DK1291352T3 - 6-O-substituerede ketolider med antibakteriel aktivitet - Google Patents

6-O-substituerede ketolider med antibakteriel aktivitet

Info

Publication number
DK1291352T3
DK1291352T3 DK02024559T DK02024559T DK1291352T3 DK 1291352 T3 DK1291352 T3 DK 1291352T3 DK 02024559 T DK02024559 T DK 02024559T DK 02024559 T DK02024559 T DK 02024559T DK 1291352 T3 DK1291352 T3 DK 1291352T3
Authority
DK
Denmark
Prior art keywords
alkyl
substituted
heteroaryl
aryl
optionally substituted
Prior art date
Application number
DK02024559T
Other languages
English (en)
Inventor
Yat Sun Or
Zhenkun Ma
Richard F Clark
Daniel T Chu
Jacob J Plattner
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27107953&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1291352(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/888,350 external-priority patent/US5866549A/en
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of DK1291352T3 publication Critical patent/DK1291352T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08Hetero rings containing eight or more ring members, e.g. erythromycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00Processes for the preparation of sugar derivatives
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DK02024559T 1996-09-04 1997-09-02 6-O-substituerede ketolider med antibakteriel aktivitet DK1291352T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70777696A 1996-09-04 1996-09-04
US08/888,350 US5866549A (en) 1996-09-04 1997-07-03 6-O-substituted ketolides having antibacterial activity

Publications (1)

Publication Number Publication Date
DK1291352T3 true DK1291352T3 (da) 2005-09-19

Family

ID=27107953

Family Applications (5)

Application Number Title Priority Date Filing Date
DK02024558T DK1291351T3 (da) 1996-09-04 1997-09-02 6-O-substituerede ketolider med antibakteriel aktivitet
DK97939765T DK0929563T3 (da) 1996-09-04 1997-09-02 6-O-substituerede ketolider med antibakteriel aktivitet
DK02024557T DK1291350T3 (da) 1996-09-04 1997-09-02 6-0-substituerede ketolider med antibakteriel aktivitet
DK02024559T DK1291352T3 (da) 1996-09-04 1997-09-02 6-O-substituerede ketolider med antibakteriel aktivitet
DK02024560T DK1291353T3 (da) 1996-09-04 1997-09-02 6-O-substituerede ketolider med antibakteriel aktivitet

Family Applications Before (3)

Application Number Title Priority Date Filing Date
DK02024558T DK1291351T3 (da) 1996-09-04 1997-09-02 6-O-substituerede ketolider med antibakteriel aktivitet
DK97939765T DK0929563T3 (da) 1996-09-04 1997-09-02 6-O-substituerede ketolider med antibakteriel aktivitet
DK02024557T DK1291350T3 (da) 1996-09-04 1997-09-02 6-0-substituerede ketolider med antibakteriel aktivitet

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK02024560T DK1291353T3 (da) 1996-09-04 1997-09-02 6-O-substituerede ketolider med antibakteriel aktivitet

Country Status (28)

