|
US9273283B2
(en)
*
|
2009-10-29 |
2016-03-01 |
The Trustees Of Dartmouth College |
Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
|
|
CA2853829C
(en)
|
2011-07-22 |
2023-09-26 |
President And Fellows Of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
|
US9458450B2
(en)
|
2012-03-15 |
2016-10-04 |
Flodesign Sonics, Inc. |
Acoustophoretic separation technology using multi-dimensional standing waves
|
|
US10704021B2
(en)
|
2012-03-15 |
2020-07-07 |
Flodesign Sonics, Inc. |
Acoustic perfusion devices
|
|
US10967298B2
(en)
|
2012-03-15 |
2021-04-06 |
Flodesign Sonics, Inc. |
Driver and control for variable impedence load
|
|
US9950282B2
(en)
|
2012-03-15 |
2018-04-24 |
Flodesign Sonics, Inc. |
Electronic configuration and control for acoustic standing wave generation
|
|
US20150017136A1
(en)
*
|
2013-07-15 |
2015-01-15 |
Cellectis |
Methods for engineering allogeneic and highly active t cell for immunotherapy
|
|
EP2855666B1
(en)
|
2012-05-25 |
2019-12-04 |
Cellectis |
Use of pre t alpha or functional variant thereof for expanding tcr alpha deficient t cells
|
|
CA2886684C
(en)
*
|
2012-10-10 |
2023-09-19 |
Sangamo Biosciences, Inc. |
T cell modifying compounds and uses thereof
|
|
ES2776698T3
(es)
|
2012-12-20 |
2020-07-31 |
Purdue Research Foundation |
Células T que expresan un receptor antigénico quimérico como terapia contra el cáncer
|
|
PL3300745T3
(pl)
|
2013-02-15 |
2020-03-31 |
The Regents Of The University Of California |
Chimeryczny receptor antygenowy i sposoby jego zastosowania
|
|
US9499855B2
(en)
|
2013-03-14 |
2016-11-22 |
Elwha Llc |
Compositions, methods, and computer systems related to making and administering modified T cells
|
|
US9587237B2
(en)
|
2013-03-14 |
2017-03-07 |
Elwha Llc |
Compositions, methods, and computer systems related to making and administering modified T cells
|
|
SG11201506974XA
(en)
*
|
2013-03-14 |
2015-10-29 |
Bellicum Pharmaceuticals Inc |
Methods for controlling t cell proliferation
|
|
JP6005572B2
(ja)
*
|
2013-03-28 |
2016-10-12 |
Kddi株式会社 |
動画像符号化装置、動画像復号装置、動画像符号化方法、動画像復号方法、およびプログラム
|
|
WO2014165707A2
(en)
*
|
2013-04-03 |
2014-10-09 |
Memorial Sloan-Kettering Cancer Center |
Effective generation of tumor-targeted t-cells derived from pluripotent stem cells
|
|
US11077144B2
(en)
|
2013-05-13 |
2021-08-03 |
Cellectis |
CD19 specific chimeric antigen receptor and uses thereof
|
|
US20230050345A1
(en)
*
|
2013-05-13 |
2023-02-16 |
Cellectis |
Methods for engineering allogeneic and highly active t cell for immunotheraphy
|
|
US11311575B2
(en)
|
2013-05-13 |
2022-04-26 |
Cellectis |
Methods for engineering highly active T cell for immunotherapy
|
|
US20230056268A1
(en)
*
|
2013-05-13 |
2023-02-23 |
Cellectis |
Methods for engineering highly active t cell for immunotheraphy
|
|
US9629877B2
(en)
|
2013-05-14 |
2017-04-25 |
Board Of Regents, The University Of Texas System |
Human application of engineered chimeric antigen receptor (CAR) T-cells
|
|
ES2883131T3
(es)
|
2013-05-29 |
2021-12-07 |
Cellectis |
Métodos para la modificación de células T para inmunoterapia utilizando el sistema de nucleasa CAS guiado por ARN
|
|
JP6608807B2
(ja)
|
2013-05-29 |
2019-11-20 |
セレクティス |
Rnaガイドcasヌクレアーゼ系を用いることによって免疫療法のためにt細胞を操作するための方法
|
|
US10208125B2
(en)
|
2013-07-15 |
2019-02-19 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Anti-mucin 1 binding agents and uses thereof
|
|
US9163284B2
(en)
|
2013-08-09 |
2015-10-20 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a Cas9 nuclease
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
|
US9388430B2
(en)
|
2013-09-06 |
2016-07-12 |
President And Fellows Of Harvard College |
Cas9-recombinase fusion proteins and uses thereof
|
|
US9228207B2
(en)
|
2013-09-06 |
2016-01-05 |
President And Fellows Of Harvard College |
Switchable gRNAs comprising aptamers
|
|
CN111218447B
(zh)
|
2013-11-07 |
2024-10-11 |
爱迪塔斯医药有限公司 |
使用统治型gRNA的CRISPR相关方法和组合物
|
|
RU2689558C1
(ru)
*
|
2013-11-22 |
2019-05-28 |
Селлектис |
Способ конструирования аллогенных и устойчивых к лекарственным препаратам т-клеток для иммунотерапии
|
|
MX378635B
(es)
|
2013-11-22 |
2025-03-10 |
Cellectis |
Método para diseñar células t resistentes a fármacos de quimioterapia para inmunoterapia.
|
|
WO2015075175A1
(en)
*
|
2013-11-22 |
2015-05-28 |
Cellectis |
Method for generating batches of allogeneic t-cells with averaged potency
|
|
WO2015077717A1
(en)
|
2013-11-25 |
2015-05-28 |
The Broad Institute Inc. |
Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status
|
|
WO2015085147A1
(en)
|
2013-12-05 |
2015-06-11 |
The Broad Institute Inc. |
Polymorphic gene typing and somatic change detection using sequencing data
|
|
US20150166982A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting pi3k point mutations
|
|
CA2934073A1
(en)
|
2013-12-20 |
2015-06-25 |
The Broad Institute, Inc. |
Combination therapy with neoantigen vaccine
|
|
JP2017504601A
(ja)
*
|
2013-12-20 |
2017-02-09 |
セレクティスCellectis |
免疫療法のためにマルチインプットシグナル感受性t細胞を操作する方法
|
|
EP3092049A1
(en)
|
2014-01-08 |
2016-11-16 |
Flodesign Sonics Inc. |
Acoustophoresis device with dual acoustophoretic chamber
|
|
EP3094354B1
(en)
|
2014-01-14 |
2018-10-17 |
Cellectis |
Chimeric antigen receptor using antigen recognition domains derived from cartilaginous fish
|
|
WO2015123339A1
(en)
|
2014-02-11 |
2015-08-20 |
The Regents Of The University Of Colorado, A Body Corporate |
Crispr enabled multiplexed genome engineering
|
|
RU2021123419A
(ru)
*
|
2014-02-14 |
2021-10-22 |
Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем |
Химерные антигенные рецепторы и способы их получения
|
|
CN106132423B
(zh)
|
2014-02-14 |
2020-07-31 |
贝里坤制药股份有限公司 |
用诱导型嵌合多肽活化t细胞的方法
|
|
KR102157924B1
(ko)
|
2014-02-14 |
2020-10-26 |
셀렉티스 |
면역 세포들 및 병리 세포들 둘 다에 존재하는 항원을 타겟팅하기 위하여 조작된 면역치료용 세포들
|
|
US10196608B2
(en)
*
|
2014-02-21 |
2019-02-05 |
Cellectis |
Method for in situ inhibition of regulatory T cells
|
|
US20230027993A1
(en)
|
2014-03-05 |
2023-01-26 |
Autolus Limited |
Methods
|
|
US11385233B2
(en)
|
2015-03-05 |
2022-07-12 |
Autolus Limited |
Methods of depleting malignant T-cells
|
|
RU2744046C2
(ru)
*
|
2014-03-05 |
2021-03-02 |
Отолус Лимитед |
ХИМЕРНЫЙ АНТИГЕННЫЙ РЕЦЕПТОР (CAR) С АНТИГЕНСВЯЗЫВАЮЩИМИ ДОМЕНАМИ К КОНСТАНТНОЙ ОБЛАСТИ β Т-КЛЕТОЧНОГО РЕЦЕПТОРА
|
|
RU2752933C2
(ru)
|
2014-03-11 |
2021-08-11 |
Селлектис |
Способ создания т-клеток, пригодных для аллогенной трансплантации
|
|
MX370272B
(es)
|
2014-03-19 |
2019-12-09 |
Cellectis |
Receptores de antigeno quimerico especifico de cd123 para inmunoterapia de cancer.
