-04-15 1994-04-14 Sphingoglycolipid und verwendung davon Expired - Fee Related DE69416306T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8863093 1993-04-15
PCT/JP1994/000625 WO1994024142A1 (en) 1993-04-15 1994-04-14 Novel sphingoglycolipid and use thereof

Publications (2)

Publication Number Publication Date
DE69416306D1 true DE69416306D1 (de) 1999-03-11
DE69416306T2 DE69416306T2 (de) 1999-06-17

Family

ID=13948136

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69416306T Expired - Fee Related DE69416306T2 (de) 1993-04-15 1994-04-14 Sphingoglycolipid und verwendung davon

Country Status (11)

Country Link
US (1) US5780441A (de)
EP (1) EP0694558B1 (de)
JP (1) JP4020958B2 (de)
KR (1) KR100281265B1 (de)
CN (1) CN1045302C (de)
AT (1) ATE176237T1 (de)
AU (1) AU683653B2 (de)
CA (1) CA2160566C (de)
DE (1) DE69416306T2 (de)
TW (1) TW295588B (de)
WO (1) WO1994024142A1 (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW261533B (de) * 1992-07-16 1995-11-01 Kirin Brewery
TW555562B (en) * 1996-12-27 2003-10-01 Kirin Brewery Method for activation of human antigen-presenting cells, activated human antigen-presenting cells and use thereof
CA2280130C (en) * 1997-02-05 2007-12-18 Kirin Beer Kabushiki Kaisha Lyophilized compositions containing sphingoglycolipid and process for preparing them
KR100527950B1 (ko) * 1997-04-10 2005-11-09 기린 비루 가부시키가이샤 알파-글리코실세라미드를 함유하는 엔케이티 세포활성화제
TW575420B (en) * 1997-09-22 2004-02-11 Kirin Brewery Composition for enhancing cellular immunogenicity comprising alpha-glycosylceramides
DE69943314D1 (de) * 1998-02-12 2011-05-12 Kapil N Bhalla Sphingolipid-derivate und verfahren zu deren verwendung
JPH11269189A (ja) * 1998-03-19 1999-10-05 Nissin Food Prod Co Ltd 免疫調節作用を有する化合物
JP4099267B2 (ja) * 1998-08-07 2008-06-11 株式会社紀文フードケミファ 乳化剤および乳化組成物
US7718644B2 (en) 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
US7879840B2 (en) 2005-08-25 2011-02-01 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7393652B2 (en) 2000-05-10 2008-07-01 The Trustees Of Columbia University In The City Of New York Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
US8022058B2 (en) 2000-05-10 2011-09-20 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
EP1434859A2 (de) * 2001-07-25 2004-07-07 New York University Verwendung von glycosylceramiden als adjuvantien für vakzine gegen infektionen und krebs
WO2003105769A2 (en) 2002-06-13 2003-12-24 New York University Synthetic c-glycolipid and its use for treating cancer infectious diseases and autoimmune diseases
US9809654B2 (en) 2002-09-27 2017-11-07 Vaccinex, Inc. Targeted CD1d molecules
US7544678B2 (en) 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
AU2004220548A1 (en) 2003-03-07 2004-09-23 The Trustees Of Columbia University, In The City Of New York Type 1 ryanodine receptor-based methods
US7645873B2 (en) * 2003-03-20 2010-01-12 The Scripps Research Institute 6″-amino-6″-deoxygalactosylceramides
US7771726B2 (en) * 2003-10-08 2010-08-10 New York University Use of synthetic glycolipids as universal adjuvants for vaccines against cancer and infectious diseases
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
AU2005235080A1 (en) * 2004-03-31 2005-11-03 New York University Novel synthetic C-glycolipids, their synthesis and use to treat infections, cancer and autoimmune diseases
US8022043B2 (en) * 2004-08-27 2011-09-20 Albert Einstein College Of Medicine Of Yeshiva University Ceramide derivatives as modulators of immunity and autoimmunity
AU2005280163B2 (en) * 2004-08-27 2011-11-24 Albert Einstein College Of Medicine, Inc. Ceramide derivatives as modulators of immunity and autoimmunity
US8513008B2 (en) 2004-10-07 2013-08-20 Argos Therapeutics, Inc. Mature dendritic cell compositions and methods for culturing same
CN101080487B (zh) 2004-10-07 2012-11-14 阿戈斯治疗公司 成熟树突细胞组合物及其培养方法
DK1848813T3 (da) 2005-01-28 2013-07-15 Univ Brigham Young Aktivering af bakterielt glycolipid fra CD1D-begrænsede NKT-celler
US7704990B2 (en) 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
EP1776963A1 (de) 2005-10-19 2007-04-25 Gbf-Gesellschaft Für Biotechnologische Forschung Mbh Hexosylceramiden als Adjuvantien und ihre Verwendung in pharmazeutischen Zusammensetzungen
US20070231344A1 (en) * 2005-10-28 2007-10-04 The Brigham And Women's Hospital, Inc. Conjugate vaccines for non-proteinaceous antigens
US8227581B2 (en) * 2006-04-07 2012-07-24 The Scripps Research Institute Modified α-galactosyl ceramides for staining and stimulating natural killer T cells
WO2008005824A1 (en) * 2006-06-30 2008-01-10 The Scripps Research Institute Adjuvants and methods of use
CA2678618C (en) 2007-02-21 2019-03-12 Vaccinex, Inc. Modulation of nkt cell activity with antigen-loaded cd1d molecules
US8916164B2 (en) * 2007-08-29 2014-12-23 Abivax Methods of enhancing adjuvaticity of vaccine compositions
EP2058011A1 (de) * 2007-11-07 2009-05-13 Wittycell NKT-Zellen aktivierende, kovalent gebundene Glykolipid-Antigene und/oder Arzneimittel
EP2060252A1 (de) 2007-11-19 2009-05-20 Wittycell Neue Formulierung von Galactosylceramid-Derivaten
BRPI0820960B8 (pt) * 2007-12-05 2021-05-25 Abivax composição, composição farmacêutica, e uso da composição
US9220767B2 (en) * 2008-10-08 2015-12-29 Abivax Vaccine composition for use against influenza
AU2010203451B2 (en) * 2009-01-08 2016-06-30 Albert Einstein College Of Medicine, Inc. Bacterial vaccines with cell wall-associated ceramide-like glycolipids and uses thereof
WO2010083728A1 (en) 2009-01-23 2010-07-29 Dapeng Zhou Nanoparticle formulated glycolipid antigens for immunotherapy
EP2647384B1 (de) 2010-12-02 2018-05-23 Riken IMMUNTHERAPIE MIT ALLO-NKT-ZELLEN, ZELLEN FÜR DIE IMMUNTHERAPIE MIT UMGEORDNETER aplha KETTE DES T-ZELL REZEPTOR (TCR)-GENS IN GLEICHMÄSSIGE V alpha-J alpha-ANORDNUNG UND LAGERUNG VON NKT-ZELLEN AUS DIESEN ZELLEN
EP2889039B1 (de) 2012-08-22 2017-11-08 Regimmune Corporation Präparat zur vorbeugung oder behandlung von typ-1-diabetes
AU2013339046A1 (en) 2012-11-05 2015-05-21 Regimmune Corporation Immune-tolerance inducer
PL2923208T3 (pl) 2012-11-21 2019-09-30 Institut National De La Santé Et De La Recherche Médicale (Inserm) Sposoby określania ryzyka ostrej choroby przeszczep przeciwko gospodarzowi
US9371352B2 (en) 2013-02-08 2016-06-21 Vaccinex, Inc. Modified glycolipids and methods of making and using the same
CN106726875B (zh) * 2016-11-24 2019-05-21 晨光生物科技集团股份有限公司 一种含鞘糖脂类物质的提取物的制备方法
WO2022118913A1 (ja) 2020-12-04 2022-06-09 株式会社レグイミューン 体内動態が改善されたＣＤ１ｄリガンド化合物含有リポソーム製剤

