ES8505691A1 - Un procedimiento para preparar derivados de cefem - Google Patents
Un procedimiento para preparar derivados de cefemInfo
- Publication number
- ES8505691A1 ES8505691A1 ES534297A ES534297A ES8505691A1 ES 8505691 A1 ES8505691 A1 ES 8505691A1 ES 534297 A ES534297 A ES 534297A ES 534297 A ES534297 A ES 534297A ES 8505691 A1 ES8505691 A1 ES 8505691A1
- Authority
- ES
- Spain
- Prior art keywords
- carboxymethoxyphenylacetamido
- substituted
- same
- alkanoyloxy
- preparations containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- GHUZIVNTUZTXLL-LDZOIKDWSA-N 2-[[(6R)-8-oxo-4-[(2-phenylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-en-7-yl]oxy]acetic acid Chemical class C(=O)(O)COC1[C@@H]2N(C=CC(S2)NC(CC2=CC=CC=C2)=O)C1=O GHUZIVNTUZTXLL-LDZOIKDWSA-N 0.000 title abstract 2
- 230000000844 anti-bacterial effect Effects 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical class C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000005194 alkoxycarbonyloxy group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001782 cephems Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
- C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR DERIVADOS DECEFEM.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) O UNA SAL DEL MISMO, CON UN COMPUESTO DE FORMULA (III) EN UN DISOLVENTE INERTE Y A UNA TEMPERATURA ENTRE C50JC Y B50JC, PARA OBTENER UN COMPUESTO DE FORMULA (I), Y SUS SALES FARMACEUTICAMENTE ACEPTABLES O SIENDO R1 HIDROXI, ALCANOILOXI DE (1 A 4), R2 -H O METOXI, R3 ALCANOILOXI DE (1 A 4), UN ANILLO HETEROCICLICO-TIO U OTROS, A UN GRUPO DE FORMULA (IV); Y R4 Y R5 H O UN GRUPO ALQUILO DE (1 A 4).SE UTILIZA COMO AGENTES ANTIBACTERIANAS CONTRA BACTERIAS GAMMA-(-).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP21772682A JPS59108791A (ja) | 1982-12-14 | 1982-12-14 | 7−カルボキシメトキシフエニルアセトアミド−3−セフエム誘導体、その製造方法およびそれからなる抗菌剤 |
JP3601783A JPS59161389A (ja) | 1983-03-07 | 1983-03-07 | 7−カルボキシメトキシフエニルアセトアミドセフエム誘導体,その製造法およびそれからなる抗菌剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8505691A1 true ES8505691A1 (es) | 1985-06-01 |
ES534297A0 ES534297A0 (es) | 1985-06-01 |
Family
ID=26375029
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES528003A Expired ES8506025A1 (es) | 1982-12-14 | 1983-12-13 | Un procedimiento para preparar derivados de cefem |
ES534297A Granted ES534297A0 (es) | 1982-12-14 | 1984-07-13 | Un procedimiento para preparar derivados de cefem |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES528003A Expired ES8506025A1 (es) | 1982-12-14 | 1983-12-13 | Un procedimiento para preparar derivados de cefem |
Country Status (16)
Country | Link |
---|---|
US (1) | US4546176A (es) |
KR (1) | KR840007012A (es) |
AT (1) | ATA435283A (es) |
AU (1) | AU2082783A (es) |
BE (1) | BE898442A (es) |
CH (1) | CH656131A5 (es) |
DE (1) | DE3345093A1 (es) |
DK (1) | DK572183A (es) |
ES (2) | ES8506025A1 (es) |
FR (1) | FR2569195B1 (es) |
GB (1) | GB2132613B (es) |
IT (1) | IT1169969B (es) |
NL (1) | NL8304272A (es) |
PH (1) | PH20168A (es) |
SE (1) | SE8306882L (es) |
YU (1) | YU237283A (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5232918A (en) * | 1987-07-23 | 1993-08-03 | Imperial Chemical Industries Plc | Cephalosporin derivatives |
