PT1291350E - Cetolidos 6-o-substituidos que possuem actividade antibacteriana - Google Patents
Cetolidos 6-o-substituidos que possuem actividade antibacterianaInfo
- Publication number
- PT1291350E PT1291350E PT02024557T PT02024557T PT1291350E PT 1291350 E PT1291350 E PT 1291350E PT 02024557 T PT02024557 T PT 02024557T PT 02024557 T PT02024557 T PT 02024557T PT 1291350 E PT1291350 E PT 1291350E
- Authority
- PT
- Portugal
- Prior art keywords
- alkyl
- substituted
- heteroaryl
- aryl
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cephalosporin Compounds (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70777696A | 1996-09-04 | 1996-09-04 | |
US08/888,350 US5866549A (en) | 1996-09-04 | 1997-07-03 | 6-O-substituted ketolides having antibacterial activity |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1291350E true PT1291350E (pt) | 2005-09-30 |
Family
ID=27107953
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT97939765T PT929563E (pt) | 1996-09-04 | 1997-09-02 | Cetolidos 6-0-substituidos possuindo actividade antibacteriana |
PT02024558T PT1291351E (pt) | 1996-09-04 | 1997-09-02 | Cetolidos 6-o-substituidos possuindo actividade antibacteriana |
PT02024557T PT1291350E (pt) | 1996-09-04 | 1997-09-02 | Cetolidos 6-o-substituidos que possuem actividade antibacteriana |
PT02024560T PT1291353E (pt) | 1996-09-04 | 1997-09-02 | Cetolidos 6-o-substituidos possuindo actividade antibacteriana |
PT02024559T PT1291352E (pt) | 1996-09-04 | 1997-09-02 | Cetolidos 6-o-substituidos possuindo actividade antibacteriana |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT97939765T PT929563E (pt) | 1996-09-04 | 1997-09-02 | Cetolidos 6-0-substituidos possuindo actividade antibacteriana |
PT02024558T PT1291351E (pt) | 1996-09-04 | 1997-09-02 | Cetolidos 6-o-substituidos possuindo actividade antibacteriana |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT02024560T PT1291353E (pt) | 1996-09-04 | 1997-09-02 | Cetolidos 6-o-substituidos possuindo actividade antibacteriana |
PT02024559T PT1291352E (pt) | 1996-09-04 | 1997-09-02 | Cetolidos 6-o-substituidos possuindo actividade antibacteriana |
Country Status (28)
Country | Link |
---|---|
US (4) | US6075133A (pt) |
EP (5) | EP1291353B1 (pt) |
JP (1) | JP4597274B2 (pt) |
KR (5) | KR20050044816A (pt) |
CN (4) | CN1680419A (pt) |
AT (5) | ATE296832T1 (pt) |
BG (1) | BG63547B1 (pt) |
BR (1) | BR9711661A (pt) |
CA (1) | CA2263972C (pt) |
CZ (1) | CZ300106B6 (pt) |
DE (5) | DE69733370T2 (pt) |
DK (5) | DK1291350T3 (pt) |
ES (5) | ES2242813T3 (pt) |
HK (1) | HK1021537A1 (pt) |
HR (5) | HRP970473B1 (pt) |
HU (1) | HU230166B1 (pt) |
ID (1) | ID19406A (pt) |
IL (1) | IL128681A0 (pt) |
NO (1) | NO314230B1 (pt) |
NZ (1) | NZ334274A (pt) |
PL (1) | PL188173B1 (pt) |
PT (5) | PT929563E (pt) |
RO (1) | RO121473B1 (pt) |
RU (1) | RU2192427C2 (pt) |
SI (1) | SI20023B (pt) |
SK (5) | SK286181B6 (pt) |
TR (1) | TR199901127T2 (pt) |
WO (1) | WO1998009978A1 (pt) |
Families Citing this family (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6495348B1 (en) | 1993-10-07 | 2002-12-17 | Regents Of The University Of Minnesota | Mitomycin biosynthetic gene cluster |
UA51730C2 (uk) * | 1996-09-04 | 2002-12-16 | Ебботт Лабораторіз | 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців |
AP1060A (en) * | 1998-01-02 | 2002-04-23 | Pfizer Prod Inc | Novel erythromycin derivatives. |
ATE243219T1 (de) | 1998-04-24 | 2003-07-15 | Pfizer Prod Inc | 9a, 11b-dehydro derivative von 9-oxime-3-keto-6-0-methylerythromycin |
US6265202B1 (en) | 1998-06-26 | 2001-07-24 | Regents Of The University Of Minnesota | DNA encoding methymycin and pikromycin |