|
|
CA2944528C
(en)
|
2014-04-03 |
2021-08-10 |
Cellectis |
Cd33 specific chimeric antigen receptors for cancer immunotherapy
|
|
JP2017513472A
(ja)
*
|
2014-04-11 |
2017-06-01 |
セレクティスCellectis |
アルギニンおよび/またはトリプトファン枯渇微小環境に対して抵抗性を有する免疫細胞を作製するための方法
|
|
CA2945620C
(en)
|
2014-04-14 |
2022-12-06 |
Cellectis |
Bcma (cd269) specific chimeric antigen receptors for cancer immunotherapy
|
|
KR102595473B1
(ko)
*
|
2014-04-18 |
2023-10-30 |
에디타스 메디신, 인코포레이티드 |
암 면역요법을 위한 crispr-cas-관련 방법, 조성물 및 구성성분
|
|
EP3137498A1
(en)
|
2014-05-02 |
2017-03-08 |
Cellectis |
Cs1 specific multi-chain chimeric antigen receptor
|
|
AU2015289644A1
(en)
|
2014-07-15 |
2017-02-02 |
Juno Therapeutics, Inc. |
Engineered cells for adoptive cell therapy
|
|
WO2016016344A1
(en)
|
2014-07-29 |
2016-02-04 |
Cellectis |
Ror1(ntrkr1)specific chimeric antigen receptors for cancer immunotherapy
|
|
EP3177718B1
(en)
|
2014-07-30 |
2022-03-16 |
President and Fellows of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
|
CA2956482A1
(en)
|
2014-07-31 |
2016-02-04 |
Cellectis |
Ror1 specific multi-chain chimeric antigen receptor
|
|
PL3177640T3
(pl)
|
2014-08-08 |
2020-11-02 |
The Board Of Trustees Of The Leland Stanford Junior University |
Charakteryzujące się wysokim powinowactwem środki terapeutyczne naśladujące PD-11 i sposoby ich wykorzystania
|
|
EP3189148A4
(en)
|
2014-09-02 |
2018-05-02 |
Bellicum Pharmaceuticals, Inc. |
Costimulation of chimeric antigen receptors by myd88 and cd40 polypeptides
|
|
DK3189073T4
(da)
|
2014-09-04 |
2025-08-18 |
Cellectis |
Trofoblastglykoprotein (5t4, tpbg)-specifikke kimære antigenreceptorer til cancerimmunterapi
|
|
EP3209679A1
(en)
*
|
2014-10-24 |
2017-08-30 |
BCRT Holding BV |
T cell-based immunotherapeutics
|
|
EP3215168B1
(en)
|
2014-10-31 |
2023-08-02 |
The Trustees of the University of Pennsylvania |
Altering gene expression in modified t cells and uses thereof
|
|
SG10202002324SA
(en)
*
|
2014-11-05 |
2020-05-28 |
Juno Therapeutics Inc |
Methods for transduction and cell processing
|
|
GB201421096D0
(en)
*
|
2014-11-27 |
2015-01-14 |
Imp Innovations Ltd |
Genome editing methods
|
|
ES3049406T3
(en)
|
2014-12-19 |
2025-12-16 |
Broad Inst Inc |
Methods for profiling the t-cell-receptor repertoire
|
|
EP3234193B1
(en)
|
2014-12-19 |
2020-07-15 |
Massachusetts Institute of Technology |
Molecular biomarkers for cancer immunotherapy
|
|
AU2016211671B2
(en)
|
2015-01-26 |
2022-05-26 |
Fate Therapeutics, Inc. |
Methods and compositions for inducing hematopoietic cell differentiation
|
|
CA2973529A1
(en)
|
2015-01-26 |
2016-08-04 |
Cellectis |
Cll1-specific multi-chain chimeric antigen receptor
|
|
KR101755431B1
(ko)
*
|
2015-02-02 |
2017-07-12 |
단국대학교 산학협력단 |
키메릭 항원 수용체(Chimeric antigen receptor) 전달용 CTLA-4 타겟팅 트랜스-스플라이싱 라이보자임 및 이의 용도
|
|
AU2016214301B2
(en)
*
|
2015-02-06 |
2022-05-19 |
Cellectis |
Primary hematopoietic cells genetically engineered by slow release of nucleic acids using nanoparticles
|
|
US20170151281A1
(en)
|
2015-02-19 |
2017-06-01 |
Batu Biologics, Inc. |
Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer
|
|
AU2016222887B2
(en)
|
2015-02-24 |
2022-07-14 |
The Regents Of The University Of California |
Binding-triggered transcriptional switches and methods of use thereof
|
|
RU2688692C2
(ru)
*
|
2015-03-02 |
2019-05-22 |
Инновейтив Целлюлар Терапевтикс КО., ЛТД. |
Фармацевтическая композиция, обладающая противоопухолевым эффектом, и способ снижения ингибирующего эффекта pd-l1 на т-клетки человека
|
|
EP3268388A1
(en)
*
|
2015-03-11 |
2018-01-17 |
Cellectis |
Methods for engineering allogeneic t cell to increase their persistence and/or engraftment into patients
|
|
JP7362249B2
(ja)
*
|
2015-03-20 |
2023-10-17 |
チルドレンズ ナショナル メディカル センター |
ナイーブt細胞集団からのウイルスまたは他の抗原に特異的なt細胞の生成
|
|
GB201504840D0
(en)
*
|
2015-03-23 |
2015-05-06 |
Ucl Business Plc |
Chimeric antigen receptor
|
|
BR112017020750A2
(pt)
*
|
2015-03-27 |
2018-06-26 |
Harvard College |
células t modificadas e métodos de produção e utilização das mesmas
|
|
WO2016166268A1
(en)
|
2015-04-17 |
2016-10-20 |
Cellectis |
Engineering animal or plant genome using dna-guided argonaute interference systems (dais) from mesophilic prokaryotes
|
|
US11377651B2
(en)
|
2016-10-19 |
2022-07-05 |
Flodesign Sonics, Inc. |
Cell therapy processes utilizing acoustophoresis
|
|
US11021699B2
(en)
|
2015-04-29 |
2021-06-01 |
FioDesign Sonics, Inc. |
Separation using angled acoustic waves
|
|
US11708572B2
(en)
|
2015-04-29 |
2023-07-25 |
Flodesign Sonics, Inc. |
Acoustic cell separation techniques and processes
|
|
WO2016179319A1
(en)
*
|
2015-05-04 |
2016-11-10 |
Cellerant Therapeutics, Inc. |
Chimeric antigen receptors with ctla4 signal transduction domains
|
|
CA2988854A1
(en)
|
2015-05-08 |
2016-11-17 |
President And Fellows Of Harvard College |
Universal donor stem cells and related methods
|
|
MX382223B
(es)
*
|
2015-05-12 |
2025-03-13 |
Sangamo Therapeutics Inc |
Regulacion de expresion genica mediada por nucleasa.
|
|
CN114634943A
(zh)
|
2015-05-18 |
2022-06-17 |
T细胞受体治疗公司 |
使用融合蛋白对tcr重编程的组合物和方法
|
|
PE20180670A1
(es)
|
2015-05-20 |
2018-04-19 |
Broad Inst Inc |
Neoantigenos compartidos
|
|
US10752670B2
(en)
|
2015-05-20 |
2020-08-25 |
Cellectis |
Anti-GD3 specific chimeric antigen receptors for cancer immunotherapy
|
|
CN108174607A
(zh)
|
2015-05-29 |
2018-06-15 |
朱诺治疗学股份有限公司 |
用于遗传工程改造的细胞中调节抑制性相互作用的组合物和方法
|
|
WO2016205749A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
|
WO2017001572A1
(en)
|
2015-06-30 |
2017-01-05 |
Cellectis |
Methods for improving functionality in nk cell by gene inactivation using specific endonuclease
|
|
CA2991301A1
(en)
*
|
2015-07-13 |
2017-01-19 |
Sangamo Therapeutics, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering
|
|
US20170014449A1
(en)
*
|
2015-07-13 |
2017-01-19 |
Elwha LLC, a limited liability company of the State of Delaware |
Site-specific epigenetic editing
|
|
MA42895A
(fr)
*
|
2015-07-15 |
2018-05-23 |
Juno Therapeutics Inc |
Cellules modifiées pour thérapie cellulaire adoptive
|
|
US11474085B2
(en)
|
2015-07-28 |
2022-10-18 |
Flodesign Sonics, Inc. |
Expanded bed affinity selection
|
|
US11459540B2
(en)
|
2015-07-28 |
2022-10-04 |
Flodesign Sonics, Inc. |
Expanded bed affinity selection
|
|
GB2592821B
(en)
|
2015-07-31 |
2022-01-12 |
Univ Minnesota |
Modified cells and methods of therapy
|
|
AU2016307050A1
(en)
*
|
2015-08-11 |
2018-02-15 |
Cellectis |
Cells for immunotherapy engineered for targeting CD38 antigen and for CD38 gene inactivation
|
|
US11890301B2
(en)
|
2015-08-28 |
2024-02-06 |
The Trustees Of The University Of Pennsylvania |
Methods and compositions for cells expressing a chimeric intracellular signaling molecule
|
|
EP3340998B1
(en)
*
|
2015-08-28 |
2023-01-11 |
The Trustees of the University of Pennsylvania |
Methods and compositions for cells expressing a chimeric intracellular signaling molecule
|
|
KR20250013291A
(ko)
*
|
2015-10-05 |
2025-01-31 |
프리시젼 바이오사이언시스 인코포레이티드 |
변형된 인간 t 세포 수용체 알파 불변 영역 유전자를 포함하는 유전자 변형된 세포
|
|
EP3940070A1
(en)
|
2015-10-05 |
2022-01-19 |
Precision Biosciences, Inc. |
Engineered meganucleases with recognition sequences found in the human t cell receptor alpha constant region gene
|
|
US12241053B2
(en)
|
2015-10-09 |
2025-03-04 |
The Brigham And Women's Hospital, Inc. |
Modulation of novel immune checkpoint targets
|
|
WO2017070429A1
(en)
*
|
2015-10-22 |
2017-04-27 |
Regents Of The University Of Minnesota |
Methods involving editing polynucleotides that encode t cell receptor
|
|
SG11201803173VA
(en)
|
2015-10-23 |
2018-05-30 |
Harvard College |
Nucleobase editors and uses thereof
|
|
WO2017075465A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3
|
|
WO2017075478A2
