DK1291353T3 - 6-O-substituerede ketolider med antibakteriel aktivitet - Google Patents

6-O-substituerede ketolider med antibakteriel aktivitet

Info

Publication number
DK1291353T3
DK1291353T3 DK02024560T DK02024560T DK1291353T3 DK 1291353 T3 DK1291353 T3 DK 1291353T3 DK 02024560 T DK02024560 T DK 02024560T DK 02024560 T DK02024560 T DK 02024560T DK 1291353 T3 DK1291353 T3 DK 1291353T3
Authority
DK
Denmark
Prior art keywords
alkyl
substituted
heteroaryl
aryl
optionally substituted
Prior art date
Application number
DK02024560T
Other languages
English (en)
Inventor
Yat Sun Or
Zhenkun Ma
Richard F Clark
Daniel T Chu
Jacob J Plattner
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27107953&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1291353(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/888,350 external-priority patent/US5866549A/en
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of DK1291353T3 publication Critical patent/DK1291353T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cephalosporin Compounds (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK02024560T 1996-09-04 1997-09-02 6-O-substituerede ketolider med antibakteriel aktivitet DK1291353T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70777696A 1996-09-04 1996-09-04
US08/888,350 US5866549A (en) 1996-09-04 1997-07-03 6-O-substituted ketolides having antibacterial activity
EP97939765A EP0929563B1 (en) 1996-09-04 1997-09-02 6-o-substituted ketolides having antibacterial activity

Publications (1)

Publication Number Publication Date
DK1291353T3 true DK1291353T3 (da) 2005-10-03

Family

ID=27107953

Family Applications (5)

Application Number Title Priority Date Filing Date
DK02024557T DK1291350T3 (da) 1996-09-04 1997-09-02 6-0-substituerede ketolider med antibakteriel aktivitet
DK97939765T DK0929563T3 (da) 1996-09-04 1997-09-02 6-O-substituerede ketolider med antibakteriel aktivitet
DK02024559T DK1291352T3 (da) 1996-09-04 1997-09-02 6-O-substituerede ketolider med antibakteriel aktivitet
DK02024558T DK1291351T3 (da) 1996-09-04 1997-09-02 6-O-substituerede ketolider med antibakteriel aktivitet
DK02024560T DK1291353T3 (da) 1996-09-04 1997-09-02 6-O-substituerede ketolider med antibakteriel aktivitet

Family Applications Before (4)

Application Number Title Priority Date Filing Date
DK02024557T DK1291350T3 (da) 1996-09-04 1997-09-02 6-0-substituerede ketolider med antibakteriel aktivitet
DK97939765T DK0929563T3 (da) 1996-09-04 1997-09-02 6-O-substituerede ketolider med antibakteriel aktivitet
DK02024559T DK1291352T3 (da) 1996-09-04 1997-09-02 6-O-substituerede ketolider med antibakteriel aktivitet
DK02024558T DK1291351T3 (da) 1996-09-04 1997-09-02 6-O-substituerede ketolider med antibakteriel aktivitet

Country Status (28)

