NO20001439L - 3'-N-modifiserte 6-O-substituerte erytromycin ketolid- derivater med antibakteriell aktivitet - Google Patents

3'-N-modifiserte 6-O-substituerte erytromycin ketolid- derivater med antibakteriell aktivitet

Info

Publication number
NO20001439L
NO20001439L NO20001439A NO20001439A NO20001439L NO 20001439 L NO20001439 L NO 20001439L NO 20001439 A NO20001439 A NO 20001439A NO 20001439 A NO20001439 A NO 20001439A NO 20001439 L NO20001439 L NO 20001439L
Authority
NO
Norway
Prior art keywords
modified
antibacterial activity
substituted erythromycin
erythromycin ketolide
ketolide derivatives
Prior art date
Application number
NO20001439A
Other languages
English (en)
Other versions
NO20001439D0 (no
Inventor
Yat Sun Or
Zhenkun Ma
Daniel T Chu
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of NO20001439D0 publication Critical patent/NO20001439D0/no
Publication of NO20001439L publication Critical patent/NO20001439L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Nye 3'-N-modifiserte 6-O-substituerte erytromycin ketolidforbindelser og farmasøytisk godkjente salter og estere derav med antibakteriell aktivitet med formel (I), (II), (111), (IV) eller (V), blandinger innbefattende en terapeutisk effektiv mengde av en forbindelse i den foreliggende oppfinnelsen i kombinasjon med en farmasøytisk godkjent bærer, i tillegg til en fremgangsmåte for behandling av bakterielle infeksjoner ved administrering til et pattedyr av en farmasøytisk blanding inneholdende en terapeutisk effektiv mengde av en forbindelse i den foreliggende oppfinnelsen.
NO20001439A 1997-09-30 2000-03-20 3'-N-modifiserte 6-O-substituerte erytromycin ketolid- derivater med antibakteriell aktivitet NO20001439L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94087197A 1997-09-30 1997-09-30
US13312198A 1998-08-12 1998-08-12
PCT/US1998/019311 WO1999016779A1 (en) 1997-09-30 1998-09-16 3'-n-modified 6-o-substituted erythromycin ketolide derivatives having antibacterial activity

Publications (2)

Publication Number Publication Date
NO20001439D0 NO20001439D0 (no) 2000-03-20
NO20001439L true NO20001439L (no) 2000-05-29

Family

ID=26831064

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20001439A NO20001439L (no) 1997-09-30 2000-03-20 3'-N-modifiserte 6-O-substituerte erytromycin ketolid- derivater med antibakteriell aktivitet

Country Status (22)

Country Link
EP (1) EP1025114B1 (no)
JP (1) JP2001518476A (no)
KR (1) KR20010030807A (no)
CN (1) CN1271363A (no)
AR (1) AR015727A1 (no)
AT (1) ATE260293T1 (no)
AU (1) AU737310B2 (no)
BG (1) BG104340A (no)
BR (1) BR9812577A (no)
CA (1) CA2303930A1 (no)
CO (1) CO4990958A1 (no)
DE (1) DE69821964T2 (no)
DK (1) DK1025114T3 (no)
ES (1) ES2217579T3 (no)
HU (1) HUP0004579A3 (no)
IL (1) IL134608A0 (no)
NO (1) NO20001439L (no)
PL (1) PL339575A1 (no)
PT (1) PT1025114E (no)
SK (1) SK4562000A3 (no)
TR (1) TR200000805T2 (no)
WO (1) WO1999016779A1 (no)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4573925B2 (ja) * 1998-07-09 2010-11-04 アベンティス・ファーマ・ソシエテ・アノニム 新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用
WO2000063224A2 (en) * 1999-04-16 2000-10-26 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6355620B1 (en) * 1999-05-14 2002-03-12 Abbott Laboratories C-2 modified erythromycin derivatives
US6437106B1 (en) * 1999-06-24 2002-08-20 Abbott Laboratories Process for preparing 6-o-substituted erythromycin derivatives
CN1197870C (zh) 2000-08-14 2005-04-20 大正制药株式会社 一种红霉素衍生物的制备方法及其中间体
US20020111317A1 (en) * 2000-09-25 2002-08-15 Leonard Katz Sixteen-membered macrolide compounds
ITMI20021726A1 (it) 2002-08-01 2004-02-02 Zambon Spa Macrolidi ad attivita' antiinfiammatoria.
TW200420573A (en) 2002-09-26 2004-10-16 Rib X Pharmaceuticals Inc Bifunctional heterocyclic compounds and methods of making and using same
US8202843B2 (en) * 2004-02-27 2012-06-19 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
CN1950388A (zh) * 2004-02-27 2007-04-18 瑞伯-X医药品有限公司 大环化合物以及其制作和使用方法
WO2006080954A1 (en) * 2004-07-28 2006-08-03 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
EP1807439A2 (en) * 2004-10-25 2007-07-18 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
WO2006129257A2 (en) * 2005-05-30 2006-12-07 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
DK1934238T3 (en) * 2005-08-24 2017-09-18 Melinta Therapeutics Inc TRIAZOL COMPOUNDS AND METHODS FOR THE PREPARATION AND USE OF THESE
US8470985B2 (en) 2005-08-24 2013-06-25 Rib-X Pharmaceuticals, Inc. Triazole compounds and methods of making and using the same
WO2007060518A2 (en) * 2005-11-23 2007-05-31 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
US8124744B2 (en) * 2006-05-01 2012-02-28 Taisho Pharmaceutical Co., Ltd. Macrolide derivatives
WO2008099368A1 (en) * 2007-02-15 2008-08-21 Ranbaxy Laboratories Limited Macrolide derivatives as antibacterial agents
WO2008111020A2 (en) * 2007-03-14 2008-09-18 Ranbaxy Laboratories Limited Macrolide derivatives as antibacterial agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
DK0876388T3 (da) * 1995-11-08 2004-06-07 Abbott Lab Tricykliske erythromycinderivater

Also Published As

Publication number Publication date
PL339575A1 (en) 2000-12-18
CO4990958A1 (es) 2000-12-26
AU9317698A (en) 1999-04-23
KR20010030807A (ko) 2001-04-16
TR200000805T2 (tr) 2000-10-23
BG104340A (en) 2001-01-31
EP1025114B1 (en) 2004-02-25
ATE260293T1 (de) 2004-03-15
IL134608A0 (en) 2001-04-30
DE69821964T2 (de) 2004-12-30
PT1025114E (pt) 2004-07-30
AU737310B2 (en) 2001-08-16
DK1025114T3 (da) 2004-07-05
NO20001439D0 (no) 2000-03-20
SK4562000A3 (en) 2000-09-12
ES2217579T3 (es) 2004-11-01
CN1271363A (zh) 2000-10-25
JP2001518476A (ja) 2001-10-16
WO1999016779A1 (en) 1999-04-08
DE69821964D1 (de) 2004-04-01
CA2303930A1 (en) 1999-04-08
HUP0004579A3 (en) 2001-11-28
HUP0004579A2 (hu) 2001-05-28
AR015727A1 (es) 2001-05-16
BR9812577A (pt) 2000-10-17
EP1025114A1 (en) 2000-08-09

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Legal Events

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