BR0214748A - Derivados 6-oacil-cetolidas de eritromicina, úteis como antibacterianos - Google Patents

Derivados 6-oacil-cetolidas de eritromicina, úteis como antibacterianos

Info

Publication number
BR0214748A
BR0214748A BR0214748-3A BR0214748A BR0214748A BR 0214748 A BR0214748 A BR 0214748A BR 0214748 A BR0214748 A BR 0214748A BR 0214748 A BR0214748 A BR 0214748A
Authority
BR
Brazil
Prior art keywords
oacyl
antibacterials
erythromycin
derivatives useful
ketolide derivatives
Prior art date
Application number
BR0214748-3A
Other languages
English (en)
Inventor
Todd C Henninger
Mark J Macielag
Manomi A Tennakoon
Xiaodong Xu
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of BR0214748A publication Critical patent/BR0214748A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

"DERIVADOS 6-OACIL-CETOLIDAS DE ERITROMICINA, úTEIS COMO ANTIBACTERIANOS". Descreve-se 6-O-acil-cetolidas antibacterianas da fórmula (I): onde R^ 1^, R^ 2^,R^ 3^,R^ 4^, W, X, X<39>, Y e Y<39> são como aqui descritos, e onde os substituintes têm os significados indicados na descrição. Estes compostos são úteis como agentes anticabterianos.
BR0214748-3A 2001-12-05 2002-11-21 Derivados 6-oacil-cetolidas de eritromicina, úteis como antibacterianos BR0214748A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33856601P 2001-12-05 2001-12-05
US39251302P 2002-06-28 2002-06-28
PCT/US2002/037433 WO2003050132A1 (en) 2001-12-05 2002-11-21 6-o-acyl ketolide derivatives of erythromycine useful as antibacterials

Publications (1)

Publication Number Publication Date
BR0214748A true BR0214748A (pt) 2004-11-23

Family

ID=26991254

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0214748-3A BR0214748A (pt) 2001-12-05 2002-11-21 Derivados 6-oacil-cetolidas de eritromicina, úteis como antibacterianos

Country Status (16)

Country Link
US (1) US6825170B2 (pt)
EP (1) EP1453847A1 (pt)
JP (1) JP2005511752A (pt)
CN (1) CN1585775A (pt)
AR (1) AR038005A1 (pt)
AU (1) AU2002346475A1 (pt)
BR (1) BR0214748A (pt)
CA (1) CA2469304A1 (pt)
HU (1) HUP0500018A3 (pt)
IL (1) IL162292A0 (pt)
MX (1) MXPA04005424A (pt)
NZ (1) NZ533282A (pt)
PL (1) PL370714A1 (pt)
RU (1) RU2004117082A (pt)
TW (1) TW200418497A (pt)
WO (1) WO2003050132A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005531603A (ja) * 2002-05-31 2005-10-20 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ３−デスクラジノシル−６−ｏ−カルバモイルおよび６−ｏ−カルボノイルマクロライド抗菌剤
WO2004078771A1 (ja) * 2003-03-07 2004-09-16 Taisho Pharmaceutical Co., Ltd. ２－フルオロ－６－ｏ－置換ケトライド誘導体
US20050250713A1 (en) * 2004-04-26 2005-11-10 Bin Zhu 11,12-Cyclic thiocarbamate macrolide antibacterial agents
EP2129225B1 (en) * 2007-04-03 2012-12-05 E. I. Du Pont de Nemours and Company Substituted benzene fungicides
DE102009004061A1 (de) 2009-01-08 2010-07-15 Merck Patent Gmbh Pyridazinonderivate
BR112013009823A2 (pt) 2010-10-22 2016-07-05 Bayer Ip Gmbh novos compostos heterocíclicos como pesticidas
CN103958525A (zh) 2011-11-30 2014-07-30 埃科特莱茵药品有限公司 3,7-二取代八氢-2H-吡啶并[4,3-e][1,3]噁嗪-2-酮抗生素
JP6437523B2 (ja) 2013-04-04 2018-12-12 プレジデント アンド フェローズ オブ ハーバード カレッジ マクロライドならびにそれらの調製および使用の方法
AR097617A1 (es) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
US10633407B2 (en) 2014-10-08 2020-04-28 President And Fellows Of Harvard College 14-membered ketolides and methods of their preparation and use
EP3273969A4 (en) 2015-03-25 2018-11-21 President and Fellows of Harvard College Macrolides with modified desosamine sugars and uses thereof
CN110028447B (zh) * 2019-05-17 2022-10-14 济南大学 一种2-一氟甲基喹啉衍生物的制备方法