Country Link
US (4) US6075133A (da)
EP (5) EP1291353B1 (da)
JP (1) JP4597274B2 (da)
KR (5) KR20050044816A (da)
CN (4) CN1680419A (da)
AT (5) ATE296832T1 (da)
BG (1) BG63547B1 (da)
BR (1) BR9711661A (da)
CA (1) CA2263972C (da)
CZ (1) CZ300106B6 (da)
DE (5) DE69733370T2 (da)
DK (5) DK1291350T3 (da)
ES (5) ES2242813T3 (da)
HK (1) HK1021537A1 (da)
HR (5) HRP970473B1 (da)
HU (1) HU230166B1 (da)
ID (1) ID19406A (da)
IL (1) IL128681A0 (da)
NO (1) NO314230B1 (da)
NZ (1) NZ334274A (da)
PL (1) PL188173B1 (da)
PT (5) PT929563E (da)
RO (1) RO121473B1 (da)
RU (1) RU2192427C2 (da)
SI (1) SI20023B (da)
SK (5) SK286181B6 (da)
TR (1) TR199901127T2 (da)
WO (1) WO1998009978A1 (da)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495348B1 (en) 1993-10-07 2002-12-17 Regents Of The University Of Minnesota Mitomycin biosynthetic gene cluster
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
ATE243219T1 (de) 1998-04-24 2003-07-15 Pfizer Prod Inc 9a, 11b-dehydro derivative von 9-oxime-3-keto-6-0-methylerythromycin
US6265202B1 (en) 1998-06-26 2001-07-24 Regents Of The University Of Minnesota DNA encoding methymycin and pikromycin
FR2780977B1 (fr) * 1998-07-09 2000-09-01 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2792637B1 (fr) * 1999-04-26 2001-06-01 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
JP4573925B2 (ja) 1998-07-09 2010-11-04 アベンティス・ファーマ・ソシエテ・アノニム 新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用
FR2785612A1 (fr) * 1998-11-10 2000-05-12 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
CA2349338C (en) * 1998-11-03 2005-12-06 Pfizer Products Inc. Novel macrolide antibiotics
DK1161438T3 (da) * 1999-03-15 2004-08-30 Abbott Lab 6-O-substituerede makrolider, som har antibakteriel aktivitet
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
ES2272273T3 (es) 1999-04-16 2007-05-01 Kosan Biosciences, Inc. Agentes antiinfecciosos macrolidos.
US6939861B2 (en) 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6420535B1 (en) * 1999-06-07 2002-07-16 Abbott Laboratories 6-O-carbamate ketolide derivatives
EP1181300B1 (en) * 1999-06-07 2003-09-17 Abbott Laboratories 6-o-carbamate ketolide derivatives
US6437106B1 (en) * 1999-06-24 2002-08-20 Abbott Laboratories Process for preparing 6-o-substituted erythromycin derivatives
US6417366B2 (en) * 1999-06-24 2002-07-09 Abbott Laboratories Preparation of quinoline-substituted carbonate and carbamate derivatives
EP1101769A3 (en) 1999-11-18 2001-10-24 Pfizer Products Inc. Nitrogen containing erythromycin derivatives
US6472372B1 (en) 2000-12-06 2002-10-29 Ortho-Mcneil Pharmaceuticals, Inc. 6-O-Carbamoyl ketolide antibacterials
WO2003004509A2 (en) * 2001-07-03 2003-01-16 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
WO2003024986A1 (en) 2001-09-17 2003-03-27 Ortho-Mcneil Pharmaceutical, Inc. 6-o-carbamate-11,12-lacto-ketolide antimicrobials
US6673774B2 (en) * 2001-12-03 2004-01-06 Enanta Pharmaceuticals, Inc. 11-O-substituted macrolides and their descladinose derivatives
BR0214748A (pt) 2001-12-05 2004-11-23 Ortho Mcneil Pharm Inc Derivados 6-oacil-cetolidas de eritromicina, úteis como antibacterianos
JP2005522453A (ja) * 2002-02-13 2005-07-28 アボット・ラボラトリーズ マクロライド抗菌化合物
US6831068B2 (en) * 2002-02-13 2004-12-14 Abbott Laboratories Macrolide antibacterial compounds
US20030162729A1 (en) * 2002-02-13 2003-08-28 Zhenkun Ma Macrolides with activity against methicillin-resistant staphylococcus aureus
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
US6995143B2 (en) 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
US7273853B2 (en) * 2002-05-13 2007-09-25 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
US7910558B2 (en) * 2002-05-13 2011-03-22 Enanta Pharmaceuticals, Inc. Bridged macrocyclic compounds and processes for the preparation thereof
US6841664B2 (en) * 2002-07-25 2005-01-11 Enanra Pharmaceuticals, Inc. 6,11-4-carbon bridged ketolides
US6825172B2 (en) 2002-05-31 2004-11-30 Janssen Pharmaceutica, Nv 3-descladinosyl-6-O-carbamoyl and 6-O-carbonoyl macrolide antibacterial agents
WO2004078771A1 (ja) * 2003-03-07 2004-09-16 Taisho Pharmaceutical Co., Ltd. ２－フルオロ－６－ｏ－置換ケトライド誘導体
CA2529817C (en) 2003-03-10 2013-02-12 Optimer Pharmaceuticals, Inc. Novel antibacterial agents
US7163924B2 (en) * 2003-04-25 2007-01-16 Chiron Corporation Ketolide derivatives
US20040254126A1 (en) * 2003-06-05 2004-12-16 Yao-Ling Qiu 11-12 Bicyclic erythromycin derivatives
US6790835B1 (en) * 2003-06-05 2004-09-14 Enanta Pharmaceuticals, Inc. Bicyclic macrolide derivatives
US20050101548A1 (en) * 2003-09-12 2005-05-12 Xiaodong Lin Antimicrobial derivatives