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by use of immune cell gene signatures
|
|
WO2017075451A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1
|
|
EP3368051A4
(en)
|
2015-10-30 |
2019-06-26 |
Children's National Medical Center |
GENERATION OF HPV ANTIGEN-SPECIFIC T CELLS FROM A NAIVEN T CELL POPULATION
|
|
PT3371314T
(pt)
|
2015-11-04 |
2023-08-31 |
Fate Therapeutics Inc |
Modificação genómica de células pluripotentes
|
|
CA3003152A1
(en)
|
2015-11-04 |
2017-05-11 |
Fate Therapeutics, Inc. |
Methods and compositions for inducing hematopoietic cell differentiation
|
|
CA3004421A1
(en)
*
|
2015-11-05 |
2017-05-11 |
Baylor College Of Medicine |
An efficient, scalable patient-derived xenograft system based on a chick chorioallantoic membrane (cam) in vivo model
|
|
WO2017087708A1
(en)
|
2015-11-19 |
2017-05-26 |
The Brigham And Women's Hospital, Inc. |
Lymphocyte antigen cd5-like (cd5l)-interleukin 12b (p40) heterodimers in immunity
|
|
CN108699557B
(zh)
|
2015-12-04 |
2025-08-15 |
诺华股份有限公司 |
用于免疫肿瘤学的组合物和方法
|
|
EP3389677B1
(en)
*
|
2015-12-18 |
2024-06-26 |
Sangamo Therapeutics, Inc. |
Targeted disruption of the t cell receptor
|
|
CN105505869A
(zh)
*
|
2015-12-21 |
2016-04-20 |
河南大学淮河医院 |
一种针对肿瘤干细胞的嵌合抗原受体t细胞
|
|
EP3184548A1
(en)
*
|
2015-12-23 |
2017-06-28 |
Miltenyi Biotec GmbH |
Chimeric antigen receptor with cytokine receptor activating or blocking domain
|
|
SG10201913805RA
(en)
|
2016-01-08 |
2020-03-30 |
Univ California |
Conditionally active heterodimeric polypeptides and methods of use thereof
|
|
CN109311984A
(zh)
*
|
2016-03-11 |
2019-02-05 |
蓝鸟生物公司 |
基因组编辑的免疫效应细胞
|
|
GB201604213D0
(en)
*
|
2016-03-11 |
2016-04-27 |
Proximagen Ltd |
Drug combination and its use in therapy
|
|
WO2017177137A1
(en)
*
|
2016-04-07 |
2017-10-12 |
Bluebird Bio, Inc. |
Chimeric antigen receptor t cell compositions
|
|
JP7282521B2
(ja)
|
2016-04-08 |
2023-05-29 |
パーデュー・リサーチ・ファウンデイション |
Car t細胞療法のための方法および組成物
|
|
EP3443001B1
(en)
|
2016-04-11 |
2025-04-30 |
Obsidian Therapeutics, Inc. |
REGULATED BIOCIRCUIT SYSTEMS
|
|
EP4628587A2
(en)
|
2016-04-15 |
2025-10-08 |
Memorial Sloan Kettering Cancer Center |
Transgenic t cell and chimeric antigen receptor t cell compositions and related methods
|
|
WO2017178586A1
(en)
|
2016-04-15 |
2017-10-19 |
Cellectis |
A method of engineering prodrug-specific hypersensitive t-cells for immunotherapy by gene expression
|
|
CN109153727A
(zh)
*
|
2016-04-15 |
2019-01-04 |
酵活有限公司 |
靶向免疫治疗剂的多特异性抗原结合构建体
|
|
WO2017178585A1
(en)
|
2016-04-15 |
2017-10-19 |
Cellectis |
A method of engineering drug-specific hypersensitive t-cells for immunotherapy by gene inactivation
|
|
EP3446119A1
(en)
|
2016-04-18 |
2019-02-27 |
The Broad Institute Inc. |
Improved hla epitope prediction
|
|
WO2017192536A1
(en)
|
2016-05-02 |
2017-11-09 |
University Of Kansas |
Eliminating mhc restriction from the t cell receptor as a strategy for immunotherapy
|
|
US11214789B2
(en)
|
2016-05-03 |
2022-01-04 |
Flodesign Sonics, Inc. |
Concentration and washing of particles with acoustics
|
|
US11085035B2
(en)
|
2016-05-03 |
2021-08-10 |
Flodesign Sonics, Inc. |
Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
|
|
US10017760B2
(en)
|
2016-06-24 |
2018-07-10 |
Inscripta, Inc. |
Methods for generating barcoded combinatorial libraries
|
|
US11466291B2
(en)
|
2016-07-06 |
2022-10-11 |
Cellectis |
Sequential gene editing in primary immune cells
|
|
US11384156B2
(en)
|
2016-07-25 |
2022-07-12 |
The Nemours Foundation |
Adoptive T-cell therapy using EMPD-specific chimeric antigen receptors for treating IgE-mediated allergic diseases
|
|
EP3494138A1
(en)
|
2016-08-02 |
2019-06-12 |
TCR2 Therapeutics Inc. |
Compositions and methods for tcr reprogramming using fusion proteins
|
|
JP7231935B2
(ja)
|
2016-08-03 |
2023-03-08 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
アデノシン核酸塩基編集因子およびそれらの使用
|
|
CA3032429A1
(en)
|
2016-08-03 |
2018-02-08 |
Washington University |
Gene editing of car-t cells for the treatment of t cell malignancies with chimeric antigen receptors
|
|
CA3033327A1
(en)
|
2016-08-09 |
2018-02-15 |
President And Fellows Of Harvard College |
Programmable cas9-recombinase fusion proteins and uses thereof
|
|
US11630103B2
(en)
|
2016-08-17 |
2023-04-18 |
The Broad Institute, Inc. |
Product and methods useful for modulating and evaluating immune responses
|
|
CA3034882A1
(en)
|
2016-08-24 |
2018-03-01 |
Sangamo Therapeutics, Inc. |
Regulation of gene expression using engineered nucleases
|
|
WO2018039438A1
(en)
|
2016-08-24 |
2018-03-01 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
BR112019003327A2
(pt)
*
|
2016-08-24 |
2019-07-02 |
Sangamo Therapeutics, Inc. |
nucleases manipuladas de alvo específico
|
|
ES2981703T3
(es)
|
2016-09-02 |
2024-10-10 |
Lentigen Tech Inc |
Composiciones y métodos para tratar cáncer con DuoCars
|
|
WO2018049025A2
(en)
|
2016-09-07 |
2018-03-15 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses
|
|
CA3035455A1
(en)
|
2016-09-08 |
2018-03-15 |
Bluebird Bio, Inc. |
Pd-1 homing endonuclease variants, compositions, and methods of use
|
|
CA3036972A1
(en)
|
2016-09-14 |
2018-03-22 |
Janssen Biotech, Inc. |
Chimeric antigen receptors comprising bcma-specific fibronectin type iii domains and uses thereof
|
|
US12499971B2
(en)
|
2016-09-28 |
2025-12-16 |
The Broad Institute, Inc. |
Systematic screening and mapping of regulatory elements in non-coding genomic regions, methods, compositions, and applications thereof
|
|
AU2017338827B2
(en)
|
2016-10-03 |
2023-08-31 |
Juno Therapeutics, Inc. |
HPV-specific binding molecules
|
|
JP7248571B2
(ja)
|
2016-10-05 |
2023-03-29 |
フジフィルム セルラー ダイナミクス,インコーポレイテッド |
MeCP2が破壊された誘導多能性幹細胞からの成熟系列の生成
|
|
GB2564823B8
(en)
|
2016-10-07 |
2022-06-29 |
Tcr2 Therapeutics Inc |
Compositions and methods for TCR reprogramming using fusion proteins
|
|
WO2018067991A1
(en)
|
2016-10-07 |
2018-04-12 |
The Brigham And Women's Hospital, Inc. |
Modulation of novel immune checkpoint targets
|
|
MX2019004156A
(es)
*
|
2016-10-11 |
2019-09-26 |
Bluebird Bio Inc |
Variantes de endonucleasa homing de receptor de linfocitos t alfa (tcralpha).
|
|
WO2018071868A1
(en)
|
2016-10-14 |
2018-04-19 |
President And Fellows Of Harvard College |
Aav delivery of nucleobase editors
|
|
CA3041068A1
(en)
|
2016-10-18 |
2018-04-26 |
Regents Of The University Of Minnesota |
Tumor infiltrating lymphocytes and methods of therapy
|
|
JP7236380B2
(ja)
*
|
2016-10-19 |
2023-03-09 |
セレクティス |
治療に適したtalエフェクターヌクレアーゼ(talen)改変同種異系細胞
|
|
KR20190127655A
(ko)
|
2016-10-19 |
2019-11-13 |
프로디자인 소닉스, 인크. |
음향학에 의한 친화성 세포 추출
|
|
WO2018073393A2
(en)
|
2016-10-19 |
2018-04-26 |
Cellectis |
Tal-effector nuclease (talen) -modified allogenic cells suitable for therapy
|
|
AU2017347637B2
(en)
*
|
2016-10-19 |
2024-02-15 |
Cellectis |
Targeted gene insertion for improved immune cells therapy
|
|
WO2018073394A1
(en)
|
2016-10-19 |
2018-04-26 |
Cellectis |
Cell death inducing chimeric antigen receptors
|
|
WO2018073391A1
(en)
|
2016-10-19 |
2018-04-26 |
Cellectis |
Targeted gene insertion for improved immune cells therapy
|
|
EP3321280B8
(en)
|
2016-11-10 |
2021-03-10 |
Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts |
Immune modulators for reducing immune-resistance in melanoma and other proliferative diseases
|
|
WO2018087276A1
(en)
|
2016-11-10 |
2018-05-17 |
Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts |
Or10h1 modulators and uses thereof
|
|
WO2018089386A1
(en)
|
2016-11-11 |
2018-05-17 |
The Broad Institute, Inc. |
Modulation of intestinal epithelial cell differentiation, maintenance and/or function through t cell action
|
|
CA3044593A1
(en)
|
2016-11-22 |
2018-05-31 |
TCR2 Therapeutics Inc. |
Compositions and methods for tcr reprogramming using fusion proteins
|
|
IL266892B2
(en)
