IL145777A0 - Macrolide antiinfective agents - Google Patents

Macrolide antiinfective agents

Info

Publication number
IL145777A0
IL145777A0 IL14577700A IL14577700A IL145777A0 IL 145777 A0 IL145777 A0 IL 145777A0 IL 14577700 A IL14577700 A IL 14577700A IL 14577700 A IL14577700 A IL 14577700A IL 145777 A0 IL145777 A0 IL 145777A0
Authority
IL
Israel
Prior art keywords
sub
substituted
unsubstituted
alkyl
amino
Prior art date
Application number
IL14577700A
Other languages
English (en)
Original Assignee
Kosan Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kosan Biosciences Inc filed Critical Kosan Biosciences Inc
Publication of IL145777A0 publication Critical patent/IL145777A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL14577700A 1999-04-16 2000-04-14 Macrolide antiinfective agents IL145777A0 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US12972999P 1999-04-16 1999-04-16
US14017599P 1999-06-18 1999-06-18
US17215499P 1999-12-17 1999-12-17
US17215999P 1999-12-17 1999-12-17
US17380599P 1999-12-30 1999-12-30
US17380499P 1999-12-30 1999-12-30
US09/550,045 US6395710B1 (en) 1999-04-16 2000-04-14 Macrolide antiinfective agents
PCT/US2000/009914 WO2000063224A2 (en) 1999-04-16 2000-04-14 Macrolide antiinfective agents

Publications (1)

Publication Number Publication Date
IL145777A0 true IL145777A0 (en) 2002-07-25

Family

ID=27568857

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14577700A IL145777A0 (en) 1999-04-16 2000-04-14 Macrolide antiinfective agents
IL145777A IL145777A (en) 1999-04-16 2001-10-04 History 3 - Descladinosil - 3 - Oxo - Erythromycin A 12,11 - Cyclic cyclamate and anti-inflammatory drugs containing them

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL145777A IL145777A (en) 1999-04-16 2001-10-04 History 3 - Descladinosil - 3 - Oxo - Erythromycin A 12,11 - Cyclic cyclamate and anti-inflammatory drugs containing them

Country Status (16)

