IL145777A0 - Macrolide antiinfective agents - Google Patents
Macrolide antiinfective agentsInfo
- Publication number
- IL145777A0 IL145777A0 IL14577700A IL14577700A IL145777A0 IL 145777 A0 IL145777 A0 IL 145777A0 IL 14577700 A IL14577700 A IL 14577700A IL 14577700 A IL14577700 A IL 14577700A IL 145777 A0 IL145777 A0 IL 145777A0
- Authority
- IL
- Israel
- Prior art keywords
- sub
- substituted
- unsubstituted
- alkyl
- amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12972999P | 1999-04-16 | 1999-04-16 | |
US14017599P | 1999-06-18 | 1999-06-18 | |
US17215499P | 1999-12-17 | 1999-12-17 | |
US17215999P | 1999-12-17 | 1999-12-17 | |
US17380599P | 1999-12-30 | 1999-12-30 | |
US17380499P | 1999-12-30 | 1999-12-30 | |
US09/550,045 US6395710B1 (en) | 1999-04-16 | 2000-04-14 | Macrolide antiinfective agents |
PCT/US2000/009914 WO2000063224A2 (en) | 1999-04-16 | 2000-04-14 | Macrolide antiinfective agents |
Publications (1)
Publication Number | Publication Date |
---|---|
IL145777A0 true IL145777A0 (en) | 2002-07-25 |
Family
ID=27568857
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14577700A IL145777A0 (en) | 1999-04-16 | 2000-04-14 | Macrolide antiinfective agents |
IL145777A IL145777A (en) | 1999-04-16 | 2001-10-04 | History 3 - Descladinosil - 3 - Oxo - Erythromycin A 12,11 - Cyclic cyclamate and anti-inflammatory drugs containing them |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL145777A IL145777A (en) | 1999-04-16 | 2001-10-04 | History 3 - Descladinosil - 3 - Oxo - Erythromycin A 12,11 - Cyclic cyclamate and anti-inflammatory drugs containing them |
Country Status (16)
Country | Link |
---|---|
US (3) | US6395710B1 (xx) |
EP (1) | EP1171446B1 (xx) |
JP (1) | JP2003523938A (xx) |
KR (2) | KR100710605B1 (xx) |
CN (1) | CN1241931C (xx) |
AT (1) | ATE340183T1 (xx) |
AU (2) | AU775637B2 (xx) |
BR (1) | BR0010680A (xx) |
CA (1) | CA2369816A1 (xx) |
DE (1) | DE60030847T2 (xx) |
ES (1) | ES2272273T3 (xx) |
ID (1) | ID30547A (xx) |
IL (2) | IL145777A0 (xx) |
MX (1) | MXPA01010524A (xx) |
NZ (1) | NZ515027A (xx) |
WO (2) | WO2000063224A2 (xx) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AP1060A (en) * | 1998-01-02 | 2002-04-23 | Pfizer Prod Inc | Novel erythromycin derivatives. |
BR9916969A (pt) | 1999-01-27 | 2001-11-06 | Pfizer Prod Inc | Antibióticos cetólidos |
US6451768B1 (en) | 1999-04-16 | 2002-09-17 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
US6590083B1 (en) * | 1999-04-16 | 2003-07-08 | Ortho-Mcneil Pharmaceutical, Inc. | Ketolide antibacterials |
ATE271062T1 (de) | 2000-06-30 | 2004-07-15 | Pfizer Prod Inc | Makrolid-antibiotika |
US6472372B1 (en) | 2000-12-06 | 2002-10-29 | Ortho-Mcneil Pharmaceuticals, Inc. | 6-O-Carbamoyl ketolide antibacterials |
MXPA03008460A (es) * | 2001-03-21 | 2004-06-30 | Dow Agrosciences Llc | Derivados pesticidas de espinosina. |
WO2003024986A1 (en) | 2001-09-17 | 2003-03-27 | Ortho-Mcneil Pharmaceutical, Inc. | 6-o-carbamate-11,12-lacto-ketolide antimicrobials |
NZ533282A (en) | 2001-12-05 | 2006-09-29 | Ortho Mcneil Pharm Inc | 6-O-Acyl ketolide derivatives of erythromycine useful as antibacterials |
US8063021B2 (en) * | 2002-01-17 | 2011-11-22 | Kosan Biosciences Incorporated | Ketolide anti-infective compounds |
ES2337134T3 (es) | 2002-03-12 | 2010-04-21 | Bristol-Myers Squibb Company | Derivados de c3-ciano-epotilona. |
US20040014691A1 (en) * | 2002-04-25 | 2004-01-22 | Searle Xenia Beebe | 9-Oxime macrolide antibacterials |
US20040009932A1 (en) * | 2002-04-26 | 2004-01-15 | Kathleen Phelan | Antibacterial compounds with activity against penicillin-resistant streptococcus pneumoniae |