|
2016-12-02 |
2025-10-01 |
Univ Southern California |
Artificial immune receptors and methods of using them
|
|
EP3548622A1
(en)
|
2016-12-02 |
2019-10-09 |
Juno Therapeutics, Inc. |
Engineered b cells and related compositions and methods
|
|
WO2018115189A1
(en)
|
2016-12-21 |
2018-06-28 |
Cellectis |
Stably enginereed proteasome inhibitor resistant immune cells for immunotherapy
|
|
CA3048211A1
(en)
|
2016-12-23 |
2018-06-28 |
Macrogenics, Inc. |
Adam9-binding molecules, and methods of use thereof
|
|
US10745677B2
(en)
|
2016-12-23 |
2020-08-18 |
President And Fellows Of Harvard College |
Editing of CCR5 receptor gene to protect against HIV infection
|
|
CN110268050B
(zh)
*
|
2017-01-10 |
2024-09-13 |
综合医院公司 |
经修饰的t细胞和它们的使用方法
|
|
EP3574116A1
(en)
|
2017-01-24 |
2019-12-04 |
The Broad Institute, Inc. |
Compositions and methods for detecting a mutant variant of a polynucleotide
|
|
TW201839136A
(zh)
|
2017-02-06 |
2018-11-01 |
瑞士商諾華公司 |
治療血色素異常症之組合物及方法
|
|
US11649288B2
(en)
|
2017-02-07 |
2023-05-16 |
Seattle Children's Hospital |
Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents
|
|
JP7236398B2
(ja)
*
|
2017-02-15 |
2023-03-09 |
2セブンティ バイオ インコーポレイテッド |
ドナー修復鋳型多重ゲノム編集
|
|
WO2018160622A1
(en)
|
2017-02-28 |
2018-09-07 |
Endocyte, Inc. |
Compositions and methods for car t cell therapy
|
|
US12390514B2
(en)
|
2017-03-09 |
2025-08-19 |
President And Fellows Of Harvard College |
Cancer vaccine
|
|
EP3592853A1
(en)
|
2017-03-09 |
2020-01-15 |
President and Fellows of Harvard College |
Suppression of pain by gene editing
|
|
JP2020510439A
(ja)
|
2017-03-10 |
2020-04-09 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
シトシンからグアニンへの塩基編集因子
|
|
WO2018167486A1
(en)
|
2017-03-15 |
2018-09-20 |
Oxford Biomedica (Uk) Limited |
Method
|
|
CN110832075A
(zh)
|
2017-03-22 |
2020-02-21 |
诺华股份有限公司 |
用于免疫肿瘤学的组合物和方法
|
|
KR20240116572A
(ko)
|
2017-03-23 |
2024-07-29 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제
|
|
WO2018178377A1
(en)
|
2017-03-31 |
2018-10-04 |
Cellectis Sa |
Universal anti-cd22 chimeric antigen receptor engineered immune cells
|
|
WO2018183908A1
(en)
|
2017-03-31 |
2018-10-04 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for treating ovarian tumors
|
|
WO2018183921A1
(en)
|
2017-04-01 |
2018-10-04 |
The Broad Institute, Inc. |
Methods and compositions for detecting and modulating an immunotherapy resistance gene signature in cancer
|
|
CN118370809A
(zh)
|
2017-04-03 |
2024-07-23 |
百欧恩泰美国公司 |
蛋白质抗原及其用途
|
|
US20200071773A1
(en)
|
2017-04-12 |
2020-03-05 |
Massachusetts Eye And Ear Infirmary |
Tumor signature for metastasis, compositions of matter methods of use thereof
|
|
CA3059643A1
(en)
|
2017-04-13 |
2018-10-18 |
Cellectis |
New sequence specific reagents targeting ccr5 in primary hematopoietic cells
|
|
AU2018256436B2
(en)
|
2017-04-19 |
2024-12-05 |
Board Of Regents, The University Of Texas System |
Immune cells expressing engineered antigen receptors
|
|
DK3391907T3
(da)
|
2017-04-20 |
2020-03-09 |
Iomx Therapeutics Ag |
Intracellulær kinase sik3, der er associeret med resistens over for antitumorimmunresponser, og anvendelser deraf
|
|
WO2018209324A2
(en)
|
2017-05-11 |
2018-11-15 |
The Broad Institute, Inc. |
Methods and compositions of use of cd8+ tumor infiltrating lymphocyte subtypes and gene signatures thereof
|
|
CN110914289B
(zh)
|
2017-05-12 |
2024-05-14 |
克里斯珀医疗股份公司 |
用于工程化细胞的材料和方法及其在免疫肿瘤学中的用途
|
|
US11560566B2
(en)
|
2017-05-12 |
2023-01-24 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
|
|
US11166985B2
(en)
|
2017-05-12 |
2021-11-09 |
Crispr Therapeutics Ag |
Materials and methods for engineering cells and uses thereof in immuno-oncology
|
|
EP3625342B1
(en)
|
2017-05-18 |
2022-08-24 |
The Broad Institute, Inc. |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
US11241485B2
(en)
|
2017-06-12 |
2022-02-08 |
Obsidian Therapeutics, Inc. |
PDE5 compositions and methods for immunotherapy
|
|
US11897953B2
(en)
|
2017-06-14 |
2024-02-13 |
The Broad Institute, Inc. |
Compositions and methods targeting complement component 3 for inhibiting tumor growth
|
|
US20210139870A1
(en)
|
2017-06-19 |
2021-05-13 |
Cellectis |
Anti-hbv combination therapies involving specific endonucleases
|
|
DK3538645T3
(da)
|
2017-06-20 |
2021-04-19 |
Inst Curie |
Immunceller der mangler suv39h1
|
|
CN111373260A
(zh)
*
|
2017-06-22 |
2020-07-03 |
得克萨斯大学体系董事会 |
产生调节性免疫细胞的方法及其用途
|
|
US9982279B1
(en)
|
2017-06-23 |
2018-05-29 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
US10011849B1
(en)
|
2017-06-23 |
2018-07-03 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
CN111511375A
(zh)
|
2017-06-30 |
2020-08-07 |
因提玛生物科学公司 |
用于基因治疗的腺相关病毒载体
|
|
CA3067914A1
(en)
*
|
2017-06-30 |
2019-01-03 |
Cellectis |
Cellular immunotherapy for repetitive administration
|
|
CA3068465A1
(en)
|
2017-06-30 |
2019-01-03 |
Precision Biosciences, Inc. |
Genetically-modified t cells comprising a modified intron in the t cell receptor alpha gene
|
|
GB201710973D0
(en)
|
2017-07-07 |
2017-08-23 |
Avacta Life Sciences Ltd |
Scaffold proteins
|
|
EP3640333A4
(en)
|
2017-07-14 |
2020-12-30 |
Cure Genetics Co., Ltd |
GENE EDITING SYSTEM AND GENE EDITING METHOD
|
|
US12049643B2
(en)
|
2017-07-14 |
2024-07-30 |
The Broad Institute, Inc. |
Methods and compositions for modulating cytotoxic lymphocyte activity
|
|
JP7280238B2
(ja)
|
2017-07-17 |
2023-05-23 |
ヤンセン バイオテツク,インコーポレーテツド |
フィブロネクチンiii型ドメインに対する抗原結合領域及びその使用方法
|
|
EP3638260A1
(en)
|
2017-07-21 |
2020-04-22 |
Cellectis |
Engineered immune cells resistant to tumor microoenvironment
|
|
WO2019016360A1
(en)
|
2017-07-21 |
2019-01-24 |
Cellectis |
MODIFIED IMMUNE CELLS RESISTANT TO TUMOR MICRO-ENVIRONMENT
|
|
CN118206655A
(zh)
*
|
2017-07-25 |
2024-06-18 |
得克萨斯大学体系董事会 |
增强的嵌合抗原受体及其用途
|
|
WO2019020733A1
(en)
|
2017-07-26 |
2019-01-31 |
Cellectis |
METHODS OF IMMUNE CELL SELECTION OF THE ANTIGEN-DEPENDENT CHIMERIC ANTIGENIC RECEPTOR (CAR)
|
|
EP3658573A1
(en)
|
2017-07-28 |
2020-06-03 |
President and Fellows of Harvard College |
Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace)
|
|
WO2019139645A2
(en)
|
2017-08-30 |
2019-07-18 |
President And Fellows Of Harvard College |
High efficiency base editors comprising gam
|
|
KR20200055037A
(ko)
|
2017-09-19 |
2020-05-20 |
메사추세츠 인스티튜트 오브 테크놀로지 |
키메라 항원 수용체 t 세포 요법을 위한 조성물 및 그의 용도
|
|
AU2018338318B2
(en)
|
2017-09-21 |
2022-12-22 |
Massachusetts Institute Of Technology |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
WO2019070755A1
(en)
|
2017-10-02 |
2019-04-11 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING A GENETIC SIGNATURE OF IMMUNOTHERAPY RESISTANCE IN CANCER
|
|
US11952408B2
(en)
|
2017-10-03 |
2024-04-09 |
Juno Therapeutics, Inc. |
HPV-specific binding molecules
|
|
WO2019072824A1
(en)
|
2017-10-09 |
2019-04-18 |
Cellectis |
IMPROVED ANTI-CD123 CAR IN UNIVERSAL MODIFIED IMMUNE T LYMPHOCYTES
|
|
AU2018352592C1
(en)
|
2017-10-16 |
2025-09-25 |
Beam Therapeutics, Inc. |
Uses of adenosine base editors
|
|
WO2019076486A1
(en)
|
2017-10-19 |
2019-04-25 |
Cellectis |
TARGETED GENE INTEGRATION OF NK INHIBITOR GENES FOR ENHANCED IMMUNE CELL THERAPY
|
|
KR20200094147A
(ko)
|
2017-10-31 |
2020-08-06 |
알로젠 테라퓨틱스 인코포레이티드 |
동종이계 키메라 항원 수용체 t 세포를 투여하기 위한 방법 및 조성물
|
|
WO2019094955A1
(en)
|
2017-11-13 |
2019-05-16 |
The Broad Institute, Inc. |
Methods and compositions for targeting developmental and oncogenic programs in h3k27m gliomas
|
|
WO2019094983A1
(en)
|
2017-11-13 |
2019-05-16 |
The Broad Institute, Inc. |
Methods and compositions for treating cancer by targeting the clec2d-klrb1 pathway
|
|
MX2020004967A
(es)
|
2017-11-17 |
2020-08-27 |
Iovance Biotherapeutics Inc |
Expansion de linfocitos infiltrantes del tumor (til) de aspirados con aguja fina y biopsias por puncion.