US5491139A (en) * | 1988-10-24 | 1996-02-13 | The Procter & Gamble Company | Antimicrobial quinolonyl lactams |
US5180719A (en) * | 1988-10-24 | 1993-01-19 | Norwich Eaton Pharmaceuticals, Inc. | Antimicrobial quinolonyl lactam esters |
EP0997466A1 (en) * | 1988-10-24 | 2000-05-03 | PROCTER & GAMBLE PHARMACEUTICALS, INC. | Novel antimicrobial lactam-quinolones |
CA2001203C (en) * | 1988-10-24 | 2001-02-13 | Thomas P. Demuth, Jr. | Novel antimicrobial dithiocarbamoyl quinolones |
US5273973A (en) * | 1988-10-24 | 1993-12-28 | Norwich Eaton Pharmaceuticals, Inc. | Antimicrobial quinolonyl esters |
US5328908A (en) * | 1988-10-24 | 1994-07-12 | Procter & Gamble Pharmaceuticals, Inc. | Antimicrobial quinolone thioureas |
ES2147721T3 (es) * | 1990-04-18 | 2000-10-01 | Procter & Gamble Pharma | Quinolonil lactamas antimicrobianas. |
US5244892A (en) * | 1990-10-16 | 1993-09-14 | Kyorin Pharmaceutical Co., Ltd. | Cephem compounds, and antibacterial agents |
NZ290722A (en) * | 1994-08-02 | 1999-03-29 | Procter & Gamble | A process for making derivatives of quinolonyl lactam (qla's); intermediates |
JPH10504815A (ja) * | 1994-08-02 | 1998-05-12 | ザ、プロクター、エンド、ギャンブル、カンパニー | 抗微生物化合物の製造方法 |
US7091196B2 (en) * | 2002-09-26 | 2006-08-15 | Rib-X Pharmaceuticals, Inc. | Bifunctional heterocyclic compounds and methods of making and using same |
JP2006523229A (ja) * | 2003-03-05 | 2006-10-12 | リブ−エックス ファーマシューティカルズ,インコーポレイテッド | 二官能性複素環式化合物ならびにその製造および使用方法 |
US20070149463A1 (en) * | 2003-10-30 | 2007-06-28 | Oyelere Adegboyega K | Bifunctional macrolide heterocyclic compounds and methods of making and using the same |
JP2007512256A (ja) * | 2003-11-18 | 2007-05-17 | リブ−エックス ファーマシューティカルズ,インコーポレイテッド | 二官能性マクロライド複素環化合物ならびにこれらを製造する方法およびこれらを使用する方法 |
CN102816194A (zh) * | 2004-02-27 | 2012-12-12 | 瑞伯-X医药品有限公司 | 大环化合物以及其制作和使用方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR208171A1 (es) * | 1972-09-29 | 1976-12-09 | Ciba Geigy Ag | Procedimiento para la obtencion de nuevos derivados del acido cef-3-em-4-carboxilico |
US4338439A (en) * | 1976-08-26 | 1982-07-06 | Eli Lilly And Company | 7-[2-[(Substituted benzoyl]amino]acetamido]cephalosporins |
SE8009049L (sv) * | 1980-03-04 | 1981-09-05 | Eisai Co Ltd | 7alfa-metoxicefalosporinderivat, sett for framstellning derav och antibakteriella lekemedel innehallande dessa foreningar |
US4468394A (en) * | 1981-04-02 | 1984-08-28 | Eisai Co., Ltd. | Cephalosporin compounds |
-
1983
- 1983-10-20 US US06/544,406 patent/US4546176A/en not_active Expired - Fee Related
- 1983-10-31 AU AU20827/83A patent/AU2082783A/en not_active Abandoned
- 1983-11-04 GB GB08329554A patent/GB2132613B/en not_active Expired
- 1983-11-23 PH PH29873A patent/PH20168A/en unknown
- 1983-12-05 YU YU02372/83A patent/YU237283A/xx unknown
- 1983-12-12 IT IT24122/83A patent/IT1169969B/it active
- 1983-12-12 FR FR8319876A patent/FR2569195B1/fr not_active Expired
- 1983-12-12 NL NL8304272A patent/NL8304272A/nl not_active Application Discontinuation
- 1983-12-13 SE SE8306882A patent/SE8306882L/xx not_active Application Discontinuation
- 1983-12-13 ES ES528003A patent/ES8506025A1/es not_active Expired
- 1983-12-13 BE BE0/212036A patent/BE898442A/fr not_active IP Right Cessation