GB0327720D0 (en) 2003-11-28 2003-12-31 Biotica Tech Ltd Erythromycins and process for their preparation
WO2005067564A2 (en) * 2004-01-07 2005-07-28 Enanta Pharmaceuticals, Inc. 6-11 bicyclic erythromycin derivatives
US7265094B2 (en) * 2004-01-09 2007-09-04 Enanta Pharmaceuticals, Inc. 9N-substituted 6-11 bicyclic erythromycin derivatives
US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
FR2874922A1 (fr) * 2004-07-30 2006-03-10 Palumed Sa Molecules hybrides qa ou q est une aminoquinoleine et a est un residu antibiotique, leur synthese et leurs utilisations en tant qu'agent antibacterien
BRPI0514381A (pt) * 2004-07-30 2008-06-10 Palumed Sa compostos hìbridos de aminoquinolina-antibiótico, composições farmacêuticas, método de preparação e uso destes
WO2006065743A2 (en) * 2004-12-13 2006-06-22 Enanta Pharmaceuticals, Inc. Tetracylic bicyclolides
EP1836211B1 (en) * 2004-12-21 2010-03-03 Pfizer Products Inc. Macrolides
US7517859B2 (en) * 2005-05-04 2009-04-14 Enanta Pharmaceuticals, Inc. Spirocyclic bicyclolides
US20060252710A1 (en) * 2005-05-04 2006-11-09 Guoqiang Wang 6-11 Bridged oxime erythromycin derivatives
US7384922B2 (en) * 2005-05-04 2008-06-10 Enanta Pharmaceuticals, Inc. 6-11 bridged oxime erythromycin derivatives
JP5015016B2 (ja) 2006-02-07 2012-08-29 大正製薬株式会社 １０ａ−アザライド化合物
WO2008023248A2 (en) 2006-08-24 2008-02-28 Wockhardt Research Centre Novel macrolides and ketolides having antimicrobial activity
US8293715B2 (en) 2007-08-06 2012-10-23 Taisho Pharmaceutical Co., Ltd. 10a-Azalide compound crosslinked at 10a- and 12-positions
US8273720B2 (en) * 2007-09-17 2012-09-25 Enanta Pharmaceuticals, Inc. 6,11-bicyclolides: bridged biaryl macrolide derivatives
US8354383B2 (en) * 2007-09-17 2013-01-15 Enanta Pharmaceuticals, Inc. 6,11-bridged biaryl macrolides
US20090118506A1 (en) * 2007-09-17 2009-05-07 In Jong Kim 6,11-bridged biaryl macrolides
CN101917850B (zh) 2007-10-25 2016-01-13 森普拉制药公司 大环内酯类抗菌剂的制备方法
TW200946109A (en) * 2008-05-09 2009-11-16 Enanta Pharm Inc Anti-bacterial activity of 9-hydroxy derivatives 6, 11-bicyclolides
WO2009139181A1 (ja) 2008-05-15 2009-11-19 大正製薬株式会社 ４員環構造を有する１０ａ－アザライド化合物
WO2010048599A1 (en) 2008-10-24 2010-04-29 Cempra Pharmaceuticals, Inc. Methods for treating gastrointestinal diseases
BRPI1011959A2 (pt) 2009-05-27 2016-04-26 Wockhardt Research Center compostos de cetolídeo tendo atividade antimicrobiana.
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
JP5914335B2 (ja) 2009-09-10 2016-05-11 センプラ ファーマシューティカルズ，インコーポレイテッド マラリア、結核、及びｍａｃ病の治療方法
NZ602544A (en) 2010-03-22 2014-11-28 Cempra Pharmaceuticals Inc Crystalline forms of a macrolide, and uses therefor
US9051346B2 (en) 2010-05-20 2015-06-09 Cempra Pharmaceuticals, Inc. Process for preparing triazole-containing ketolide antibiotics
US8796474B1 (en) 2010-08-23 2014-08-05 Rutgers, The State University Of New Jersey Macrolide compounds and methods and intermediates useful for their preparation
JP6042334B2 (ja) 2010-09-10 2016-12-14 センプラ ファーマシューティカルズ，インコーポレイテッド 疾患治療のための水素結合形成フルオロケトライド
PL2673285T3 (pl) 2010-12-09 2017-12-29 Wockhardt Limited Związki ketolidowe
AR085286A1 (es) * 2011-02-21 2013-09-18 Taisho Pharmaceutical Co Ltd Derivado de macrolido sustituido en la posicion c-4
JP5718488B2 (ja) 2011-03-01 2015-05-13 ウォックハート リミテッド ケトライド中間体の調製方法
KR101795838B1 (ko) 2011-03-22 2017-11-08 욱크하르트 리미티드 케톨리드 화합물의 제조 방법
CN102766181A (zh) * 2011-05-06 2012-11-07 上海医药工业研究院 6-o-取代的红霉素衍生物的制备方法
CN102766089A (zh) * 2011-05-06 2012-11-07 上海医药工业研究院 3-(3-喹啉基)-2-丙烯-1-卤代物及其制备方法
SG11201405895UA (en) * 2012-03-27 2014-10-30 Cempra Pharmaceuticals Inc Parenteral formulations for administering macrolide antibiotics
JP5857008B2 (ja) * 2012-08-20 2016-02-10 大正製薬株式会社 Ｃ−４”位置換マクロライド誘導体を含有する医薬
GB201217310D0 (en) 2012-09-27 2012-11-14 C10 Pharma As Compounds
US9861616B2 (en) 2013-03-14 2018-01-09 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
JP6675973B2 (ja) 2013-03-15 2020-04-08 センプラ ファーマシューティカルズ，インコーポレイテッド マクロライド抗菌薬を調製するための集束的な方法
AR102810A1 (es) 2014-08-18 2017-03-29 Taisho Pharmaceutical Co Ltd Derivado de macrólido sustituido en la posición c-4
WO2018067663A2 (en) * 2016-10-04 2018-04-12 Biopharmati Sa Ketolides having antibacterial activity
US11420995B2 (en) 2017-03-03 2022-08-23 Synovo Gmbh Anti-infective and anti-inflammatory compounds
CN109942653B (zh) * 2019-02-27 2021-06-25 北京理工大学 一种红霉素衍生物及其制备方法
JP2023504262A (ja) * 2019-12-02 2023-02-02 アリクァンタムアールエクス，インコーポレイテッド 疾患の治療のためのセスロマイシンの塩及び多形体 セスロマイシンの塩及び多形体
CN113817008B (zh) * 2021-07-15 2023-05-23 湖州师范学院 新型琥珀酰基十六元大环内酯的制备方法及用途

