MX9700872A - Procedimiento para producir antimicrobianos de quinolonil-lactama y compuestos intermediarios novedosos. - Google Patents

Procedimiento para producir antimicrobianos de quinolonil-lactama y compuestos intermediarios novedosos.

Info

Publication number
MX9700872A
MX9700872A MX9700872A MX9700872A MX9700872A MX 9700872 A MX9700872 A MX 9700872A MX 9700872 A MX9700872 A MX 9700872A MX 9700872 A MX9700872 A MX 9700872A MX 9700872 A MX9700872 A MX 9700872A
Authority
MX
Mexico
Prior art keywords
moiety
compound
formula
lactam
iii
Prior art date
Application number
MX9700872A
Other languages
English (en)
Inventor
Jared Lynn Randall
Jane Ellen Godlewski
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of MX9700872A publication Critical patent/MX9700872A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/02—Preparation
    • C07D463/04—Preparation by forming the ring or condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

La presente invencion provee procedimientos para producir compuestos de la estructura (Q-Lü)-L-(L²-B), en donde (I) Q es una entidad quinolona; (II) B es una entidad lactama; y (III) L, Lü, y L² comprenden juntos una entidad enlazante; comprenden los pasos de: (1) copulacion de un compuesto de formula (III) con un compuesto que contiene lactama para formar un compuesto intermedio; y (2) ciclizacion del intermediario mediante reaccion con un compuesto orgánico de silicio para dar un compuesto de la formula (Q-Lü)-L-(L²-B); preferiblemente, el procedimiento comprende adicionalmente un paso anterior al paso de copulacion en donde se forman formas protegidas del compuesto de formula (III) y el compuesto de lactama; y pasos de desproteccion después del paso de ciclizacion, en donde se eliminan los grupos protectores; compuestos antimicrobianos preferidos producidos mediante estos procedimientos son aquellos en donde la entidad beta-lactama es un penem, un carbapenem, una cefema, o una carbacefema; también se prefieren los compuestos en donde Lü, L y L² forman una entidad carbamato, o una entidad amina secundaria o terciaria; la presente invencion también provee compuestos intermedios novedosos de la formula (M-Lü)-L-(L²-B), en donde (I) M tiene una estructura de acuerdo a la formula (IV), (II) B es una entidad lactama, y (III) L, Lü, y L² comprenden juntos una entidad enlazante.
MX9700872A 1994-08-02 1995-08-01 Procedimiento para producir antimicrobianos de quinolonil-lactama y compuestos intermediarios novedosos. MX9700872A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28477194A 1994-08-02 1994-08-02
PCT/US1995/009649 WO1996004286A1 (en) 1994-08-02 1995-08-01 Process for making quinolonyl lactam antimicrobials and novel intermediate compounds

Publications (1)

Publication Number Publication Date
MX9700872A true MX9700872A (es) 1997-05-31

Family

ID=23091468

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9700872A MX9700872A (es) 1994-08-02 1995-08-01 Procedimiento para producir antimicrobianos de quinolonil-lactama y compuestos intermediarios novedosos.

Country Status (13)

Country Link
US (1) US5801242A (es)
EP (1) EP0775145A1 (es)
JP (1) JPH10503521A (es)
KR (1) KR100239200B1 (es)
CN (1) CN1159809A (es)
AU (1) AU3154095A (es)
BR (1) BR9508513A (es)
CA (1) CA2196539C (es)
FI (1) FI970426A (es)
MX (1) MX9700872A (es)
NO (1) NO970428L (es)
NZ (1) NZ290722A (es)
WO (1) WO1996004286A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6020443A (en) * 1996-02-08 2000-02-01 Advanced Polymer Technologies, Inc. Polymerization of low grade DCPD monomers using an olefin metathesis catalyst
AU2001257490A1 (en) * 2000-05-02 2001-11-12 Newbiotics, Inc. Improved beta-lactam antibiotics
CA2427831C (en) * 2000-12-14 2009-08-18 The Procter & Gamble Company Cyclization process step in the making of quinolones and naphthyridines
US6803469B2 (en) * 2002-08-05 2004-10-12 The Procter & Gamble Company Process for preparing quinolone antibiotic intermediates
AR096135A1 (es) 2013-05-02 2015-12-09 Actelion Pharmaceuticals Ltd Derivados de la quinolona

