DK1161438T3 - 6-O-substituerede makrolider, som har antibakteriel aktivitet - Google Patents

6-O-substituerede makrolider, som har antibakteriel aktivitet

Info

Publication number
DK1161438T3
DK1161438T3 DK00913805T DK00913805T DK1161438T3 DK 1161438 T3 DK1161438 T3 DK 1161438T3 DK 00913805 T DK00913805 T DK 00913805T DK 00913805 T DK00913805 T DK 00913805T DK 1161438 T3 DK1161438 T3 DK 1161438T3
Authority
DK
Denmark
Prior art keywords
antibacterial activity
macrolides
group
optionally substituted
proviso
Prior art date
Application number
DK00913805T
Other languages
English (en)
Inventor
Yat Sun Or
Richard F Clark
Zhenkun Ma
Michael J Rupp
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of DK1161438T3 publication Critical patent/DK1161438T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK00913805T 1999-03-15 2000-03-08 6-O-substituerede makrolider, som har antibakteriel aktivitet DK1161438T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27049799A 1999-03-15 1999-03-15
PCT/US2000/006033 WO2000055168A1 (en) 1999-03-15 2000-03-08 6-o-substituted macrolides having antibacterial activity

Publications (1)

Publication Number Publication Date
DK1161438T3 true DK1161438T3 (da) 2004-08-30

Family

ID=23031548

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00913805T DK1161438T3 (da) 1999-03-15 2000-03-08 6-O-substituerede makrolider, som har antibakteriel aktivitet

Country Status (25)

Country Link
EP (1) EP1161438B1 (da)
JP (1) JP2002539217A (da)
KR (1) KR20020008127A (da)
CN (1) CN1343215A (da)
AT (1) ATE266036T1 (da)
AU (1) AU3517700A (da)
BG (1) BG105865A (da)
BR (1) BR0008731A (da)
CA (1) CA2367431C (da)
CO (1) CO5271742A1 (da)
CZ (1) CZ20013223A3 (da)
DE (1) DE60010442T2 (da)
DK (1) DK1161438T3 (da)
ES (1) ES2222189T3 (da)
HK (1) HK1044157A1 (da)
HU (1) HUP0201067A3 (da)
IL (1) IL144542A0 (da)
NO (1) NO20014380D0 (da)
NZ (1) NZ513206A (da)
PL (1) PL350650A1 (da)
PT (1) PT1161438E (da)
SK (1) SK13162001A3 (da)
TR (1) TR200102522T2 (da)
WO (1) WO2000055168A1 (da)
ZA (1) ZA200106181B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA01010524A (es) * 1999-04-16 2002-03-14 Kosan Biosciences Inc Agentes macrolidos anti-infecciosos.
GB0031312D0 (en) 2000-12-21 2001-02-07 Glaxo Group Ltd Macrolides
TWI246515B (en) * 2001-05-30 2006-01-01 Abbott Lab An arylation method for the functionalization of O-allyl erythromycin derivatives
WO2003068791A2 (en) * 2002-02-13 2003-08-21 Abbott Laboratories Macrolides with activity against methicillin-resistant staphylococcus aureus
TWI328009B (en) 2003-05-21 2010-08-01 Glaxo Group Ltd Quinoline derivatives as phosphodiesterase inhibitors
WO2007016525A2 (en) 2005-07-29 2007-02-08 Resverlogix Corp. Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
EP2086970B1 (en) * 2006-08-24 2014-02-26 Novartis AG 2-(pyrazin-2-yl)-thiazole and 2-(1h pyrazol-3-yl)-thiazole derivatives as well as related compounds as stearoyl-coa desaturase (scd) inhibitors for the treatment of metabolic, cardiovascular and other disorders
BRPI0718509A2 (pt) 2006-09-22 2015-09-29 Novartis Ag compostos orgânicos heterocíclicos
MX2009006728A (es) 2006-12-20 2009-09-09 Novartis Ag Heterociclos de 5 miembros 2-sustituidos como inhibidores de scd.
DK2118074T3 (da) 2007-02-01 2014-03-10 Resverlogix Corp Forbindelser til forebyggelse og behandling af hjertekarsygdomme
ES2532402T3 (es) 2008-06-26 2015-03-26 Resverlogix Corporation Métodos de preparación de derivados de quinazolinona
NZ594332A (en) 2009-01-08 2013-09-27 Resverlogix Corp Compounds for the prevention and treatment of cardiovascular disease
NZ755378A (en) 2009-03-18 2022-07-29 Resverlogix Corp Novel quinazolinones and related compounds for use as anti-inflammatory agents
US9757368B2 (en) 2009-04-22 2017-09-12 Resverlogix Corp. Anti-inflammatory agents
PT2773354T (pt) 2011-11-01 2019-07-17 Resverlogix Corp Formulações orais de libertação imediata para quinazolinonas substituídas
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
US9765039B2 (en) 2012-11-21 2017-09-19 Zenith Epigenetics Ltd. Biaryl derivatives as bromodomain inhibitors
CA2895905A1 (en) 2012-12-21 2014-06-26 Zenith Epigenetics Corp. Novel heterocyclic compounds as bromodomain inhibitors
CN104650166B (zh) * 2014-11-17 2017-12-05 广东东阳光药业有限公司 一种大环内酯的制备方法
CA2977308A1 (en) 2015-03-13 2016-09-22 Resverlogix Corp. Compositions and therapeutic methods for the treatment of complement-associated diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE296308T1 (de) * 1996-09-04 2005-06-15 Abbott Lab 6-o-substituierte ketoliden mit antibakteriellen wirkung
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців

Also Published As

Publication number Publication date
BG105865A (en) 2002-05-31
TR200102522T2 (tr) 2001-12-21
EP1161438B1 (en) 2004-05-06
CN1343215A (zh) 2002-04-03
ZA200106181B (en) 2002-10-26
CA2367431A1 (en) 2000-09-21
ES2222189T3 (es) 2005-02-01
ATE266036T1 (de) 2004-05-15
DE60010442D1 (de) 2004-06-09
CO5271742A1 (es) 2003-04-30
HUP0201067A3 (en) 2004-07-28
HK1044157A1 (zh) 2002-10-11
NO20014380L (no) 2001-09-10
JP2002539217A (ja) 2002-11-19
NO20014380D0 (no) 2001-09-10
PT1161438E (pt) 2004-09-30
BR0008731A (pt) 2002-09-24
CA2367431C (en) 2008-06-10
PL350650A1 (en) 2003-01-27
AU3517700A (en) 2000-10-04
SK13162001A3 (sk) 2001-12-03
NZ513206A (en) 2004-02-27
KR20020008127A (ko) 2002-01-29
EP1161438A1 (en) 2001-12-12
HUP0201067A2 (en) 2002-08-28
WO2000055168A1 (en) 2000-09-21
IL144542A0 (en) 2002-05-23
DE60010442T2 (de) 2005-05-12
CZ20013223A3 (cs) 2002-01-16

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