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR960000434B1 (ko) * 1986-12-17 1996-01-06 다이쇼 세이야꾸 가부시끼가이샤 에리스로마이신 a유도체 및 그의 제조 방법
WO1992006991A1 (fr) * 1990-10-15 1992-04-30 Taisho Pharmaceutical Co., Ltd. Erythromycine modifiee en 2' ou derive de cette substance
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
EP0559896B1 (en) * 1990-11-28 1997-08-27 Taisho Pharmaceutical Co. Ltd 6-o-methylerythromycin a derivative
WO1993013663A1 (en) * 1992-01-17 1993-07-22 Abbott Laboratories Method of directing biosynthesis of specific polyketides
US5523399A (en) * 1991-12-27 1996-06-04 Taisho Pharmaceutical Co., Ltd. 5-O-desosaminylerythronolide derivatives
CA2093303C (en) * 1992-04-09 1998-11-24 Abraham Araya Aluminosilicates
WO1993021199A1 (en) * 1992-04-22 1993-10-28 Taisho Pharmaceutical Co., Ltd. 5-o-desosaminylerythronolide a derivative
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2702480B1 (fr) * 1993-03-09 1995-04-28 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2713226B1 (fr) * 1993-12-03 1996-01-05 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2718450B1 (fr) * 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2719587B1 (fr) * 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2732023B1 (fr) * 1995-03-22 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2732684B1 (fr) * 1995-04-06 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2738571B1 (fr) * 1995-09-11 1997-10-17 Roussel Uclaf Nouveaux derives de la 5-0-desosaminyl 6-0-methyl- erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs
JP2000500133A (ja) * 1995-11-08 2000-01-11 アボツト・ラボラトリーズ 三環式エリスロマイシン誘導体
US6274715B1 (en) * 1995-11-08 2001-08-14 Abbott Laboratories Tricyclic erythromycin derivatives
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
AU4472797A (en) * 1996-10-31 1998-05-22 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
US6171807B1 (en) * 1996-11-13 2001-01-09 Associates Of Cape Cod, Inc. Detection and quantitation of endotoxin by fluorescence polarization