CA2487918A1 (en) | 2002-05-31 | 2003-12-11 | Janssen Pharmaceutica N.V. | 3-descladinosyl-6-o-carbamoyl and 6-o-carbonoyl macrolide antibacterial agents |
WO2004003169A2 (en) | 2002-06-28 | 2004-01-08 | Kosan Biosciences, Inc. | Recombinant genes for polyketide modifying enzymes |
CN100363359C (zh) * | 2002-08-29 | 2008-01-23 | 菲塞股份有限公司 | 运动内酯化合物 |
CA2801100A1 (en) | 2003-03-10 | 2004-09-23 | Optimer Pharmaceuticals, Inc. | Macrolides and processes for their preparation |
US7407941B2 (en) * | 2003-08-26 | 2008-08-05 | Pfizer, Inc. | N-desmethyl-N-substituted-11-deoxyerythromycin compounds |
US20050113319A1 (en) * | 2003-08-26 | 2005-05-26 | Christopher Carreras | 11-Deoxy-6,9-ether erythromycin compounds |
WO2005067919A1 (en) * | 2003-12-24 | 2005-07-28 | Enanta Pharmaceuticals, Inc. | 11-csubsituted erythromycin derivatives |
PT1836211E (pt) * | 2004-12-21 | 2010-04-08 | Pfizer Prod Inc | Macrólidos |
US7595300B2 (en) | 2005-12-13 | 2009-09-29 | Kosan Biosciences Incorporated | 7-quinolyl ketolide antibacterial agents |
CN105732745A (zh) | 2007-10-25 | 2016-07-06 | 森普拉制药公司 | 大环内酯类抗菌剂的制备方法 |
KR101589960B1 (ko) * | 2008-02-08 | 2016-01-29 | 바실리어 파마슈티카 아게 | Pde 억제를 통해 중재되는 질환의 치료를 위한 마크로라이드 |
CN107854477A (zh) | 2008-10-24 | 2018-03-30 | 森普拉制药公司 | 使用含三唑的大环内酯治疗抗性疾病的方法 |
US9937194B1 (en) | 2009-06-12 | 2018-04-10 | Cempra Pharmaceuticals, Inc. | Compounds and methods for treating inflammatory diseases |
WO2011032052A1 (en) | 2009-09-10 | 2011-03-17 | Cempra Pharmaceuticals, Inc. | Methods for treating malaria, tuberculosis and mac diseases |
EP2550286B1 (en) | 2010-03-22 | 2015-12-09 | Cempra Pharmaceuticals, Inc. | Crystalline forms of a macrolide, and uses therefor |
PL2571506T3 (pl) | 2010-05-20 | 2017-10-31 | Cempra Pharmaceuticals Inc | Sposoby sporządzania makrolidów i ketolidów oraz ich produktów pośrednich |
US8796474B1 (en) | 2010-08-23 | 2014-08-05 | Rutgers, The State University Of New Jersey | Macrolide compounds and methods and intermediates useful for their preparation |
KR20180110181A (ko) | 2010-09-10 | 2018-10-08 | 셈프라 파마슈티컬스, 인크. | 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드 |
US9206214B2 (en) * | 2011-03-01 | 2015-12-08 | Wockhardt Ltd. | Process for preparation of ketolide intermediates |
IN2014DN08939A (xx) | 2012-03-27 | 2015-05-22 | Cempra Pharmaceuticals Inc | |
CN102718816B (zh) * | 2012-07-11 | 2014-11-05 | 山东大学 | 4''-O-(反式-β-芳基烯丙酰胺)氨基甲酰基阿奇霉素衍生物 |
AU2014239959A1 (en) | 2013-03-14 | 2015-10-01 | Cempra Pharmaceuticals, Inc. | Methods for treating respiratory diseases and formulations therefor |
EP2968384A4 (en) | 2013-03-15 | 2017-02-15 | Cempra Pharmaceuticals, Inc. | Convergent processes for preparing macrolide antibacterial agents |
EP4153189A1 (en) * | 2020-05-22 | 2023-03-29 | Merck Sharp & Dohme LLC | Synthesis of fluorinated nucleotides |
Family Cites Families (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5141926A (en) * | 1990-04-18 | 1992-08-25 | Abbott Laboratories | Erythromycin derivatives |
IL114589A (en) | 1990-11-21 | 1999-12-22 | Roussel Uclaf | Intermediates for the preparation of the history of erythromycin |
US5523399A (en) * | 1991-12-27 | 1996-06-04 | Taisho Pharmaceutical Co., Ltd. | 5-O-desosaminylerythronolide derivatives |
JP3259429B2 (ja) * | 1992-04-22 | 2002-02-25 | 大正製薬株式会社 | 5−o−デソサミニルエリスロノライドa誘導体 |
US5527780A (en) | 1992-11-05 | 1996-06-18 | Roussel Uclaf | Erythromycin derivatives |