Country Link
US (4) US6147197A (da)
EP (5) EP1291351B1 (da)
JP (1) JP4597274B2 (da)
KR (5) KR20050044816A (da)
CN (4) CN100441591C (da)
AT (5) ATE296831T1 (da)
BG (1) BG63547B1 (da)
BR (1) BR9711661A (da)
CA (1) CA2263972C (da)
CZ (1) CZ300106B6 (da)
DE (5) DE69733723T2 (da)
DK (5) DK1291351T3 (da)
ES (5) ES2242983T3 (da)
HK (1) HK1021537A1 (da)
HR (5) HRP970473B1 (da)
HU (1) HU230166B1 (da)
ID (1) ID19406A (da)
IL (1) IL128681A0 (da)
NO (1) NO314230B1 (da)
NZ (1) NZ334274A (da)
PL (1) PL188173B1 (da)
PT (5) PT1291350E (da)
RO (1) RO121473B1 (da)
RU (1) RU2192427C2 (da)
SI (1) SI20023B (da)
SK (5) SK285536B6 (da)
TR (1) TR199901127T2 (da)
WO (1) WO1998009978A1 (da)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495348B1 (en) 1993-10-07 2002-12-17 Regents Of The University Of Minnesota Mitomycin biosynthetic gene cluster
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
DK0952157T3 (da) 1998-04-24 2003-10-13 Pfizer Prod Inc 9a, 11b-dehydroderivater af 9-oxim-3-keto-6-0-methylerythromycin
US6265202B1 (en) 1998-06-26 2001-07-24 Regents Of The University Of Minnesota DNA encoding methymycin and pikromycin
FR2792637B1 (fr) * 1999-04-26 2001-06-01 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
JP4573925B2 (ja) 1998-07-09 2010-11-04 アベンティス・ファーマ・ソシエテ・アノニム 新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用
FR2780977B1 (fr) * 1998-07-09 2000-09-01 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2785612A1 (fr) * 1998-11-10 2000-05-12 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
OA11670A (en) * 1998-11-03 2005-01-12 Pfizer Prod Inc Novel macrolide antibiotics.
BR0008731A (pt) * 1999-03-15 2002-09-24 Abbott Lab Macrolìdeos 6-0-substituìdos, tendo atividade antibacteriana
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
BR0010680A (pt) 1999-04-16 2002-02-19 Kosan Biosciences Inc Agentes antiinfecciosos de macrolìdeo
US6939861B2 (en) 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6420535B1 (en) * 1999-06-07 2002-07-16 Abbott Laboratories 6-O-carbamate ketolide derivatives
DE60005334T2 (de) * 1999-06-07 2004-06-24 Abbott Laboratories, Abbott Park 6-o-carbamat ketolide derivate
US6417366B2 (en) * 1999-06-24 2002-07-09 Abbott Laboratories Preparation of quinoline-substituted carbonate and carbamate derivatives
US6437106B1 (en) * 1999-06-24 2002-08-20 Abbott Laboratories Process for preparing 6-o-substituted erythromycin derivatives
EP1101769A3 (en) 1999-11-18 2001-10-24 Pfizer Products Inc. Nitrogen containing erythromycin derivatives
US6472372B1 (en) 2000-12-06 2002-10-29 Ortho-Mcneil Pharmaceuticals, Inc. 6-O-Carbamoyl ketolide antibacterials
WO2003004509A2 (en) * 2001-07-03 2003-01-16 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
EP1430068A1 (en) 2001-09-17 2004-06-23 Ortho-Mcneil Pharmaceutical, Inc. 6-o-carbamate-11,12-lacto-ketolide antimicrobials
US6673774B2 (en) * 2001-12-03 2004-01-06 Enanta Pharmaceuticals, Inc. 11-O-substituted macrolides and their descladinose derivatives
CA2469304A1 (en) 2001-12-05 2003-06-19 Ortho-Mcneil Pharmaceutical, Inc. 6-o acyl ketolide antibacterials
JP2005522453A (ja) * 2002-02-13 2005-07-28 アボット・ラボラトリーズ マクロライド抗菌化合物
US6831068B2 (en) * 2002-02-13 2004-12-14 Abbott Laboratories Macrolide antibacterial compounds
US20030162729A1 (en) * 2002-02-13 2003-08-28 Zhenkun Ma Macrolides with activity against methicillin-resistant staphylococcus aureus
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
US6995143B2 (en) 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
US7910558B2 (en) * 2002-05-13 2011-03-22 Enanta Pharmaceuticals, Inc. Bridged macrocyclic compounds and processes for the preparation thereof
US7273853B2 (en) * 2002-05-13 2007-09-25 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
US6841664B2 (en) * 2002-07-25 2005-01-11 Enanra Pharmaceuticals, Inc. 6,11-4-carbon bridged ketolides
EP1513856A1 (en) * 2002-05-31 2005-03-16 Janssen Pharmaceutica N.V. 3-descladinosyl-6-o-carbamoyl and 6-o-carbonoyl macrolide antibacterial agents
JPWO2004078771A1 (ja) * 2003-03-07 2006-06-08 大正製薬株式会社 2−フルオロ−6−o−置換ケトライド誘導体
EP3738591A3 (en) 2003-03-10 2021-03-24 Merck Sharp & Dohme Corp. Novel antibacterial agents
JP2006524706A (ja) * 2003-04-25 2006-11-02 カイロン コーポレイション 新規なケトライド誘導体
US20040254126A1 (en) * 2003-06-05 2004-12-16 Yao-Ling Qiu 11-12 Bicyclic erythromycin derivatives
US6790835B1 (en) * 2003-06-05 2004-09-14 Enanta Pharmaceuticals, Inc. Bicyclic macrolide derivatives
US20050101548A1 (en) * 2003-09-12 2005-05-12 Xiaodong Lin Antimicrobial derivatives