Also Published As

Publication number Publication date
DK0929563T3 (da) 2005-10-03
HRP20060278B1 (hr) 2014-04-11
CN100441591C (zh) 2008-12-10
RU2192427C2 (ru) 2002-11-10
KR20050043993A (ko) 2005-05-11
HUP9902869A3 (en) 2001-04-28
PT1291352E (pt) 2005-09-30
ATE296831T1 (de) 2005-06-15
NO991022L (no) 1999-05-03
DK1291350T3 (da) 2005-09-26
SK286181B6 (sk) 2008-04-07
HRP20060275B1 (hr) 2014-04-11
KR100610043B1 (ko) 2006-08-08
DE69733723T2 (de) 2006-04-20
HRP20060276A2 (en) 2007-10-31
HRP20060277B1 (hr) 2014-04-11
HK1021537A1 (en) 2000-06-16
DE69733369D1 (de) 2005-06-30
SK285535B6 (sk) 2007-03-01
ES2242983T3 (es) 2005-11-16
PL332009A1 (en) 1999-08-16
EP1291352A1 (en) 2003-03-12
PT929563E (pt) 2005-10-31
DE69733369T2 (de) 2006-01-26
RO121473B1 (ro) 2007-06-29
HRP20060276B1 (hr) 2014-04-25
KR100568455B1 (ko) 2006-04-07
DK1291351T3 (da) 2005-10-24
TR199901127T2 (xx) 1999-07-21
HRP20060275A2 (en) 2007-10-31
CZ300106B6 (cs) 2009-02-11
KR20000068435A (ko) 2000-11-25
US6147197A (en) 2000-11-14
JP4597274B2 (ja) 2010-12-15
CN1680420A (zh) 2005-10-12
US6075133A (en) 2000-06-13
HUP9902869A2 (hu) 2000-02-28
EP0929563B1 (en) 2005-06-01
SK28699A3 (en) 2000-03-13
IL128681A0 (en) 2000-01-31
CN1273475C (zh) 2006-09-06
BG63547B1 (bg) 2002-04-30
KR20050044816A (ko) 2005-05-12
DK1291352T3 (da) 2005-09-19
CN100460415C (zh) 2009-02-11
HRP20060277A2 (en) 2007-10-31
CA2263972A1 (en) 1998-03-12
DE69733422D1 (de) 2005-07-07
EP1291351A1 (en) 2003-03-12
DE69733422T2 (de) 2006-05-04
CZ68599A3 (cs) 1999-08-11
CN1680418A (zh) 2005-10-12
DE69733370T2 (de) 2006-02-02
EP1291351B1 (en) 2005-07-13
KR100576988B1 (ko) 2006-05-10
HRP970473A2 (en) 1998-08-31
SK285533B6 (sk) 2007-03-01
JP2001500855A (ja) 2001-01-23
ATE299508T1 (de) 2005-07-15
AU729348B2 (en) 2001-02-01
ATE296832T1 (de) 2005-06-15
PT1291350E (pt) 2005-09-30
ATE296308T1 (de) 2005-06-15
ATE296307T1 (de) 2005-06-15
EP1291353B1 (en) 2005-06-01
HRP970473B1 (en) 2007-02-28
KR100523679B1 (ko) 2005-10-26
DE69733439D1 (de) 2005-07-07
NZ334274A (en) 2001-02-23
USRE39591E1 (en) 2007-04-24
DE69733370D1 (de) 2005-06-30
PT1291353E (pt) 2005-10-31
PL188173B1 (pl) 2004-12-31
DE69733723D1 (de) 2005-08-18
EP1291352B1 (en) 2005-05-25
CN1680419A (zh) 2005-10-12
SK285536B6 (sk) 2007-03-01
EP0929563A1 (en) 1999-07-21
EP1291350A1 (en) 2003-03-12
EP1291350B1 (en) 2005-05-25
SK285534B6 (sk) 2007-03-01
EP1291353A1 (en) 2003-03-12
KR20050043994A (ko) 2005-05-11
BR9711661A (pt) 1999-08-24
HU230166B1 (hu) 2015-09-28
ES2242812T3 (es) 2005-11-16
NO314230B1 (no) 2003-02-17
ES2242813T3 (es) 2005-11-16
ID19406A (id) 1998-07-09
ES2244716T3 (es) 2005-12-16
KR20050044815A (ko) 2005-05-12
WO1998009978A1 (en) 1998-03-12
CA2263972C (en) 2008-01-29
NO991022D0 (no) 1999-03-02
ES2242811T3 (es) 2005-11-16
CN1237183A (zh) 1999-12-01
PT1291351E (pt) 2005-11-30
SI20023A (sl) 2000-02-29
US6028181A (en) 2000-02-22
HRP20060278A2 (en) 2007-10-31
SI20023B (en) 2001-02-28
AU4178097A (en) 1998-03-26
DE69733439T2 (de) 2006-05-04
BG103292A (en) 1999-12-30