|
|
JP2021503885A
(ja)
|
2017-11-22 |
2021-02-15 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
末梢血からの末梢血リンパ球(pbl)の拡大培養
|
|
WO2019106163A1
(en)
|
2017-12-01 |
2019-06-06 |
Cellectis |
Reprogramming of genetically engineered primary immune cells
|
|
JP2021507561A
(ja)
|
2017-12-14 |
2021-02-22 |
フロデザイン ソニックス, インク.Flodesign Sonics, Inc. |
音響トランスデューサドライバ及びコントローラ
|
|
EP3724214A4
(en)
|
2017-12-15 |
2021-09-01 |
The Broad Institute Inc. |
SYSTEMS AND METHODS FOR PREDICTING REPAIR RESULTS IN GENETIC ENGINEERING
|
|
WO2019126186A1
(en)
|
2017-12-18 |
2019-06-27 |
Neon Therapeutics, Inc. |
Neoantigens and uses thereof
|
|
WO2019126358A1
(en)
*
|
2017-12-22 |
2019-06-27 |
Cell Design Labs, Inc. |
Single- and multi-chain chimeric antigen receptors
|
|
KR20250048610A
(ko)
|
2017-12-22 |
2025-04-09 |
페이트 세러퓨틱스, 인코포레이티드 |
향상된 면역 효과기 세포 및 이의 용도
|
|
WO2019119822A1
(en)
*
|
2017-12-23 |
2019-06-27 |
Uwell Biopharma Inc. |
Pharmaceutical chimeric receptor composition and method thereof
|
|
WO2019129850A1
(en)
|
2017-12-29 |
2019-07-04 |
Cellectis |
Off-the-shelf engineered cells for therapy
|
|
WO2019129851A1
(en)
|
2017-12-29 |
2019-07-04 |
Cellectis |
Method for improving production of car t cells
|
|
US11994512B2
(en)
|
2018-01-04 |
2024-05-28 |
Massachusetts Institute Of Technology |
Single-cell genomic methods to generate ex vivo cell systems that recapitulate in vivo biology with improved fidelity
|
|
WO2019136459A1
(en)
|
2018-01-08 |
2019-07-11 |
Iovance Biotherapeutics, Inc. |
Processes for generating til products enriched for tumor antigen-specific t-cells
|
|
US11713446B2
(en)
|
2018-01-08 |
2023-08-01 |
Iovance Biotherapeutics, Inc. |
Processes for generating TIL products enriched for tumor antigen-specific T-cells
|
|
EP3508499A1
(en)
|
2018-01-08 |
2019-07-10 |
iOmx Therapeutics AG |
Antibodies targeting, and other modulators of, an immunoglobulin gene associated with resistance against anti-tumour immune responses, and uses thereof
|
|
JP2021509586A
(ja)
|
2018-01-08 |
2021-04-01 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
腫瘍抗原特異的t細胞について濃縮されたtil製品を生成するためのプロセス
|
|
CN112292138A
(zh)
|
2018-01-22 |
2021-01-29 |
西雅图儿童医院(Dba西雅图儿童研究所) |
Car t细胞的使用方法
|
|
AU2019216269B2
(en)
|
2018-01-30 |
2025-05-01 |
Cellectis |
Combination comprising allogeneic immune cells deficient for an antigen present on both T-cells and pathological cells and therapeutic antibody against said antigen
|
|
GB201801920D0
(en)
*
|
2018-02-06 |
2018-03-21 |
Autolus Ltd |
Polypeptides and methods
|
|
SG11202007426XA
(en)
|
2018-02-06 |
2020-09-29 |
Seattle Childrens Hospital Dba Seattle Childrens Res Inst |
Fluorescein-specific cars exhibiting optimal t cell function against fl-ple labelled tumors
|
|
EP3749687A4
(en)
*
|
2018-02-11 |
2021-12-29 |
Memorial Sloan Kettering Cancer Center |
Non-hla restricted t cell receptors and uses thereof
|
|
EP3755349A4
(en)
|
2018-02-21 |
2021-11-17 |
Board of Regents, The University of Texas System |
PROCESS FOR ACTIVATION AND EXPANSION OF NATURAL KILLER CELLS AND THEIR USES
|
|
WO2019165237A1
(en)
|
2018-02-23 |
2019-08-29 |
Endocyte, Inc. |
Sequencing method for car t cell therapy
|
|
US20210361704A1
(en)
*
|
2018-03-09 |
2021-11-25 |
TCR2 Therapeutics Inc. |
Compositions and methods for tcr reprogramming using fusion proteins
|
|
US20210017248A1
(en)
*
|
2018-03-16 |
2021-01-21 |
The Regents Of The University Of California |
Cellular signaling domain engineering in chimeric antigen receptor-modified regulatory t cells
|
|
JP7575271B2
(ja)
|
2018-03-29 |
2024-10-29 |
フェイト セラピューティクス,インコーポレイテッド |
操作された免疫エフェクター細胞およびその使用
|
|
RU2020135968A
(ru)
|
2018-04-05 |
2022-05-06 |
Джуно Терапьютикс, Инк. |
T-клеточные рецепторы и модифицированные клетки, экспрессирующие
|
|
US20210015869A1
(en)
|
2018-04-05 |
2021-01-21 |
Juno Therapeutics, Inc. |
T cells expressing a recombinant receptor, related polynucleotides and methods
|
|
CN112585276A
(zh)
|
2018-04-05 |
2021-03-30 |
朱诺治疗学股份有限公司 |
产生表达重组受体的细胞的方法和相关组合物
|
|
IL277883B2
(en)
|
2018-04-12 |
2023-12-01 |
Prec Biosciences Inc |
Optimized engineered nucleases having specificity for the human t cell receptor alpha constant region gene
|
|
US11957695B2
(en)
|
2018-04-26 |
2024-04-16 |
The Broad Institute, Inc. |
Methods and compositions targeting glucocorticoid signaling for modulating immune responses
|
|
WO2019210131A1
(en)
|
2018-04-27 |
2019-10-31 |
Iovance Biotherapeutics, Inc. |
Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy
|
|
PE20210666A1
(es)
|
2018-05-11 |
2021-03-31 |
Crispr Therapeutics Ag |
Metodos y composiciones para tratar el cancer
|
|
US12157760B2
(en)
|
2018-05-23 |
2024-12-03 |
The Broad Institute, Inc. |
Base editors and uses thereof
|
|
WO2019232542A2
(en)
|
2018-06-01 |
2019-12-05 |
Massachusetts Institute Of Technology |
Methods and compositions for detecting and modulating microenvironment gene signatures from the csf of metastasis patients
|
|
US12036240B2
(en)
|
2018-06-14 |
2024-07-16 |
The Broad Institute, Inc. |
Compositions and methods targeting complement component 3 for inhibiting tumor growth
|
|
JP7534962B2
(ja)
|
2018-06-19 |
2024-08-15 |
ビオンテック ユーエス インコーポレイテッド |
ネオ抗原およびその使用
|
|
US20210268028A1
(en)
|
2018-07-02 |
2021-09-02 |
Cellectis |
Chimeric antigen receptors (car)-expressing cells and combination treatment for immunotherapy of patients with relapse refractory adverse genetic risk aml
|
|
DK3823665T5
(da)
|
2018-07-19 |
2024-08-19 |
Regeneron Pharma |
Kimæriske antigenreceptorer med BCMA-specificitet og anvendelser deraf
|
|
CN119661659A
(zh)
*
|
2018-07-26 |
2025-03-21 |
南京传奇生物科技有限公司 |
含有nef的t细胞及其产生方法
|
|
WO2020068304A2
(en)
|
2018-08-20 |
2020-04-02 |
The Broad Institute, Inc. |
Inhibitors of rna-guided nuclease target binding and uses thereof
|
|
WO2020041387A1
(en)
|
2018-08-20 |
2020-02-27 |
The Brigham And Women's Hospital, Inc. |
Degradation domain modifications for spatio-temporal control of rna-guided nucleases
|
|
WO2020041384A1
(en)
|
2018-08-20 |
2020-02-27 |
The Broad Institute, Inc. |
3-phenyl-2-cyano-azetidine derivatives, inhibitors of rna-guided nuclease activity
|
|
CN112639102B
(zh)
|
2018-08-29 |
2024-03-01 |
南京传奇生物科技有限公司 |
抗间皮素嵌合抗原受体(car)构建体及其用途
|
|
KR20210068478A
(ko)
|
2018-09-28 |
2021-06-09 |
메사추세츠 인스티튜트 오브 테크놀로지 |
콜라겐-국재화된 면역조정성 분자 및 그의 방법
|
|
US20210382068A1
(en)
|
2018-10-02 |
2021-12-09 |
Dana-Farber Cancer Institute, Inc. |
Hla single allele lines
|
|
US20210379057A1
(en)
|
2018-10-16 |
2021-12-09 |
Massachusetts Institute Of Technology |
Nutlin-3a for use in treating a mycobacterium tuberculosis infection
|
|
US12281338B2
(en)
|
2018-10-29 |
2025-04-22 |
The Broad Institute, Inc. |
Nucleobase editors comprising GeoCas9 and uses thereof
|
|
MX2021004775A
(es)
|
2018-11-05 |
2021-06-08 |
Iovance Biotherapeutics Inc |
Expansion de linfocitos infiltrantes de tumores (tils) usando inhibidores de la via de proteina cinasa b (akt).
|
|
ES3021682T3
(en)
|
2018-11-05 |
2025-05-27 |
Iovance Biotherapeutics Inc |
Tumour infiltrating lymphocytes for use in treating nsclc patients refractory to anti-pd-1 antibodies
|
|
JP2022506586A
(ja)
|
2018-11-05 |
2022-01-17 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
腫瘍浸潤リンパ球の産生のためのプロセスおよび免疫療法におけるその使用
|
|
AU2019375416A1
(en)
|
2018-11-05 |
2021-05-27 |
Iovance Biotherapeutics, Inc. |
Selection of improved tumor reactive T-cells
|
|
EP3876977A1
(en)
|
2018-11-06 |
2021-09-15 |
The Regents Of The University Of California |
Chimeric antigen receptors for phagocytosis
|
|
WO2020099572A1
(en)
*
|
2018-11-14 |
2020-05-22 |
Fundación Pública Andaluza Progreso Y Salud |
Polynucleotide for safer and more effective immunotherapies
|
|
AU2019386140A1
(en)
|
2018-11-28 |
2021-06-24 |
Board Of Regents, The University Of Texas System |
Multiplex genome editing of immune cells to enhance functionality and resistance to suppressive environment
|
|
MX2021006393A
(es)
|
2018-11-29 |
2021-10-13 |
Univ Texas |
Metodos para expansion ex vivo de celulas exterminadoras naturales y uso de las mismas.
