ATE340183T1 - Antiinfektiöse makrolidderivate - Google Patents

Antiinfektiöse makrolidderivate

Info

Publication number
ATE340183T1
ATE340183T1 AT00922149T AT00922149T ATE340183T1 AT E340183 T1 ATE340183 T1 AT E340183T1 AT 00922149 T AT00922149 T AT 00922149T AT 00922149 T AT00922149 T AT 00922149T AT E340183 T1 ATE340183 T1 AT E340183T1
Authority
AT
Austria
Prior art keywords
sub
substituted
unsubstituted
alkyl
amino
Prior art date
Application number
AT00922149T
Other languages
English (en)
Inventor
Daniel T W Chu
Gary W Ashley
Original Assignee
Kosan Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kosan Biosciences Inc filed Critical Kosan Biosciences Inc
Application granted granted Critical
Publication of ATE340183T1 publication Critical patent/ATE340183T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
    • A23B2/00—Preservation of foods or foodstuffs, in general
    • A23B2/70—Preservation of foods or foodstuffs, in general by treatment with chemicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT00922149T 1999-04-16 2000-04-14 Antiinfektiöse makrolidderivate ATE340183T1 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US12972999P 1999-04-16 1999-04-16
US14017599P 1999-06-18 1999-06-18
US17215499P 1999-12-17 1999-12-17
US17215999P 1999-12-17 1999-12-17
US17380599P 1999-12-30 1999-12-30
US17380499P 1999-12-30 1999-12-30
US09/550,045 US6395710B1 (en) 1999-04-16 2000-04-14 Macrolide antiinfective agents

Publications (1)

Publication Number Publication Date
ATE340183T1 true ATE340183T1 (de) 2006-10-15

Family

ID=27568857

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00922149T ATE340183T1 (de) 1999-04-16 2000-04-14 Antiinfektiöse makrolidderivate

Country Status (16)

Country Link
US (3) US6395710B1 (de)
EP (1) EP1171446B1 (de)
JP (1) JP2003523938A (de)
KR (2) KR100710605B1 (de)
CN (1) CN1241931C (de)
AT (1) ATE340183T1 (de)
AU (2) AU773678B2 (de)
BR (1) BR0010680A (de)
CA (1) CA2369816A1 (de)
DE (1) DE60030847T2 (de)
ES (1) ES2272273T3 (de)
ID (1) ID30547A (de)
IL (2) IL145777A0 (de)
MX (1) MXPA01010524A (de)
NZ (1) NZ515027A (de)
WO (2) WO2000063225A2 (de)

Families Citing this family (37)