FR2780977B1 (fr) * | 1998-07-09 | 2000-09-01 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
FR2792637B1 (fr) * | 1999-04-26 | 2001-06-01 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
JP4573925B2 (ja) | 1998-07-09 | 2010-11-04 | アベンティス・ファーマ・ソシエテ・アノニム | 新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用 |
FR2785612A1 (fr) * | 1998-11-10 | 2000-05-12 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
CA2349338C (en) * | 1998-11-03 | 2005-12-06 | Pfizer Products Inc. | Novel macrolide antibiotics |
DK1161438T3 (da) * | 1999-03-15 | 2004-08-30 | Abbott Lab | 6-O-substituerede makrolider, som har antibakteriel aktivitet |
US6514944B2 (en) | 1999-04-16 | 2003-02-04 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
ES2272273T3 (es) | 1999-04-16 | 2007-05-01 | Kosan Biosciences, Inc. | Agentes antiinfecciosos macrolidos. |
US6939861B2 (en) | 1999-04-16 | 2005-09-06 | Kosan Biosciences, Inc. | Amido macrolides |
US6451768B1 (en) | 1999-04-16 | 2002-09-17 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
US6420535B1 (en) * | 1999-06-07 | 2002-07-16 | Abbott Laboratories | 6-O-carbamate ketolide derivatives |
EP1181300B1 (en) * | 1999-06-07 | 2003-09-17 | Abbott Laboratories | 6-o-carbamate ketolide derivatives |
US6437106B1 (en) * | 1999-06-24 | 2002-08-20 | Abbott Laboratories | Process for preparing 6-o-substituted erythromycin derivatives |
US6417366B2 (en) * | 1999-06-24 | 2002-07-09 | Abbott Laboratories | Preparation of quinoline-substituted carbonate and carbamate derivatives |
EP1101769A3 (en) | 1999-11-18 | 2001-10-24 | Pfizer Products Inc. | Nitrogen containing erythromycin derivatives |
US6472372B1 (en) | 2000-12-06 | 2002-10-29 | Ortho-Mcneil Pharmaceuticals, Inc. | 6-O-Carbamoyl ketolide antibacterials |
WO2003004509A2 (en) * | 2001-07-03 | 2003-01-16 | Chiron Corporation | C12 modified erythromycin macrolides and ketolides having antibacterial activity |
WO2003024986A1 (en) | 2001-09-17 | 2003-03-27 | Ortho-Mcneil Pharmaceutical, Inc. | 6-o-carbamate-11,12-lacto-ketolide antimicrobials |
US6673774B2 (en) * | 2001-12-03 | 2004-01-06 | Enanta Pharmaceuticals, Inc. | 11-O-substituted macrolides and their descladinose derivatives |
BR0214748A (pt) | 2001-12-05 | 2004-11-23 | Ortho Mcneil Pharm Inc | Derivados 6-oacil-cetolidas de eritromicina, úteis como antibacterianos |
JP2005522453A (ja) * | 2002-02-13 | 2005-07-28 | アボット・ラボラトリーズ | マクロライド抗菌化合物 |
US6831068B2 (en) * | 2002-02-13 | 2004-12-14 | Abbott Laboratories | Macrolide antibacterial compounds |
US20030162729A1 (en) * | 2002-02-13 | 2003-08-28 | Zhenkun Ma | Macrolides with activity against methicillin-resistant staphylococcus aureus |
IL163666A0 (en) | 2002-02-22 | 2005-12-18 | New River Pharmaceuticals Inc | Active agent delivery systems and methods for protecting and administering active agents |
US6995143B2 (en) | 2002-02-28 | 2006-02-07 | Basilea Pharmaceutica Ag | Macrolides with antibacterial activity |
US7273853B2 (en) * | 2002-05-13 | 2007-09-25 | Enanta Pharmaceuticals, Inc. | 6-11 bicyclic ketolide derivatives |
US7910558B2 (en) * | 2002-05-13 | 2011-03-22 | Enanta Pharmaceuticals, Inc. | Bridged macrocyclic compounds and processes for the preparation thereof |
US6841664B2 (en) * | 2002-07-25 | 2005-01-11 | Enanra Pharmaceuticals, Inc. | 6,11-4-carbon bridged ketolides |
US6825172B2 (en) | 2002-05-31 | 2004-11-30 | Janssen Pharmaceutica, Nv | 3-descladinosyl-6-O-carbamoyl and 6-O-carbonoyl macrolide antibacterial agents |
WO2004078771A1 (ja) * | 2003-03-07 | 2004-09-16 | Taisho Pharmaceutical Co., Ltd. | 2-フルオロ-6-o-置換ケトライド誘導体 |