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4598051A (en) * 1980-03-12 1986-07-01 The Regents Of The University Of California Liposome conjugates and diagnostic methods therewith
US4806466A (en) * 1981-10-29 1989-02-21 The Regents Of The University Of California Cell agglutination reagent comprising conjugates of antibody covalently bound to liposomes
IT1168205B (it) * 1983-07-21 1987-05-20 Wellcome Italia Derivato di monsialo ganglioside dotato di attivita' antibatterica, antifungina ed antitumorale, composizioni che lo contengono e procedimento per la loro preparazione
EP0146810A3 (de) * 1983-12-05 1987-05-13 Solco Basel AG Verfahren zur Herstellung von Sphingosinderivaten
JPS6157594A (ja) * 1984-08-30 1986-03-24 Suntory Ltd ガラクトスフインゴ脂質及びその製造法
DK17885D0 (da) * 1985-01-14 1985-01-14 Karlsson Karl Anders Antiviralt middel
JPS6239597A (ja) * 1985-08-13 1987-02-20 ソルコ　バ−ゼル　アクチエンゲゼルシヤフト スフインゴシン誘導体の製造方法
JPH07116209B2 (ja) * 1986-04-11 1995-12-13 メクト株式会社 シアロシルセラミド類及びその製造方法
US4990603A (en) * 1986-07-04 1991-02-05 Mect Corporation Sialic acid derivatives and process therefor
US4937232A (en) * 1986-09-15 1990-06-26 Duke University Inhibition of protein kinase C by long-chain bases
US4816450A (en) * 1986-09-15 1989-03-28 Duke University Inhibition of protein kinase C by long-chain bases
US5026557A (en) * 1987-09-09 1991-06-25 The Liposome Company, Inc. Adjuvant composition
JP2588729B2 (ja) * 1987-10-05 1997-03-12 塩野義製薬株式会社 スフィンゴシン誘導体
US5041441A (en) * 1988-04-04 1991-08-20 The Regents Of The University Of Michigan Method of chemotherapy using 1-phenyl-2-decanoylamino-3-morpholino-1-propanol
US5073543A (en) * 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
DE3840044A1 (de) * 1988-11-27 1990-06-07 Behringwerke Ag Glykosphingolipide mit kopplungsfaehiger gruppe im sphingoidanteil, ihre herstellung und verwendung
US5028715A (en) * 1989-02-06 1991-07-02 Southwest Research Institute Radioprotective agents and their method of manufacture
DE69011465T2 (de) * 1989-09-29 1995-03-23 Ajinomoto Kk Verwendung von Human-ADF (=Adult T-cell leukemia-derived factor) zur Herstellung von Medikamenten.
JP3068910B2 (ja) * 1990-11-08 2000-07-24 麒麟麦酒株式会社 新規スフィンゴ糖脂質、その製造法および使用
JPH06145189A (ja) * 1991-01-23 1994-05-24 Kitasato Inst:The スフィンゴ糖脂質
JPH0559081A (ja) * 1991-08-29 1993-03-09 Kirin Brewery Co Ltd 新規スフインゴ糖脂質、その製造法および使用
TW261533B (de) * 1992-07-16 1995-11-01 Kirin Brewery
US5567684A (en) * 1994-09-14 1996-10-22 The Regents Of The University Of California Synthetic ganglioside derivatives

