ES8201587A1 - Procedimiento de producir compuestos cefalosporinicos anti- microbianos - Google Patents
Procedimiento de producir compuestos cefalosporinicos anti- microbianosInfo
- Publication number
- ES8201587A1 ES8201587A1 ES499978A ES499978A ES8201587A1 ES 8201587 A1 ES8201587 A1 ES 8201587A1 ES 499978 A ES499978 A ES 499978A ES 499978 A ES499978 A ES 499978A ES 8201587 A1 ES8201587 A1 ES 8201587A1
- Authority
- ES
- Spain
- Prior art keywords
- alpha
- cephalosporin compounds
- arylacetamido
- acylamino
- antimicrobial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTO CEFALOSPORINICOS ANTIMICROBIANOS Y, EN PARTICULAR, PARA OBTENER COMPUESTOS DE FORMULA (I), DONDE HO-A- REPRESENTA UN GRUPO HIDROXIPIRIDILO QUE PUEDE ESTAR SUSTITUIDO CON UN GRUPO ALQUILO INFERIOR, UN GRUPO ALCANOILO INFERIOR, UN ATOMO DE HALOGENO, Y UN GRUPO ALQUILENO; R1 Y R2 PUEDEN SER IGUALES O DIFERENTES Y REPRESENTAN CADA UNO UN SUSTITUYENTE ELEGIDO DEL GRUPO FORMADO POR UN ATOMO DE HIDROGENO, UN GRUPO HIDROXILO, UN GRUPO ALQUILO INFERIOR, Y UN GRUPO HIDROXIMETILO; T ES UN GRUPO DE FORMULA (II), DONDE R3 REPRESENTA UN GRUPO CARBOXILO O UN GRUPO SULFO; Y M ES UN ATOMO DE HIDROGENO O UN CATION NO TOXICO; Y SUS SALES DE ADICION NO TOXICAS FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN COMPUESTO HO-A-COOH, DONDE HO-A- TIENE EL SIGNIFICADO YA INDICADO, CON UN COMPUESTO DE FORMULA (III), DONDE R1,R2,T Y M TIENEN LOS SIGNIFICADOS YA INDICADOS.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2853780A JPS56123989A (en) | 1980-03-05 | 1980-03-05 | 7- n acylamino-alpha-arylacetamide -3- 1-substituted tetrazole- 5-ylthiomethyl cephalosporins |
JP2853880A JPS56123990A (en) | 1980-03-05 | 1980-03-05 | 7- n-acylamino-alpha-arylacetamide -3- substituted or unsubstituted-1-pyridiniummethyl cephalosporins |
JP2853680A JPS56123988A (en) | 1980-03-05 | 1980-03-05 | Novel 7- n-acylamino-alpha-arylacetamide -3- 1-substituted tetrazole-5-ylthiomethyl cephalosporins |
Publications (2)
Publication Number | Publication Date |
---|---|
ES499978A0 ES499978A0 (es) | 1982-01-01 |
ES8201587A1 true ES8201587A1 (es) | 1982-01-01 |
Family
ID=27286231
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES499978A Expired ES8201587A1 (es) | 1980-03-05 | 1981-03-02 | Procedimiento de producir compuestos cefalosporinicos anti- microbianos |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0035413B1 (es) |
DE (1) | DE3165808D1 (es) |
ES (1) | ES8201587A1 (es) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3954734A (en) * | 1974-01-21 | 1976-05-04 | Parke, Davis & Company | Novel antibacterial amide compounds and process means for producing the same |
US4068074A (en) * | 1974-04-05 | 1978-01-10 | Yamanouchi Pharmaceutical Co., Ltd. | Cephalosporin derivatives having at the 3-position of the cephem ring a heterocyclic thiomethyl group with a carboxy or sulfo group and at the 7-position of the cephem ring an α-heterocylic acylaminophenyl-acetamide group |
US4160087A (en) * | 1974-09-06 | 1979-07-03 | Sumitomo Chemical Company, Limited | N-acylamino-α-arylacetamido cephalosporins |
GB1537949A (en) * | 1976-03-03 | 1979-01-10 | Sumitomo Chemical Co | Cephalosporins |
JPS54119497A (en) * | 1978-03-08 | 1979-09-17 | Sumitomo Chem Co Ltd | N-acylamino-alpha-arylacetamidocephalosporin derivative |
-
1981
- 1981-03-02 ES ES499978A patent/ES8201587A1/es not_active Expired
- 1981-03-05 EP EP81300917A patent/EP0035413B1/en not_active Expired
- 1981-03-05 DE DE8181300917T patent/DE3165808D1/de not_active Expired
Also Published As
Publication number | Publication date |
---|---|
EP0035413A2 (en) | 1981-09-09 |
DE3165808D1 (en) | 1984-10-11 |
ES499978A0 (es) | 1982-01-01 |
EP0035413A3 (en) | 1981-11-04 |
EP0035413B1 (en) | 1984-09-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19981001 |