CA2529817C (en) | 2003-03-10 | 2013-02-12 | Optimer Pharmaceuticals, Inc. | Novel antibacterial agents |
US7163924B2 (en) * | 2003-04-25 | 2007-01-16 | Chiron Corporation | Ketolide derivatives |
US20040254126A1 (en) * | 2003-06-05 | 2004-12-16 | Yao-Ling Qiu | 11-12 Bicyclic erythromycin derivatives |
US6790835B1 (en) * | 2003-06-05 | 2004-09-14 | Enanta Pharmaceuticals, Inc. | Bicyclic macrolide derivatives |
US20050101548A1 (en) * | 2003-09-12 | 2005-05-12 | Xiaodong Lin | Antimicrobial derivatives |
GB0327720D0 (en) | 2003-11-28 | 2003-12-31 | Biotica Tech Ltd | Erythromycins and process for their preparation |
WO2005067564A2 (en) * | 2004-01-07 | 2005-07-28 | Enanta Pharmaceuticals, Inc. | 6-11 bicyclic erythromycin derivatives |
US7265094B2 (en) * | 2004-01-09 | 2007-09-04 | Enanta Pharmaceuticals, Inc. | 9N-substituted 6-11 bicyclic erythromycin derivatives |
US7384921B2 (en) * | 2004-02-20 | 2008-06-10 | Enanta Pharmaceuticals, Inc. | Polymorphic forms of 6-11 bicyclic ketolide derivatives |
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BRPI0514381A (pt) * | 2004-07-30 | 2008-06-10 | Palumed Sa | compostos hìbridos de aminoquinolina-antibiótico, composições farmacêuticas, método de preparação e uso destes |
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EP1836211B1 (en) * | 2004-12-21 | 2010-03-03 | Pfizer Products Inc. | Macrolides |
US7517859B2 (en) * | 2005-05-04 | 2009-04-14 | Enanta Pharmaceuticals, Inc. | Spirocyclic bicyclolides |
US20060252710A1 (en) * | 2005-05-04 | 2006-11-09 | Guoqiang Wang | 6-11 Bridged oxime erythromycin derivatives |
US7384922B2 (en) * | 2005-05-04 | 2008-06-10 | Enanta Pharmaceuticals, Inc. | 6-11 bridged oxime erythromycin derivatives |
JP5015016B2 (ja) | 2006-02-07 | 2012-08-29 | 大正製薬株式会社 | 10a−アザライド化合物 |
WO2008023248A2 (en) | 2006-08-24 | 2008-02-28 | Wockhardt Research Centre | Novel macrolides and ketolides having antimicrobial activity |
US8293715B2 (en) | 2007-08-06 | 2012-10-23 | Taisho Pharmaceutical Co., Ltd. | 10a-Azalide compound crosslinked at 10a- and 12-positions |
US8273720B2 (en) * | 2007-09-17 | 2012-09-25 | Enanta Pharmaceuticals, Inc. | 6,11-bicyclolides: bridged biaryl macrolide derivatives |
US8354383B2 (en) * | 2007-09-17 | 2013-01-15 | Enanta Pharmaceuticals, Inc. | 6,11-bridged biaryl macrolides |
US20090118506A1 (en) * | 2007-09-17 | 2009-05-07 | In Jong Kim | 6,11-bridged biaryl macrolides |
CN101917850B (zh) | 2007-10-25 | 2016-01-13 | 森普拉制药公司 | 大环内酯类抗菌剂的制备方法 |
TW200946109A (en) * | 2008-05-09 | 2009-11-16 | Enanta Pharm Inc | Anti-bacterial activity of 9-hydroxy derivatives 6, 11-bicyclolides |
WO2009139181A1 (ja) | 2008-05-15 | 2009-11-19 | 大正製薬株式会社 | 4員環構造を有する10a-アザライド化合物 |
WO2010048599A1 (en) | 2008-10-24 | 2010-04-29 | Cempra Pharmaceuticals, Inc. | Methods for treating gastrointestinal diseases |
BRPI1011959A2 (pt) | 2009-05-27 | 2016-04-26 | Wockhardt Research Center | compostos de cetolídeo tendo atividade antimicrobiana. |
US9937194B1 (en) | 2009-06-12 | 2018-04-10 | Cempra Pharmaceuticals, Inc. | Compounds and methods for treating inflammatory diseases |
JP5914335B2 (ja) | 2009-09-10 | 2016-05-11 | センプラ ファーマシューティカルズ,インコーポレイテッド | マラリア、結核、及びmac病の治療方法 |
NZ602544A (en) | 2010-03-22 | 2014-11-28 | Cempra Pharmaceuticals Inc | Crystalline forms of a macrolide, and uses therefor |
US9051346B2 (en) | 2010-05-20 | 2015-06-09 | Cempra Pharmaceuticals, Inc. | Process for preparing triazole-containing ketolide antibiotics |
US8796474B1 (en) | 2010-08-23 | 2014-08-05 | Rutgers, The State University Of New Jersey | Macrolide compounds and methods and intermediates useful for their preparation |