Country Link
US (3) US6395710B1 (xx)
EP (1) EP1171446B1 (xx)
JP (1) JP2003523938A (xx)
KR (2) KR100710605B1 (xx)
CN (1) CN1241931C (xx)
AT (1) ATE340183T1 (xx)
AU (2) AU775637B2 (xx)
BR (1) BR0010680A (xx)
CA (1) CA2369816A1 (xx)
DE (1) DE60030847T2 (xx)
ES (1) ES2272273T3 (xx)
ID (1) ID30547A (xx)
IL (2) IL145777A0 (xx)
MX (1) MXPA01010524A (xx)
NZ (1) NZ515027A (xx)
WO (2) WO2000063224A2 (xx)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
BR9916969A (pt) 1999-01-27 2001-11-06 Pfizer Prod Inc Antibióticos cetólidos
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6590083B1 (en) * 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
ATE271062T1 (de) 2000-06-30 2004-07-15 Pfizer Prod Inc Makrolid-antibiotika
US6472372B1 (en) 2000-12-06 2002-10-29 Ortho-Mcneil Pharmaceuticals, Inc. 6-O-Carbamoyl ketolide antibacterials
MXPA03008460A (es) * 2001-03-21 2004-06-30 Dow Agrosciences Llc Derivados pesticidas de espinosina.
WO2003024986A1 (en) 2001-09-17 2003-03-27 Ortho-Mcneil Pharmaceutical, Inc. 6-o-carbamate-11,12-lacto-ketolide antimicrobials
NZ533282A (en) 2001-12-05 2006-09-29 Ortho Mcneil Pharm Inc 6-O-Acyl ketolide derivatives of erythromycine useful as antibacterials
US8063021B2 (en) * 2002-01-17 2011-11-22 Kosan Biosciences Incorporated Ketolide anti-infective compounds
ES2337134T3 (es) 2002-03-12 2010-04-21 Bristol-Myers Squibb Company Derivados de c3-ciano-epotilona.
US20040014691A1 (en) * 2002-04-25 2004-01-22 Searle Xenia Beebe 9-Oxime macrolide antibacterials
US20040009932A1 (en) * 2002-04-26 2004-01-15 Kathleen Phelan Antibacterial compounds with activity against penicillin-resistant streptococcus pneumoniae
CA2487918A1 (en) 2002-05-31 2003-12-11 Janssen Pharmaceutica N.V. 3-descladinosyl-6-o-carbamoyl and 6-o-carbonoyl macrolide antibacterial agents
WO2004003169A2 (en) 2002-06-28 2004-01-08 Kosan Biosciences, Inc. Recombinant genes for polyketide modifying enzymes
CN100363359C (zh) * 2002-08-29 2008-01-23 菲塞股份有限公司 运动内酯化合物
CA2801100A1 (en) 2003-03-10 2004-09-23 Optimer Pharmaceuticals, Inc. Macrolides and processes for their preparation
US7407941B2 (en) * 2003-08-26 2008-08-05 Pfizer, Inc. N-desmethyl-N-substituted-11-deoxyerythromycin compounds
US20050113319A1 (en) * 2003-08-26 2005-05-26 Christopher Carreras 11-Deoxy-6,9-ether erythromycin compounds
WO2005067919A1 (en) * 2003-12-24 2005-07-28 Enanta Pharmaceuticals, Inc. 11-csubsituted erythromycin derivatives
PT1836211E (pt) * 2004-12-21 2010-04-08 Pfizer Prod Inc Macrólidos
US7595300B2 (en) 2005-12-13 2009-09-29 Kosan Biosciences Incorporated 7-quinolyl ketolide antibacterial agents
CN105732745A (zh) 2007-10-25 2016-07-06 森普拉制药公司 大环内酯类抗菌剂的制备方法
KR101589960B1 (ko) * 2008-02-08 2016-01-29 바실리어 파마슈티카 아게 Ｐｄｅ 억제를 통해 중재되는 질환의 치료를 위한 마크로라이드
CN107854477A (zh) 2008-10-24 2018-03-30 森普拉制药公司 使用含三唑的大环内酯治疗抗性疾病的方法
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
WO2011032052A1 (en) 2009-09-10 2011-03-17 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and mac diseases
EP2550286B1 (en) 2010-03-22 2015-12-09 Cempra Pharmaceuticals, Inc. Crystalline forms of a macrolide, and uses therefor
PL2571506T3 (pl) 2010-05-20 2017-10-31 Cempra Pharmaceuticals Inc Sposoby sporządzania makrolidów i ketolidów oraz ich produktów pośrednich
US8796474B1 (en) 2010-08-23 2014-08-05 Rutgers, The State University Of New Jersey Macrolide compounds and methods and intermediates useful for their preparation
KR20180110181A (ko) 2010-09-10 2018-10-08 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
US9206214B2 (en) * 2011-03-01 2015-12-08 Wockhardt Ltd. Process for preparation of ketolide intermediates
IN2014DN08939A (xx) 2012-03-27 2015-05-22 Cempra Pharmaceuticals Inc
CN102718816B (zh) * 2012-07-11 2014-11-05 山东大学 4''-O-(反式-β-芳基烯丙酰胺)氨基甲酰基阿奇霉素衍生物
AU2014239959A1 (en) 2013-03-14 2015-10-01 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
EP2968384A4 (en) 2013-03-15 2017-02-15 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
EP4153189A1 (en) * 2020-05-22 2023-03-29 Merck Sharp & Dohme LLC Synthesis of fluorinated nucleotides