Also Published As

Publication number Publication date
EP0694558A1 (de) 1996-01-31
EP0694558B1 (de) 1999-01-27
CN1045302C (zh) 1999-09-29
AU683653B2 (en) 1997-11-20
CA2160566C (en) 2004-07-13
EP0694558A4 (de) 1996-08-21
CA2160566A1 (en) 1994-10-27
AU6513094A (en) 1994-11-08
WO1994024142A1 (en) 1994-10-27
TW295588B (de) 1997-01-11
ATE176237T1 (de) 1999-02-15
CN1124963A (zh) 1996-06-19
US5780441A (en) 1998-07-14
KR100281265B1 (ko) 2001-02-01
JP4020958B2 (ja) 2007-12-12
DE69416306T2 (de) 1999-06-17

Similar Documents

Publication Publication Date Title
ATE176237T1 (de) Sphingoglycolipid und verwendung davon
HUT54357A (en) Process for producing benzilidene-(azolylmethyl)-cycloalkane and -cycloalkene derivatives, fungicidal compositions comprising such compounds as active ingredient and intermediates usable for the production of the active ingredients
NO931529L (no) Cykliske fruktopyranosesulfitter og -sulfater med antikonvulsiv effekt
ES2149537T3 (es) Resina intercambiadora de aniones no reticulados y composicion farmaceutica que contiene la misma.
ATE109484T1 (de) Thienopyridin -derivative und diese enthaltende arzneimittel.
AU4216993A (en) Novel arylglycinamide derivatives and preparative processes therefor
EP0808825A4 (de) Phenylbenzoesäureester-derivate und flüssigkristallzubereitungen
HUT61773A (en) Process for producing spicamycin derivatives and pharmaceutical compositions containing them as active components
ES2074828T3 (es) Copoliester degradable de 4-hidroxi-prolina y composicion farmaceutica que lo contiene.
TW259785B (en) Chemical compounds
AU641686B2 (en) Benzanilides
EP0601191A4 (en) Novel tetracyclic compound.
GB2271718B (en) Antimicrobial agents comprising polyquaternary ammonium compounds
MY106839A (en) Carboxylate compounds, liquid crystal compositions containing said compounds and liquid crystal elements.
ATE147372T1 (de) Neue quaternäre ammoniumsalze und deren medizinische verwendung
ES481057A1 (es) Procedimiento para preparar una composicion protectora de - plantas que comprende como antidoto un derivado de 1,4-oxa- za-spirohidrocarburo.
HU9600300D0 (en) Thiocarbamoyl derivatives using as antimicrobial agents and process for producing of these
ATE24887T1 (de) Cycloaliphatische alkohole.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: KIRIN PHARMA KABUSHIKI KAISHA, SHIBUYA, TOKYO, JP

8339 Ceased/non-payment of the annual fee