FR2569195B1 - Derives du 7-carboxymethoxyphenylacetamido-3-cepheme utiles comme medicaments antibacteriens et procedes pour leur preparation - Google Patents

Derives du 7-carboxymethoxyphenylacetamido-3-cepheme utiles comme medicaments antibacteriens et procedes pour leur preparation

Info

Publication number
FR2569195B1
FR2569195B1 FR8319876A FR8319876A FR2569195B1 FR 2569195 B1 FR2569195 B1 FR 2569195B1 FR 8319876 A FR8319876 A FR 8319876A FR 8319876 A FR8319876 A FR 8319876A FR 2569195 B1 FR2569195 B1 FR 2569195B1
Authority
FR
France
Prior art keywords
carboxymethoxyphenylacetamido
cepheme
processes
preparation
derivatives useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8319876A
Other languages
English (en)
Other versions
FR2569195A1 (fr
Inventor
Yoshimasa Machida
Shigeto Negi
Seiichiro Nomoto
Takashi Kamiya
Kyosuke Kitoh
Isao Saito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP21772682A external-priority patent/JPS59108791A/ja
Priority claimed from JP3601783A external-priority patent/JPS59161389A/ja
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of FR2569195A1 publication Critical patent/FR2569195A1/fr
Application granted granted Critical
Publication of FR2569195B1 publication Critical patent/FR2569195B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
FR8319876A 1982-12-14 1983-12-12 Derives du 7-carboxymethoxyphenylacetamido-3-cepheme utiles comme medicaments antibacteriens et procedes pour leur preparation Expired FR2569195B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP21772682A JPS59108791A (ja) 1982-12-14 1982-12-14 ７−カルボキシメトキシフエニルアセトアミド−３−セフエム誘導体、その製造方法およびそれからなる抗菌剤
JP3601783A JPS59161389A (ja) 1983-03-07 1983-03-07 ７−カルボキシメトキシフエニルアセトアミドセフエム誘導体，その製造法およびそれからなる抗菌剤

Publications (2)

Publication Number Publication Date
FR2569195A1 FR2569195A1 (fr) 1986-02-21
FR2569195B1 true FR2569195B1 (fr) 1987-01-09

Family

ID=26375029

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8319876A Expired FR2569195B1 (fr) 1982-12-14 1983-12-12 Derives du 7-carboxymethoxyphenylacetamido-3-cepheme utiles comme medicaments antibacteriens et procedes pour leur preparation

Country Status (16)

Country Link
US (1) US4546176A (fr)
KR (1) KR840007012A (fr)
AT (1) ATA435283A (fr)
AU (1) AU2082783A (fr)
BE (1) BE898442A (fr)
CH (1) CH656131A5 (fr)
DE (1) DE3345093A1 (fr)
DK (1) DK572183A (fr)
ES (2) ES8506025A1 (fr)
FR (1) FR2569195B1 (fr)
GB (1) GB2132613B (fr)
IT (1) IT1169969B (fr)
NL (1) NL8304272A (fr)
PH (1) PH20168A (fr)
SE (1) SE8306882L (fr)
YU (1) YU237283A (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5232918A (en) * 1987-07-23 1993-08-03 Imperial Chemical Industries Plc Cephalosporin derivatives
US5491139A (en) * 1988-10-24 1996-02-13 The Procter & Gamble Company Antimicrobial quinolonyl lactams
US5180719A (en) * 1988-10-24 1993-01-19 Norwich Eaton Pharmaceuticals, Inc. Antimicrobial quinolonyl lactam esters
EP0997466A1 (fr) * 1988-10-24 2000-05-03 PROCTER & GAMBLE PHARMACEUTICALS, INC. Lactam-quinolones antimicrobiennes
CA2001203C (fr) * 1988-10-24 2001-02-13 Thomas P. Demuth, Jr. Dithiocarbamoyl quinolones antimicrobiens
US5273973A (en) * 1988-10-24 1993-12-28 Norwich Eaton Pharmaceuticals, Inc. Antimicrobial quinolonyl esters
US5328908A (en) * 1988-10-24 1994-07-12 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial quinolone thioureas
ES2147721T3 (es) * 1990-04-18 2000-10-01 Procter & Gamble Pharma Quinolonil lactamas antimicrobianas.
US5244892A (en) * 1990-10-16 1993-09-14 Kyorin Pharmaceutical Co., Ltd. Cephem compounds, and antibacterial agents
NZ290722A (en) * 1994-08-02 1999-03-29 Procter & Gamble A process for making derivatives of quinolonyl lactam (qla's); intermediates
JPH10504815A (ja) * 1994-08-02 1998-05-12 ザ、プロクター、エンド、ギャンブル、カンパニー 抗微生物化合物の製造方法
US7091196B2 (en) * 2002-09-26 2006-08-15 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same
JP2006523229A (ja) * 2003-03-05 2006-10-12 リブ−エックス ファーマシューティカルズ，インコーポレイテッド 二官能性複素環式化合物ならびにその製造および使用方法
US20070149463A1 (en) * 2003-10-30 2007-06-28 Oyelere Adegboyega K Bifunctional macrolide heterocyclic compounds and methods of making and using the same
JP2007512256A (ja) * 2003-11-18 2007-05-17 リブ−エックス ファーマシューティカルズ，インコーポレイテッド 二官能性マクロライド複素環化合物ならびにこれらを製造する方法およびこれらを使用する方法
CN102816194A (zh) * 2004-02-27 2012-12-12 瑞伯-X医药品有限公司 大环化合物以及其制作和使用方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR208171A1 (es) * 1972-09-29 1976-12-09 Ciba Geigy Ag Procedimiento para la obtencion de nuevos derivados del acido cef-3-em-4-carboxilico
US4338439A (en) * 1976-08-26 1982-07-06 Eli Lilly And Company 7-[2-[(Substituted benzoyl]amino]acetamido]cephalosporins
SE8009049L (sv) * 1980-03-04 1981-09-05 Eisai Co Ltd 7alfa-metoxicefalosporinderivat, sett for framstellning derav och antibakteriella lekemedel innehallande dessa foreningar
US4468394A (en) * 1981-04-02 1984-08-28 Eisai Co., Ltd. Cephalosporin compounds

Also Published As

Publication number Publication date
YU237283A (en) 1986-04-30
IT1169969B (it) 1987-06-03
DE3345093A1 (de) 1984-06-14
IT8324122A0 (it) 1983-12-12
NL8304272A (nl) 1984-07-02
ES8505691A1 (es) 1985-06-01
SE8306882L (sv) 1984-06-15
DK572183A (da) 1984-06-27
ES528003A0 (es) 1985-06-16
SE8306882D0 (sv) 1983-12-13
US4546176A (en) 1985-10-08
FR2569195A1 (fr) 1986-02-21
ES8506025A1 (es) 1985-06-16
PH20168A (en) 1986-10-09
GB2132613A (en) 1984-07-11
ATA435283A (de) 1986-12-15
GB2132613B (en) 1986-05-08
KR840007012A (ko) 1984-12-04
CH656131A5 (de) 1986-06-13
ES534297A0 (es) 1985-06-01
AU2082783A (en) 1984-06-21
GB8329554D0 (en) 1983-12-07
DK572183D0 (da) 1983-12-13
BE898442A (fr) 1984-06-13

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Legal Events

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ST Notification of lapse