ES482550A1 - Un procedimiento para la produccion de derivados de cefalos-porina. - Google Patents

Un procedimiento para la produccion de derivados de cefalos-porina.

Info

Publication number
ES482550A1
ES482550A1 ES482550A ES482550A ES482550A1 ES 482550 A1 ES482550 A1 ES 482550A1 ES 482550 A ES482550 A ES 482550A ES 482550 A ES482550 A ES 482550A ES 482550 A1 ES482550 A1 ES 482550A1
Authority
ES
Spain
Prior art keywords
group
hydrogen atom
lower alkoxy
alkoxy group
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES482550A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Publication of ES482550A1 publication Critical patent/ES482550A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un procedimiento para la producción de derivados de cefalosporina representados por la fórmula general I **(Fórmula-01)** donde R1 es un átomo de hidrógeno o un grupo amino; R2 y R3, que pueden ser iguales o diferentes, representan cada uno de ellos un átomo de hidrógeno, un grupo hidroxi, un grupo oxo, un grupo alquilo inferior o un grupo alcoxi interior; R4 es un átomo de hidrógeno o un grupo alcoxi inferior; R5 es un grupo acetoxi o - S-R6 (donde R6 es un grupo heterocíclico nitrogenado de 5 o 6 miembros que puede estar sustituido con un grupo alquilo inferior o alcoxi inferior) y A es un anillos heterocíclico, monociclíco o bicíclico, que contiene 1 o 2 átomos seleccionados entre nitrógeno, oxígeno y azufre, o sales no tóxicas y farmacéuticamente aceptables de los mismos; cuyo procedimiento consiste en hacer reaccionar un derivado de cefalosporina representado por la fórmula general II **(Fórmula- 02)** donde R1, R4 y R5 tienen el mismo significado que en la fórmula general I y un ácidocarboxílico heterocíclico representado por la fórmula general III **(Fórmula-03)** donde R2, R3 y A tienen el mismo significado que en la fórmula general I, o con un derivado reactivo del mismo y, si se desea, cuando el producto de fórmula general I así obtenido contiene un grupo acetoxi en la posición de R5, hacer reaccionar el producto y el tiol heterocíclico nitrogenado representado por la fórmula general IV: HS - R6 IV donde R6 tiene el mismo significado que en la fórmula general I y, si es necesario, convertir el derivado de cefalosporina de fórmula general I así obtenido en un sal del mismo.
ES482550A 1978-07-20 1979-07-17 Un procedimiento para la produccion de derivados de cefalos-porina. Expired ES482550A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP53088994A JPS6058239B2 (ja) 1978-07-20 1978-07-20 新規セフアロスポリン誘導体

Publications (1)

Publication Number Publication Date
ES482550A1 true ES482550A1 (es) 1980-04-16

Family

ID=13958356

Family Applications (1)

Application Number Title Priority Date Filing Date
ES482550A Expired ES482550A1 (es) 1978-07-20 1979-07-17 Un procedimiento para la produccion de derivados de cefalos-porina.

Country Status (7)

Country Link
US (1) US4311842A (es)
JP (1) JPS6058239B2 (es)
DE (1) DE2927683A1 (es)
ES (1) ES482550A1 (es)
FR (1) FR2431499A1 (es)
GB (1) GB2025971B (es)
IT (1) IT7968397A0 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3007685A1 (de) 1980-02-29 1981-10-01 Dr. Karl Thomae Gmbh, 7950 Biberach Neue cephylosporine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
CY1365A (en) * 1980-03-28 1987-08-07 Biochemie Gmbh New process for the production of cephalosporin antibiotics, and novel intermediates used in such process and their production
JPS5874680A (ja) * 1981-10-01 1983-05-06 Kyowa Hakko Kogyo Co Ltd β−ラクタム化合物
DE4443168A1 (de) * 1994-12-05 1996-06-13 Bayer Ag Neues hochselektives Verfahren zur Herstellung von enantiomerenreinen phenylsubstituierten 1,4-Dihydropyridin-3,5-dicarbonsäurederivaten

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110327A (en) * 1974-05-09 1978-08-29 Toyama Chemical Co., Ltd. 2,3 Diketo-piperazinocarbonylamino alkanoic acids and derivatives
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
GB1537949A (en) * 1976-03-03 1979-01-10 Sumitomo Chemical Co Cephalosporins
US4217348A (en) * 1978-09-28 1980-08-12 E. R. Squibb & Sons, Inc. Cephalosporins having an oxazolidonyloxamido substituted acyl sidechain

Also Published As

Publication number Publication date
GB2025971B (en) 1982-11-03
GB2025971A (en) 1980-01-30
JPS6058239B2 (ja) 1985-12-19
US4311842A (en) 1982-01-19
FR2431499A1 (fr) 1980-02-15
IT7968397A0 (it) 1979-07-03
JPS5515454A (en) 1980-02-02
DE2927683A1 (de) 1980-01-31

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