US6066721A (en) | 1995-07-06 | 2000-05-23 | Stanford University | Method to produce novel polyketides |
US5672491A (en) | 1993-09-20 | 1997-09-30 | The Leland Stanford Junior University | Recombinant production of novel polyketides |
FR2718450B1 (fr) * | 1994-04-08 | 1997-01-10 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
FR2719587B1 (fr) | 1994-05-03 | 1996-07-12 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
AU706445B2 (en) | 1995-07-06 | 1999-06-17 | Brown University Research Foundation | Cell-free synthesis of polyketides |
FR2739620B1 (fr) * | 1995-10-09 | 1997-12-19 | Roussel Uclaf | Nouveaux derives de la 5-0-desosaminyl 6-o-methyl erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs |
US6274715B1 (en) | 1995-11-08 | 2001-08-14 | Abbott Laboratories | Tricyclic erythromycin derivatives |
FR2742757B1 (fr) * | 1995-12-22 | 1998-01-30 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
US5750510A (en) | 1997-04-04 | 1998-05-12 | Abbott Laboratories | 3-descladinose-2,3-anhydroerythromycin derivatives |
CZ351898A3 (cs) * | 1996-05-07 | 1999-04-14 | Abbott Laboratories | 6-0-substituované erythromycinové sloučeniny a způsob jejich přípravy |
FR2748746B1 (fr) * | 1996-05-14 | 1998-08-14 | Hoechst Marion Roussel Inc | Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine |
EP0910633B1 (en) | 1996-07-05 | 2009-12-09 | Biotica Technology Limited | Hybrid polyketide synthase I gene |
US6271255B1 (en) | 1996-07-05 | 2001-08-07 | Biotica Technology Limited | Erythromycins and process for their preparation |
FR2751656B1 (fr) * | 1996-07-24 | 1998-10-16 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
UA51730C2 (uk) | 1996-09-04 | 2002-12-16 | Ебботт Лабораторіз | 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців |
IL128681A0 (en) | 1996-09-04 | 2000-01-31 | Abbott Lab | 6-O substituted ketolides having antibacterial activity |
FR2754821B1 (fr) | 1996-10-23 | 2003-04-04 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
AU4472797A (en) * | 1996-10-31 | 1998-05-22 | Taisho Pharmaceutical Co., Ltd. | Erythromycin a derivatives |
FR2757168B1 (fr) * | 1996-12-12 | 1999-06-11 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
EP0975330A1 (en) * | 1997-02-04 | 2000-02-02 | Abbott Laboratories | Pain reducing parenteral liposome formulation |
FR2760017B1 (fr) * | 1997-02-27 | 1999-04-30 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments |
IL132767A0 (en) * | 1997-06-11 | 2001-03-19 | Pfizer Prod Inc | 9-Oxime erythromycin derivatives |
HUP0004579A3 (en) * | 1997-09-30 | 2001-11-28 | Abbott Lab | 3'-n-modified 6-0-substituted erythromycin ketolide derivatives having antibacterial activity and pharmaceutical compositions comprising them |
CO4990960A1 (es) | 1997-10-29 | 2000-12-26 | Abbott Lab | Derivados de cetolidos 2-halo-6-o sustituidos |
US6124269A (en) | 1997-10-29 | 2000-09-26 | Abbott Laboratories | 2-Halo-6-O-substituted ketolide derivatives |
JP2004514643A (ja) * | 1997-10-29 | 2004-05-20 | 大正製薬株式会社 | エリスロマイシンa誘導体 |
AP1060A (en) * | 1998-01-02 | 2002-04-23 | Pfizer Prod Inc | Novel erythromycin derivatives. |
ATE275151T1 (de) | 1998-03-03 | 2004-09-15 | Pfizer Prod Inc | 3,6-ketal-makrolidantibiotika |
FR2777282B1 (fr) | 1998-04-08 | 2001-04-20 | Hoechst Marion Roussel Inc | Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments |
DK0952157T3 (da) * | 1998-04-24 | 2003-10-13 | Pfizer Prod Inc | 9a, 11b-dehydroderivater af 9-oxim-3-keto-6-0-methylerythromycin |
FR2781484B1 (fr) * | 1998-07-21 | 2001-08-10 | Hoechst Marion Roussel Inc | Nouveaux derives de la 6-deoxy erythromycine, leur procede de preparation et leur application comme medicaments |