Similar Documents

Publication Publication Date Title
DK0929563T3 (da) 6-O-substituerede ketolider med antibakteriel aktivitet
CA2096969A1 (en) 6-0-methylerythromycin a derivatives
EP0107201A3 (en) Phenyl-substituted tricyclic antibacterial agents
HK1008898A1 (en) Hetero-aromatic ring substituted phenyloxazolidinone antimicrobials
KR890005124A (ko) 세펨 화합물 및 이의 제조방법
CA2149496A1 (en) 11,21-bisphenyl-19-norpregnane derivatives
ES8704943A1 (es) Un procedimiento para la fabricacion de derivados de cefalosporina.
NZ237351A (en) Cephalosporin derivative, medicaments, intermediate compound
HUP0100184A2 (hu) Szubsztituált 2-(benzil-amino)-2-fenil-acetamid-vegyületek és ezeket tartalmazó gyógyszerkészítmények
EP0677522A4 (en) 8-METHOXYQUINOLONECARBOXYLIC ACID DERIVATIVE.
HUP9902893A2 (hu) 6-O-Szubsztituált eritromicinszármazékok és eljárás előállításukra
NZ334317A (en) beta-lactam compounds as antibacterial agents effective against methicillin-resistant and coagulase-negative Staphylococci and process for preparing the same
IE43346L (en) Cephalosporin derivatives.
ES482550A1 (es) Un procedimiento para la produccion de derivados de cefalos-porina.
EP0926139A4 (en) CHINOLINE SULFIDE DERIVATIVES
ES8707188A1 (es) Procedimiento para la preparacion de compuestos de actividad antibacteriana
ZA972324B (en) Novel herbicides.
CA2564377A1 (en) 6-o-substituted ketolides having antibacterial activity