GB0327720D0 (en) * 2003-11-28 2003-12-31 Biotica Tech Ltd Erythromycins and process for their preparation
WO2005067564A2 (en) * 2004-01-07 2005-07-28 Enanta Pharmaceuticals, Inc. 6-11 bicyclic erythromycin derivatives
WO2005070113A2 (en) * 2004-01-09 2005-08-04 Enanta Pharmaceuticals, Inc. 9n-substituted 6-11 bicyclic erythromycin derivatives
US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
AU2005279050A1 (en) * 2004-07-30 2006-03-09 Centre National De La Recherche Scientifique (Cnrs) Hybrid molecules QA where Q is an aminoquinoline and A is an antibiotic residue, and the synthesis and uses thereof as antibacterial agents
FR2874922A1 (fr) * 2004-07-30 2006-03-10 Palumed Sa Molecules hybrides qa ou q est une aminoquinoleine et a est un residu antibiotique, leur synthese et leurs utilisations en tant qu'agent antibacterien
WO2006065743A2 (en) * 2004-12-13 2006-06-22 Enanta Pharmaceuticals, Inc. Tetracylic bicyclolides
DK1836211T3 (da) 2004-12-21 2010-05-17 Pfizer Prod Inc Makrolider
US7384922B2 (en) * 2005-05-04 2008-06-10 Enanta Pharmaceuticals, Inc. 6-11 bridged oxime erythromycin derivatives
US7517859B2 (en) * 2005-05-04 2009-04-14 Enanta Pharmaceuticals, Inc. Spirocyclic bicyclolides
US20060252710A1 (en) * 2005-05-04 2006-11-09 Guoqiang Wang 6-11 Bridged oxime erythromycin derivatives
JP5015016B2 (ja) 2006-02-07 2012-08-29 大正製薬株式会社 10a−アザライド化合物
WO2008023248A2 (en) 2006-08-24 2008-02-28 Wockhardt Research Centre Novel macrolides and ketolides having antimicrobial activity
US8293715B2 (en) 2007-08-06 2012-10-23 Taisho Pharmaceutical Co., Ltd. 10a-Azalide compound crosslinked at 10a- and 12-positions
US8354383B2 (en) * 2007-09-17 2013-01-15 Enanta Pharmaceuticals, Inc. 6,11-bridged biaryl macrolides
US8273720B2 (en) * 2007-09-17 2012-09-25 Enanta Pharmaceuticals, Inc. 6,11-bicyclolides: bridged biaryl macrolide derivatives
CN104004039A (zh) * 2007-09-17 2014-08-27 英安塔制药有限公司 6,11-桥联的联芳大环内酯类
CN101917850B (zh) 2007-10-25 2016-01-13 森普拉制药公司 大环内酯类抗菌剂的制备方法
TW200946109A (en) * 2008-05-09 2009-11-16 Enanta Pharm Inc Anti-bacterial activity of 9-hydroxy derivatives 6, 11-bicyclolides
US8299035B2 (en) 2008-05-15 2012-10-30 Taisho Pharmaceutucal Co., Ltd. 10a-azalide compound having 4-membered ring structure
SI2358379T1 (sl) 2008-10-24 2016-05-31 Cempra Pharmaceuticals, Inc. Postopki biološke obrambe z makrolidi, ki vsebujejo triazol
MX2011012614A (es) 2009-05-27 2012-02-22 Wockhardt Ltd Compuestos de quetolida que tienen actividad antimicrobiana.
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
CN102724874B (zh) 2009-09-10 2018-06-01 森普拉制药公司 治疗疟疾、结核病和mac疾病的方法
KR20180101643A (ko) 2010-03-22 2018-09-12 셈프라 파마슈티컬스, 인크. 매크로라이드의 결정 형태들 및 그 용도들
CN102917708B (zh) 2010-05-20 2015-11-25 森普拉制药公司 制备大环内酯和酮内酯及其中间体的方法
US8796474B1 (en) 2010-08-23 2014-08-05 Rutgers, The State University Of New Jersey Macrolide compounds and methods and intermediates useful for their preparation
KR20180110181A (ko) 2010-09-10 2018-10-08 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
MX348084B (es) 2010-12-09 2017-05-26 Wockhardt Ltd Compuestos de cetolido.
AR085286A1 (es) * 2011-02-21 2013-09-18 Taisho Pharmaceutical Co Ltd Derivado de macrolido sustituido en la posicion c-4
CN103619849B (zh) 2011-03-01 2016-05-25 沃克哈特有限公司 酮内酯中间体的制备方法
EP2688900B1 (en) 2011-03-22 2016-09-28 Wockhardt Limited Process for preparation of ketolide compounds
CN102766089A (zh) * 2011-05-06 2012-11-07 上海医药工业研究院 3-(3-喹啉基)-2-丙烯-1-卤代物及其制备方法
CN102766181A (zh) * 2011-05-06 2012-11-07 上海医药工业研究院 6-o-取代的红霉素衍生物的制备方法
KR20140139083A (ko) 2012-03-27 2014-12-04 셈프라 파마슈티컬스, 인크. 마크롤라이드계 항생제를 투여하기 위한 비경구 제제
JP5857008B2 (ja) * 2012-08-20 2016-02-10 大正製薬株式会社 C−4”位置換マクロライド誘導体を含有する医薬
GB201217310D0 (en) 2012-09-27 2012-11-14 C10 Pharma As Compounds
US9861616B2 (en) 2013-03-14 2018-01-09 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
RU2015138797A (ru) 2013-03-15 2017-04-24 Семпра Фармасьютикалс, Инк. Конвергентные способы получения макролидных антибактериальных агентов
AR102810A1 (es) 2014-08-18 2017-03-29 Taisho Pharmaceutical Co Ltd Derivado de macrólido sustituido en la posición c-4
WO2018067663A2 (en) 2016-10-04 2018-04-12 Biopharmati Sa Ketolides having antibacterial activity
WO2018161039A1 (en) * 2017-03-03 2018-09-07 Synovo Gmbh Novel anti-infective and anti-inflammatory compounds
CN109942653B (zh) * 2019-02-27 2021-06-25 北京理工大学 一种红霉素衍生物及其制备方法
AU2020395150A1 (en) * 2019-12-02 2022-06-23 AliquantumRx, Inc. Salts and polymorphs of cethromycin for the treatment of disease salts and polymorphs of cethromycin
CN113817008B (zh) * 2021-07-15 2023-05-23 湖州师范学院 新型琥珀酰基十六元大环内酯的制备方法及用途