JP2003512013A (ja) | 1998-10-29 | 2003-04-02 | コーサン バイオサイエンシーズ, インコーポレイテッド | 組換えオレアンドライドポリケチドシンターゼ |
TR200200436T2 (tr) | 1998-11-03 | 2002-06-21 | Pfizer Inc. | Yeni makrolit antibiyotikler |
ATE344269T1 (de) | 1998-12-10 | 2006-11-15 | Pfizer Prod Inc | Carbamat und carbazat ketolid antibiotika |
BR9916969A (pt) * | 1999-01-27 | 2001-11-06 | Pfizer Prod Inc | Antibióticos cetólidos |
PL350650A1 (en) * | 1999-03-15 | 2003-01-27 | Abbott Lab | 6-o-substituted macrolides having antibacterial activity |
US6399582B1 (en) * | 1999-04-16 | 2002-06-04 | Ortho-Mcneil Pharmaceutical, Inc. | Ketolide antibacterials |
AU3832100A (en) | 1999-05-24 | 2000-12-12 | Pfizer Products Inc. | 13-methyl-erythromycin derivatives |
-
2000
- 2000-04-14 KR KR1020017013150A patent/KR100710605B1/ko not_active IP Right Cessation
- 2000-04-14 AU AU44578/00A patent/AU775637B2/en not_active Ceased
- 2000-04-14 AT AT00922149T patent/ATE340183T1/de not_active IP Right Cessation
- 2000-04-14 AU AU42379/00A patent/AU773678B2/en not_active Ceased
- 2000-04-14 WO PCT/US2000/009914 patent/WO2000063224A2/en active IP Right Grant
- 2000-04-14 EP EP00922149A patent/EP1171446B1/en not_active Expired - Lifetime
- 2000-04-14 BR BR0010680-1A patent/BR0010680A/pt not_active IP Right Cessation
- 2000-04-14 JP JP2000612314A patent/JP2003523938A/ja active Pending
- 2000-04-14 KR KR1020017013225A patent/KR20020007374A/ko not_active Application Discontinuation
- 2000-04-14 CA CA002369816A patent/CA2369816A1/en not_active Abandoned
- 2000-04-14 IL IL14577700A patent/IL145777A0/xx active IP Right Grant
- 2000-04-14 WO PCT/US2000/009915 patent/WO2000063225A2/en not_active Application Discontinuation
- 2000-04-14 ES ES00922149T patent/ES2272273T3/es not_active Expired - Lifetime
- 2000-04-14 NZ NZ515027A patent/NZ515027A/xx unknown
- 2000-04-14 DE DE60030847T patent/DE60030847T2/de not_active Expired - Fee Related
- 2000-04-14 US US09/550,045 patent/US6395710B1/en not_active Expired - Lifetime
- 2000-04-14 ID IDW00200102465A patent/ID30547A/id unknown
- 2000-04-14 CN CNB008090718A patent/CN1241931C/zh not_active Expired - Fee Related
- 2000-04-14 MX MXPA01010524A patent/MXPA01010524A/es active IP Right Grant
-
2001
- 2001-10-04 IL IL145777A patent/IL145777A/en unknown
-
2002
- 2002-02-13 US US10/075,466 patent/US6593302B2/en not_active Ceased
-
2005
- 2005-07-13 US US11/182,038 patent/USRE39836E1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US6593302B2 (en) | 2003-07-15 |
NZ515027A (en) | 2004-01-30 |
JP2003523938A (ja) | 2003-08-12 |
KR20020007372A (ko) | 2002-01-26 |
CA2369816A1 (en) | 2000-10-26 |
WO2000063225A2 (en) | 2000-10-26 |
CN1241931C (zh) | 2006-02-15 |
AU773678B2 (en) | 2004-06-03 |
WO2000063224A3 (en) | 2001-01-18 |
ES2272273T3 (es) | 2007-05-01 |
KR20020007374A (ko) | 2002-01-26 |
EP1171446B1 (en) | 2006-09-20 |
BR0010680A (pt) | 2002-02-19 |
USRE39836E1 (en) | 2007-09-11 |
AU775637B2 (en) | 2004-08-12 |
AU4237900A (en) | 2000-11-02 |
KR100710605B1 (ko) | 2007-04-24 |
MXPA01010524A (es) | 2002-03-14 |
WO2000063224A2 (en) | 2000-10-26 |
AU4457800A (en) | 2000-11-02 |
US6395710B1 (en) | 2002-05-28 |
CN1384838A (zh) | 2002-12-11 |
ATE340183T1 (de) | 2006-10-15 |
EP1171446A2 (en) | 2002-01-16 |
DE60030847D1 (de) | 2006-11-02 |
WO2000063225A3 (en) | 2001-01-18 |
DE60030847T2 (de) | 2007-04-19 |
US20020119938A1 (en) | 2002-08-29 |
IL145777A (en) | 2007-02-11 |
ID30547A (id) | 2001-12-20 |
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