ES8506025A1 - Un procedimiento para preparar derivados de cefem - Google Patents

Un procedimiento para preparar derivados de cefem

Info

Publication number
ES8506025A1
ES8506025A1 ES528003A ES528003A ES8506025A1 ES 8506025 A1 ES8506025 A1 ES 8506025A1 ES 528003 A ES528003 A ES 528003A ES 528003 A ES528003 A ES 528003A ES 8506025 A1 ES8506025 A1 ES 8506025A1
Authority
ES
Spain
Prior art keywords
carboxymethoxyphenylacetamido
substituted
same
alkanoyloxy
preparations containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES528003A
Other languages
English (en)
Other versions
ES528003A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP21772682A external-priority patent/JPS59108791A/ja
Priority claimed from JP3601783A external-priority patent/JPS59161389A/ja
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of ES8506025A1 publication Critical patent/ES8506025A1/es
Publication of ES528003A0 publication Critical patent/ES528003A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE CEFEM.CONSISTE EN HACER REACCIONAR A UN COMPUESTO DE FORMULA (II) O DE UNA DE SUS SALES CON UN GRUPO HETEROCICLO-TIOL QUE CONTIENE NITROGENO SUSTITUIDO O NO SUSTITUIDO, EN UN DISOLVENTE COMO AGUA, EN PRESENCIA DE UN HIDROGENOCARBONATO DE SODIO Y A UNA TEMPERATURA ENTRE 50 Y 70JC, PARA OBTENER UN COMPUESTO DE FORMULA (I) O SU SAL FARMACEUTICAMENTE ACEPTABLE. SIENDO; R1, HIDROXI, ALCANOILOXI DE C 1 A 4 Y OTROS; R2, H O METOXI; A UN GRUPO DE FORMULA (III) O (IV); R4, H O ALQUILO DE C 1 A 4; RK3 ALCANOILOXI DE C 1 A 4, Y RL3 UN GRUPO HETEROCICLO-TIOL QUE CONTIENE NITROGENO SUSTITUIDO O NO SUSTITUIDO.SE UTILIZAN COMO AGENTES ANTIBACTERIANOS CONTRA LAS BACTERIAS GRAM (B) Y GRAM (C).
ES528003A 1982-12-14 1983-12-13 Un procedimiento para preparar derivados de cefem Granted ES528003A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP21772682A JPS59108791A (ja) 1982-12-14 1982-12-14 ７−カルボキシメトキシフエニルアセトアミド−３−セフエム誘導体、その製造方法およびそれからなる抗菌剤
JP3601783A JPS59161389A (ja) 1983-03-07 1983-03-07 ７−カルボキシメトキシフエニルアセトアミドセフエム誘導体，その製造法およびそれからなる抗菌剤

Publications (2)

Publication Number Publication Date
ES8506025A1 true ES8506025A1 (es) 1985-06-16
ES528003A0 ES528003A0 (es) 1985-06-16

Family

ID=26375029

Family Applications (2)

Application Number Title Priority Date Filing Date
ES528003A Granted ES528003A0 (es) 1982-12-14 1983-12-13 Un procedimiento para preparar derivados de cefem
ES534297A Granted ES534297A0 (es) 1982-12-14 1984-07-13 Un procedimiento para preparar derivados de cefem

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES534297A Granted ES534297A0 (es) 1982-12-14 1984-07-13 Un procedimiento para preparar derivados de cefem

Country Status (16)