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR960000434B1 (ko) * 1986-12-17 1996-01-06 다이쇼 세이야꾸 가부시끼가이샤 에리스로마이신 a유도체 및 그의 제조 방법
US5350839A (en) * 1990-10-15 1994-09-27 Taisho Pharmaceutical Co., Ltd. 2'-position modified compound of erythromycin or its derivative
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
KR0166096B1 (ko) * 1990-11-28 1999-01-15 우에하라 아키라 6-0-메틸에리쓰로마이신 a 유도체
WO1993013663A1 (en) * 1992-01-17 1993-07-22 Abbott Laboratories Method of directing biosynthesis of specific polyketides
US5523399A (en) * 1991-12-27 1996-06-04 Taisho Pharmaceutical Co., Ltd. 5-O-desosaminylerythronolide derivatives
CA2093303C (en) * 1992-04-09 1998-11-24 Abraham Araya Aluminosilicates
DK0638585T3 (da) * 1992-04-22 1996-12-02 Taisho Pharmaceutical Co Ltd 5-O-desosaminylerythronolid-A-derivater
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2702480B1 (fr) * 1993-03-09 1995-04-28 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2713226B1 (fr) * 1993-12-03 1996-01-05 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2718450B1 (fr) * 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2719587B1 (fr) * 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2732023B1 (fr) * 1995-03-22 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2732684B1 (fr) * 1995-04-06 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2738571B1 (fr) * 1995-09-11 1997-10-17 Roussel Uclaf Nouveaux derives de la 5-0-desosaminyl 6-0-methyl- erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs
PT876388E (pt) * 1995-11-08 2004-07-30 Abbott Lab Derivados de eritromicina triciclica
US6274715B1 (en) 1995-11-08 2001-08-14 Abbott Laboratories Tricyclic erythromycin derivatives
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
WO1998018808A1 (en) * 1996-10-31 1998-05-07 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
US6171807B1 (en) * 1996-11-13 2001-01-09 Associates Of Cape Cod, Inc. Detection and quantitation of endotoxin by fluorescence polarization

