JPS56123988A - Novel 7- n-acylamino-alpha-arylacetamide -3- 1-substituted tetrazole-5-ylthiomethyl cephalosporins - Google Patents
Novel 7- n-acylamino-alpha-arylacetamide -3- 1-substituted tetrazole-5-ylthiomethyl cephalosporinsInfo
- Publication number
- JPS56123988A JPS56123988A JP2853680A JP2853680A JPS56123988A JP S56123988 A JPS56123988 A JP S56123988A JP 2853680 A JP2853680 A JP 2853680A JP 2853680 A JP2853680 A JP 2853680A JP S56123988 A JPS56123988 A JP S56123988A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound shown
- ylthiomethyl
- salt
- arylacetamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:A compound shown by the formula I (HO-A- is hydroxypyridyl wherein pyridine ring is substituted or unsubstituted; R1 is OH; R2-3 are substituent group selected from the group consisting of H, dialkylamino, etc.; X is lower alkylene; Y is carboxyl, or sulfonic acid) or its salt.
EXAMPLE: 7-[ D-α-( 4-hydroxy-6-methylpyridine-3-carboxyamide )-α-( 4-hydroxyphenyl )acetamide ]-3-( 1-carboxymethyl-1H-tetrazole-5-ylthiomethyl )-3-cephem-4- carboxylic acid.
USE: An antibacterial agent. Effective against Gram-positive and Gram-negative bacteria (especially against Pseudomonas aeruginosa, Serratia, etc.). Having a small side effect.
PROCESS: A compound shown by the formula HO-A-COOH or its reactive derivative is reacted with a compound shown by the formula II or its salt or its derivative to give a compound shown by the formula I or its salt.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2853680A JPS56123988A (en) | 1980-03-05 | 1980-03-05 | Novel 7- n-acylamino-alpha-arylacetamide -3- 1-substituted tetrazole-5-ylthiomethyl cephalosporins |
ES499978A ES499978A0 (en) | 1980-03-05 | 1981-03-02 | PROCEDURE FOR PRODUCING ANTI-MICROBIAL CEPHALOSPORINIC COMPOUNDS |
CA000372303A CA1152489A (en) | 1980-03-05 | 1981-03-04 | ANTIMICROBIAL 7- (.alpha.-ACYLAMINO-.alpha.-ARYLACETAMIDO)-3- (SUBSTITUTED METHYL) CEPHALOSPORIN COMPOUNDS, THEIR COMPOSITIONS AND PRODUCTION THEREOF |
DE8181300917T DE3165808D1 (en) | 1980-03-05 | 1981-03-05 | Antimicrobial 7-(alpha-acylamino-alpha-arylacetamido)-3-(substituted methyl)cephalosporin compounds, their compositions and production |
US06/240,666 US4390535A (en) | 1980-03-05 | 1981-03-05 | Antimicrobial 7-(α-acylamino-α-arylacetamido)-3-(substituted methyl)cephalosporin compounds |
EP81300917A EP0035413B1 (en) | 1980-03-05 | 1981-03-05 | Antimicrobial 7-(alpha-acylamino-alpha-arylacetamido)-3-(substituted methyl)cephalosporin compounds, their compositions and production |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2853680A JPS56123988A (en) | 1980-03-05 | 1980-03-05 | Novel 7- n-acylamino-alpha-arylacetamide -3- 1-substituted tetrazole-5-ylthiomethyl cephalosporins |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS56123988A true JPS56123988A (en) | 1981-09-29 |
Family
ID=12251383
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2853680A Pending JPS56123988A (en) | 1980-03-05 | 1980-03-05 | Novel 7- n-acylamino-alpha-arylacetamide -3- 1-substituted tetrazole-5-ylthiomethyl cephalosporins |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56123988A (en) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS50157388A (en) * | 1974-06-07 | 1975-12-19 | ||
JPS5293790A (en) * | 1976-02-02 | 1977-08-06 | Sumitomo Chem Co Ltd | 7-(n-acylamino-alpha-arylacetamide) cephalosporins |
JPS5549385A (en) * | 1978-10-05 | 1980-04-09 | Yamanouchi Pharmaceut Co Ltd | Novel antibacterial compound |
-
1980
- 1980-03-05 JP JP2853680A patent/JPS56123988A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS50157388A (en) * | 1974-06-07 | 1975-12-19 | ||
JPS5293790A (en) * | 1976-02-02 | 1977-08-06 | Sumitomo Chem Co Ltd | 7-(n-acylamino-alpha-arylacetamide) cephalosporins |
JPS5549385A (en) * | 1978-10-05 | 1980-04-09 | Yamanouchi Pharmaceut Co Ltd | Novel antibacterial compound |
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