BR112021018684A2 - Métodos para aumentar a eficiência de esgotamento de células tcr¿¿+ - Google Patents

Métodos para aumentar a eficiência de esgotamento de células tcr¿¿+

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Publication number
BR112021018684A2
BR112021018684A2 BR112021018684A BR112021018684A BR112021018684A2 BR 112021018684 A2 BR112021018684 A2 BR 112021018684A2 BR 112021018684 A BR112021018684 A BR 112021018684A BR 112021018684 A BR112021018684 A BR 112021018684A BR 112021018684 A2 BR112021018684 A2 BR 112021018684A2
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Brazil
Prior art keywords
tcr
methods
efficiency
cell
increase
Prior art date
Application number
BR112021018684A
Other languages
English (en)
Inventor
Hongxiu Ning
M Lee Janet
W Leonard Mark
Yajin Ni
Original Assignee
Allogene Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Allogene Therapeutics Inc filed Critical Allogene Therapeutics Inc
Publication of BR112021018684A2 publication Critical patent/BR112021018684A2/pt

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
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    • A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
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    • C12N2510/00—Genetically modified cells

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  • Organic Chemistry (AREA)
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Abstract

métodos para aumentar a eficiência de esgotamento de células tcraß+ trata-se de métodos melhorados para esgotamento robusto de células tcr+ e produção de populações de células tcr-, que podem ser benéficas para minimizar o risco de gvhd em pacientes que estejam recebendo terapia com células t car alogênicas. são fornecidos aqui métodos que aumentam a eficiência de esgotamento de células tcr+ de uma população de células a fim de reduzir significativamente quaisquer níveis residuais de células tcr+ presentes em populações celulares nas quais a expressão de tcr endógeno foi reduzida ou eliminada. também são fornecidos populações celulares e kits associados.
BR112021018684A 2019-03-21 2020-03-20 Métodos para aumentar a eficiência de esgotamento de células tcr¿¿+ BR112021018684A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962821768P 2019-03-21 2019-03-21
PCT/US2020/024059 WO2020191378A1 (en) 2019-03-21 2020-03-20 METHODS FOR ENHANCING TCRαβ+ CELL DEPLETION EFFICIENCY

Publications (1)

Publication Number Publication Date
BR112021018684A2 true BR112021018684A2 (pt) 2021-11-23

Family

ID=70296049

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021018684A BR112021018684A2 (pt) 2019-03-21 2020-03-20 Métodos para aumentar a eficiência de esgotamento de células tcr¿¿+

Country Status (11)

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US (1) US20200317780A1 (pt)
EP (1) EP3941488A1 (pt)
JP (1) JP2022524958A (pt)
KR (1) KR20210144679A (pt)
CN (1) CN113490502A (pt)
AU (1) AU2020240339A1 (pt)
BR (1) BR112021018684A2 (pt)
CA (1) CA3130701A1 (pt)
IL (1) IL286909A (pt)
MX (1) MX2021010998A (pt)
WO (1) WO2020191378A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4353253A1 (en) * 2022-10-10 2024-04-17 Charité - Universitätsmedizin Berlin Purification of tcr-modified t cells using tcr-specific car-nk cells

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US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
US6319494B1 (en) 1990-12-14 2001-11-20 Cell Genesys, Inc. Chimeric chains for receptor-associated signal transduction pathways
WO1992022653A1 (en) 1991-06-14 1992-12-23 Genentech, Inc. Method for making humanized antibodies
IL104570A0 (en) 1992-03-18 1993-05-13 Yeda Res & Dev Chimeric genes and cells transformed therewith
WO1999029888A1 (en) 1997-12-05 1999-06-17 The Scripps Research Institute Humanization of murine antibody
JP5128935B2 (ja) 2004-03-31 2013-01-23 ジェネンテック， インコーポレイテッド ヒト化抗ＴＧＦ−β抗体
JP2008504821A (ja) * 2004-07-01 2008-02-21 バイレクシス コーポレイション ベクター・パッケージング細胞系列
US10391126B2 (en) * 2011-11-18 2019-08-27 Board Of Regents, The University Of Texas System CAR+ T cells genetically modified to eliminate expression of T-cell receptor and/or HLA
GB201206559D0 (en) 2012-04-13 2012-05-30 Ucl Business Plc Polypeptide
GB2508414A (en) * 2012-11-30 2014-06-04 Max Delbrueck Centrum Tumour specific T cell receptors (TCRs)
IL290744B2 (en) 2014-02-04 2024-10-01 Kite Pharma Inc Methods for the production of autologous T cells used in the treatment of B-cell malignancies and other types of cancer and preparations thereof
MX2017005698A (es) * 2014-10-31 2017-06-29 Univ Pennsylvania Alteracion de la expresion genetica en celulas t modificadas con el receptor de antigeno quimerico (cart) y usos de las mismas.
CA2973642A1 (en) 2015-01-26 2016-08-04 Rinat Neuroscience Corporation Mab-driven chimeric antigen receptor systems for sorting/depleting engineered immune cells
CN109476722A (zh) * 2015-07-21 2019-03-15 诺华股份有限公司 用于改善免疫细胞的功效和扩张的方法
CN107828730B (zh) * 2017-11-07 2019-04-30 南京北恒生物科技有限公司 具有抗体药物抗性的通用型cart/tcrt细胞及其构建方法

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Publication number Publication date
IL286909A (en) 2021-10-31
EP3941488A1 (en) 2022-01-26
CN113490502A (zh) 2021-10-08
US20200317780A1 (en) 2020-10-08
CA3130701A1 (en) 2020-09-24
JP2022524958A (ja) 2022-05-11
KR20210144679A (ko) 2021-11-30
WO2020191378A1 (en) 2020-09-24
AU2020240339A1 (en) 2021-08-26
MX2021010998A (es) 2021-10-13

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