UY23617A1 - Procedimiento para la preparación de derivados de antibióticos macrólidos de anillos de 16 miembros.- - Google Patents

Procedimiento para la preparación de derivados de antibióticos macrólidos de anillos de 16 miembros.-

Info

Publication number
UY23617A1
UY23617A1 UY23617A UY23617A UY23617A1 UY 23617 A1 UY23617 A1 UY 23617A1 UY 23617 A UY23617 A UY 23617A UY 23617 A UY23617 A UY 23617A UY 23617 A1 UY23617 A1 UY 23617A1
Authority
UY
Uruguay
Prior art keywords
derivatives
pct
procedure
preparation
member rings
Prior art date
Application number
UY23617A
Other languages
English (en)
Inventor
J Hecker Scott
R Jefson Martin
W Mcfarland James
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of UY23617A1 publication Critical patent/UY23617A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Radiation-Therapy Devices (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se refiere a un procedimiento para la preparación de un compuesto de la fórmula I (figura 1) o II (figura 2) y las sales aceptables farmaceuticamente de los mismos en donde m es 0 o 1; Q está seleccionado del grupo formado por azetidin-1-ilo, pirrolidin-1-ilo, piperidin-1-ilo, entre otros; R1 está seleccionado a partir del grupo formado por morfolino-(C2-C4)alquilo, piperidino-(C2-C4)alquilo, entre otros. Como ejemplo no limitante: Dihidrocloruro de 20-(azetidin-1-il)-20-deoxorepromicina. Los derivados de antibióticos macrólidos de la invención son útiles frente a patógenos bacterianos y micoplásmicos en animales. Igualmente se describe una composición farmacéutica de dichos derivados y su empleo en el tratamiento de infecciones bacterianas y micoplásmicas en animales.
UY23617A 1992-07-15 1993-07-14 Procedimiento para la preparación de derivados de antibióticos macrólidos de anillos de 16 miembros.- UY23617A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91424292A 1992-07-15 1992-07-15
US99624392A 1992-12-23 1992-12-23

Publications (1)

Publication Number Publication Date
UY23617A1 true UY23617A1 (es) 1994-01-05

Family

ID=27129638

Family Applications (1)

Application Number Title Priority Date Filing Date
UY23617A UY23617A1 (es) 1992-07-15 1993-07-14 Procedimiento para la preparación de derivados de antibióticos macrólidos de anillos de 16 miembros.-

Country Status (22)

