WO1999011651A3 - 3-descladinose 6-o-substituded erythromycin derivatives - Google Patents

3-descladinose 6-o-substituded erythromycin derivatives Download PDF

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Publication number
WO1999011651A3
WO1999011651A3 PCT/US1998/018125 US9818125W WO9911651A3 WO 1999011651 A3 WO1999011651 A3 WO 1999011651A3 US 9818125 W US9818125 W US 9818125W WO 9911651 A3 WO9911651 A3 WO 9911651A3
Authority
WO
WIPO (PCT)
Prior art keywords
descladinose
substituded
compound
pharmaceutically acceptable
erythromycin derivatives
Prior art date
Application number
PCT/US1998/018125
Other languages
French (fr)
Other versions
WO1999011651A2 (en
Inventor
Yat Sun Or
Leping Li
Michael J Rupp
Daniel T Chu
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Priority to JP2000508689A priority Critical patent/JP2001515844A/en
Priority to EP98941119A priority patent/EP1027360A2/en
Priority to AU89253/98A priority patent/AU8925398A/en
Priority to CA002301642A priority patent/CA2301642A1/en
Publication of WO1999011651A2 publication Critical patent/WO1999011651A2/en
Publication of WO1999011651A3 publication Critical patent/WO1999011651A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Novel multicyclic erythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having a formula selected from the group consisting of (I), (II), (III), (IV) and (V), compositions comprising a therapeutically eff ective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically effective amount of a compound of formulas (I)-(V).
PCT/US1998/018125 1997-09-02 1998-09-01 3-descladinose 6-o-substituded erythromycin derivatives WO1999011651A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2000508689A JP2001515844A (en) 1997-09-02 1998-09-01 3-Deskradinose 6-O-substituted erythromycin derivatives
EP98941119A EP1027360A2 (en) 1997-09-02 1998-09-01 3-descladinose 6-o-substituded erythromycin derivatives
AU89253/98A AU8925398A (en) 1997-09-02 1998-09-01 3-descladinose 6-o-substituded erythromycin derivatives
CA002301642A CA2301642A1 (en) 1997-09-02 1998-09-01 3-descladinose 6-o-substituded erythromycin derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92168897A 1997-09-02 1997-09-02
US08/921,688 1997-09-02

Publications (2)

Publication Number Publication Date
WO1999011651A2 WO1999011651A2 (en) 1999-03-11
WO1999011651A3 true WO1999011651A3 (en) 1999-05-06

Family

ID=25445830

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/018125 WO1999011651A2 (en) 1997-09-02 1998-09-01 3-descladinose 6-o-substituded erythromycin derivatives

Country Status (9)

Country Link
EP (1) EP1027360A2 (en)
JP (1) JP2001515844A (en)
AR (1) AR017260A1 (en)
AU (1) AU8925398A (en)
CA (1) CA2301642A1 (en)
CO (1) CO4960636A1 (en)
SA (1) SA99191151A (en)
WO (1) WO1999011651A2 (en)
ZA (1) ZA987689B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1147121T3 (en) 1999-01-27 2004-04-13 Pfizer Prod Inc ketolide
US6437106B1 (en) * 1999-06-24 2002-08-20 Abbott Laboratories Process for preparing 6-o-substituted erythromycin derivatives
US20020115621A1 (en) 2000-08-07 2002-08-22 Wei-Gu Su Macrolide antibiotics
CN1197870C (en) 2000-08-14 2005-04-20 大正制药株式会社 Process for producing erythromycin derivative
TWI246515B (en) 2001-05-30 2006-01-01 Abbott Lab An arylation method for the functionalization of O-allyl erythromycin derivatives
CA2487918A1 (en) * 2002-05-31 2003-12-11 Janssen Pharmaceutica N.V. 3-descladinosyl-6-o-carbamoyl and 6-o-carbonoyl macrolide antibacterial agents
ITMI20021726A1 (en) * 2002-08-01 2004-02-02 Zambon Spa MACROLIDS WITH ANTI-INFLAMMATORY ACTIVITY.
BRPI0519135A2 (en) 2004-12-21 2008-12-23 Pfizer Prod Inc macrolides
CN105418706B (en) * 2015-10-27 2019-05-17 华南理工大学 A kind of macrolides antimicrobial compound and the preparation method and application thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0194833A2 (en) * 1985-03-12 1986-09-17 Beecham Group Plc Erythromycin derivatives
EP0216169A2 (en) * 1985-08-28 1987-04-01 Beecham Group Plc Erythromycin derivatives
US5444051A (en) * 1990-11-21 1995-08-22 Roussel Uclaf Erythromycin compounds
WO1997017356A1 (en) * 1995-11-08 1997-05-15 Abbott Laboratories Tricyclic erythromycin derivatives
WO1997042204A1 (en) * 1996-05-07 1997-11-13 Abbott Laboratories 6-o-substituted erythromycins and method for making them
WO1998018808A1 (en) * 1996-10-31 1998-05-07 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
WO1998018807A1 (en) * 1996-10-31 1998-05-07 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8421429D0 (en) * 1984-08-23 1984-09-26 Beecham Group Plc Chemical compounds

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0194833A2 (en) * 1985-03-12 1986-09-17 Beecham Group Plc Erythromycin derivatives
EP0216169A2 (en) * 1985-08-28 1987-04-01 Beecham Group Plc Erythromycin derivatives
US5444051A (en) * 1990-11-21 1995-08-22 Roussel Uclaf Erythromycin compounds
WO1997017356A1 (en) * 1995-11-08 1997-05-15 Abbott Laboratories Tricyclic erythromycin derivatives
WO1997042204A1 (en) * 1996-05-07 1997-11-13 Abbott Laboratories 6-o-substituted erythromycins and method for making them
WO1998018808A1 (en) * 1996-10-31 1998-05-07 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
WO1998018807A1 (en) * 1996-10-31 1998-05-07 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MORIMOO S. ET AL.: "Chemical modifications of erythromycins. II. Synthesis and antibacterial activity of o-alkyl derivatives of erythromycin A", THE JOURNAL OF ANTIBIOTICS, vol. 43, 1990, pages 286 - 294, XP002093093 *
SUWA T ET AL: "UPTAKE OF O-ALKYL ERYTHROMYCIN DERIVATIVES IN THE LUNG TISSUE AND CELLS OF RATS", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 79, no. 9, September 1989 (1989-09-01), pages 783/784, XP002035991 *

Also Published As

Publication number Publication date
ZA987689B (en) 1999-02-24
JP2001515844A (en) 2001-09-25
CA2301642A1 (en) 1999-03-11
CO4960636A1 (en) 2000-09-25
EP1027360A2 (en) 2000-08-16
SA99191151A (en) 2005-12-03
WO1999011651A2 (en) 1999-03-11
AU8925398A (en) 1999-03-22
AR017260A1 (en) 2001-09-05

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