|
|
US20200268797A1
(en)
|
2018-11-30 |
2020-08-27 |
Janssen Biotech, Inc. |
Gamma delta t cells and uses thereof
|
|
MX2021006194A
(es)
|
2018-12-02 |
2021-06-30 |
Fate Therapeutics Inc |
Inmunoterapias mediante el uso de celulas efectoras potenciadas derivadas de ipsc.
|
|
US12404500B2
(en)
|
2018-12-10 |
2025-09-02 |
Novo Nordisk A/S |
Homing endonuclease variants
|
|
WO2020131586A2
(en)
|
2018-12-17 |
2020-06-25 |
The Broad Institute, Inc. |
Methods for identifying neoantigens
|
|
US20220193131A1
(en)
|
2018-12-19 |
2022-06-23 |
Iovance Biotherapeutics, Inc. |
Methods of Expanding Tumor Infiltrating Lymphocytes Using Engineered Cytokine Receptor Pairs and Uses Thereof
|
|
US11739156B2
(en)
|
2019-01-06 |
2023-08-29 |
The Broad Institute, Inc. Massachusetts Institute of Technology |
Methods and compositions for overcoming immunosuppression
|
|
US12351837B2
(en)
|
2019-01-23 |
2025-07-08 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
BR112021016875A2
(pt)
|
2019-03-01 |
2022-01-04 |
Iovance Biotherapeutics Inc |
Processo para expansão de linfócitos de sangue periférico
|
|
US20220154282A1
(en)
|
2019-03-12 |
2022-05-19 |
The Broad Institute, Inc. |
Detection means, compositions and methods for modulating synovial sarcoma cells
|
|
EP3942023A1
(en)
|
2019-03-18 |
2022-01-26 |
The Broad Institute, Inc. |
Compositions and methods for modulating metabolic regulators of t cell pathogenicity
|
|
GB2601617B
(en)
|
2019-03-19 |
2024-02-21 |
Broad Inst Inc |
Methods and compositions for editing nucleotide sequences
|
|
KR20210144679A
(ko)
*
|
2019-03-21 |
2021-11-30 |
알로젠 테라퓨틱스 인코포레이티드 |
TCRαβ+ 세포 고갈 효율을 향상시키는 방법
|
|
KR20240122580A
(ko)
|
2019-04-03 |
2024-08-12 |
프리시젼 바이오사이언시스 인코포레이티드 |
마이크로RNA-적응 shRNA(shRNAmiR)를 포함하는 유전자-변형 면역 세포
|
|
US12473543B2
(en)
|
2019-04-17 |
2025-11-18 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
JP7664180B2
(ja)
*
|
2019-04-26 |
2025-04-17 |
アロジーン セラピューティクス,インコーポレイテッド |
リツキシマブ耐性キメラ抗原受容体およびその用途
|
|
US11013764B2
(en)
|
2019-04-30 |
2021-05-25 |
Myeloid Therapeutics, Inc. |
Engineered phagocytic receptor compositions and methods of use thereof
|
|
EA202192975A1
(ru)
|
2019-04-30 |
2022-02-01 |
Криспр Терапьютикс Аг |
Аллогенная клеточная терапия b-клеточных злокачественных новообразований с применением генетически сконструированных т-клеток, нацеливающихся на cd19
|
|
EP3736330A1
(en)
|
2019-05-08 |
2020-11-11 |
European Molecular Biology Laboratory |
Modified adeno-associated virus (aav) particles for gene therapy
|
|
US20220249559A1
(en)
|
2019-05-13 |
2022-08-11 |
Iovance Biotherapeutics, Inc. |
Methods and compositions for selecting tumor infiltrating lymphocytes and uses of the same in immunotherapy
|
|
US20220235340A1
(en)
|
2019-05-20 |
2022-07-28 |
The Broad Institute, Inc. |
Novel crispr-cas systems and uses thereof
|
|
WO2020243371A1
(en)
|
2019-05-28 |
2020-12-03 |
Massachusetts Institute Of Technology |
Methods and compositions for modulating immune responses
|
|
CA3142425A1
(en)
*
|
2019-06-01 |
2020-12-10 |
Sivec Biotechnologies, Llc |
A bacterial platform for delivery of gene-editing systems to eukaryotic cells
|
|
EP3990491A1
(en)
|
2019-06-26 |
2022-05-04 |
Massachusetts Institute of Technology |
Immunomodulatory fusion protein-metal hydroxide complexes and methods thereof
|
|
WO2021005009A1
(en)
|
2019-07-05 |
2021-01-14 |
Iomx Therapeutics Ag |
Antibodies binding igc2 of igsf11 (vsig3) and uses thereof
|
|
US20220251572A1
(en)
|
2019-07-23 |
2022-08-11 |
Mnemo Therapeutics |
Immune cells defective for suv39h1
|
|
PH12022550102A1
(en)
|
2019-07-24 |
2022-11-21 |
Regeneron Pharma |
Chimeric antigen receptors with mage-a4 specificity and uses thereof
|
|
WO2021030627A1
(en)
|
2019-08-13 |
2021-02-18 |
The General Hospital Corporation |
Methods for predicting outcomes of checkpoint inhibition and treatment thereof
|
|
US12421557B2
(en)
|
2019-08-16 |
2025-09-23 |
The Broad Institute, Inc. |
Methods for predicting outcomes and treating colorectal cancer using a cell atlas
|
|
CA3148179A1
(en)
*
|
2019-08-20 |
2021-02-25 |
Bruce J. Mccreedy Jr. |
Lymphodepletion dosing regimens for cellular immunotherapies
|
|
CN114514242A
(zh)
|
2019-08-27 |
2022-05-17 |
詹森生物科技公司 |
嵌合抗原受体系统及其用途
|
|
US20220298501A1
(en)
|
2019-08-30 |
2022-09-22 |
The Broad Institute, Inc. |
Crispr-associated mu transposase systems
|
|
MX2022002613A
(es)
|
2019-09-03 |
2022-06-02 |
Myeloid Therapeutics Inc |
Metodos y composiciones para la integracion del genoma.
|
|
AU2020345943A1
(en)
|
2019-09-10 |
2022-03-31 |
Obsidian Therapeutics, Inc. |
CA2-IL15 fusion proteins for tunable regulation
|
|
WO2021061648A1
(en)
|
2019-09-23 |
2021-04-01 |
Massachusetts Institute Of Technology |
Methods and compositions for stimulation of endogenous t cell responses
|
|
US12297426B2
(en)
|
2019-10-01 |
2025-05-13 |
The Broad Institute, Inc. |
DNA damage response signature guided rational design of CRISPR-based systems and therapies
|
|
US12394502B2
(en)
|
2019-10-02 |
2025-08-19 |
The General Hospital Corporation |
Method for predicting HLA-binding peptides using protein structural features
|
|
US11981922B2
(en)
|
2019-10-03 |
2024-05-14 |
Dana-Farber Cancer Institute, Inc. |
Methods and compositions for the modulation of cell interactions and signaling in the tumor microenvironment
|
|
US12195725B2
(en)
|
2019-10-03 |
2025-01-14 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for modulating and detecting tissue specific TH17 cell pathogenicity
|
|
US11793787B2
(en)
|
2019-10-07 |
2023-10-24 |
The Broad Institute, Inc. |
Methods and compositions for enhancing anti-tumor immunity by targeting steroidogenesis
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
CA3151961A1
(en)
|
2019-10-18 |
2021-04-22 |
Mohammadreza PAKYARI |
Cal-t constructs and uses thereof
|
|
EP4048295A1
(en)
|
2019-10-25 |
2022-08-31 |
Iovance Biotherapeutics, Inc. |
Gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy
|
|
US11844800B2
(en)
|
2019-10-30 |
2023-12-19 |
Massachusetts Institute Of Technology |
Methods and compositions for predicting and preventing relapse of acute lymphoblastic leukemia
|
|
AR120538A1
(es)
*
|
2019-11-25 |
2022-02-23 |
Univ Kyoto |
Banco de células maestras de células t
|
|
JP2023504081A
(ja)
*
|
2019-11-27 |
2023-02-01 |
ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム |
神経膠芽細胞腫及び他の癌を処置するためのナチュラルキラー細胞免疫療法
|
|
JP7749561B2
(ja)
|
2019-12-11 |
2025-10-06 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
腫瘍浸潤リンパ球(til)の産生のためのプロセス及びそれを使用する方法
|
|
US10980836B1
(en)
|
2019-12-11 |
2021-04-20 |
Myeloid Therapeutics, Inc. |
Therapeutic cell compositions and methods of manufacturing and use thereof
|
|
CA3161488A1
(en)
*
|
2019-12-11 |
2021-06-17 |
Daniel Getts |
Therapeutic cell compositions and methods for manufacture and uses thereof
|
|
WO2021130250A1
(en)
|
2019-12-23 |
2021-07-01 |
Cellectis |
New mesothelin specific chimeric antigen receptors (car) for solid tumors cancer immunotherapy
|
|
US11865168B2
(en)
|
2019-12-30 |
2024-01-09 |
Massachusetts Institute Of Technology |
Compositions and methods for treating bacterial infections
|
|
US20230076768A1
(en)
|
2020-01-14 |
2023-03-09 |
Synthekine, Inc. |
IL2 Orthologs and Methods of Use
|
|
US20230340537A1
(en)
|
2020-01-17 |
2023-10-26 |
The Broad Institute, Inc. |
Small type ii-d cas proteins and methods of use thereof
|
|
US12165747B2
(en)
|
2020-01-23 |
2024-12-10 |
The Broad Institute, Inc. |
Molecular spatial mapping of metastatic tumor microenvironment
|
|
CN115175929A
(zh)
|
2020-02-24 |
2022-10-11 |
艾洛基治疗公司 |
活性增强的bcma car-t细胞
|
|
CN115552015A
(zh)
*
|
2020-02-28 |
2022-12-30 |
香港中文大学 |
经由同时敲入和基因破坏来改造免疫细胞
|
|
KR20220150918A
(ko)
|
2020-03-03 |
2022-11-11 |
얀센 바이오테크 인코포레이티드 |
γδ T 세포 및 이의 용도
|
|
KR20240096884A