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5141926A (en) * 1990-04-18 1992-08-25 Abbott Laboratories Erythromycin derivatives
IL114589A (en) 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of the history of erythromycin
US5523399A (en) * 1991-12-27 1996-06-04 Taisho Pharmaceutical Co., Ltd. 5-O-desosaminylerythronolide derivatives
JP3259429B2 (ja) * 1992-04-22 2002-02-25 大正製薬株式会社 ５−ｏ−デソサミニルエリスロノライドａ誘導体
US5527780A (en) 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
US6066721A (en) 1995-07-06 2000-05-23 Stanford University Method to produce novel polyketides
US5672491A (en) 1993-09-20 1997-09-30 The Leland Stanford Junior University Recombinant production of novel polyketides
FR2718450B1 (fr) * 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2719587B1 (fr) 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
AU706445B2 (en) 1995-07-06 1999-06-17 Brown University Research Foundation Cell-free synthesis of polyketides
FR2739620B1 (fr) * 1995-10-09 1997-12-19 Roussel Uclaf Nouveaux derives de la 5-0-desosaminyl 6-o-methyl erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs
US6274715B1 (en) 1995-11-08 2001-08-14 Abbott Laboratories Tricyclic erythromycin derivatives
FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US5750510A (en) 1997-04-04 1998-05-12 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
CZ351898A3 (cs) * 1996-05-07 1999-04-14 Abbott Laboratories 6-0-substituované erythromycinové sloučeniny a způsob jejich přípravy
FR2748746B1 (fr) * 1996-05-14 1998-08-14 Hoechst Marion Roussel Inc Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine
EP0910633B1 (en) 1996-07-05 2009-12-09 Biotica Technology Limited Hybrid polyketide synthase I gene
US6271255B1 (en) 1996-07-05 2001-08-07 Biotica Technology Limited Erythromycins and process for their preparation
FR2751656B1 (fr) * 1996-07-24 1998-10-16 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
UA51730C2 (uk) 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
IL128681A0 (en) 1996-09-04 2000-01-31 Abbott Lab 6-O substituted ketolides having antibacterial activity
FR2754821B1 (fr) 1996-10-23 2003-04-04 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
AU4472797A (en) * 1996-10-31 1998-05-22 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
FR2757168B1 (fr) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
EP0975330A1 (en) * 1997-02-04 2000-02-02 Abbott Laboratories Pain reducing parenteral liposome formulation
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
IL132767A0 (en) * 1997-06-11 2001-03-19 Pfizer Prod Inc 9-Oxime erythromycin derivatives
HUP0004579A3 (en) * 1997-09-30 2001-11-28 Abbott Lab 3'-n-modified 6-0-substituted erythromycin ketolide derivatives having antibacterial activity and pharmaceutical compositions comprising them
CO4990960A1 (es) 1997-10-29 2000-12-26 Abbott Lab Derivados de cetolidos 2-halo-6-o sustituidos
US6124269A (en) 1997-10-29 2000-09-26 Abbott Laboratories 2-Halo-6-O-substituted ketolide derivatives
JP2004514643A (ja) * 1997-10-29 2004-05-20 大正製薬株式会社 エリスロマイシンａ誘導体
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
ATE275151T1 (de) 1998-03-03 2004-09-15 Pfizer Prod Inc 3,6-ketal-makrolidantibiotika
FR2777282B1 (fr) 1998-04-08 2001-04-20 Hoechst Marion Roussel Inc Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments
DK0952157T3 (da) * 1998-04-24 2003-10-13 Pfizer Prod Inc 9a, 11b-dehydroderivater af 9-oxim-3-keto-6-0-methylerythromycin
FR2781484B1 (fr) * 1998-07-21 2001-08-10 Hoechst Marion Roussel Inc Nouveaux derives de la 6-deoxy erythromycine, leur procede de preparation et leur application comme medicaments
JP2003512013A (ja) 1998-10-29 2003-04-02 コーサン バイオサイエンシーズ， インコーポレイテッド 組換えオレアンドライドポリケチドシンターゼ
TR200200436T2 (tr) 1998-11-03 2002-06-21 Pfizer Inc. Yeni makrolit antibiyotikler
ATE344269T1 (de) 1998-12-10 2006-11-15 Pfizer Prod Inc Carbamat und carbazat ketolid antibiotika
BR9916969A (pt) * 1999-01-27 2001-11-06 Pfizer Prod Inc Antibióticos cetólidos
PL350650A1 (en) * 1999-03-15 2003-01-27 Abbott Lab 6-o-substituted macrolides having antibacterial activity
US6399582B1 (en) * 1999-04-16 2002-06-04 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
AU3832100A (en) 1999-05-24 2000-12-12 Pfizer Products Inc. 13-methyl-erythromycin derivatives

Also Published As

Publication number Publication date
US6593302B2 (en) 2003-07-15
NZ515027A (en) 2004-01-30
JP2003523938A (ja) 2003-08-12
KR20020007372A (ko) 2002-01-26
CA2369816A1 (en) 2000-10-26
WO2000063225A2 (en) 2000-10-26
CN1241931C (zh) 2006-02-15
AU773678B2 (en) 2004-06-03
WO2000063224A3 (en) 2001-01-18
ES2272273T3 (es) 2007-05-01
KR20020007374A (ko) 2002-01-26
EP1171446B1 (en) 2006-09-20
BR0010680A (pt) 2002-02-19
USRE39836E1 (en) 2007-09-11
AU775637B2 (en) 2004-08-12
AU4237900A (en) 2000-11-02
KR100710605B1 (ko) 2007-04-24
MXPA01010524A (es) 2002-03-14
WO2000063224A2 (en) 2000-10-26
AU4457800A (en) 2000-11-02
US6395710B1 (en) 2002-05-28
CN1384838A (zh) 2002-12-11
ATE340183T1 (de) 2006-10-15
EP1171446A2 (en) 2002-01-16
DE60030847D1 (de) 2006-11-02
WO2000063225A3 (en) 2001-01-18
DE60030847T2 (de) 2007-04-19
US20020119938A1 (en) 2002-08-29
IL145777A (en) 2007-02-11
ID30547A (id) 2001-12-20

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