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US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6590083B1 (en) * 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
ES2222966T3 (es) 2000-06-30 2005-02-16 Pfizer Products Inc. Macrolidos antibioticos.
US6472372B1 (en) 2000-12-06 2002-10-29 Ortho-Mcneil Pharmaceuticals, Inc. 6-O-Carbamoyl ketolide antibacterials
EP1373290B1 (de) * 2001-03-21 2014-08-20 Dow AgroSciences LLC Pestizide spinosyn verbindungen
CA2460947A1 (en) 2001-09-17 2003-03-27 Ortho-Mcneil Pharmaceutical, Inc. 6-o-carbamate-11,12-lacto-ketolide antimicrobials
NZ533282A (en) 2001-12-05 2006-09-29 Ortho Mcneil Pharm Inc 6-O-Acyl ketolide derivatives of erythromycine useful as antibacterials
US8063021B2 (en) * 2002-01-17 2011-11-22 Kosan Biosciences Incorporated Ketolide anti-infective compounds
DK1483251T3 (da) 2002-03-12 2010-04-12 Bristol Myers Squibb Co C3-cyano-epothilon-derivater
US20040014691A1 (en) * 2002-04-25 2004-01-22 Searle Xenia Beebe 9-Oxime macrolide antibacterials
US20040009932A1 (en) * 2002-04-26 2004-01-15 Kathleen Phelan Antibacterial compounds with activity against penicillin-resistant streptococcus pneumoniae
AU2003234650A1 (en) 2002-05-31 2003-12-19 Janssen Pharmaceutica N.V. 3-descladinosyl-6-o-carbamoyl and 6-o-carbonoyl macrolide antibacterial agents
US7427493B2 (en) 2002-06-28 2008-09-23 Kosan Biosciences Incorporated Recombinant genes for polyketide modifying enzymes
CN100363359C (zh) * 2002-08-29 2008-01-23 菲塞股份有限公司 运动内酯化合物
EP1638549A4 (de) * 2003-03-10 2011-06-15 Optimer Pharmaceuticals Inc Neue antibakterielle mittel
US7407941B2 (en) * 2003-08-26 2008-08-05 Pfizer, Inc. N-desmethyl-N-substituted-11-deoxyerythromycin compounds
US20050113319A1 (en) * 2003-08-26 2005-05-26 Christopher Carreras 11-Deoxy-6,9-ether erythromycin compounds
WO2005067919A1 (en) * 2003-12-24 2005-07-28 Enanta Pharmaceuticals, Inc. 11-csubsituted erythromycin derivatives
DK1836211T3 (da) * 2004-12-21 2010-05-17 Pfizer Prod Inc Makrolider
US7595300B2 (en) 2005-12-13 2009-09-29 Kosan Biosciences Incorporated 7-quinolyl ketolide antibacterial agents
US9453042B2 (en) * 2007-10-25 2016-09-27 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
CA2714389C (en) * 2008-02-08 2016-10-18 Basilea Pharmaceutica Ag Macrolides and uses of macrolides
HRP20160222T1 (hr) 2008-10-24 2016-04-08 Cempra Pharmaceuticals, Inc. Biozaštite uporabom makrolida koji sadrže triazol
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
EP2475253B1 (de) 2009-09-10 2016-10-26 Cempra Pharmaceuticals, Inc. Verfahren zur behandlung von malaria, tuberkulose und mac-erkrankungen
JP5711352B2 (ja) 2010-03-22 2015-04-30 センプラ ファーマシューティカルズ，インコーポレイテッド マクロライドの結晶形、およびその使用
CN102917708B (zh) 2010-05-20 2015-11-25 森普拉制药公司 制备大环内酯和酮内酯及其中间体的方法
US8796474B1 (en) 2010-08-23 2014-08-05 Rutgers, The State University Of New Jersey Macrolide compounds and methods and intermediates useful for their preparation
US9815863B2 (en) 2010-09-10 2017-11-14 Cempra Pharmaceuticals, Inc. Hydrogen bond forming fluoro ketolides for treating diseases
US9206214B2 (en) * 2011-03-01 2015-12-08 Wockhardt Ltd. Process for preparation of ketolide intermediates
IN2014DN08939A (de) 2012-03-27 2015-05-22 Cempra Pharmaceuticals Inc
CN102718816B (zh) * 2012-07-11 2014-11-05 山东大学 4''-O-(反式-β-芳基烯丙酰胺)氨基甲酰基阿奇霉素衍生物
CA2905975A1 (en) 2013-03-14 2014-09-25 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
EP2968384A4 (de) 2013-03-15 2017-02-15 Cempra Pharmaceuticals, Inc. Konvergente verfahren zur herstellung antibakterieller makrolidmittel
US20230174567A1 (en) * 2020-05-22 2023-06-08 Merck Sharp & Dohme Llc Synthesis of fluorinated nucleotides

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JP3259429B2 (ja) * 1992-04-22 2002-02-25 大正製薬株式会社 ５−ｏ−デソサミニルエリスロノライドａ誘導体
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FR2718450B1 (fr) * 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
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CN1179046C (zh) 1996-07-05 2004-12-08 拜奥蒂卡技术有限公司 新型红霉素、其制备方法、用途和含其的药物组合物
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Also Published As

Publication number Publication date
IL145777A0 (en) 2002-07-25
IL145777A (en) 2007-02-11
KR100710605B1 (ko) 2007-04-24
WO2000063224A2 (en) 2000-10-26
AU773678B2 (en) 2004-06-03
WO2000063225A2 (en) 2000-10-26
EP1171446A2 (de) 2002-01-16
CN1241931C (zh) 2006-02-15
WO2000063224A3 (en) 2001-01-18
US20020119938A1 (en) 2002-08-29
AU4237900A (en) 2000-11-02
BR0010680A (pt) 2002-02-19
ES2272273T3 (es) 2007-05-01
DE60030847T2 (de) 2007-04-19
DE60030847D1 (de) 2006-11-02
USRE39836E1 (en) 2007-09-11
NZ515027A (en) 2004-01-30
CN1384838A (zh) 2002-12-11
US6593302B2 (en) 2003-07-15
AU4457800A (en) 2000-11-02
AU775637B2 (en) 2004-08-12
CA2369816A1 (en) 2000-10-26
WO2000063225A3 (en) 2001-01-18
JP2003523938A (ja) 2003-08-12
MXPA01010524A (es) 2002-03-14
US6395710B1 (en) 2002-05-28
EP1171446B1 (de) 2006-09-20
KR20020007374A (ko) 2002-01-26
KR20020007372A (ko) 2002-01-26
ID30547A (id) 2001-12-20

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