(ko)
|
2020-03-10 |
2024-06-26 |
매사추세츠 인스티튜트 오브 테크놀로지 |
조작된 기억-유사 nk 세포 및 이의 조성물을 생성하기 위한 방법
|
|
EP4118112A1
(en)
|
2020-03-10 |
2023-01-18 |
Massachusetts Institute of Technology |
Compositions and methods for immunotherapy of npm1c-positive cancer
|
|
CN113402612A
(zh)
|
2020-03-17 |
2021-09-17 |
西比曼生物科技(香港)有限公司 |
靶向cd19和cd20的联合嵌合抗原受体及其应用
|
|
US20210340524A1
(en)
|
2020-05-01 |
2021-11-04 |
Massachusetts Institute Of Technology |
Methods for identifying chimeric antigen receptor-targeting ligands and uses thereof
|
|
US12433954B2
(en)
|
2020-05-01 |
2025-10-07 |
Massachusetts Institute Of Technology |
Methods of activating anti-CD19 chimeric antigen receptor (CAR) T cells using amphiphilic ligand conjugates comprising CAR-targeting protein sequence motifs
|
|
JP2023523855A
(ja)
|
2020-05-04 |
2023-06-07 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
腫瘍浸潤リンパ球の製造方法及び免疫療法におけるその使用
|
|
AU2021268253A1
(en)
|
2020-05-06 |
2022-12-08 |
Cellectis S.A. |
Methods for targeted insertion of exogenous sequences in cellular genomes
|
|
DE112021002672T5
(de)
|
2020-05-08 |
2023-04-13 |
President And Fellows Of Harvard College |
Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz
|
|
EP3910331A1
(en)
|
2020-05-15 |
2021-11-17 |
iOmx Therapeutics AG |
Intracellular kinase associated with resistance against t-cell mediated cytotoxicity, and uses thereof
|
|
EP4168538A4
(en)
|
2020-06-19 |
2024-03-20 |
Fate Therapeutics, Inc. |
COMBINATION OF IPSC-DERIVED EFFECTOR CELL TYPES FOR IMMUNOTHERAPY USE
|
|
EP4176261A1
(en)
|
2020-07-03 |
2023-05-10 |
Cellectis S.A. |
Method for determining potency of chimeric antigen receptor expressing immune cells
|
|
US20240010720A1
(en)
|
2020-07-06 |
2024-01-11 |
Iomx Therapeutics Ag |
Antibodies binding igv of igsf11 (vsig3) and uses thereof
|
|
WO2022016119A1
(en)
|
2020-07-17 |
2022-01-20 |
Simurx, Inc. |
Chimeric myd88 receptors for redirecting immunosuppressive signaling and related compositions and methods
|
|
US20230248825A1
(en)
|
2020-07-24 |
2023-08-10 |
Cellectis S.A. |
T-cells expressing immune cell engagers in allogenic settings
|
|
US20230303974A1
(en)
|
2020-07-30 |
2023-09-28 |
Institut Curie |
Immune Cells Defective for SOCS1
|
|
MX2023001244A
(es)
|
2020-07-31 |
2023-05-16 |
Cellectis Sa |
Celulas t que expresan dos car.
|
|
US20220031751A1
(en)
|
2020-08-03 |
2022-02-03 |
Kyverna Therapeutics, Inc. |
Methods of producing t regulatory cells, methods of transducing t cells, and uses of the same
|
|
US20230321239A1
(en)
|
2020-08-14 |
2023-10-12 |
H. Lee Moffitt Cancer Center And Research Institute Inc. |
Chimeric antigen receptor t cells for treating autoimmunity
|
|
WO2022076606A1
(en)
|
2020-10-06 |
2022-04-14 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
|
|
US20230372397A1
(en)
|
2020-10-06 |
2023-11-23 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
|
|
GB2617474A
(en)
|
2020-11-04 |
2023-10-11 |
Myeloid Therapeutics Inc |
Engineered chimeric fusion protein compositions and methods of use thereof
|
|
CA3201533A1
(en)
|
2020-11-11 |
2022-05-19 |
European Molecular Biology Laboratory |
Modified viral particles for gene therapy
|
|
WO2022109277A1
(en)
*
|
2020-11-20 |
2022-05-27 |
Pact Pharma, Inc. |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER USING A TGFβRII ENGINEERED T CELL THERAPY
|
|
US20220162288A1
(en)
|
2020-11-25 |
2022-05-26 |
Catamaran Bio, Inc. |
Cellular therapeutics engineered with signal modulators and methods of use thereof
|
|
EP4251746A1
(en)
|
2020-11-30 |
2023-10-04 |
Cellectis SA |
Use of aminoquinoline compounds for higher gene integration
|
|
EP4255922A1
(en)
|
2020-12-03 |
2023-10-11 |
Century Therapeutics, Inc. |
Genetically engineered cells and uses thereof
|
|
US11661459B2
(en)
|
2020-12-03 |
2023-05-30 |
Century Therapeutics, Inc. |
Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
|
|
WO2022133149A1
(en)
|
2020-12-17 |
2022-06-23 |
Iovance Biotherapeutics, Inc. |
Treatment of cancers with tumor infiltrating lymphocytes
|
|
US20240299539A1
(en)
|
2020-12-17 |
2024-09-12 |
Iovance Biotherapeutics, Inc. |
Treatment with tumor infiltrating lymphocyte therapies in combination with ctla-4 and pd-1 inhibitors
|
|
JP2024500847A
(ja)
|
2020-12-18 |
2024-01-10 |
センチュリー セラピューティクス,インコーポレイテッド |
適合可能な受容体特異性を有するキメラ抗原受容体システム
|
|
JP2024500511A
(ja)
*
|
2020-12-23 |
2024-01-09 |
広東菲鵬制▲薬▼股▲ふん▼有限公司 |
抗pd-l1抗体及びその使用
|
|
TW202242117A
(zh)
|
2020-12-30 |
2022-11-01 |
美商亞勞諾斯醫療公司 |
包含多順反子表現卡匣之重組載體及其使用方法
|
|
EP4274907A4
(en)
|
2021-01-08 |
2025-01-15 |
Cellanome, Inc. |
DEVICES AND METHODS FOR THE ANALYSIS OF BIOLOGICAL SAMPLES
|
|
EP4284919A1
(en)
|
2021-01-29 |
2023-12-06 |
Iovance Biotherapeutics, Inc. |
Methods of making modified tumor infiltrating lymphocytes and their use in adoptive cell therapy
|
|
WO2022165419A1
(en)
|
2021-02-01 |
2022-08-04 |
Kyverna Therapeutics, Inc. |
Methods for increasing t-cell function
|
|
GB2623191A
(en)
|
2021-03-17 |
2024-04-10 |
Myeloid Therapeutics Inc |
Engineered chimeric fusion protein compositions and methods of use thereof
|
|
TW202304480A
(zh)
|
2021-03-19 |
2023-02-01 |
美商艾歐凡斯生物治療公司 |
腫瘤浸潤淋巴球(til)中之與cd39/cd69選擇及基因剔除相關之til擴增之方法
|
|
CN118019546A
(zh)
|
2021-03-23 |
2024-05-10 |
艾欧凡斯生物治疗公司 |
肿瘤浸润淋巴细胞的cish基因编辑及其在免疫疗法中的用途
|
|
JP2024515189A
(ja)
|
2021-04-19 |
2024-04-05 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
細胞免疫療法におけるキメラ共刺激受容体、ケモカイン受容体、及びそれらの使用
|
|
MX2023012760A
(es)
|
2021-04-30 |
2023-11-13 |
Cellectis Sa |
Nuevos cars anti-muc1 y celulas inmunitarias editadas geneticamente para inmunoterapia contra el cancer de tumores solidos.
|
|
KR20240005854A
(ko)
|
2021-05-04 |
2024-01-12 |
리제너론 파아마슈티컬스, 인크. |
Mage-a4 특이성을 갖는 키메라 항원 수용체 및 이들의 용도
|
|
GB2623653A
(en)
|
2021-05-11 |
2024-04-24 |
Myeloid Therapeutics Inc |
Methods and compositions for genomic integration
|
|
JP2024519029A
(ja)
|
2021-05-17 |
2024-05-08 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
Pd-1遺伝子編集された腫瘍浸潤リンパ球及び免疫療法におけるその使用
|
|
CA3218475A1
(en)
|
2021-05-21 |
2022-11-24 |
Shipra DAS |
Enhancing efficacy of t-cell-mediated immunotherapy by modulating cancer-associated fibroblasts in solid tumors
|
|
WO2022266203A1
(en)
|
2021-06-15 |
2022-12-22 |
Allogene Therapeutics, Inc. |
Selective targeting of host cd70+ alloreactive cells to prolong allogeneic car t cell persistence
|
|
EP4370139A4
(en)
|
2021-07-14 |
2025-10-15 |
Synthekine Inc |
METHODS AND COMPOSITIONS FOR USE IN CELL THERAPY FOR NEOPLASTIC DISEASE
|
|
US20240365776A1
(en)
|
2021-07-22 |
2024-11-07 |
Iovance Biotherapeutics, Inc |
Method for cryopreservation of solid tumor fragments
|
|
WO2023009716A1
(en)
|
2021-07-28 |
2023-02-02 |
Iovance Biotherapeutics, Inc. |
Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with kras inhibitors
|
|
JP2024528029A
(ja)
|
2021-07-29 |
2024-07-26 |
武田薬品工業株式会社 |
メソテリンを特異的に標的とする操作された免疫細胞及びその使用
|
|
IL310550A
(en)
|
2021-08-04 |
2024-03-01 |
Univ Colorado Regents |
LAT-activating chimeric antigen receptor T cells and methods of using them
|
|
KR20240109615A
(ko)
|
2021-09-09 |
2024-07-11 |
이오반스 바이오테라퓨틱스, 인크. |
Pd-1 talen 녹다운을 사용한 til 생성물의 생성 방법
|
|
JP2024541911A
(ja)
|
2021-10-27 |
2024-11-13 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
患者特異的免疫療法のための細胞の製造を調整するためのシステム及び方法
|
|
WO2023081715A1
(en)
|
2021-11-03 |
2023-05-11 |
Viracta Therapeutics, Inc. |
Combination of car t-cell therapy with btk inhibitors and methods of use thereof
|
|
WO2023081900A1
(en)
|
2021-11-08 |
2023-05-11 |
Juno Therapeutics, Inc. |
Engineered t cells expressing a recombinant t cell receptor (tcr) and related systems and methods
|
|
MX2024006051A
(es)
|
2021-11-23 |
2024-06-26 |
Cellectis Sa |
Nuevos andamios de proteinas tale con relaciones de actividad en objetivo/fuera de objetivo mejoradas.