Also Published As

Publication number Publication date
EP1291352A1 (en) 2003-03-12
HK1021537A1 (en) 2000-06-16
ES2242812T3 (es) 2005-11-16
KR20050043994A (ko) 2005-05-11
CZ68599A3 (cs) 1999-08-11
ATE296831T1 (de) 2005-06-15
HRP20060276A2 (en) 2007-10-31
SK285534B6 (sk) 2007-03-01
KR100576988B1 (ko) 2006-05-10
SI20023A (sl) 2000-02-29
PT929563E (pt) 2005-10-31
ES2244716T3 (es) 2005-12-16
USRE39591E1 (en) 2007-04-24
HUP9902869A3 (en) 2001-04-28
KR20050044815A (ko) 2005-05-12
HU230166B1 (hu) 2015-09-28
BG103292A (en) 1999-12-30
CN1680418A (zh) 2005-10-12
DE69733369D1 (de) 2005-06-30
CN1237183A (zh) 1999-12-01
DE69733422D1 (de) 2005-07-07
EP0929563A1 (en) 1999-07-21
PT1291353E (pt) 2005-10-31
ATE296832T1 (de) 2005-06-15
ES2242813T3 (es) 2005-11-16
CA2263972C (en) 2008-01-29
SK285536B6 (sk) 2007-03-01
TR199901127T2 (xx) 1999-07-21
DE69733422T2 (de) 2006-05-04
DK0929563T3 (da) 2005-10-03
ES2242983T3 (es) 2005-11-16
ES2242811T3 (es) 2005-11-16
KR20050044816A (ko) 2005-05-12
US6147197A (en) 2000-11-14
AU729348B2 (en) 2001-02-01
DK1291351T3 (da) 2005-10-24
SI20023B (en) 2001-02-28
RU2192427C2 (ru) 2002-11-10
SK28699A3 (en) 2000-03-13
KR100568455B1 (ko) 2006-04-07
EP1291353B1 (en) 2005-06-01
EP1291351A1 (en) 2003-03-12
DE69733723T2 (de) 2006-04-20
DK1291353T3 (da) 2005-10-03
DE69733370T2 (de) 2006-02-02
PL332009A1 (en) 1999-08-16
CZ300106B6 (cs) 2009-02-11
EP0929563B1 (en) 2005-06-01
CN100460415C (zh) 2009-02-11
PT1291352E (pt) 2005-09-30
CA2263972A1 (en) 1998-03-12
DE69733439T2 (de) 2006-05-04
ID19406A (id) 1998-07-09
CN1680419A (zh) 2005-10-12
BG63547B1 (bg) 2002-04-30
DE69733439D1 (de) 2005-07-07
HRP20060275B1 (hr) 2014-04-11
HRP20060278A2 (en) 2007-10-31
HRP970473A2 (en) 1998-08-31
WO1998009978A1 (en) 1998-03-12
NO314230B1 (no) 2003-02-17
ATE299508T1 (de) 2005-07-15
EP1291350A1 (en) 2003-03-12
ATE296307T1 (de) 2005-06-15
CN100441591C (zh) 2008-12-10
KR100523679B1 (ko) 2005-10-26
NO991022D0 (no) 1999-03-02
RO121473B1 (ro) 2007-06-29
KR20050043993A (ko) 2005-05-11
DE69733370D1 (de) 2005-06-30
SK286181B6 (sk) 2008-04-07
HRP20060277A2 (en) 2007-10-31
DK1291350T3 (da) 2005-09-26
DE69733723D1 (de) 2005-08-18
EP1291352B1 (en) 2005-05-25
NO991022L (no) 1999-05-03
US6075133A (en) 2000-06-13
PL188173B1 (pl) 2004-12-31
KR20000068435A (ko) 2000-11-25
HUP9902869A2 (hu) 2000-02-28
PT1291351E (pt) 2005-11-30
HRP20060277B1 (hr) 2014-04-11
PT1291350E (pt) 2005-09-30
AU4178097A (en) 1998-03-26
JP4597274B2 (ja) 2010-12-15
HRP20060278B1 (hr) 2014-04-11
CN1273475C (zh) 2006-09-06
SK285535B6 (sk) 2007-03-01
KR100610043B1 (ko) 2006-08-08
SK285533B6 (sk) 2007-03-01
HRP970473B1 (en) 2007-02-28
EP1291351B1 (en) 2005-07-13
JP2001500855A (ja) 2001-01-23
BR9711661A (pt) 1999-08-24
NZ334274A (en) 2001-02-23
HRP20060275A2 (en) 2007-10-31
IL128681A0 (en) 2000-01-31
CN1680420A (zh) 2005-10-12
EP1291353A1 (en) 2003-03-12
EP1291350B1 (en) 2005-05-25
US6028181A (en) 2000-02-22
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DE69733369T2 (de) 2006-01-26
HRP20060276B1 (hr) 2014-04-25

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