HUP0004579A2 - Antibakteriális hatású, a 3'-N-pozícióban módosított szerkezetű 6-0-szubsztituált-eritromicin-ketolid-származékok és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Antibakteriális hatású, a 3'-N-pozícióban módosított szerkezetű 6-0-szubsztituált-eritromicin-ketolid-származékok és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0004579A2
HUP0004579A2 HU0004579A HUP0004579A HUP0004579A2 HU P0004579 A2 HUP0004579 A2 HU P0004579A2 HU 0004579 A HU0004579 A HU 0004579A HU P0004579 A HUP0004579 A HU P0004579A HU P0004579 A2 HUP0004579 A2 HU P0004579A2
Authority
HU
Hungary
Prior art keywords
modified
pharmaceutical compositions
antibacterial activity
substituted erythromycin
ketolide derivatives
Prior art date
Application number
HU0004579A
Other languages
English (en)
Inventor
Daniel T. Chu
Zhenkun Ma
Yat Sun Or
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of HUP0004579A2 publication Critical patent/HUP0004579A2/hu
Publication of HUP0004579A3 publication Critical patent/HUP0004579A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Above=83;>(57) A találmány új, antimikrobiális hatású, félszintetikusmakrolidekre, az azokat tartalmazó gyógyszerkészítményekre, és azazokkal végzett orvosi kezelésre vonatkozik. Közelebbről, a találmány3'-N- pozícióban módosított szerkezetű 6-O-szubsztituált-eritromicin-ketolid származékokra, az előállításukra vonatkozó eljárásokra, azezeket a vegyületeket tartalmazó készítményekre, és e készítményekbakteriális fertőzések kezelésére való alkalmazására vonatkozik. Ó
HU0004579A 1997-09-30 1998-09-16 3'-n-modified 6-0-substituted erythromycin ketolide derivatives having antibacterial activity and pharmaceutical compositions comprising them HUP0004579A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94087197A 1997-09-30 1997-09-30
US13312198A 1998-08-12 1998-08-12
PCT/US1998/019311 WO1999016779A1 (en) 1997-09-30 1998-09-16 3'-n-modified 6-o-substituted erythromycin ketolide derivatives having antibacterial activity

Publications (2)

Publication Number Publication Date
HUP0004579A2 true HUP0004579A2 (hu) 2001-05-28
HUP0004579A3 HUP0004579A3 (en) 2001-11-28

Family

ID=26831064

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0004579A HUP0004579A3 (en) 1997-09-30 1998-09-16 3'-n-modified 6-0-substituted erythromycin ketolide derivatives having antibacterial activity and pharmaceutical compositions comprising them

Country Status (22)

Country Link
EP (1) EP1025114B1 (hu)
JP (1) JP2001518476A (hu)
KR (1) KR20010030807A (hu)
CN (1) CN1271363A (hu)
AR (1) AR015727A1 (hu)
AT (1) ATE260293T1 (hu)
AU (1) AU737310B2 (hu)
BG (1) BG104340A (hu)
BR (1) BR9812577A (hu)
CA (1) CA2303930A1 (hu)
CO (1) CO4990958A1 (hu)
DE (1) DE69821964T2 (hu)
DK (1) DK1025114T3 (hu)
ES (1) ES2217579T3 (hu)
HU (1) HUP0004579A3 (hu)
IL (1) IL134608A0 (hu)
NO (1) NO20001439L (hu)
PL (1) PL339575A1 (hu)
PT (1) PT1025114E (hu)
SK (1) SK4562000A3 (hu)
TR (1) TR200000805T2 (hu)
WO (1) WO1999016779A1 (hu)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4573925B2 (ja) * 1998-07-09 2010-11-04 アベンティス・ファーマ・ソシエテ・アノニム 新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用
US6395710B1 (en) * 1999-04-16 2002-05-28 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6355620B1 (en) * 1999-05-14 2002-03-12 Abbott Laboratories C-2 modified erythromycin derivatives
US6437106B1 (en) * 1999-06-24 2002-08-20 Abbott Laboratories Process for preparing 6-o-substituted erythromycin derivatives
CN1197870C (zh) * 2000-08-14 2005-04-20 大正制药株式会社 一种红霉素衍生物的制备方法及其中间体
AU2002230386A1 (en) * 2000-09-25 2002-04-29 Kosan Biosciences, Inc. Sixteen-membered macrolide compounds
ITMI20021726A1 (it) 2002-08-01 2004-02-02 Zambon Spa Macrolidi ad attivita' antiinfiammatoria.
AR043050A1 (es) 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
CN108101948A (zh) * 2004-02-27 2018-06-01 瑞伯-X医药品有限公司 大环化合物以及其制作和使用方法
EP2716647A3 (en) 2004-02-27 2014-08-20 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
EP1794171A2 (en) * 2004-07-28 2007-06-13 Ranbaxy Laboratories, Ltd. Ketolide derivatives as antibacterial agents
WO2006046112A2 (en) * 2004-10-25 2006-05-04 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
WO2006129257A2 (en) * 2005-05-30 2006-12-07 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
EP1934237A2 (en) 2005-08-24 2008-06-25 Rib-X Pharmaceuticals, Inc. Triazole compounds and methods of making and using the same
JP5395432B2 (ja) * 2005-08-24 2014-01-22 リブ−エックス ファーマシューティカルズ，インコーポレイテッド トリアゾール化合物ならびにこれを作製する方法および使用する方法
EP1957508A2 (en) * 2005-11-23 2008-08-20 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
JP5126685B2 (ja) * 2006-05-01 2013-01-23 大正製薬株式会社 マクロライド誘導体
WO2008099368A1 (en) * 2007-02-15 2008-08-21 Ranbaxy Laboratories Limited Macrolide derivatives as antibacterial agents
WO2008111020A2 (en) * 2007-03-14 2008-09-18 Ranbaxy Laboratories Limited Macrolide derivatives as antibacterial agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
WO1997017356A1 (en) * 1995-11-08 1997-05-15 Abbott Laboratories Tricyclic erythromycin derivatives

Also Published As

Publication number Publication date
NO20001439L (no) 2000-05-29
CN1271363A (zh) 2000-10-25
AU9317698A (en) 1999-04-23
BR9812577A (pt) 2000-10-17
NO20001439D0 (no) 2000-03-20
HUP0004579A3 (en) 2001-11-28
JP2001518476A (ja) 2001-10-16
IL134608A0 (en) 2001-04-30
ES2217579T3 (es) 2004-11-01
ATE260293T1 (de) 2004-03-15
CA2303930A1 (en) 1999-04-08
SK4562000A3 (en) 2000-09-12
EP1025114B1 (en) 2004-02-25
EP1025114A1 (en) 2000-08-09
KR20010030807A (ko) 2001-04-16
AR015727A1 (es) 2001-05-16
WO1999016779A1 (en) 1999-04-08
CO4990958A1 (es) 2000-12-26
BG104340A (en) 2001-01-31
DE69821964T2 (de) 2004-12-30
PT1025114E (pt) 2004-07-30
PL339575A1 (en) 2000-12-18
AU737310B2 (en) 2001-08-16
DE69821964D1 (de) 2004-04-01
DK1025114T3 (da) 2004-07-05
TR200000805T2 (tr) 2000-10-23

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