|
|
WO2023126458A1
(en)
|
2021-12-28 |
2023-07-06 |
Mnemo Therapeutics |
Immune cells with inactivated suv39h1 and modified tcr
|
|
WO2023133509A2
(en)
*
|
2022-01-08 |
2023-07-13 |
Carogen Corporation |
Multi-antigen therapeutic vaccines to treat or prevent chronic hepatitis b virus infection
|
|
CA3243419A1
(en)
|
2022-01-28 |
2023-08-03 |
Iovance Biotherapeutics, Inc. |
CYTOKINE-ASSOCIATED TUMOR-INFILTRATING LYMPHOCYTE COMPOSITIONS AND PROCESSES
|
|
CN118891374A
(zh)
|
2022-03-24 |
2024-11-01 |
南京传奇生物科技有限公司 |
制备dna文库和检测逆转录病毒整合位点的方法
|
|
WO2023196877A1
(en)
|
2022-04-06 |
2023-10-12 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
|
|
CA3247423A1
(en)
|
2022-04-08 |
2023-10-12 |
Fate Therapeutics, Inc. |
CELLS WITH A SOLID TUMOR-TARGETING SKELETON AND THEIR USE
|
|
US20250222029A1
(en)
|
2022-04-08 |
2025-07-10 |
Fate Therapeutics, Inc. |
Chimeric antigen receptor for tumor targeting
|
|
EP4507704A1
(en)
|
2022-04-15 |
2025-02-19 |
Iovance Biotherapeutics, Inc. |
Til expansion processes using specific cytokine combinations and/or akti treatment
|
|
CA3251533A1
(en)
|
2022-05-10 |
2023-11-16 |
Iovance Biotherapeutics, Inc. |
TREATMENT OF CANCER PATIENTS WITH TUMOR-INFILTRATING LYMPHOCYTE THERAPIES IN COMBINATION WITH AN IL-15R AGONIST
|
|
EP4279085A1
(en)
|
2022-05-20 |
2023-11-22 |
Mnemo Therapeutics |
Compositions and methods for treating a refractory or relapsed cancer or a chronic infectious disease
|
|
AU2023279849A1
(en)
|
2022-06-03 |
2024-12-05 |
Cellectis Sa |
Tale base editors for gene and cell therapy
|
|
US20250281613A1
(en)
|
2022-06-30 |
2025-09-11 |
Cellectis S.A. |
Enhancing safety of t-cell-mediated immunotherapy
|
|
JP2025524921A
(ja)
*
|
2022-07-29 |
2025-08-01 |
レジェンド バイオテック アイルランド リミテッド |
細胞療法の持続性を促進するための方法
|
|
WO2024055018A1
(en)
|
2022-09-09 |
2024-03-14 |
Iovance Biotherapeutics, Inc. |
Processes for generating til products using pd-1/tigit talen double knockdown
|
|
CA3267168A1
(en)
|
2022-09-09 |
2024-03-14 |
Laurent Poirot |
PROCESSES FOR GENERING TIL PRODUCTS USING DOUBLE INACTIVATION OF TALEN PD-1/TIGIT
|
|
AU2023347814A1
(en)
*
|
2022-09-19 |
2025-04-10 |
Emendobio Inc. |
Biallelic knockout of ctla4
|
|
WO2024062138A1
(en)
|
2022-09-23 |
2024-03-28 |
Mnemo Therapeutics |
Immune cells comprising a modified suv39h1 gene
|
|
WO2024077256A1
(en)
|
2022-10-07 |
2024-04-11 |
The General Hospital Corporation |
Methods and compositions for high-throughput discovery ofpeptide-mhc targeting binding proteins
|
|
WO2024094775A1
(en)
|
2022-11-03 |
2024-05-10 |
Cellectis S.A. |
Enhancing efficacy and safety of t-cell-mediated immunotherapy
|
|
WO2024098024A1
(en)
|
2022-11-04 |
2024-05-10 |
Iovance Biotherapeutics, Inc. |
Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof
|
|
EP4612277A1
(en)
|
2022-11-04 |
2025-09-10 |
Iovance Biotherapeutics, Inc. |
Methods for tumor infiltrating lymphocyte (til) expansion related to cd39/cd103 selection
|
|
WO2024112711A2
(en)
|
2022-11-21 |
2024-05-30 |
Iovance Biotherapeutics, Inc. |
Methods for assessing proliferation potency of gene-edited t cells
|
|
EP4623072A2
(en)
|
2022-11-21 |
2025-10-01 |
Iovance Biotherapeutics, Inc. |
Two-dimensional processes for the expansion of tumor infiltrating lymphocytes and therapies therefrom
|
|
WO2024118836A1
(en)
|
2022-11-30 |
2024-06-06 |
Iovance Biotherapeutics, Inc. |
Processes for production of tumor infiltrating lymphocytes with shortened rep step
|
|
WO2024124044A1
(en)
|
2022-12-07 |
2024-06-13 |
The Brigham And Women’S Hospital, Inc. |
Compositions and methods targeting sat1 for enhancing anti¬ tumor immunity during tumor progression
|
|
WO2024121385A1
(en)
|
2022-12-09 |
2024-06-13 |
Cellectis S.A. |
Two-dose regimen in immunotherapy
|
|
CN116284370B
(zh)
*
|
2023-02-27 |
2024-05-28 |
南京立顶医疗科技有限公司 |
一种多聚体糖化血红蛋白单克隆抗体及制备方法
|
|
WO2024246301A1
(en)
|
2023-06-02 |
2024-12-05 |
Cellectis Sa |
Methods for identifying tale base editors off-sites
|
|
AU2024311741A1
(en)
|
2023-06-20 |
2025-12-18 |
Allogene Therapeutics, Inc. |
Methods of detection for engineered cells
|
|
TW202511280A
(zh)
|
2023-07-21 |
2025-03-16 |
義大利商博雷亞醫療有限責任公司 |
製備表面修飾之病毒外殼之方法
|
|
TW202519537A
(zh)
|
2023-07-21 |
2025-05-16 |
義大利商博雷亞醫療有限責任公司 |
經化學遺傳表面修飾之病毒顆粒
|
|
LU504827B1
(en)
|
2023-07-28 |
2025-01-28 |
Univ Saarland |
Compounds and compositions for use in the treatment of lung diseases
|
|
CN116987699B
(zh)
*
|
2023-09-05 |
2024-08-27 |
深圳市艾迪贝克生物医药有限公司 |
用于制备通用型car-t细胞的基因片段、其工具系统及应用
|
|
EP4520334A1
(en)
|
2023-09-07 |
2025-03-12 |
Mnemo Therapeutics |
Methods and compositions for improving immune response
|
|
WO2025054540A1
(en)
|
2023-09-08 |
2025-03-13 |
Iovance Biotherapeutics, Inc. |
Methods of gene-editing using programmable nucleases
|
|
WO2025059533A1
(en)
|
2023-09-13 |
2025-03-20 |
The Broad Institute, Inc. |
Crispr enzymes and systems
|
|
WO2025072571A1
(en)
|
2023-09-27 |
2025-04-03 |
Cellanome, Inc. |
Cell culture within microfluidic structures
|
|
CN117164714B
(zh)
*
|
2023-10-08 |
2024-04-23 |
北京奇迈永华生物科技有限公司 |
一种靶向bcma的抗体及其应用
|
|
WO2025097055A2
(en)
|
2023-11-02 |
2025-05-08 |
The Broad Institute, Inc. |
Compositions and methods of use of t cells in immunotherapy
|
|
WO2025101484A1
(en)
|
2023-11-06 |
2025-05-15 |
Iovance Biotherapeutics, Inc. |
Treatment of endometrial cancers with tumor infiltrating lymphocyte therapies
|
|
WO2025117544A1
(en)
|
2023-11-29 |
2025-06-05 |
The Broad Institute, Inc. |
Engineered omega guide molecule and iscb compositions, systems, and methods of use thereof
|
|
WO2025163107A1
(en)
|
2024-02-01 |
2025-08-07 |
Institut Gustave Roussy |
Immune cells defective for znf217 and uses thereof
|
|
WO2025171182A1
(en)
|
2024-02-08 |
2025-08-14 |
Iovance Biotherapeutics, Inc. |
Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with cancer vaccine
|
|
WO2025196087A1
(en)
|
2024-03-19 |
2025-09-25 |
Borea Therapeutics S.R.L. |
Targeting tissues in the cns
|
|
CN118027211A
(zh)
*
|
2024-04-11 |
2024-05-14 |
上海惠盾因泰生物科技有限公司 |
一种识别重组egf-crm197疫苗的单克隆抗体及其应用
|
|
WO2025235851A1
(en)
|
2024-05-10 |
2025-11-13 |
Juno Therapeutics, Inc. |
Genetically engineered t cells expressing a cd19 chimeric antigen receptor (car) and uses thereof for allogeneic cell therapy
|
|
CN120058920B
(zh)
*
|
2025-04-29 |
2025-09-09 |
山东省农业科学院家禽研究所(山东省无特定病原鸡研究中心) |
抗s11型鸭疫里默氏杆菌单克隆抗体及其阻断elisa抗体检测试剂盒和应用
|