JP6042334B2 (ja) | 2010-09-10 | 2016-12-14 | センプラ ファーマシューティカルズ,インコーポレイテッド | 疾患治療のための水素結合形成フルオロケトライド |
PL2673285T3 (pl) | 2010-12-09 | 2017-12-29 | Wockhardt Limited | Związki ketolidowe |
AR085286A1 (es) * | 2011-02-21 | 2013-09-18 | Taisho Pharmaceutical Co Ltd | Derivado de macrolido sustituido en la posicion c-4 |
JP5718488B2 (ja) | 2011-03-01 | 2015-05-13 | ウォックハート リミテッド | ケトライド中間体の調製方法 |
KR101795838B1 (ko) | 2011-03-22 | 2017-11-08 | 욱크하르트 리미티드 | 케톨리드 화합물의 제조 방법 |
CN102766181A (zh) * | 2011-05-06 | 2012-11-07 | 上海医药工业研究院 | 6-o-取代的红霉素衍生物的制备方法 |
CN102766089A (zh) * | 2011-05-06 | 2012-11-07 | 上海医药工业研究院 | 3-(3-喹啉基)-2-丙烯-1-卤代物及其制备方法 |
SG11201405895UA (en) * | 2012-03-27 | 2014-10-30 | Cempra Pharmaceuticals Inc | Parenteral formulations for administering macrolide antibiotics |
JP5857008B2 (ja) * | 2012-08-20 | 2016-02-10 | 大正製薬株式会社 | C−4”位置換マクロライド誘導体を含有する医薬 |
GB201217310D0 (en) | 2012-09-27 | 2012-11-14 | C10 Pharma As | Compounds |
US9861616B2 (en) | 2013-03-14 | 2018-01-09 | Cempra Pharmaceuticals, Inc. | Methods for treating respiratory diseases and formulations therefor |
JP6675973B2 (ja) | 2013-03-15 | 2020-04-08 | センプラ ファーマシューティカルズ,インコーポレイテッド | マクロライド抗菌薬を調製するための集束的な方法 |
AR102810A1 (es) | 2014-08-18 | 2017-03-29 | Taisho Pharmaceutical Co Ltd | Derivado de macrólido sustituido en la posición c-4 |
WO2018067663A2 (en) * | 2016-10-04 | 2018-04-12 | Biopharmati Sa | Ketolides having antibacterial activity |
US11420995B2 (en) | 2017-03-03 | 2022-08-23 | Synovo Gmbh | Anti-infective and anti-inflammatory compounds |
CN109942653B (zh) * | 2019-02-27 | 2021-06-25 | 北京理工大学 | 一种红霉素衍生物及其制备方法 |
JP2023504262A (ja) * | 2019-12-02 | 2023-02-02 | アリクァンタムアールエクス,インコーポレイテッド | 疾患の治療のためのセスロマイシンの塩及び多形体 セスロマイシンの塩及び多形体 |
CN113817008B (zh) * | 2021-07-15 | 2023-05-23 | 湖州师范学院 | 新型琥珀酰基十六元大环内酯的制备方法及用途 |
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KR960000434B1 (ko) * | 1986-12-17 | 1996-01-06 | 다이쇼 세이야꾸 가부시끼가이샤 | 에리스로마이신 a유도체 및 그의 제조 방법 |
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IL99995A (en) * | 1990-11-21 | 1997-11-20 | Roussel Uclaf | Erythromycin derivatives, their preparation and pharmaceutical compositions containing them |
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FR2719587B1 (fr) * | 1994-05-03 | 1996-07-12 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
FR2732023B1 (fr) * | 1995-03-22 | 1997-04-30 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
FR2732684B1 (fr) * | 1995-04-06 | 1997-04-30 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
FR2738571B1 (fr) * | 1995-09-11 | 1997-10-17 | Roussel Uclaf | Nouveaux derives de la 5-0-desosaminyl 6-0-methyl- erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs |
JP2000500133A (ja) * | 1995-11-08 | 2000-01-11 | アボツト・ラボラトリーズ | 三環式エリスロマイシン誘導体 |
US6274715B1 (en) * | 1995-11-08 | 2001-08-14 | Abbott Laboratories | Tricyclic erythromycin derivatives |
UA51730C2 (uk) * | 1996-09-04 | 2002-12-16 | Ебботт Лабораторіз | 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців |
AU4472797A (en) * | 1996-10-31 | 1998-05-22 | Taisho Pharmaceutical Co., Ltd. | Erythromycin a derivatives |
US6171807B1 (en) * | 1996-11-13 | 2001-01-09 | Associates Of Cape Cod, Inc. | Detection and quantitation of endotoxin by fluorescence polarization |
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1997
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1998
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1999
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2000
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2004
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2006
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