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE279886C (es) *
US4383946A (en) * 1980-03-27 1983-05-17 Merck & Co., Inc. Process for the preparation of 1-carbapenems and intermediates via silyl-substituted dithioacetals
NL8005041A (nl) * 1980-09-05 1982-04-01 Gist Brocades Nv Werkwijze voor de bereiding van thioethers, alsmede gesilyleerde thiolen voor toepassing bij deze werkwijze.
US4546176A (en) * 1982-12-14 1985-10-08 Eisai Co., Ltd. 7-Carboxymethoxyphenylacetamido-3-cephem derivatives and antibacterial preparations containing the same
EP0181521A1 (en) * 1984-10-19 1986-05-21 Otsuka Pharmaceutical Co., Ltd. Antimicrobial 1-substituted Phenyl-4-oxoquinoline-3-carboxylic acid compounds
US4755513A (en) * 1985-01-30 1988-07-05 Otsuka Pharmaceutical Company, Limited Antimicrobial 1-substituted phenyl-4-oxoquinoline-3-carboxylic acid compounds
DE3509769A1 (de) * 1985-03-19 1986-09-25 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von carbapenemzwischenprodukten
US4684648A (en) * 1985-05-10 1987-08-04 Otsuka Pharmaceutical Company Limited Antimicrobial 1-substituted phenyl-4-oxoquinoline-3-carboxylic acid compounds and compositions thereof
DE3542644A1 (de) * 1985-12-03 1987-06-04 Hoechst Ag Verfahren zur herstellung von cefodizim
JPS62215591A (ja) * 1986-03-14 1987-09-22 Dainippon Pharmaceut Co Ltd ピリドベンズオキサジン誘導体の製造法およびその中間体
EP0242789A3 (en) * 1986-04-25 1990-09-05 Dainippon Pharmaceutical Co., Ltd. Novel quinoline derivates and processes for preparation thereof
US4920120A (en) * 1988-01-25 1990-04-24 Warner-Lambert Company Antibacterial agents
CS273349B2 (en) * 1988-03-31 1991-03-12 Hoffmann La Roche Method of cephalosporin's new derivatives production
EP0366193A3 (en) * 1988-10-24 1992-01-08 Norwich Eaton Pharmaceuticals, Inc. Novel antimicrobial quinolonyl lactams
SG67307A1 (en) * 1988-10-24 1999-09-21 Procter & Gamble Pharma Novel antimicrobial quinolonyl lactam esters
US5273973A (en) * 1988-10-24 1993-12-28 Norwich Eaton Pharmaceuticals, Inc. Antimicrobial quinolonyl esters
US5328908A (en) * 1988-10-24 1994-07-12 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial quinolone thioureas
ZA912279B (en) * 1990-04-09 1992-02-26 Hoffmann La Roche Carbapenem compounds
KR920004385A (ko) * 1990-08-09 1992-03-27 와꾸나가 기스께 신규 삼환화합물 또는 그의 염, 이의 제조방법 및 이를 함유하는 항균제
IT1248011B (it) * 1991-06-07 1995-01-05 Mediolanum Farmaceutici Spa Procedimento per la preparazione dell'acido 9-fluoro-10- (4-metil-1-piperazinil)-7-oxo-2,3-diidro-7h-pirido (1,2,3-de) (1,4)benzotiadin-6-carbossilico cloridrato.
BR9206590A (pt) * 1991-10-01 1995-04-25 Procter & Gamble Pharma Processo para a obtenção de quinolonil lactamas antimicrobianas
EG20543A (en) * 1992-10-30 1999-07-31 Procter & Gamble Process for preparing of novel antimicrobial -5- (n-heterosubstituted amino) quinolones

Also Published As

Publication number Publication date
CA2196539A1 (en) 1996-02-15
AU3154095A (en) 1996-03-04
US5801242A (en) 1998-09-01
WO1996004286A1 (en) 1996-02-15
JPH10503521A (ja) 1998-03-31
FI970426A0 (fi) 1997-01-31
EP0775145A1 (en) 1997-05-28
KR100239200B1 (ko) 2000-03-02
NO970428L (no) 1997-04-02
NZ290722A (en) 1999-03-29
BR9508513A (pt) 1998-06-02
CN1159809A (zh) 1997-09-17
CA2196539C (en) 2001-05-15
NO970428D0 (no) 1997-01-31
FI970426A (fi) 1997-03-25

Similar Documents

Publication Publication Date Title
PT100920A (pt) Processo para a preparacao de quinolonil-lactamas antimicrobianas
HUT42437A (en) Process for preparing optically activeacyl azetidinones
ATE208374T1 (de) Beta-laktam und cepham verbindungen und ihre herstellung
SG68556A1 (en) Novel method of producing 7-(substituted)-9-[(substituted glycyl)-amido]-6-demethyl-6-deoxytetracyclines
MX9700872A (es) Procedimiento para producir antimicrobianos de quinolonil-lactama y compuestos intermediarios novedosos.
AU1198897A (en) 1-benzenesulfonyl pyrrolidine derivatives as bradykinin receptor antagonists
ATE112778T1 (de) Verfahren zur herstellung von penem-verbindungen.
DE60130916D1 (de) Neue beta-lactamverbindungen und verfahren zu deren herstellung
UA50705C2 (uk) СПОСОБИ ОДЕРЖАННЯ ПРОМІЖНИХ СПОЛУК <font face="Symbol">b</font>-МЕТИЛКАРБАПЕНЕМУ, ПРОМІЖНІ CПОЛУКИ
TW277059B (es)
IE56235B1 (en) Penems,pharmaceutical compositions containing them,process for preparing them
CZ230195A3 (en) Process for preparing condensed carbapenem derivative and intermediate for preparing thereof
MY105332A (en) Process for preparing penem esters
EP0238252A3 (en) Preparation of azetidinones and novel intermediates
ATE210115T1 (de) Verfahren zur herstellung von (1'r,3s,4r)4- acylthioazetidinonen