JPS56123988A - Novel 7- n-acylamino-alpha-arylacetamide -3- 1-substituted tetrazole-5-ylthiomethyl cephalosporins - Google Patents

Novel 7- n-acylamino-alpha-arylacetamide -3- 1-substituted tetrazole-5-ylthiomethyl cephalosporins

Info

Publication number
JPS56123988A
JPS56123988A JP2853680A JP2853680A JPS56123988A JP S56123988 A JPS56123988 A JP S56123988A JP 2853680 A JP2853680 A JP 2853680A JP 2853680 A JP2853680 A JP 2853680A JP S56123988 A JPS56123988 A JP S56123988A
Authority
JP
Japan
Prior art keywords
formula
compound shown
ylthiomethyl
salt
arylacetamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2853680A
Other languages
Japanese (ja)
Inventor
Hirotada Yamada
Seiichi Jinbo
Takao Okuda
Hiroshi Noguchi
Hisao Tohiki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Priority to JP2853680A priority Critical patent/JPS56123988A/en
Priority to ES499978A priority patent/ES499978A0/en
Priority to CA000372303A priority patent/CA1152489A/en
Priority to DE8181300917T priority patent/DE3165808D1/en
Priority to US06/240,666 priority patent/US4390535A/en
Priority to EP81300917A priority patent/EP0035413B1/en
Publication of JPS56123988A publication Critical patent/JPS56123988A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:A compound shown by the formula I (HO-A- is hydroxypyridyl wherein pyridine ring is substituted or unsubstituted; R1 is OH; R2-3 are substituent group selected from the group consisting of H, dialkylamino, etc.; X is lower alkylene; Y is carboxyl, or sulfonic acid) or its salt.
EXAMPLE: 7-[ D-α-( 4-hydroxy-6-methylpyridine-3-carboxyamide )-α-( 4-hydroxyphenyl )acetamide ]-3-( 1-carboxymethyl-1H-tetrazole-5-ylthiomethyl )-3-cephem-4- carboxylic acid.
USE: An antibacterial agent. Effective against Gram-positive and Gram-negative bacteria (especially against Pseudomonas aeruginosa, Serratia, etc.). Having a small side effect.
PROCESS: A compound shown by the formula HO-A-COOH or its reactive derivative is reacted with a compound shown by the formula II or its salt or its derivative to give a compound shown by the formula I or its salt.
COPYRIGHT: (C)1981,JPO&Japio
JP2853680A 1980-03-05 1980-03-05 Novel 7- n-acylamino-alpha-arylacetamide -3- 1-substituted tetrazole-5-ylthiomethyl cephalosporins Pending JPS56123988A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2853680A JPS56123988A (en) 1980-03-05 1980-03-05 Novel 7- n-acylamino-alpha-arylacetamide -3- 1-substituted tetrazole-5-ylthiomethyl cephalosporins
ES499978A ES499978A0 (en) 1980-03-05 1981-03-02 PROCEDURE FOR PRODUCING ANTI-MICROBIAL CEPHALOSPORINIC COMPOUNDS
CA000372303A CA1152489A (en) 1980-03-05 1981-03-04 ANTIMICROBIAL 7- (.alpha.-ACYLAMINO-.alpha.-ARYLACETAMIDO)-3- (SUBSTITUTED METHYL) CEPHALOSPORIN COMPOUNDS, THEIR COMPOSITIONS AND PRODUCTION THEREOF
DE8181300917T DE3165808D1 (en) 1980-03-05 1981-03-05 Antimicrobial 7-(alpha-acylamino-alpha-arylacetamido)-3-(substituted methyl)cephalosporin compounds, their compositions and production
US06/240,666 US4390535A (en) 1980-03-05 1981-03-05 Antimicrobial 7-(α-acylamino-α-arylacetamido)-3-(substituted methyl)cephalosporin compounds
EP81300917A EP0035413B1 (en) 1980-03-05 1981-03-05 Antimicrobial 7-(alpha-acylamino-alpha-arylacetamido)-3-(substituted methyl)cephalosporin compounds, their compositions and production

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2853680A JPS56123988A (en) 1980-03-05 1980-03-05 Novel 7- n-acylamino-alpha-arylacetamide -3- 1-substituted tetrazole-5-ylthiomethyl cephalosporins

Publications (1)

Publication Number Publication Date
JPS56123988A true JPS56123988A (en) 1981-09-29

Family

ID=12251383

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2853680A Pending JPS56123988A (en) 1980-03-05 1980-03-05 Novel 7- n-acylamino-alpha-arylacetamide -3- 1-substituted tetrazole-5-ylthiomethyl cephalosporins

Country Status (1)

Country Link
JP (1) JPS56123988A (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50157388A (en) * 1974-06-07 1975-12-19
JPS5293790A (en) * 1976-02-02 1977-08-06 Sumitomo Chem Co Ltd 7-(n-acylamino-alpha-arylacetamide) cephalosporins
JPS5549385A (en) * 1978-10-05 1980-04-09 Yamanouchi Pharmaceut Co Ltd Novel antibacterial compound

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50157388A (en) * 1974-06-07 1975-12-19
JPS5293790A (en) * 1976-02-02 1977-08-06 Sumitomo Chem Co Ltd 7-(n-acylamino-alpha-arylacetamide) cephalosporins
JPS5549385A (en) * 1978-10-05 1980-04-09 Yamanouchi Pharmaceut Co Ltd Novel antibacterial compound

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