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8521402D0 (en) 1985-08-28 1985-10-02 Beecham Group Plc Chemical compounds
IL114589A (en) 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of the history of erythromycin
US5559256A (en) 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
US5780473A (en) 1995-02-06 1998-07-14 Bristol-Myers Squibb Company Substituted biphenyl sulfonamide endothelin antagonists
ES2218604T3 (es) 1995-11-08 2004-11-16 Abbott Laboratories Derivados triciclicos de eritromicina.
EP0906103A1 (en) 1995-12-29 1999-04-07 Smithkline Beecham Corporation Vitronectin receptor antagonists
DE69710731T2 (de) 1996-07-17 2002-10-24 Novartis Ag Anilinopeptid-derivate
UA51730C2 (uk) 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
KR100523679B1 (ko) 1996-09-04 2005-10-26 아보트 러보러터리즈 항균 활성을 지닌 6-ｏ-치환된 케톨라이드
UA56197C2 (uk) 1996-11-08 2003-05-15 Зенека Лімітед Гетероциклічні похідні
UA59384C2 (uk) 1996-12-20 2003-09-15 Пфайзер, Інк. Похідні сульфонамідів та амідів як агоністи простагландину, фармацевтична композиція та способи лікування на їх основі
US6034069A (en) 1997-09-30 2000-03-07 Abbott Laboratories 3-'N-modified 6-O-substituted erythromycin ketolide derivatives having antibacterial activity
CO4990960A1 (es) 1997-10-29 2000-12-26 Abbott Lab Derivados de cetolidos 2-halo-6-o sustituidos
AR015986A1 (es) 1997-10-29 2001-05-30 Abbott Lab Derivados de eritromicina puenteados en 6,11, composiciones farmaceuticas que los contienen, su uso para la manufactura de un medicamento y procedimientospara su preparacion
AP1060A (en) 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
US5992683A (en) 1998-08-31 1999-11-30 Kimberly-Clark Worldwide, Inc. Clip lift for sheet dispensing system
US6458771B1 (en) 1999-04-16 2002-10-01 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
ATE340183T1 (de) 1999-04-16 2006-10-15 Kosan Biosciences Inc Antiinfektiöse makrolidderivate
US6355620B1 (en) 1999-05-14 2002-03-12 Abbott Laboratories C-2 modified erythromycin derivatives
CN1351608A (zh) 1999-05-24 2002-05-29 辉瑞产品公司 13－甲基红霉素衍生物
ATE250076T1 (de) * 1999-06-07 2003-10-15 Abbott Lab 6-o-carbamat ketolide derivate
ES2306674T3 (es) * 1999-12-02 2008-11-16 Abbott Laboratories Derivados cetolidos 6-o-alquil-2-nor-2-sustituidos.
EP1114826A3 (en) 1999-12-29 2001-10-31 Pfizer Products Inc. Novel antibacterial and prokinetic macrolides
EP1146051A3 (en) 2000-04-10 2001-10-31 Pfizer Products Inc. Erythromycin A derivatives
UY26964A1 (es) 2000-10-16 2002-06-20 Abbott Lab Derivados de eritromicina 6-0-sustituidos con mayor tolerancia gastrointestinal
US6472372B1 (en) * 2000-12-06 2002-10-29 Ortho-Mcneil Pharmaceuticals, Inc. 6-O-Carbamoyl ketolide antibacterials
WO2003090760A1 (en) 2002-04-25 2003-11-06 Abbott Laboratories Oxolide antibacterials
JP2005530758A (ja) 2002-04-30 2005-10-13 アボット・ラボラトリーズ 三環式マクロライド系抗菌化合物

Also Published As

Publication number Publication date
US6825170B2 (en) 2004-11-30
US20030220272A1 (en) 2003-11-27
IL162292A0 (en) 2005-11-20
CN1585775A (zh) 2005-02-23
HUP0500018A3 (en) 2009-09-28
TW200418497A (en) 2004-10-01
HUP0500018A2 (en) 2006-09-28
JP2005511752A (ja) 2005-04-28
RU2004117082A (ru) 2005-04-10
AU2002346475A1 (en) 2003-06-23
PL370714A1 (en) 2005-05-30
NZ533282A (en) 2006-09-29
MXPA04005424A (es) 2005-06-20
EP1453847A1 (en) 2004-09-08
WO2003050132A1 (en) 2003-06-19
CA2469304A1 (en) 2003-06-19
AR038005A1 (es) 2004-12-22

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A(S) 8A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2108 DE 31/05/2011.