Country Link
US (1) US5545624A (es)
EP (1) EP0649430B1 (es)
JP (1) JP2836964B2 (es)
KR (1) KR950702570A (es)
CN (1) CN1083068A (es)
AT (1) ATE161265T1 (es)
AU (1) AU4401093A (es)
BR (1) BR9306741A (es)
CA (1) CA2140243A1 (es)
CZ (1) CZ9995A3 (es)
DE (1) DE69315839T2 (es)
DK (1) DK0649430T3 (es)
FI (1) FI933204A (es)
GR (1) GR3026064T3 (es)
HU (1) HUT65330A (es)
IL (1) IL106263A0 (es)
MX (1) MX9304301A (es)
PL (1) PL307137A1 (es)
SK (1) SK4795A3 (es)
TW (1) TW226373B (es)
UY (1) UY23617A1 (es)
WO (1) WO1994002496A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994021657A1 (en) * 1993-03-18 1994-09-29 Pfizer Inc. Antibacterial 16-membered ring macrolides containing olefins at c-20
CA2167201A1 (en) * 1993-07-15 1995-01-26 Kristin M. Lundy Amide derivatives of 16-membered ring antibiotic macrolides
ES2076107B1 (es) * 1993-09-20 1996-04-01 Pfizer Derivados de antibioticos macrolidos de anillos de 16 miembros.
AU3121095A (en) * 1994-09-22 1996-04-09 Pfizer Inc. Antibiotic macrolides
EP0778283A3 (en) * 1995-12-05 1998-01-28 Pfizer Inc. Antibiotic macrolides
US6605599B1 (en) * 1997-07-08 2003-08-12 Bristol-Myers Squibb Company Epothilone derivatives
AU763732B2 (en) * 1999-08-30 2003-07-31 Zaidan Hojin Biseibutsu Kagaku Kenkyukai Macrolide antibiotics and treatment of pasteurellosis
US20020111317A1 (en) * 2000-09-25 2002-08-15 Leonard Katz Sixteen-membered macrolide compounds
US6664240B2 (en) * 2001-11-15 2003-12-16 Enanta Pharmaceuticals, Inc. Tylosin derivatives having antibacterial activity
ES2337134T3 (es) 2002-03-12 2010-04-21 Bristol-Myers Squibb Company Derivados de c3-ciano-epotilona.
US7247617B2 (en) * 2004-07-13 2007-07-24 Kosan Biosciences Incorporated Sixteen-member macrolide antiinfective agents
CN101506220B (zh) * 2006-07-28 2012-10-17 英特威国际有限公司 大环内酯合成方法
US8227429B2 (en) 2006-07-28 2012-07-24 Intervet International B.V. Macrolide synthesis process and solid-state forms
AU2012342548B2 (en) 2011-11-25 2017-08-24 Bayer Intellectual Property Gmbh Antibacterial tylosin derivatives and methods for their preparation
FR2995605B1 (fr) * 2012-09-18 2014-09-19 Sanofi Sa Derives de macrolides, leur preparation et leur application therapeutique.
JP6494600B2 (ja) 2013-05-23 2019-04-03 バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ａｎｉｍａｌ Ｈｅａｌｔｈ Ｇｍｂｈ タイロシン誘導体およびその調製方法
CN104788519B (zh) * 2014-01-22 2018-07-20 镇江威特药业有限责任公司 十六元环三胺内酯衍生物及其应用
CN105777828A (zh) * 2014-12-22 2016-07-20 菏泽市方明制药有限公司 一种用低质量的泰乐菌素制备高质量替米考星的方法
US10287275B2 (en) 2015-04-16 2019-05-14 Victor Pharma Co., Ltd. Zhenjiang 16-member triamilide derivatives and uses thereof
CN117510561B (zh) * 2023-11-30 2024-04-02 中国农业科学院饲料研究所 一种泰乐菌素衍生物及其制备方法与应用
CN117304241B (zh) * 2023-11-30 2024-03-01 中国农业科学院饲料研究所 一种大环内酯类化合物及其制备方法与应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3975372A (en) * 1975-02-28 1976-08-17 Schering Corporation Preparation of 12,13-desepoxy-12,13-dehydrorosamicin
IL69666A (en) * 1982-09-13 1987-10-20 Lilly Co Eli 20-amino-20-deoxo-5-o-mycaminosyl-23-o-mycinosyltylonolide derivatives,their preparation and veterinary antibiotic use
US4443436A (en) * 1982-09-13 1984-04-17 Eli Lilly And Company C-20-Modified macrolide derivatives of the macrolide antibiotics tylosin, desmycosin, macrocin, and lactenocin
JPS59225199A (ja) * 1983-02-10 1984-12-18 Microbial Chem Res Found ２０，２３−ジデオキシ−２３−アルキレンイミノ−２０−置換アミノマイカミノシルレロノライド
IL71032A0 (en) * 1983-02-28 1984-05-31 Lilly Co Eli C-20 and c-23-modified macrolide derivatives
US4468511A (en) * 1983-02-28 1984-08-28 Eli Lilly And Company C-20- And C-23-Modified macrolide derivatives
JPS59181299A (ja) * 1983-03-31 1984-10-15 Microbial Chem Res Found ２０，２３−ジデオキシ−２０，２３−ビス置換アミノ−マイカミノシルレロノライド
US4921947A (en) * 1986-03-31 1990-05-01 Eli Lilly And Company Process for preparing macrolide derivatives
US4820694A (en) * 1986-09-29 1989-04-11 Eli Lilly And Company Modifications of 3-O-demethylmycinose in macrocin and lactenocin
US4920103A (en) * 1986-09-29 1990-04-24 Eli Lilly And Company Modifications of mycinose and 3-O-demethylmycinose in tylosin-type macrolides
EP0262903A3 (en) * 1986-09-29 1988-11-02 Eli Lilly And Company New acyl derivatives of 20-modified tylosin and desmycosin compounds
FR2638458A1 (fr) * 1988-10-27 1990-05-04 Adir Nouveaux derives de la tylosine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
KR950702570A (ko) 1995-07-29
CN1083068A (zh) 1994-03-02
TW226373B (es) 1994-07-11
WO1994002496A1 (en) 1994-02-03
HUT65330A (en) 1994-05-02
SK4795A3 (en) 1995-07-11
IL106263A0 (en) 1993-11-15
AU4401093A (en) 1994-02-14
FI933204A (fi) 1994-01-16
DE69315839D1 (de) 1998-01-29
JP2836964B2 (ja) 1998-12-14
DE69315839T2 (de) 1998-04-09
HU9302016D0 (en) 1993-10-28
FI933204A0 (fi) 1993-07-14
GR3026064T3 (en) 1998-05-29
EP0649430A1 (en) 1995-04-26
JPH07504922A (ja) 1995-06-01
CZ9995A3 (en) 1995-07-12
CA2140243A1 (en) 1994-02-03
US5545624A (en) 1996-08-13
ATE161265T1 (de) 1998-01-15
BR9306741A (pt) 1998-12-08
MX9304301A (es) 1994-02-28
DK0649430T3 (da) 1998-02-09
PL307137A1 (en) 1995-05-02
EP0649430B1 (en) 1997-12-17

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