- 1983-12-13 DK DK572183A patent/DK572183A/da not_active Application Discontinuation
- 1983-12-13 CH CH6649/83A patent/CH656131A5/de not_active IP Right Cessation
- 1983-12-13 DE DE19833345093 patent/DE3345093A1/de not_active Withdrawn
- 1983-12-14 AT AT0435283A patent/ATA435283A/de not_active Application Discontinuation
- 1983-12-14 KR KR1019830005939A patent/KR840007012A/ko not_active Application Discontinuation
-
1984
- 1984-07-13 ES ES534297A patent/ES534297A0/es active Granted
Also Published As
Publication number | Publication date |
---|---|
YU237283A (en) | 1986-04-30 |
IT1169969B (it) | 1987-06-03 |
DE3345093A1 (de) | 1984-06-14 |
IT8324122A0 (it) | 1983-12-12 |
NL8304272A (nl) | 1984-07-02 |
SE8306882L (sv) | 1984-06-15 |
DK572183A (da) | 1984-06-27 |
ES528003A0 (es) | 1985-06-16 |
SE8306882D0 (sv) | 1983-12-13 |
US4546176A (en) | 1985-10-08 |
FR2569195A1 (fr) | 1986-02-21 |
ES8506025A1 (es) | 1985-06-16 |
PH20168A (en) | 1986-10-09 |
GB2132613A (en) | 1984-07-11 |
ATA435283A (de) | 1986-12-15 |
GB2132613B (en) | 1986-05-08 |
KR840007012A (ko) | 1984-12-04 |
CH656131A5 (de) | 1986-06-13 |
ES534297A0 (es) | 1985-06-01 |
AU2082783A (en) | 1984-06-21 |
GB8329554D0 (en) | 1983-12-07 |
DK572183D0 (da) | 1983-12-13 |
BE898442A (fr) | 1984-06-13 |
FR2569195B1 (fr) | 1987-01-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES8506025A1 (es) | Un procedimiento para preparar derivados de cefem | |
CA2096969A1 (en) | 6-0-methylerythromycin a derivatives | |
ES8306157A1 (es) | Un procedimiento para la produccion de un acido 7-(amino sustituido o no sustituido)-3-metil sustituido-a3-cefem-4-carboxilico. | |
ES8704943A1 (es) | Un procedimiento para la fabricacion de derivados de cefalosporina. | |
ES2001794A6 (es) | Un procedimiento para la preparacion de derivados de quinolina | |
EP0612751A3 (en) | Compounds for the preparation of cephem derivatives. | |
ES8606360A1 (es) | Un derivado de cefalosporina. | |
ES8202021A1 (es) | Un procedimiento para la preparacion de un compuesto de ce- falosporina | |
HUT73172A (en) | 3`-aziridino-anthracycline derivatives, pharmaceutical compns. contg. the said compds, process to prepare them and their use | |
ES8302021A1 (es) | Procedimiento para la preparacion de 3-0-desmenlistamicina b. | |
IE43346L (en) | Cephalosporin derivatives. | |
ES8304973A1 (es) | Un procedimiento para la preparacion de nuevos derivados de tiocarbapenem 3-sustituidos. | |
EP0287116A3 (en) | Thiadiazolylacetamide cephem derivatives | |
ES2014041A6 (es) | Un procedimiento para preparar un derivado de amina. | |
ES8307819A1 (es) | "un metodo de producir derivados de cefalosporina". | |
ES454469A1 (es) | Un procedimiento de produccion de derivados de 7-(4-carboxi-butiramido)-7-metoxicefalosporina. | |
ES8201587A1 (es) | Procedimiento de producir compuestos cefalosporinicos anti- microbianos | |
ES8200650A1 (es) | Procedimiento para preparar derivados de 2,5-dialcohilfeni- lurea | |
JPS56123990A (en) | 7- n-acylamino-alpha-arylacetamide -3- substituted or unsubstituted-1-pyridiniummethyl cephalosporins | |
AU2231897A (en) | Tricyclic compounds, their production and use | |
ES8506313A1 (es) | Un procedimiento para la preparacion de nuevos derivados de 7-oxo-1-azabiciclo(3.2.0)hepteno. |