Country Link
US (1) US4546176A (es)
KR (1) KR840007012A (es)
AT (1) ATA435283A (es)
AU (1) AU2082783A (es)
BE (1) BE898442A (es)
CH (1) CH656131A5 (es)
DE (1) DE3345093A1 (es)
DK (1) DK572183A (es)
ES (2) ES528003A0 (es)
FR (1) FR2569195B1 (es)
GB (1) GB2132613B (es)
IT (1) IT1169969B (es)
NL (1) NL8304272A (es)
PH (1) PH20168A (es)
SE (1) SE8306882L (es)
YU (1) YU237283A (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5232918A (en) * 1987-07-23 1993-08-03 Imperial Chemical Industries Plc Cephalosporin derivatives
CA2001203C (en) * 1988-10-24 2001-02-13 Thomas P. Demuth, Jr. Novel antimicrobial dithiocarbamoyl quinolones
US5328908A (en) * 1988-10-24 1994-07-12 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial quinolone thioureas
EP0997466A1 (en) * 1988-10-24 2000-05-03 PROCTER & GAMBLE PHARMACEUTICALS, INC. Novel antimicrobial lactam-quinolones
US5180719A (en) * 1988-10-24 1993-01-19 Norwich Eaton Pharmaceuticals, Inc. Antimicrobial quinolonyl lactam esters
US5273973A (en) * 1988-10-24 1993-12-28 Norwich Eaton Pharmaceuticals, Inc. Antimicrobial quinolonyl esters
US5491139A (en) * 1988-10-24 1996-02-13 The Procter & Gamble Company Antimicrobial quinolonyl lactams
AU640481B2 (en) * 1990-04-18 1993-08-26 Norwich Eaton Pharmaceuticals, Inc. Penicillan or cephalosporin derivatives of quinolonyl
US5244892A (en) * 1990-10-16 1993-09-14 Kyorin Pharmaceutical Co., Ltd. Cephem compounds, and antibacterial agents
MX9700872A (es) * 1994-08-02 1997-05-31 Procter & Gamble Procedimiento para producir antimicrobianos de quinolonil-lactama y compuestos intermediarios novedosos.
NZ290721A (en) * 1994-08-02 1999-03-29 Procter & Gamble Process for making quinolone-containing antimicrobial compounds
TW200420573A (en) * 2002-09-26 2004-10-16 Rib X Pharmaceuticals Inc Bifunctional heterocyclic compounds and methods of making and using same
KR20060002800A (ko) * 2003-03-05 2006-01-09 립-엑스 파마슈티칼즈, 인크. 이관능성 헤테로시클릭 화합물, 및 그의 제조 및 사용 방법
JP2007509980A (ja) * 2003-10-30 2007-04-19 リブ−エックス ファーマシューティカルズ，インコーポレイテッド 二官能性マクロライド複素環式化合物およびそれらの化合物を調製および使用する方法
JP2007512256A (ja) * 2003-11-18 2007-05-17 リブ−エックス ファーマシューティカルズ，インコーポレイテッド 二官能性マクロライド複素環化合物ならびにこれらを製造する方法およびこれらを使用する方法
CN102816194A (zh) * 2004-02-27 2012-12-12 瑞伯-X医药品有限公司 大环化合物以及其制作和使用方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR208171A1 (es) * 1972-09-29 1976-12-09 Ciba Geigy Ag Procedimiento para la obtencion de nuevos derivados del acido cef-3-em-4-carboxilico
US4338439A (en) * 1976-08-26 1982-07-06 Eli Lilly And Company 7-[2-[(Substituted benzoyl]amino]acetamido]cephalosporins
DK548380A (da) * 1980-03-04 1981-09-05 Eisai Co Ltd 7alfa-methoxycephalsporinderivater og fremgangsmaade til fremstilling deraf
US4468394A (en) * 1981-04-02 1984-08-28 Eisai Co., Ltd. Cephalosporin compounds

Also Published As

Publication number Publication date
US4546176A (en) 1985-10-08
SE8306882L (sv) 1984-06-15
GB8329554D0 (en) 1983-12-07
ES8505691A1 (es) 1985-06-01
GB2132613B (en) 1986-05-08
CH656131A5 (de) 1986-06-13
GB2132613A (en) 1984-07-11
YU237283A (en) 1986-04-30
DK572183A (da) 1984-06-27
BE898442A (fr) 1984-06-13
PH20168A (en) 1986-10-09
SE8306882D0 (sv) 1983-12-13
IT8324122A0 (it) 1983-12-12
ES528003A0 (es) 1985-06-16
ES534297A0 (es) 1985-06-01
DK572183D0 (da) 1983-12-13
DE3345093A1 (de) 1984-06-14
FR2569195B1 (fr) 1987-01-09
ATA435283A (de) 1986-12-15
AU2082783A (en) 1984-06-21
IT1169969B (it) 1987-06-03
FR2569195A1 (fr) 1986-02-21
KR840007012A (ko) 1984-12-04
NL8304272A (nl) 1984-07-02

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